A decennial booster dose of reduced antigen content diphtheria, tetanus, acellular pertussis vaccine (Boostrix™) is immunogenic and well tolerated in adults
Auteur Robert Booy
Auteur Olivier Van der Meeren
Auteur Su-Peing Ng
Auteur Froilan Celzo
Auteur Gunasekaran Ramakrishnan
Auteur Jeanne-Marie Jacquet
Résumé Reduced-antigen-content diphtheria-tetanus-acellular-pertussis (dTpa) vaccines are predominantly recommended for once-in-a-lifetime use. A second dTpa (Boostrix™, GlaxoSmithKline Biologicals) administration in 164 adults previously vaccinated with dTpa 10 years previously was evaluated. Before the decennial booster, 89.4% and 94.8% subjects were seroprotected (antibodies ≥0.1 IU/mL) for diphtheria and tetanus, respectively. One-month post-booster, all subjects were seroprotected/seropositive against all vaccine antigens. Robust GMC increases indicated a booster response similar to the first booster. The decennial booster was well tolerated without serious adverse events, consistent with product experience. This study supports replacing traditional Td boosters with dTpa, and use of Boostrix™ as a decennial booster. This study is registered at www.clinicaltrials.com NCT00548171.
Publication Vaccine
Volume 29
Numéro 1
Pages 45-50
Date Dec 10, 2010
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1016/j.vaccine.2010.10.025
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