The response of hepatitis B vaccination on seronegative adults with different vaccination schedules
Auteur Jun Yao
Auteur Jing Li
Auteur Yongdi Chen
Auteur Huan Shan
Auteur Xue-wei Dai
Auteur Lin-na Yang
Auteur Zheng-gang Jiang
Auteur Jing-jing Ren
Auteur Kai-jin Xu
Auteur Bing Ruan
Auteur Shi-gui Yang
Auteur Bing Wang
Auteur Tian-sheng Xie
Auteur Qian Li
Volume 11
Numéro 5
Pages 1102-1107
Publication Human Vaccines & Immunotherapeutics
ISSN 2164-554X
Date 2015
Résumé The purpose of this study was to compare the response of hepatitis B vaccination with different vaccination schedules among seronegative adults, and to provide suitable vaccination schedules for floating and fixed population. The study included adults aged 20 to 39 y without prior history of vaccination with hepatitis B vaccine. The serum samples were collected and tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels. Out of all, 686 adults who were negative for anti-HBs, anti-HBc and HBsAg were vaccinated with 10 ug hepatitis B vaccine at 0, 1 and 3, 6 or 12 month schedules, and their antibody titers were monitored. The rates of completion of the vaccination in floating and fixed population were 90.4% and 94.1% respectively (p = 0.061). The anti-HBs positive rates in adults vaccinated at 0, 1 and 3 ,6 or 12 month were 83.9%, 88.2% and 94.2% respectively (P = 0.0003). The corresponding geometric mean titers (GMTs) were 61.19 (95%CI:47.10-81.23) mIU/mL, 214.04(95%CI:157.14-291.61) mIU/mL and 345.78(95%CI:251.25-475.77) mIU/mL, respectively ( P < 0.0001). Vaccination of hepatitis B with both 0-1-6 and 0-1-12 month schedules in adults result in better level of immune responses. Also, a longer vaccination schedule (0-1-12 month) may be more suitable for floating population and 0-1-6 month schedule is recommended for the fixed population.
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doi:10.4161/21645515.2014.985500
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