Successful hepatitis B immunization in non- and low responding health care workers
Auteur Ulrich Heininger
Auteur Muriel Gambon
Auteur Verena Gruber
Auteur Daniela Margelli
Résumé Health care workers (HCW) are at increased risk for acquisition of hepatitis B virus (HBV) infection from occupational exposure. This can be prevented by active immunization. We performed a retrospective chart review of HCW who were persistent low (anti-HBs antibody values <100 U/L) or non responders (<10 U/L) after 6 active immunizations and demonstrate successful immunization (anti-HBs ≥100 U/l) after a total of 8-14 vaccine doses in 13 such HCW by use of various vaccination schedules. This "proof of principle" should encourage occupational health care providers to convince HCW to accept further vaccine doses until the targeted threshold considered to be the correlate of immunity has been reached. Prospective studies should be performed to determine the optimal schedule of further booster doses for HCW who are persistent non or low responders.
Publication Human Vaccines
Volume 6
Numéro 9
Date Sep 19, 2010
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.4161/hv.6.9.12420
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