Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers
Auteur Thomas H Connor
Auteur D Gayle DeBord
Auteur Jack R Pretty
Auteur Marc S Oliver
Auteur Tracy S Roth
Auteur Peter S J Lees
Auteur Edward F Krieg
Auteur Bonnie Rogers
Auteur Carmen P Escalante
Auteur Christine A Toennis
Auteur John C Clark
Auteur Belinda C Johnson
Auteur Melissa A McDiarmid
Résumé OBJECTIVE: This study evaluated health care worker exposure to antineoplastic drugs.
METHODS: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay.
RESULTS: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay.
CONCLUSIONS: Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.
Publication Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine
Volume 52
Numéro 10
Pages 1019-1027
Date Oct 2010
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1097/JOM.0b013e3181f72b63
Laisser une réponse
Vous devez etre connectez Pour poster un commentaire