DNA damage, glutathione, and total antioxidant capacity in anesthesia nurses

Publié le 08 février 2011 • Catégorie(s) : Risques chimiques • Mot(s) clef(s) : personnel infirmier

Auteur    Seval Izdes
Auteur    Semra Sardas
Auteur    Ela Kadioglu
Auteur    Ali Esat Karakaya
Résumé    The possibilities of a potential mutagenic/carcinogenic action of waste anesthetic gases in occupationally exposed anesthesia personnel have been previously reported in several studies. The aim of this study was to assess the DNA damage, reduced glutathione (GSH), and total antioxidant capacity (TAC) in anesthesia nurses. DNA damage was determined with comet assay, GSH levels were measured spectrophotometrically, and TAC was determined by using Randox kit. Anesthesia nurses (n = 40) showed increased DNA damage in terms of mean percentage of the total DNA in the comet tail compared to controls (n = 40) (p < .001). Mean TAC and GSH levels of the anesthesia nurses were significantly lower than that of the controls (p < .001, p < .05, respectively). The results of this study indicate that occupational exposure to anesthetic gases induce DNA damage, which may lead to changes in TAC and GSH levels.
Publication    Archives of Environmental & Occupational Health
Volume    65
Numéro    4
Pages    211-217
Date    2010 Oct-Dec