Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators
Auteur Lauren Y Cao
Auteur James S Taylor
Auteur Apra Sood
Auteur Debora Murray
Auteur Paul D Siegel
Résumé BACKGROUND: Rubber gloves are one of the most frequent causes of occupational allergic contact dermatitis, especially in health care workers. OBSERVATIONS: We describe 23 patients with allergic contact dermatitis due to rubber accelerators in rubber gloves, some with disseminated dermatitis, treated during a 2-year period. Three had IgE-mediated latex allergies. Sixteen were health care workers from a single institution whose dermatitis was temporally related to the switch to latex-safe gloves. Each had positive patch test reactions to 1 or more rubber accelerators, including carbamates, thiurams, 2-mercaptobenzothiazole, and 1,3-diphenylguanidine. Chemical analysis of 6 glove samples identified 2-mercaptobenzothiazole in 4 and zinc diethyldithiocarbamate in 1. There were discordances between patch test results for glove chemicals and glove swatches and between available information on chemicals used during glove production and chemicals detected during glove analysis. Although these factors may complicate the search for culprit and alternative gloves, dermatitis cleared in each of 9 patients with follow-up data and for whom alternative gloves were provided based on published information of glove composition. CONCLUSIONS: Allergic contact dermatitis due to synthetic rubber gloves occurs even with the use of latex-safe products. More knowledge about chemicals present in these gloves, to which the skin is exposed during use, is necessary to prevent and treat allergic contact dermatitis.
Publication Archives of Dermatology
Volume 146
Numéro 9
Pages 1001-1007
Date Sep 2010
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1001/archdermatol.2010.219
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