Interventions to increase seasonal influenza vaccine coverage in healthcare workers: A systematic review and meta-regression analysis
Auteur Theodore Lytras
Auteur Frixos Kopsachilis
Auteur Elisavet Mouratidou
Auteur Dimitris Papamichail
Auteur Stefanos Bonovas
Volume 12
Numéro 3
Pages 671-681
Publication Human Vaccines & Immunotherapeutics
ISSN 2164-554X
Date Mar 03, 2016
Résumé Influenza vaccination is recommended for healthcare workers (HCWs), but coverage is often low. We reviewed studies evaluating interventions to increase seasonal influenza vaccination coverage in HCWs, including a meta-regression analysis to quantify the effect of each component. Fourty-six eligible studies were identified. Domains conferring a high risk of bias were identified in most studies. Mandatory vaccination was the most effective intervention component (Risk Ratio of being unvaccinated [RRunvacc] = 0.18, 95% CI: 0.08-0.45), followed by « soft » mandates such as declination statements (RRunvacc = 0.64, 95% CI: 0.45-0.92), increased awareness (RRunvacc = 0.83, 95% CI: 0.71-0.97) and increased access (RRunvacc = 0.88, 95% CI: 0.78-1.00). For incentives the difference was not significant, while for education no effect was observed. Heterogeneity was substantial (τ(2) = 0.083). These results indicate that effective alternatives to mandatory HCWs influenza vaccination do exist, and need to be further explored in future studies.
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doi:10.1080/21645515.2015.1106656
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