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Dermatitis. 2005 Mar;16(1):22-7.
A topical cream containing a zinc gel (allergy guard) as a prophylactic against latex glove-related contact dermatitis.
‘Modak S, Gaonkar TA, Shintre M, Sampath L, Caraos L, Geraldo I.
College of Physicians and Surgeons of Columbia University, New York, NY.’
BACKGROUND: Many health care workers are sensitized to the proteins in natural rubber latex and get contact dermatitis as a result of wearing latex gloves. OBJECTIVE: The aim of the study was to evaluate a topical formulation containing a zinc gel (Allergy Guard) as a prophylactic against latex glove-related contact dermatitis. METHODS: The study was carried out with volunteers who exhibited mild to moderate contact dermatitis (type IV) after wearing latex gloves as per the protocol. RESULTS: Allergy Guard significantly reduced skin irritation in volunteers who exhibited type IV hypersensitivity when exposed to latex gloves. Allergy Guard also exhibited a barrier effect as shown by the permeation of chlorophyllin dye into the skin of volunteers. Allergy Guard prevented dermal irritation induced by sodium lauryl sulfate. CONCLUSION: Topical formulations containing a zinc gel may be used to delay or prevent latex sensitivity, especially among health care professionals.
MeSH Terms: Administration, Topical – Dermatitis, Occupational/pathology – Dermatitis, Occupational/prevention & control* – Dermatologic Agents/administration & dosage* – Gels – Hand Dermatoses/pathology – Hand Dermatoses/prevention & control* – Humans –
Publication Types: Clinical Trial – Controlled Clinical Trial