____
Citation 1
Authors
Collas H. Delbarre M. De Preville PA. Courville P. Neveu C. Dompmartin A.
Balguerie X. Lemaistre B. Rzeznik JC. Thiebot B. Boullie MC. Bravard P.
Michel Y. Krug M. Le Corvaisier-Pieto C. Young P. Thomine E. Boivin C. Ziade
J. Pellerin A. Hellot MF. Leroy D. Lauret P. Benichou J. Joly P.
Title
[Evaluation of the diagnosis of pigmented tumors of the skin and factors
leading to a decision to excise. Dermatologists of the Postgraduate
Association of Haute-Normandie]. [French]
Original Title
Evaluation du diagnostic des tumeurs pigmentees de la peau et des elements
conduisant a une decision d'exerese. Dermatologues de l'Association de FMC
de
Haute-Normandie.
Source
Annales de Dermatologie et de Venereologie. 126(6-7):494-500, 1999 Jun-Jul.
Abstract
INTRODUCTION: The necessity of excising melanomas characterized by a slight
thickness at an early stage, leads dermatologists to remove pigmented
lesions which do not correspond to melanomas. The aims of this study were:
a) to prospectively assess the accuracy of melanoma diagnosis, b) to
quantify the number of excisions performed according to the degree of
melanoma suspicion, c) to determine the specific clinical sign or signs of
relevant diagnostic value. PATIENTS AND METHODS: This study was conducted
prospectively from January 1996 to August 1997 by dermatologists in private
practice and dermatologists from a University Hospital staff. When it was
decided to excise a pigmented lesion, a form was filled out choosing the
most appropriate clinical diagnosis, the degree of melanoma suspicion, and
clinical signs which lead to surgery. Based on histological findings as the
reference, the sensitivity, specificity, accuracy of melanoma diagnosis and
the kappa test that evaluates the concordance between clinical and
histological diagnosis, were performed. The diagnostic value of clinical
signs was assessed by variance analysis. RESULTS: Of the 353 excised
lesions, 38 (10.7 p. 100) were identified as melanoma on histologic
examination. The sensitivity, the specificity and diagnostic accuracy were:
79 p. 100, 94 p. 100 and 53 p. 100 respectively. The kappa test concordance
between clinical and histological diagnosis was 0.66. Two hundred and two
lesions (57 p. 100) were excised even though the clinical suspicion of
melanoma was poorly considered. Only one of these 202 lesions was identified
histologically as a true melanoma. Thirty seven (24.5 p. 100) of the 151
remaining excised lesions with an "average" or "strong" suspicion were true
melanomas. The clinical signs considered, alone or associated, had a poor
predictive positive value (< 38 p. 100). An analytical approach performed
with a logistic model permitted the identification of two associated signs
suggesting a best diagnostic value. DISCUSSION: This is the only study, to
our knowledge, reported in the literature which prospectively assesses the
sensitivity, specificity and concordance between clinical and histological
diagnosis of melanoma. Results were considered from average to good. The
originality of this study was to assess the number of pigmented lesions
excised according to the degree of melanoma suspicion, suggesting the
possibility of reducing the number of nevi removed when the melanoma risk
was considered clinically poor. Finally, this study emphasizes the limits of
clinical semiology and the need for future diagnostic methods in the
assessment of melanoma.
____
Citation 2
Authors
Le Blanc-Louvry I. Ducrotte P. Manouvrier JL. Peillon C. Testart J. Denis P.
Title
Motility of the Roux-en-Y hepaticojejunostomy in asymptomatic patients.
Source
American Journal of Gastroenterology. 94(9):2501-8, 1999 Sep.
Abstract
OBJECTIVE: The aim of our study was to describe the motility in the limb,
the duodenum, and the jejunum distal to the limb after Roux-en-Y
hepaticojejunostomy in patients who remained asymptomatic postoperatively.
Our objective was to obtain reference manometric recordings for interpretion
of recordings in symptomatic patients. METHODS: Manometric recordings were
obtained in the Roux-en-Y limb in 13 patients 15.6 +/- 1.1 days
postoperatively, using a probe inserted into the limb during surgery and
coming out through the abdominal wall. The recording openings were
positioned in the limb itself in eight patients, and also in the jejunum
immediately distal to the limb in five patients. In four of eight patients,
limb manometry was combined with duodenal manometry using a second probe
introduced nasally. RESULTS: Phase IIIs were recorded in all 13 patients,
either spontaneously or after trimebutine stimulation (100 mg i.v.). Phase
IIIs occurred spontaneously in 12 patients. They always migrated throughout
the Roux-en-Y limb, and were also most often observed in the distal jejunum;
migration stopped in the distal jejunum in three of five patients. Phase
IIIs in the limb occurred independently from duodenal phase IIIs. In the
limbs, the duration of phase IIIs was longer (p < 0.02), and the migration
slower than in the duodenum (p < 0.001) and in controls (p < 0.02). In nine
of 13 patients, injection of trimebutine (100 mg i.v.) initiated phase III
in the Roux limb or in the distal jejunum within 2 min. During the combined
recordings, trimebutine initiated phase III simultaneously in the duodenum
and in the limb. The response to meals in the limb was poorer than in
controls. Interruption of phase IIIs was shorter, and the area under the
postprandial curve was smaller (p < 0.01) for each postprandial half-h.
Postprandial motility was poorer in the limb than in the distal small bowel
(p < 0.01). CONCLUSIONS: In asymptomatic patients, interdigestive motility
is present in the hepaticojejunostomy Roux-en-Y limb, but it is abnormal
because of slow migration of phase IIIs. The second abnormality observed in
the limb is a response to meals that is both short and of low amplitude.
____
Citation 3
Authors
Thomine JM. Duparc F. Dujardin F. Biga N.
Title
[Transgluteal approach to the hip by anterior hemimyotomy of the gluteus
medius]. [French]
Original Title
Abord transgluteal de hanche par hemimyotomie anterieure du gluteus medius.
Source
Revue de Chirurgie Orthopedique et Reparatrice de l Appareil Moteur.
85(5):520-5, 1999 Sep.
Abstract
Authors describe a transgluteal approach of the hip which is not based on
the somewhat unsure common insertion of gluteus medius and vastus lateralis.
Anatomical basis and technical particularities of division of anterior part
of gluteus medius, of gluteus minimus and capsule are given which allow
preservation of gluteal nerve, stability of the joint, and solid reparation
of abductor muscles.
____
Citation 4
Authors
Madigan P. Ziegler RG. Benichou J. Byrne C. Hoover RN.
Title
Re: "Population attributable fraction estimation for established breast
cancer risk factors: considering the issues of high prevalence and
unmodifiability" [letter; comment].
Source
American Journal of Epidemiology. 150(5):543-4, 1999 Sep 1.
____
Citation 5
Authors
Bonmarchand G. Chevron V. Menard JF. Girault C. Moritz-Berthelot F. Pasquis
P. Leroy J.
Title
Effects of pressure ramp slope values on the work of breathing during
pressure support ventilation in restrictive patients [see comments]
[published erratum appears in Crit Care Med 1999 Jul;27(7):1404].
Source
Critical Care Medicine. 27(4):715-22, 1999 Apr.
Abstract
OBJECTIVE: To investigate, in restrictive patients, the influence of
pressure ramp slope values on the efficacy of pressure support ventilation.
DESIGN: Prospective study. SETTING: A university hospital medical intensive
care unit. PATIENTS: Twelve intubated restrictive patients. INTERVENTIONS:
Patients were randomly assigned to four sequences in which the values of the
slope of the pressure ramp increase were modulated so that the plateau
pressure was reached within a predetermined time: 0.1, 0.50, 1, or 1.50
secs. The more rapidly the pressure plateau was achieved, the higher was the
initial flow rate. For convenience, these four different ventilatory
settings were termed T 0.1, T 0.5, T 1, and T 1.5. MEASUREMENTS AND MAIN
RESULTS: We measured the following parameters 10 mins after application of
each pressure ramp slope: inspiratory work of breathing, breathing pattern,
and intrinsic PEEP (PEEPi). Work of breathing was evaluated using Campbell's
diagram, and expressed as a percentage of the values observed under
spontaneous ventilation. A marked interindividual variation of the values
for work of breathing was observed under spontaneous ventilation; the mean
value for work of breathing was 1.97 +/- 0.82 joule/L, with a range of 1.22
to 4.10 joule/L. Comparison between the means for each sequence and each
variable measured was performed by two-way analysis of variance with
internal comparisons between sequences by Duncan's test. Between the first
(T 0.1) and the last (T 1.5) sequence, the reduction of values of the
pressure ramp slope induced a progressive increase in the values for work of
breathing, regardless of the mode of expression (in joule, joule/L, or
joule/min). The values for work of breathing (joule/ L), expressed as a
percentage of the values observed under spontaneous ventilation, increased
from 44.2 +/- 14.4% to 78.3 +/- 17.8% (p < .001). In contrast, the reduction
of the pressure ramp slope values and initial flow rate did not induce any
significant change in tidal volume, respiratory frequency, and PEEPi.
CONCLUSION: Among the four tested slope values, the steepest was that which
induced the lowest possible work of breathing in restrictive patients
ventilated by pressure support ventilation. In this type of patient, we
therefore suggest that the programmed pressure value should be reached by
using a steep pressure ramp slope.
____
Citation 6
Authors
Gehanno JF. Kohen-Couderc L. Lemeland JF. Leroy J.
Title
Nosocomial meningococcemia in a physician.
Source
Infection Control & Hospital Epidemiology. 20(8):564-5, 1999 Aug.
Abstract
We report the case of a pediatrician who developed meningococcal meningitis
after performing endotracheal intubation without protection on a child who
was suspected of having meningoencephalitis. This case emphasizes the
necessity for healthcare workers who perform high-risk procedures to use
personal protection devices (i.e., respirators and protective goggles).
Unprotected healthcare workers with high exposure to Neisseria meningitidis
should receive chemoprophylaxis.
____
Citation 7
Authors
Gehanno JF. Pestel-Caron M. Nouvellon M. Caillard JF.
Title
Nosocomial pertussis in healthcare workers from a pediatric emergency unit
in
France.
Source
Infection Control & Hospital Epidemiology. 20(8):549-52, 1999 Aug.
Abstract
OBJECTIVE: After pertussis was diagnosed in July 1997 in a 55-year-old nurse
(case) from a pediatric emergency unit who had a respiratory illness and
paroxysmal cough for 5 weeks, an epidemiological investigation was initiated
to determine if other healthcare workers (HCWs) from the same unit also had
pertussis. DESIGN: Interviews were conducted to assess symptoms occurring in
the previous months. Two sera were collected 2 to 3 months apart for 59 of
61 HCWs of the unit. The IgG response to pertussis toxin was determined
using Western blot assay. SETTING: Pediatric emergency unit (61 HCWs) of a
2,500-bed university hospital. RESULTS: There was a total of 10 (5 confirmed
and 5 probable) cases of pertussis identified in this outbreak. Nine HCWs
(15%) had results suggesting recent or acute pertussis. To avoid
transmission to patients and other HCWs, all HCWs with cough were treated
for 14 days with erythromycin, and those having acute cough were given a
5-day sick leave. Despite these measures, a new acute pertussis case was
identified in a 41-year-old nurse, with a positive culture from
nasopharyngeal aspirates. Thus, all HCWs in the unit were prescribed
spiramycin for 10 days to prevent any further spread of pertussis.
CONCLUSION: Pertussis should be considered a threat to HCWs who are in
contact with children. For HCWs, diagnosis of pertussis should be made on a
clinical basis, giving greater importance to sensitivity of diagnosis
criteria, and on early bacterial identification by culture of the organism
or by polymerase chain reaction. RECOMMENDATIONS: In case of pertussis in an
HCW, all staff in the unit who have had unprotected and intensive contact
with that person should be provided with macrolide treatment to stop any
transmission to colleagues and to young patients. Furthermore, the
possibility of providing these HCWs with acellular pertussis vaccines
warrants further investigation.
____
Citation 8
Authors
Coulouarn Y. Jegou S. Tostivint H. Vaudry H. Lihrmann I.
Title
Cloning, sequence analysis and tissue distribution of the mouse and rat
urotensin II precursors.
Source
FEBS Letters. 457(1):28-32, 1999 Aug 20.
Abstract
Urotensin II (UII) is a cyclic neuropeptide initially isolated from the
caudal neurosecretory system of teleost fish. The recent cloning of the UII
precursor in frog and human has demonstrated that the peptide is not
restricted to the fish urophysis but that it is also expressed in the
central nervous system of tetrapods. Here, we describe the characterization
of the cDNAs encoding prepro-UII in mouse and rat. A comparison of the
primary structures of mouse and rat UII with those of other vertebrate UII
reveals that the sequence of the cyclic region of the molecule (CFWKYC) has
been fully conserved. In contrast, the N-terminal flanking domain of
prepro-UII has markedly diverged with only 48% sequence identity between the
mouse or rat and the human precursors. In situ hybridization histochemistry
showed that the prepro-UII gene is predominantly expressed in motoneurons of
the brainstem and spinal cord, suggesting that UII may play a role in the
control of neuromuscular functions.
____
Citation 9
Authors
Schneider P. Jerome MV. Paysant J. Soria PC. Vannier JP.
Title
The role of angiogenesis in leukemia proliferation [letter].
Source
American Journal of Pathology. 155(3):1007-8, 1999 Sep.
____
Citation 10
Authors
Campion D. Dumanchin C. Hannequin D. Dubois B. Belliard S. Puel M.
Thomas-Anterion C. Michon A. Martin C. Charbonnier F. Raux G. Camuzat A.
Penet C. Mesnage V. Martinez M. Clerget-Darpoux F. Brice A. Frebourg T.
Title
Early-onset autosomal dominant Alzheimer disease: prevalence, genetic
heterogeneity, and mutation spectrum.
Source
American Journal of Human Genetics. 65(3):664-70, 1999 Sep.
Abstract
To determine the prevalence of early-onset Alzheimer disease (EOAD) and of
autosomal dominant forms of EOAD (ADEOAD), we performed a population-based
study in the city of Rouen (426,710 residents). EOAD was defined as onset of
disease at age <61 years, and ADEOAD was defined as the occurrence of at
least three EOAD cases in three generations. Using these stringent criteria,
we calculated that the EOAD and ADEOAD prevalences per 100,000 persons at
risk were 41.2 and 5.3, respectively. We then performed a mutational
analysis of the genes for amyloid precursor protein (APP), presenilin 1
(PSEN1), and presenilin 2 (PSEN2) in 34 families with ADEOAD ascertained in
France. In 19 (56%) of these families, we identified 16 distinct PSEN1
missense mutations, including 4 (Thr147Ile, Trp165Cys, Leu173Trp, and
Ser390Ile) not reported elsewhere. APP mutations, including a novel mutation
located at codon 715, were identified in 5 (15%) of the families. In the 10
remaining ADEOAD families and in 9 additional autosomal dominant Alzheimer
disease families that did not fulfill the strict criteria for ADEOAD, no
PSEN1, PSEN2, or APP mutation was identified. These results show that (1)
PSEN1 and APP mutations account for 71% of ADEOAD families and (2)
nonpenetrance at age <61 years is probably infrequent for PSEN1 or APP
mutations.
____
Citation 11
Authors
Bettega G. Favre E. Goga D. Mercier J. Peron JM.
Title
[A journal that meets your expectations (editorial)]. [French]
Original Title
Une revue a la hauteur de vos ambitions....
Source
Revue de Stomatologie et de Chirurgie Maxillo-Faciale. 100(2):69, 1999 May.
____
Citation 12
Authors
Colonna L.
Title
[Biological treatment of depression]. [French]
Original Title
Traitements biologiques de la depression.
Source
Revue du Praticien. 49(7):733-8, 1999 Apr 1.
Abstract
Pharmacotherapy remains the main medical means of treating depression, and
constant progress during recent years has led to the present availability of
many effective and well tolerated drugs. Some essential conditions should be
present for optimum therapeutic efficacy. The appropriate indications should
be precisely defined. The most active and best tolerated product should be
chosen for each patient. The medical treatment should be associated with
psychotherapy. Finally, the patient should be followed-up with regard to
restoration of his relations with his family, social and professional
groups. Much progress remains to be made. The most important are better
knowledge of the mechanisms of action of antidepressants and of the
pathophysiopsychological mechanisms of depression. Some rare cases of very
severe depression, either unresponsive to medical treatment or when such
treatment is contraindicated, still require the use of electroconvulsive
therapy. Light therapy is used in seasonal affective disorder.
____
Citation 13
Authors
Costantino JP. Gail MH. Pee D. Anderson S. Redmond CK. Benichou J. Wieand
HS.
Title
Validation studies for models projecting the risk of invasive and total
breast cancer incidence.
Source
Journal of the National Cancer Institute. 91(18):1541-8, 1999 Sep 15.
Abstract
BACKGROUND: In 1989, Gail and colleagues developed a model for estimating
the risk of breast cancer in women participating in a program of annual
mammographic screening (designated herein as model 1). A modification of
this model to project the absolute risk of developing only invasive breast
cancer is referred to herein as model 2. We assessed the validity of both
models by employing data from women enrolled in the Breast Cancer Prevention
Trial. METHODS: We used data from 5969 white women who were at least 35
years of age and without a history of breast cancer. These women were in the
placebo arm of the trial and were screened annually. The average follow-up
period was 48.4 months. We compared the observed number of breast cancers
with the predicted numbers from the models. RESULTS: In terms of absolute
risk, the ratios of total expected to observed numbers of cancers (95%
confidence intervals [CIs]) were 0.84 (0. 73-0.97) for model 1 and 1.03
(0.88-1.21) for model 2, respectively. Within the age groups of 49 years or
less, 50-59 years, and 60 years or more, the ratios of expected to observed
numbers of breast cancers (95% CIs) for model 1 were 0.91 (0.73-1.14), 0.96
(0.73-1. 28), and 0.66 (0.52-0.86), respectively. Thus, model 1
underestimated breast cancer risk in women more than 59 years of age. For
model 2, the risk ratios (95% CIs) were 0.93 (0.72-1.22), 1.13 (0.83-1.55),
and 1.05 (0.80-1.41), respectively. Both models exhibited a tendency to
overestimate risk for women classified in the higher quintiles of predicted
5-year risk and to underestimate risk for those in the lower quintiles of
the same. CONCLUSION: Despite some limitations, these methods provide useful
information on breast cancer risk for women who plan to participate in an
annual mammographic screening program.
____
Citation 14
Authors
Proust F. Laquerriere A. Constantin B. Ruchoux MM. Vannier JP. Freger P.
Title
Simultaneous presentation of atypical teratoid/rhabdoid tumor in siblings.
Source
Journal of Neuro-Oncology. 43(1):63-70, 1999 May.
Abstract
Atypical rhabdoid/teratoid tumor (ATT/RHT) is a rare malignant neoplasm
which appears in early childhood. The present paper describes clinical and
pathological features of ATT/RHT which occurred simultaneously in 2 sisters
diagnosed at a 15 day interval. Both children were treated by surgical
resection, subtotal in the first case and total in the second.
Postoperatively, chemotherapy followed by radiotherapy, 50.4 Gy on the
posterior fossa, were administered. Despite this therapy, both sisters died
at 14 months and 26 months respectively. The tumors express vimentin and
EMA; cells contained intracytoplasmic inclusions. No karyotypic anomaly was
detected. This is the first description of familial ATT/RHT.
____
Citation 15
Authors
Mayet E. Michel P. Joly P. Belanyi P. Ducrotte P. Paillot B.
Title
[Esophageal cancer and Bazex' acrokeratosis: cutaneous development and
parallel neoplastic development]. [French]
Original Title
Cancer de l'oesophage et acrokeratose de Bazex: l'evolution cutanee est
parallele a l'evolution neoplasique.
Source
Gastroenterologie Clinique et Biologique. 23(6-7):791-2, 1999 Jun-Jul.
____
Citation 16
Authors
Jonkers C. Lochs H. Lerebours E. Meier R. Messing B. Soeters PB.
Title
Survey to establish the current status of artificial nutritional support in
Europe.
Source
Clinical Nutrition. 18(3):179-88, 1999 Jun.
____
Citation 17
Authors
Laroche M. Delpech B. Bernard J. Constantin A. Mazieres B.
Title
Measurement of bone mineral density by dual X-ray absorptiometry in Paget's
disease before and after pamidronate treatment.
Source
Calcified Tissue International. 65(3):188-91, 1999 Sep.
Abstract
Third-generation bisphosphonates are now currently used in the treatment of
Paget's disease of bone. Dual X-ray absorptiometry may make it possible to
quantify the action of these bisphosphonates on bone mineral density (BMD)
in pagetic and nonpagetic bone. We used Lunar DPX, a total-body software
program (automatic analysis and/or manual windows according to the site and
bilateral or unilateral pagetic involvement) to study BMD in 28 patients (18
men, 10 women, mean age 69.8 years) with Paget's disease before and 6 months
after infusions of 60 mg (alkaline phosphatase <350 IU) or 120 mg (ALP >350
IU) of pamidronate. Before treatment, in the 28 patients, the BMD of
trabecular pagetic bone was 25% higher than that of nonpagetic bone; in
cortical pagetic bone the BMD was 35% higher. After treatment, the BMD of
trabecular pagetic bone increased by only 1.17%. the BMD of cortical pagetic
bone increased by 1.37% whereas nonpagetic cortical bone lost 0.84%,
independently of the levels of parathyroid hormone or the administration of
calcium and vitamin D.
____
Citation 18
Authors
Chajara A. Raoudi M. Delpech B. Courel M. Leroy M. Basuyau JP. Levesque H.
Title
Effects of diabetes and insulin treatment of diabetic rats on hyaluronan and
hyaluronectin production in injured aorta.
Source
Journal of Vascular Research. 36(3):209-21, 1999 May-Jun.
Abstract
The present study was conducted to determine the effect of diabetes with and
without insulin treatment on the production of hyaluronen (HA) and
distribution of hyaluronectin (HN) in the rat aorta 14 days after injury
with a catheter balloon. Injury increased intima-media wet weight (+11%) and
DNA content (+37.5%). This increase was slightly enhanced in untreated
diabetic rats (+14.7% for wet weight and +48.9% for DNA content) and was
significantly greater in diabetic rats treated with insulin (+28.9% for wet
weight and +54% for DNA content). HA content increase in the injured aorta
of nondiabetic rats (+43.6%) was similar in untreated diabetic (+44.7%) and
more pronounced in diabetic rats treated with insulin (+91.3%). HA was
markedly expressed in the neointima of nondiabetic rats, particularly near
the lumen of the aorta. In untreated diabetic rats, HA was present
throughout the neointima and not mainly close to the lumen. HA staining in
the neointima of diabetic rats treated with insulin was similar to that in
nondiabetic rats. HN was strongly expressed throughout the neointima of all
groups. Injury enhanced the production of a high molecular mass HN (>400
kDa); this was not observed either in untreated or in insulin-treated
diabetic rats. In conclusion, insulin treatment promoted the proliferative
response of aorta to injury and this was associated mainly with increased HA
production. This finding suggests that HA, which has been shown to play a
crucial role in smooth muscle cell proliferation and migration, may be
involved in the promoting effect of insulin treatment on arterial wall
reaction to injury.
____
Citation 19
Authors
Similowski T. Muir JF.
Title
[Series on "respiratory resuscitation" published under the aegis of the
Resuscitation Group of the French-Language Society of Pneumology]. [French]
Original Title
Serie "reanimation respiratoire" publiee sous l'egide du groupe reanimation
de la societe de pneumologie de langue francaise.
Source
Revue des Maladies Respiratoires. 16(3):305-6, 1999 Jun.
____
Citation 20
Authors
Meurice JC. Murris Espin M. Muir JF.
Title
[The Review of Respiratory Diseases on the verge of the XXIst century].
[French]
Original Title
La Revue des Maladies Respiratoires a l'oree du XXIe siecle.
Source
Revue des Maladies Respiratoires. 16(3):267-8, 1999 Jun.
____
Citation 21
Authors
Masson S. Daveau M. Hiron M. Lyoumi S. Lebreton JP. Teniere P. Scotte M.
Title
Differential regenerative response and expression of growth factors
following
hepatectomy of variable extent in rats.
Source
Liver. 19(4):312-7, 1999 Aug.
Abstract
AIMS/BACKGROUND: Liver regeneration is a physiological mechanism which leads
to restoration of the hepatic parenchyma following hepatectomy or toxic
injury. This process is mediated by a wide variety of cytokines and growth
factors. The aim of the present study was to evaluate the influence of
hepatectomy extent on the levels of intrahepatic mRNAs for cell-cycle
markers and growth factors in rats submitted to a 30%, two-third or 80%
hepatectomy. METHODS: Cyclins, thymidine kinase and growth factors mRNA
levels were quantitatively assessed by RT-PCR at different time points
post-hepatectomy (2h, 6h, 12h, days 1, 2, 6). RESULTS: As compared with a
two-third hepatectomy, cyclins and thymidine kinase mRNA levels were
increased but with a delayed peak at day 2 in the 80% hepatectomy group and
showed a progressive increase until day 6 in the 30% hepatectomy group; mRNA
levels for HGF or TGFalpha were increased with a delayed peak at 12 h or day
2 in the 80% hepatectomy group, respectively and this delay was more
pronounced in the 30% hepatectomy group with a peak at day 1 or day 6.
CONCLUSION: A regenerative response occurs whatever the extent of
hepatectomy but the course of regeneration and expression of growth factors
differs according to the volume of resected liver. A better knowledge of
these events could improve the clinical results of hepatic resection for
primary or metastatic liver disease.
____
Citation 22
Authors
Blot E. Delastre O. Levesque H.
Title
[Modulation of angiogenesis. A new therapeutic tool for vascular diseases].
[Review] [26 refs] [French]
Original Title
La modulation de l'angiogenese. Un nouvel outil therapeutique pour les
maladies vasculaires.
Source
Journal des Maladies Vasculaires. 24(3):189-93, 1999 Jun.
Abstract
Angiogenesis permits the growth of new vessels. This process may be modified
during the course of some pathological phenomenon, i.e. cancer,
atherosclerosis or diabetes. After a brief description of angiogenesis
pathophysiology, the therapeutic possibilities in cardiovascular diseases
are discussed. Initial results of therapeutic trials in coronary and
peripheral artery diseases are detailed, and perspectives for the future are
reviewed. [References: 26]
____
Citation 23
Authors
Levesque H. Marie I.
Title
[Infection and vascular purpura]. [Review] [30 refs] [French]
Original Title
Infection et purpura vasculaire.
Source
Journal des Maladies Vasculaires. 24(3):177-82, 1999 Jun.
Abstract
Palpable purpura is the hallmark of cutaneous vasculitis. Small-vessel
vasculitis is a common vasculitis manifestation associated with acute or
chronic infection. It is also characteristic of a systemic disease whether
infectious or not. The pathogenic mechanisms appear to be complex: immune
complex formation, vessel damage or altered vessel function mediated
directly by infectious agents, humoral or cellular immunologic response. It
is also a reaction to mixed cryoglobulinemia. Diagnosis of cutaneous
vasculitis is simple (palpable purpuric eruption, nodules, vesiculobullous
lesions, ulcerations), but etiological investigation is often difficult
because the infectious origin is only rarely demonstrated. This type of
purpura occurs in bacterial endocarditis and therefore blood cultures must
be performed in any febrile patient particularly in the presence of a
cardiac murmur. In fact the viral, parasitic or bacterial infectious origin
is demonstrated in less than 30% of the cases of leucocytoclastic
vasculitis. While focal sepsis is often found and its eradication should be
followed-up, its role has not been proven particularly as antibiotics alone
themselves can cause hypersensitivity vasculitis. Finally, mention must be
made of virus induced vasculitis (B and C hepatitis, cytomegalovirus,
parvovirus), antiviral treatment which permits better control of vasculitis.
[References: 30]
____
Citation 24
Authors
Thirion B. Darmoni SJ.
Title
CliniWeb: Managing clinical information on the World-Wide-Web [letter;
comment].
Source
Journal of the American Medical Informatics Association. 4(1):71, 1997
Jan-Feb.
____
Citation 25
Authors
Fillastre JP.
Title
[Is it possible to reduce the incidence of aminoglycoside-induced
nephrotoxicity?]. [Review] [24 refs] [French]
Original Title
Peut-on diminuer l'incidence de la nephrotoxicite des aminoglycosides.
Source
Bulletin de l Academie Nationale de Medecine. 183(5):973-82; discussion 983,
1999.
Abstract
The incidence of nephrotoxicity due to aminoglycosides should be sharply
reduced. The indications for prescribing these antibiotics should be limited
to infectious disorders induced by aerobic Gram-negative bacteria and by
some Gram-positive bacteria requiring treatment in specialized hospital
units using an association of aminoglycosides and another antibiotic. Daily
doses should not exceed those indicated by the manufacturer, and the length
of treatment should be as short as possible, with a relay to other
antibiotics that are not or are less nephrotoxic. The possibilities for
reducing the incidence of nephrotoxicity are few. It is not possible to
prevent the antibiotic from entering the renal tubular cell or from
producing deleterious effects therein. However, by using short-term
intravenous infusion as the administration route, prolonged contact between
the antibiotic and its receptors on the brush borders of the proximal
tubular cells can be avoided, particularly since the process of cellular
absorption is saturable. Essentially, doses should be adapted according to
the age and the glomerular filtration of the patient, since renal function
usually decreases with age. Volemic and hydroelectrolytic disorders favour
nephrotoxicity and should be corrected. Associations with other nephrotoxic
drugs should either be avoided or used with increased caution. The same is
true in special situations such as endotoxaemia, severe renal parenchymatous
infections and cholestasis. In any case, given the well-known insidious
onset of nephropathy, aminoglycoside treatment always requires laboratory
follow-up consisting of repeated testing of creatinemia during the two weeks
of treatment. [References: 24]
____
Citation 26
Authors
Gomord V. Wee E. Faye L.
Title
Protein retention and localization in the endoplasmic reticulum and the
golgi
apparatus. [Review] [109 refs]
Source
Biochimie. 81(6):607-18, 1999 Jun.
Abstract
Protein transport along the secretory pathway is supported by a noria of
vesicles that bud and fuse, load and unload their cargo from one compartment
into the other. However, despite this constant flow-through of proteins and
lipids the various compartments of the secretory pathway are able to
maintain their own specific composition. Here, we discuss recent insights
into mechanisms of protein retention and localization that are necessary for
the maintenance of endoplasmic reticulum (ER)- and Golgi-associated typical
functions such as protein folding and glycosylation in plant cells.
[References: 109]
____
Citation 27
Authors
Duclohier H. Kociolek K. Stasiak M. Leplawy MT. Marshall GR.
Title
C-terminally shortened alamethicin on templates: influence of the linkers on
conductances.
Source
Biochimica et Biophysica Acta. 1420(1-2):14-22, 1999 Aug 20.
Abstract
In order to test the influence of chemical modifications designed to allow
covalent coupling of channel-forming peptide motifs into variable sized
oligomers, a series of alamethicin derivatives was prepared. The building
block encompassing the N-terminal 1-17 residues of alamethicin behaved
normally in the conductance assay on planar lipid bilayers, albeit at higher
concentration and with a slightly reduced voltage-dependence. A linker
Ac-K-OCH(2)C(6)H(4)CH(3)p attached via the epsilon amino group of lysine to
the C-terminus of alamethicin(1-17) increased membrane affinity. The latter
was further enhanced in a dimer and a tetramer in which alamethicin(1-17)
chains were tethered to di- or tetra-lysine linkers, respectively, but
macroscopic current-voltage curves displayed much reduced
voltage-dependencies and reversed hysteresis. An usual behaviour with high
voltage-dependence was restored with the modified dimer of alamethicin(1-17)
in which alanine separated the two consecutive lysine residues in the
linker. Of special interest was the development of a 'negative resistance'
branch in macroscopic current-voltage curves for low concentrations of this
dimer with the more flexible linker. Single channel events displayed only
one single open state with fast kinetics and whose conductance matches that
of the alamethicin heptamer or octamer.
