Veille documentaire MTPH

Eur J Epidemiol. 2007 Feb 13; [Epub ahead of print]
Hepatitis B vaccination in women healthcare workers: A seroepidemiological survey.
Locquet C, Marande JL, Choudat D, Vidal-Trecan G.
Service de Medecine du Travail, Faculte de Medecine, Universite Paris Descartes, 45, rue des Saints-Peres, 75006, Paris, France, celine.locquet@univ-paris5.fr.
OBJECTIVE: To assess the concentration and kinetics of antibody response after hepatitis B vaccination among women healthcare workers. Design. Longitudinal retrospective seroepidemiological survey among women vaccinated against hepatitis B working in a university hospital and followed-up in an occupational health department. A structured form was used to collect socio-demographic characteristics, clinical data, age at vaccination, vaccination schedule, measurement of antibodies to hepatitis B
surface antigen (anti-HBs antibody). Subjects were considered seronegative against hepatitis B when anti-HBs antibody concentration was less than 10 mIU/ml. Setting. A 1260-bed general hospital in Paris, France. Participants. All women healthcare workers visiting the occupational health department between January 1997 1st and December 2000 31st and who had a measurement of anti-HBs antibody. RESULTS: Irrespective of the age at the primary vaccination, 810 (92%) women were seropositive (anti-HBs antibody >/= 10 mIU/ml). Only 22 women (4.5%) vaccinated before 26 years of age were seronegative, against 46 (13.2%) vaccinated after 25 years of age (p /=10 mIU/ml.