Veille documentaire MTPH

Pathol Biol (Paris). 2008 Apr 3; [Epub ahead of print]
IFNgamma and antibody responses among French nurses during a tuberculosis contact tracing investigation.
Herrmann JL, Simonney N, Bergeron A, Ducreux-Adolphe N, Porcher R, Rouveau M, Allez M, Leportier M, Tazi A, Lemann M, Lagrange PH.
Microbiology Department, Raymond Poincare-Hospital, 104, boulevard Raymond-Poincare, 92380 Garches, France; Equipe d’accueil, EA3510, University Paris-7, France.
STUDY: A comparative study which compared PPD skin testing inserted according to the French Society of Pneumology’s recommendations and interferon gamma release assay (IGRA) (QuantiFERON((R)) TB Gold In-tube, QF-TB-IT, Cellestis, Carnegie, Australia) was performed during a tuberculosis contact investigation in our hospital. PATIENTS: Nineteen French health-care workers (HCWs) volunteered to participate. All of the HCW enrolled were BCG vaccinated and had a normal chest X-ray at entry. RESULTS: Among the HCW, 68.4% were TST positive. By comparison, only 31.6% had a positive QF-TB-IT result. We took advantage of the negative tube and the corresponding plasma for antibody detection by ELISA. None were ELISA positive. Fourteen HCWs were followed up. None of the HCWs accepted a course of antiTB chemoprophylaxis. Despite the difficulty in establishing a trend in kinetics, we saw the complexity of interpretation of a dynamic T-cell response after contact with an index case. CONCLUSION: This initial and first French picture provides us with the observation that only 44% of TST-positive HCW were IGRA positive, and the IGRA test allowed the detection of LTBI in two TST negative HCWs.
PubMed