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Médecine du travail du personnel hospitalier

An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers

Auteur     Abdullah S Madhun
Auteur     Per Espen Akselsen
Auteur     Haakon Sjursen
Auteur     Gabriel Pedersen
Auteur     Signe Svindland
Auteur     Jane Kristin Nøstbakken
Auteur     Mona Nilsen
Auteur     Kristin Mohn
Auteur     Asne Jul-Larsen
Auteur     Ingrid Smith
Auteur     Diane Major
Auteur     John Wood
Auteur     Rebecca J Cox
Résumé     Mass vaccination was the most effective prophylaxis for protecting the population during the influenza H1N1 pandemic. We have evaluated the tolerability, immunogenicity and kinetics of the antibody response to a monovalent oil-in-water (AS03) adjuvanted human pandemic split influenza A/California/7/2009 H1N1 (3.75μg haemagglutinin) vaccine in health care workers. Vaccination elicited a rapid and early protective level of haemagglutination inhibition antibody from 6 to 7 days post vaccination, and by 14 to 21 days post vaccination, up to 98% of vaccinees had protective antibody titres which persisted for at least 3 months in 84-92% of subjects. A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic.
Publication     Vaccine
Date     Oct 26, 2010

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doi:10.1016/j.vaccine.2010.10.038

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