Veille documentaire MTPH

Auteur     William G Lindsley
Auteur     Francoise M Blachere
Auteur     Kristina A Davis
Auteur     Terri A Pearce
Auteur     Melanie A Fisher
Auteur     Rashida Khakoo
Auteur     Stephen M Davis
Auteur     Mark E Rogers
Auteur     Robert E Thewlis
Auteur     Jose A Posada
Auteur     John B Redrow
Auteur     Ismail B Celik
Auteur     Bean T Chen
Auteur     Donald H Beezhold
Résumé     BACKGROUND: Considerable controversy exists with regard to whether influenza virus and respiratory syncytial virus (RSV) are spread by the inhalation of infectious airborne particles and about the importance of this route, compared with droplet or contact transmission. METHODS: Airborne particles were collected in an urgent care clinic with use of stationary and personal aerosol samplers. The amounts of airborne influenza A, influenza B, and RSV RNA were determined using real-time quantitative polymerase chain reaction. Health care workers and patients participating in the study were tested for influenza. RESULTS: Seventeen percent of the stationary samplers contained influenza A RNA, 1% contained influenza B RNA, and 32% contained RSV RNA. Nineteen percent of the personal samplers contained influenza A RNA, none contained influenza B RNA, and 38% contained RSV RNA. The number of samplers containing influenza RNA correlated well with the number and location of patients with influenza (r= 0.77). Forty-two percent of the influenza A RNA was in particles < or = 4.1 microm in aerodynamic diameter, and 9% of the RSV RNA was in particles < or = 4.1 microm. CONCLUSIONS: Airborne particles containing influenza and RSV RNA were detected throughout a health care facility. The particles were small enough to remain airborne for an extended time and to be inhaled deeply into the respiratory tract. These results support the possibility that influenza and RSV can be transmitted by the airborne route and suggest that further investigation of the potential of these particles to transmit infection is warranted.
Publication     Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Volume     50
Numéro     5
Pages     693-698
Date     Mar 1, 2010