1: Ann Fr Anesth Reanim. 2009 Jun 30. [Epub ahead of print]
[The annual congress of Adarpef.]
[Article in French]
Courrèges P, Laudenbach V.
Service de pédiatrie néonatale et réanimation, 1, rue de Germont, 76031 Rouen
cedex, France.
Publication Types:
EDITORIAL
PMID: 19574020 [PubMed - as supplied by publisher]
2: Chest. 2009 Jun 30. [Epub ahead of print]
Pressure Reduction During Exhalation in Sleep Apnea Patients Treated by CPAP.
Pépin JL, Muir JF, Gentina T, Dauvilliers Y, Tamisier R, Sapene M, Escourrou P,
Fleury B, Philip-Joet F, Philip P, d'Ortho MP.
From the HP2 Laboratory (Drs. Pépin and Tamisier), Institut National de la Santé
et de la Recherche Médicale (INSERM), Equipe Région INSERM 17, Grenoble
University Hospital, Grenoble, France; Clinique de La Louvière (Dr. Gentina),
Lille, France; University Hospital of Montpellier (Dr. Dauvilliers), Montpellier,
France; Polyclinique de Bordeaux (Dr. Sapene), Bordeaux, France; Groupe
Henri-Mondor Albert Chennevier (Dr. d'Ortho), Service de Physiologie-Explorations
Fonctionnelles, Assistance Publique-Hôpitaux de Paris, Créteil, France; Institut
National de la Santé et de la Recherche Médicale (INSERM) [Dr. d'Ortho], Unité
841, Créteil, F-94010 France; Université Paris-7-Denis Diderot (Dr. d'Ortho),
Faculté de Médecine Xavier Bichat, Paris, France; Service de
Physiologie-Explorations Fonctionnelles (Dr. Escourrou), Hôpital A. Béclère,
Assistance Publique-Hôpitaux de Paris, Clamart, France; Service de Pneumologie
(Dr. Fleury), Hôpital St Antoine, Assistance Publique-Hôpitaux de Paris, Paris,
France; Service de Pneumologie (Dr. Philip-Joet), Hôpital St Joseph, Assistance
Publique-Hôpitaux de Marseille, Marseille, France; Service de
Physiologie-Explorations Fonctionnelles (Dr. Philip), Hôpital Pellegrin,
Bordeaux, France; and Service de Pneumologie (Dr. Muir), Hôpital Boisguillaume,
Rouen, France.
Introduction This French, multicenter, randomized double blind controlled trial
tested the hypothesis that pressure reduction during exhalation (C-Flex(TM))
would improve CPAP compliance, comfort and quality of life. Methods 218 newly
diagnosed sleep apnea patients (7 centers, age 55 +/- 11years, BMI 31 +/- 6
kilograms/m(2), Apnea+Hypopnea Index 44 +/- 21/h) were randomly assigned to 3
months of CPAP (108 patients) or C-Flex (110 patients). Objective compliance,
generic (SF-36) and disease specific (GrenobleSAQOL) quality of life
questionnaires, and visual analog scales for CPAP comfort and side effects were
measured at baseline and after 3 months. After 3 months, patients in the CPAP arm
were moved to C-Flex for 3 additional months (open study). Results An intention
to treat analysis demonstrated that there were no differences at 3 months between
C-Flex and CPAP in terms of compliance, rate of side effects and comfort. Low
compliers on CPAP (< 4 h of use) significantly improved this outcome during the
open study (p = 0.04). There was a significant improvement in 6/8 of the generic
and all the domains of the specific quality of life questionnaire in both groups
using eitherCPAP or C-Flex. Conclusion In unselected sleep apnea patients C-Flex
was associated with similar outcomes to standard CPAP. Low compliers on CPAP
improved their adherence when moving to C-Flex.
PMID: 19567496 [PubMed - as supplied by publisher]
3: Chaos. 2009 Jun;19(2):028505.
Identifying chaos from heart rate: the right task?
Freitas U, Roulin E, Muir JF, Letellier C.
CORIA UMR 6614, Universite de Rouen, Av. de l'Universite, BP 12, F-76801
Saint-Etienne du Rouvray Cedex, France.
Providing a conclusive answer to the question "is this dynamics chaotic?" remains
very challenging when experimental data are investigated. We showed that such a
task is actually a difficult problem in the case of heart rates. Nevertheless, an
appropriate dynamical analysis can discriminate healthy subjects from patients.
PMID: 19566280 [PubMed - in process]
4: Mov Disord. 2009 Jun 26. [Epub ahead of print]
Infraclinical postural instability in early-stage Parkinson's disease?
Chastan N, Weber J.
Department of Neurophysiology, Rouen University Hospital and EA 4311 (ADEN),
Institute for Biomedical Research, University of Rouen, Rouen, France.
PMID: 19562757 [PubMed - as supplied by publisher]
5: Rev Stomatol Chir Maxillofac. 2009 Jun 23. [Epub ahead of print]
[Gingivoperiosteoplasty associated to bone graft: Radiological evaluation.]
[Article in French]
Boland FX, Drikes S, Persac S, Peron JM, Delcampe P.
Service de chirurgie maxillofaciale et stomatologie, CHU de Rouen, 1, rue de
Germont, 76000 Rouen, France.
INTRODUCTION: Gingivoperiosteoplasty associated to bone graft is part of a
therapeutic strategy applied to the first 20 years of a patient's life.
Management is pluridisciplinary. Most authors recommend a bone graft in mixed
dentition at the end of premaxillary growth. Retroalveolar and panoramic
radiography are the most often used to assess the bone height of the grafted
site. We retrospectively studied the radiographies of 57 alveolar grafts in 44
patients. MATERIAL AND METHODS: Between 1999 and 2005, 44 patients underwent
gingivoperiosteoplasty associated to bone graft. Thirteen underwent bilateral
reconstruction. The surgical interventions were performed by the same surgeon.
One year after surgery, the panoramic radiographies were analyzed by a single
expert. The bone height compared to roots of adjacent teeth was classified in
four grades. Grades 1 and 2 were considered as satisfactory or good and grades 3
and 4 not satisfactory and an indication for a new bone graft. In case of
bilateral cleft, each side was analyzed independently. RESULTS: Grades 1 and 2
accounted for 84.2% of grafts. There was no statistical difference in alveolar
bone height between patients presenting with agenesis of the lateral incisive.
Eighty-one percent of patients grafted with mixed dentition (66% of the cases)
had satisfactory results (35% of grade 1 and 46% of grade 2). Patients operated
on after 15 years (n=15) had good results in 75% of the cases, 33% were bilateral
cleft patients. There was no statistical difference between patients operated on
early and those with delayed surgery. DISCUSSION: Radiological results for
gingivoperiosteoplasty associated to bone graft are satisfactory. The procedure
is easy, cheap, and reproducible. Evaluation with panoramic radiography is not as
accurate as with the Denta Scan. CT scan is not used systematically to follow up
alveolar cleft palate in children so as to limit irradiation. Volumetric
tomography (cone beam) may be the best assessment.
PMID: 19555984 [PubMed - as supplied by publisher]
6: Eur Psychiatry. 2009 Jun 19. [Epub ahead of print]
The Emotional Stroop task: A comparison between schizophrenic subjects and
controls.
Demily C, Attala N, Fouldrin G, Czernecki V, Ménard JF, Lamy S, Dubois B, Thibaut
F.
INSERM U614, Psychiatry, Faculty of Medicine, Rouen University Hospital Charles
Nicolle, 1, rue de Germont, 76031 Rouen, France.
The colour-word Emotional Stroop task (ES task) has been proposed to assess the
interferences between emotion and attention. Using this task, first, we examined
how attention (using reaction times) can be modified by emotionally relevant
words in schizophrenics as compared with controls as a function of the emotional
significance of the word; second, we tested the assumption that schizophrenics
with the most negative symptoms will show higher impairment in relationship to
negative emotional words. In general, schizophrenics were slower to react. In
both groups, mean reaction times were slower for emotional as compared with
neutral words. No significant differences were observed between negative and
positive words either in schizophrenics (n=21) or in controls (n=20). Even in the
most negative schizophrenic patients, there were no differences between negative
and positive words. There were no significant interactions between type of
stimulus and any clinical variables (PANSS negative or non negative
categorization, etc.). Also, there were no statistically significant correlations
between reaction times and neuroleptic dosage or anhedonia scores. In conclusion,
schizophrenia patients showed the same degree of interference from emotional
words as compared with controls. Moreover, patients with a higher level of
negative symptoms did not differently experience positive and negative words.
PMID: 19541456 [PubMed - as supplied by publisher]
7: Arch Pediatr. 2009 Jun;16(6):594-5.
[Bone mass evaluation in children: technical measurements, perspectives.]
[Article in French]
Blondiaux E, Cellier C, Mallet E.
Service d'imagerie pédiatrique et foetale, CHU de Rouen, Hôpital Charles-Nicolle,
1, rue de Germont, 76031 Rouen cedex, France.
PMID: 19541097 [PubMed - in process]
8: Arch Pediatr. 2009 Jun;16(6):505-7.
[Management of acute asthma exacerbation in childhood: French recommendations.]
[Article in French]
Marguet C, Michelet I, Couderc L, Lubrano M.
Unité de pneumologie et allergologie, CRCM, département de pédiatrie médicale,
CHU Charles-Nicolle, 76031 Rouen cedex, France.
PMID: 19541064 [PubMed - in process]
9: Joint Bone Spine. 2009 Jun 11. [Epub ahead of print]
Diagnostic and prognostic usefulness of antibodies to citrullinated peptides.
Goëb V, Jouen F, Gilbert D, Le Loët X, Tron F, Vittecoq O.
Service de Rhumatologie, Institut de Recherche Biomédicale, CHU-Hôpitaux de
Rouen, France; Inserm U905, IFRMP, University of Rouen, France.
The diagnosis of rheumatoid arthritis (RA) must be made early, because prompt
initiation of treatments tailored to disease activity is crucial to improve
structural and functional outcomes. Anti-citrullinated peptide antibodies (ACPAs)
are well-established diagnostic markers for RA and should be included in the
classification criteria. Here, we describe the main tests for detecting ACPAs and
we underline the diagnostic and prognostic usefulness of ACPAs in patients with
RA. The presence of ACPAs predicts poorer functional and structural outcomes, and
ACPA titers respond to some of the medications used in RA. Therefore, ACPA titers
should be determined at regular intervals throughout follow-up.
PMID: 19524474 [PubMed - as supplied by publisher]
10: Obes Surg. 2009 Jun 11. [Epub ahead of print]
Abdominoplasty After Major Weight Loss: Improvement of Quality of Life and
Psychological Status.
Lazar CC, Clerc I, Deneuve S, Auquit-Auckbur I, Milliez PY.
Department of Plastic and Reconstructive Surgery, Rouen University Hospital, 1
rue de Germont, 76000, Rouen, France, lazarcalin@yahoo.fr.
Abdominoplasty provides a reconstructive but rarely aesthetic cosmetic solution
after major weight loss. Few articles document quality of life (QOL) issues and
the psychological impact of abdominoplasty on obese patients. We report a
retrospective study of 41 abdominoplasties performed after an average weight loss
of 40.2 kg. Data were obtained through review of patient medical files,
double-blind surgical and psychological examinations, and two specifically
designated questionnaires used to assess pre-abdominoplasty body perception and
QOL, post-body contouring perception of improvement, and psychological status. To
date, 14 patients have regained >10 kg; 84.6% have improved QOL; 86.5% have
improved psychological status; 74% have better sexual relations; 53.9% admit
liking their body; 76.9% are satisfied with the results of abdominoplasty; and
96.1% would be willing to undergo abdominoplasty again. Anterior dermolipectomy
improves both QOL and psychological status. Provision of patient education,
multidisciplinary management, and long-term follow up are necessary to obtain
satisfactory results.
PMID: 19517201 [PubMed - as supplied by publisher]
11: J Clin Endocrinol Metab. 2009 Jun 9. [Epub ahead of print]
LONG-TERM RESULTS OF STEREOTACTIC RADIOSURGERY IN SECRETORY PITUITARY ADENOMAS.
Castinetti F, Nagai M, Morange I, Dufour H, Caron P, Chanson P, Cortet-Rudelli C,
Kuhn JM, Conte-Devolx B, Regis J, Brue T.
Service d'Endocrinologie, diabète et maladies métaboliques, et Centre de
reference des maladies rares d'origine hypophysaires DEFHY, Hôpital de la Timone,
Marseille, France; Service de neurochirurgie fonctionnelle stereotaxique, Hôpital
de la Timone, Marseille, France; Service de Neurochirurgie, Hôpital de la Timone,
Marseille, France; Service d'Endocrinologie - Maladies métaboliques - Nutrition -
CHU de Toulouse - Hôpital Larrey - Pôle Cardio-Vasculaire et Métabolique - 24
Chemin de Pouvourville TSA 30030 FR-31059 TOULOUSE CEDEX 9 France; Assistance
Publique-Hôpitaux de Paris, Service d'Endocrinologie et des Maladies de la
Reproduction, Hôpital de Bicêtre, Université Paris Sud 11, INSERM U693. F-94275
Le Kremlin-Bicêtre, France; Centre Hospitalier Universitaire de Lille, 58 Avenue
de l'Amiral Courbet FR-59130 LAMBERSART France; Institut Fédératif de Recherches
Multidisciplinaires sur les Peptides - INSERM U 413 - UA CNRS IFRMP 23- CHU de
Rouen - 147 Avenue du Maréchal Juin - FR-76230 BOIS-GUILLAUME France.
Context: To date, no study reported long-term follow-up results of Gamma Knife
stereotactic radiosurgery (SR). Objective: To determine long-term efficacy and
adverse effects of SR in secreting pituitary adenomas. Design: Retrospective
study of patients treated by SR in the center of Marseille, France, with a
follow-up at least equal to 60 months. Patients: 76 patients were treated by SR
for acromegaly (n=43), Cushing's disease (CD, n=18) or prolactinoma (n=15), as a
primary (n=27) or adjunctive post-surgical treatment (n=49). Main Outcome
Measures: After withdrawal of antisecretory drugs, patients were considered in
remission if they had mean GH levels < 2 ng/ml and normal IGF1 (acromegaly),
normal 24h urinary free cortisol and cortisol < 50 nmol/l after low dose
dexamethasone test (CD), or 2 consecutive normal samplings of prolactin levels
(prolactinoma). Results: After a mean follow-up of 96 months, 44.7% of the
patients were in remission. Mean time to remission was 42.6 months. Twelve
patients presented late remission at least 48 months after SR. Two patients with
CD presented late recurrence 72 and 96 months after SR. Forty percent of patients
treated primarily with SR were in remission. Target volume and initial hormone
levels were significant predictive factors of remission in univariate analysis.
Radiation-induced hypopituitarism was observed in 23% patients; in half of them,
hypopituitarism was observed after a mean time of 48 to 96 months. Twenty-four
patients were followed more than 120 months: rates of remission and
hypopituitarism were similar to the whole cohort. Conclusions: SR is an effective
and safe primary or adjunctive treatment in selected patients with secreting
pituitary adenomas.
PMID: 19509108 [PubMed - as supplied by publisher]
12: Org Biomol Chem. 2009 Jun 21;7(12):2612-8. Epub 2009 May 18.
Rational design of central selective acetylcholinesterase inhibitors by means of
a "bio-oxidisable prodrug" strategy.
Bohn P, Le Fur N, Hagues G, Costentin J, Torquet N, Papamicaël C, Marsais F,
Levacher V.
Laboratoire de Chimie Organique Fine et Hétérocyclique, UMR 6014, IRCOF, CNRS,
Université et INSA de Rouen, B.P. 08, F-76131, Mont-Saint-Aignan Cedex, France.
This work deals with the design of a bio-oxidisable prodrug strategy for the
development of new central selective acetylcholinesterase inhibitors. This
prodrug approach is expected to reduce peripheral anticholinesterase activity
responsible for various side effects observed with presently marketed AChE
inhibitors. The design of these new AChE inhibitors in quinoline series is
roughly based on cyclic analogues of rivastigmine. The key activation step of the
prodrug involves an oxidation of an N-alkyl-1,4-dihydroquinoline 1 to the
corresponding quinolinium salt 2 unmasking the positive charge required for
binding to the catalytic anionic site of the enzyme. The synthesis of a set of
1,4-dihydroquinolines 1 and their corresponding quinolinium salts 2 is presented.
An in vitro biological evaluation revealed that while all reduced forms 1 were
unable to exhibit any anticholinesterase activity (IC50 > 10(6) nM), most of the
quinolinium salts 2 displayed high AChE inhibitory activity (IC50 ranging from 6
microM to 7 nM). These preliminary in vitro assays validate the use of these
cyclic analogues of rivastigmine in quinoline series as appealing chemical tools
for further in vivo development of this bio-oxidisable prodrug approach.
Publication Types:
Research Support, Non-U.S. Gov't
PMID: 19503937 [PubMed - in process]
13: Mod Pathol. 2009 Jun 5. [Epub ahead of print]
Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite
instability are correlated with the number and spectrum of frameshift mutations.
Tougeron D, Fauquembergue E, Rouquette A, Le Pessot F, Sesboüé R, Laurent M,
Berthet P, Mauillon J, Di Fiore F, Sabourin JC, Michel P, Tosi M, Frébourg T,
Latouche JB.
[1] Inserm, U614, Faculty of Medicine, Institute for Medical Research, Rouen,
Northwest Cancéropôle, France [2] Digestive Oncology Unit, Department of
Gastroenterology, University Hospital, Rouen, Northwest Cancéropôle, France.
Colorectal cancers with microsatellite instability are characterized by an
important density of tumor-infiltrating lymphocytes and a good prognosis.
Microsatellite instability results from the inactivation of the DNA mismatch
repair system and induces secondary somatic frameshift mutations within target
genes harboring repeat sequences in their coding frame. By disrupting the open
reading frame, frameshift mutations can result in the appearance of potentially
immunogenic neopeptides. To determine the frameshift mutations inducing a T-cell
response during the development of a tumor with microsatellite instability, we
studied in 61 colorectal cancer patients with microsatellite instability, using a
fluorescent multiplex PCR comparative analysis, the relative frequency of
frameshift mutations within 19 target genes and analyzed the correlation of these
frameshift mutations with the density of CD3+ tumor-infiltrating lymphocytes. The
four most frequently mutated genes were ACVR2 (92%), TAF1B (84%), ASTE1/HT001
(80%) and TGFBR2 (77%). The vast majority (95%) of the tumors exhibited at least
three frameshift mutations, and the number of frameshift mutations was associated
with tumor progression (TNM stage, wall invasion and tumor diameter).
Tumor-infiltrating lymphocyte density was associated with the overall number of
frameshift mutations and with the presence of frameshift mutations within two
target genes, namely ASTE1/HT001 and PTEN. These results strongly argue for the
clinical relevance of immunotherapy of colorectal cancers with microsatellite
instability.Modern Pathology advance online publication, 5 June 2009;
doi:10.1038/modpathol.2009.80.
PMID: 19503063 [PubMed - as supplied by publisher]
14: Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun 2. [Epub ahead of print]
Adenosine A(2A) receptor deficient mice are partially resistant to limbic
seizures.
El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM.
Unité de Neuropsychopharmacologie Expérimentale, F.R.E. 2735 C.N.R.S., I.F.R.M.P.
23, U.F.R. Médecine & Pharmacie, 22 Boulevard Gambetta, 76183, Rouen Cedex,
France.
The neuromodulator adenosine, acting through activation of four defined
metabotropic receptors called A(1), A(2A), A(2B) and A(3,) has been proposed as
an endogenous anticonvulsant. Here, the consequences of deleting the adenosine
A(2A) receptor have been examined in different experimental models of epilepsy.
A(2A)R KO mice were not protected against seizures originating from brainstem
structures, namely electroshock-induced seizures. The intensities of seizures
induced by pentylenetetrazol or pilocarpine, as well as the percentages of
convulsing mice, were significantly reduced in A(2A) receptor knockout (A(2A)R
KO) animals. A(2A)R KO mice exhibited reduced pentylenetetrazol-induced kindled
seizures, demonstrating an important role of the A(2A) receptor in the
acquisition of kindling. These data suggest that adenosine stimulating A(2A)
receptors modulates excitatory neurotransmission and exacerbates limbic seizures.
It is therefore suggested that adenosine A(2A) receptor antagonists might offer
protection from some epileptic syndromes.
PMID: 19488739 [PubMed - as supplied by publisher]
15: Gastroenterol Clin Biol. 2009 Jun-Jul;33(6-7):485-7. Epub 2009 May 27.
Unusual skeletal muscle metastasis from gastric adenocarcinoma.
Tougeron D, Hamidou H, Dujardin F, Maillard C, Di Fiore F, Michel P.
Digestive Oncology Unit, Department of Gastroenterology, Rouen University
Hospital, Northwest Cancéropôle, 1, rue de Germont, Rouen, France.
Patients with gastric adenocarcinoma frequently develop hepatic metastases or
peritoneal carcinosis but involvement of the skeletal muscle is extremely rare.
We report the case of a 71-year-old man with a painful soft tissue mass in the
right shoulder. Two years previously, the patient had been treated for a locally
advanced gastric carcinoma (surgery plus chemoradiotherapy). Surgical exploration
with biopsy showed skeletal muscle metastasis from the gastric adenocarcinoma in
the deltoid muscle. Chemoradiotherapy resulted in complete regression of symptoms
from the metastatic lesion. The patient is alive and free of recurrence in the
deltoid muscle after a follow-up of 13 months. Based on this case study, the
difficulty of diagnosing skeletal muscle metastases, the prognosis and treatment
options are discussed.
PMID: 19477611 [PubMed - in process]
16: Gastroenterol Clin Biol. 2009 Jun-Jul;33(6-7):491-2. Epub 2009 May 26.
Predictive and prognostic factors in patients with an oesophageal carcinoma
treated with chemoradiotherapy: The key role of nutritional parameters.
Duclos A, Di Fiore F, Lecleire S, Michel P.
Digestive Oncology Unit, Hepatogastroenterology Department, Charles Nicolle
Hospital, Rouen University Hospital, 1, rue de Germont, 76031 Rouen cedex,
France.
Publication Types:
Letter
PMID: 19473797 [PubMed - in process]
17: Ann Thorac Surg. 2009 Jun;87(6):1946-8.
Coronary artery dissection after surgical cryoablation procedure.
Doguet F, Le Guillou V, Litzler PY, Bouchart F, Nafeh-Bizet C, Cribier A, Bessou
JP.
Department of Thoracic and Cardiovascular Surgery, Rouen University Hospital,
Rouen, France. fabien.doguet@chu-rouen.fr
Cryoablation can be used to treat atrial fibrillation (AF) surgically. We
describe a 71-year-old woman who underwent cryoablation after 6 months of AF.
Four hours post-surgery, electrocardiographic changes were observed in the
circumflex artery territory associated with hemodynamic instability, which
responded to inotropic agents. Angiography revealed a diffuse circumflex artery
spasm with a heterogeneous aspect of the posterior branch evoking a dissection.
Platelet anti-aggregant and trinitrine therapy were started. Recovery was
uneventful and the patient was discharged on day 13. Cryoablation-associated
circumflex artery dissection is rare. Caution is required when locating the
ablation lines to avoid coronary artery injury.
Publication Types:
Case Reports
PMID: 19463634 [PubMed - indexed for MEDLINE]
18: Gynecol Obstet Fertil. 2009 Jun;37(6):463. Epub 2009 May 17.
[She won't be a mother, nor a surrogate-mother.]
[Article in French]
Marpeau L.
Clinique gynécologique et obstétricale, hôpital Charles-Nicolle, CHU de Rouen, 1,
rue de Germont, 76031 Rouen cedex, France.
Publication Types:
Editorial
PMID: 19447665 [PubMed - in process]
19: Gastroenterol Clin Biol. 2009 Jun-Jul;33(6-7):488-90. Epub 2009 May 9.
Translocation of an intra-uterine contraceptive device with sigmoid penetration
through an endometriosic nodule.
Vandaele N, Iwanicki-Caron I, Piat M, Hervé S, Ducrotté P.
Department of Gastroenterology, CHU de Rouen, 1, rue de Germont 76000 Rouen,
France.
The intra-uterine device (IUD) is the most common existing reversible
contraception. Uterine perforation occurs in 0.6 to 3.4 per 1000 insertions. We
describe the first report of IUD translocation and subsequent penetration of the
sigmoid through an endometriosic nodule. A 44-year-old gravida 2 para 2 woman
consulted for rectal bleeding and melena. Rectosigmoidoscopy revealed ischemic
colitis secondary to the use of NSAIDs, which explained the bleeding, but also
sigmoid perforation from part of an intra-uterine device. This was discovered by
chance. Perforation had occurred though an endometriosic nodule.
PMID: 19428208 [PubMed - in process]
20: Orthop Traumatol Surg Res. 2009 Jun;95(4 Suppl):41-8. Epub 2009 May 7.
Clinical examination of the foot and the ankle. Data collection and
interpretation of the pathogenic causal sequence of disorders.
Biga N.
Surgery-Rouen University Hospital, University of Rouen, 1, rue de Germont, 76031
Rouen cedex, France. norman.biga@chu-rouen.fr
The clinical examination remains the irreplaceable stage in assessing foot and
the ankle disorders. It comprises a complete inventory of the patient's
complaints and the data obtained from the physical examination. Afterwards, it
should concentrate on establishing consistency between symptoms that can be
disparate, to link them in a logical pathogenic causal pattern to be used in
developing a treatment programme. These correlations are the most often obvious
and only require confirmation with standard X-rays. In the absence of
consistency, and if a diagnosis is difficult to establish, recourse to more
sophisticated investigations (CT scan, MRI or an intra-articular local
anaesthetic test) becomes worthwhile. To achieve maximum value, the physical
examination must be based on prerequisite knowledge of functional anatomy,
admittedly basic but covering all the bone and joint, ligament, muscle, skin and
neurovascular components. All these structures being closely interrelated. This
organization allows for remarkable protection mechanisms and the capacity to
endure considerable cyclic stress. This interdependence can also command chains
of injury difficult to unravel. The examination must thus be methodical and
comprehensive: history taking (ranking of symptoms, evaluation of the patient's
psychological profile); physical examination, standing, on a podoscope, gait
analysis, lying down (trophic disorders, joint range of motion, muscle testing);
standard X-rays, always weight bearing. This discursive organization, essential
in everyday practice, avoids the sequence "symptom --> MRI --> surgical
indication" which is a professional and intellectual deviance; it enables the
development, in terms of advantages against risks, or an appropriate treatment
plan in the best conditions.
PMID: 19427281 [PubMed - in process]
21: Respir Physiol Neurobiol. 2009 Jun 30;167(2):208-13. Epub 2009 May 3.
Impact of swallowing and ventilation on oropharyngeal cortical representation.
Gallas S, Marie JP, Leroi AM, Verin E.
Department of Physiology, Rouen University Hospital, 1 rue de Germont, 76031
Rouen Cedex, France.
Our aim was to determine whether ventilation and swallowing tasks can modify
oropharyngeal cortical motor organisation. Mylohyoid motor-evoked potentials
(MEP) induced by non-focal (NF) and focal (F) magnetic stimulations were recorded
in nine healthy volunteers four times, with 1 week between each recording.
Baseline values were evaluated and their reproducibility was assessed 1 week
later. Thereafter, the subjects were asked to perform swallowing and ventilation
tasks in random order 15 min per day for 1 week. The NF MEP amplitudes after the
swallowing and ventilation tasks increased after effortful swallows (p<0.001) and
ventilation efforts (p<0.001). The F MEP amplitudes obtained after focal cortical
stimulations increased after effortful swallows (p<0.01) and ventilation efforts
(p<0.05). The cortical magnitude of the oropharyngeal muscle representation
increased after swallowing practice (p<0.01). In conclusion, swallowing and
ventilation tasks modified the motor cortex of oropharyngeal muscles and should
be evaluated for use in rehabilitation strategies.
PMID: 19410663 [PubMed - in process]
22: Vet Parasitol. 2009 Jun 10;162(3-4):230-5. Epub 2009 Mar 25.
In vitro efficacy of nitro- and halogeno-thiazolide/thiadiazolide derivatives
against Sarcocystis neurona.
Gargala G, Le Goff L, Ballet JJ, Favennec L, Stachulski AV, Rossignol JF.
Parasitology Department, University of Rouen, France.
gilles.gargala@univ-rouen.fr
Sarcocystis neurona is an obligate intracellular parasite that causes equine
protozoal myeloencephalitis (EPM). The aim of this work was to document
inhibitory activities of nitazoxanide (NTZ, [2-acetolyloxy-N-(5-nitro
2-thiazolyl) benzamide]) and new thiazolides/thiadiazolides on S. neurona in
vitro development, and investigate their structure-activity relationships. S.
neurona was grown in bovine turbinate cell cultures. At concentrations varying
from 1.0 to 5.0mg/L, nitazoxanide and 21 of 32 second generation
thiazolide/thiadiazolide agents exerted a > or =95% maximum inhibition on S.
neurona development. Most active agents were either NO(2) or halogen substituted
in position 5 of their thiazole moiety. In contrast, other 5-substitutions such
as hydrogen, methyl, SO(2)CH(3), and CH(3) negatively impacted activity. Compared
with derivatives with an acetylated benzene moiety, deacetylated compounds which
most probably represent primary metabolites exhibited similar inhibitory
activities. Present data provide the first evidence of in vitro inhibitory
activities of nitazoxanide and new thiazolides/thiadiazolides on S. neurona
development. Active halogeno-thiazolide/thiadiazolides may provide a valuable
nitro-free alternative to nitazoxanide for EPM treatment depending on further
evaluation of their in vivo activities.
Publication Types:
Research Support, Non-U.S. Gov't
PMID: 19369006 [PubMed - in process]
23: J Cereb Blood Flow Metab. 2009 Jun;29(6):1146-58. Epub 2009 Apr 15.
Newborn- and adult-derived brain microvascular endothelial cells show age-related
differences in phenotype and glutamate-evoked protease release.
Legros H, Launay S, Roussel BD, Marcou-Labarre A, Calbo S, Catteau J, Leroux P,
Boyer O, Ali C, Marret S, Vivien D, Laudenbach V.
EA 4309 Neovasc Microvascular Endothelium and Neonatal Brain Lesions, IHURBM,
IFRMP 23, School of Medicine and Pharmacy, University of Rouen, Rouen, France.
helene.legros@univ-rouen.fr
Few data are available on the involvement of brain microvascular endothelial
cells (BMECs) in excitotoxic neonatal brain lesions. Therefore, we developed an
original approach for investigating mouse-derived BMECs in vitro. We hypothesized
that newborn and adult BMEC cultures would show age-related differences in
phenotype and sensitivity to glutamate. Expression of the monocarboxylate
transporter, MCT1, was higher in neonatal than in adult BMECs, whereas expression
of the glucose transporter, GLUT1, was higher in adult than in neonatal BMECs
that overexpressed the N-methyl-D-aspartate receptor NR1 subunit (NMDAR1)
compared with adult BMECs. The ability of neonatal and adult BMECs to be
activated by glutamate was confirmed through intracellular calcium ([Ca2+]i)
recording. The glutamate-induced [Ca2+]i increase was blocked by the selective
NMDAR antagonist, MK-801. Significant glutamate-evoked concentration-dependent
release of tissue-type plasminogen activator (t-PA) and matrix metalloproteinases
(MMPs) activities was found in supernatants of neonatal, but not in adult BMECs.
The glutamate-mediated release of t-PA, MMP-2, and MMP-9 proteolytic activities
in neonatal BMECs was blocked by MK-801. Conceivably, this protease release from
neonatal BMECs may participate in neonatal brain lesions.
Publication Types:
Research Support, Non-U.S. Gov't
PMID: 19367295 [PubMed - indexed for MEDLINE]
24: Eur Heart J. 2009 Jun;30(12):1537. Epub 2009 Mar 28.
Diagnosis and follow-up of Wegener's granulomatosis by cardiac magnetic
resonance.
Caudron J, Fares J, Dominique S, Dacher JN.
Department of Radiology, University Hospital of Rouen, 1 rue de Germont, Rouen
Cedex, France.
PMID: 19329802 [PubMed - in process]
25: Ann Endocrinol (Paris). 2009 Jun;70(3):192-3. Epub 2009 Mar 14.
Autocrine/paracrine regulations of steroidogenesis in adrenocortical hyperplasias
and tumors.
Lefebvre H, Duparc C, Cartier D, Contesse V, Perraudin V, Bertherat J, Plouin PF,
Reznik Y, Kuhn JM, Louiset E.
Laboratory, Rouen University Hospital, University of Rouen, Inserm U413/EA4310,
DC2N, IFRMP 23, Rouen, France. Herve.Lefebvre@chu-rouen.fr
Publication Types:
Research Support, Non-U.S. Gov't
PMID: 19286160 [PubMed - in process]
26: Purinergic Signal. 2009 Jun;5(2):151-61. Epub 2009 Feb 21.
Characterisation of the R276A gain-of-function mutation in the ectodomain of
murine P2X7.
Adriouch S, Scheuplein F, Bähring R, Seman M, Boyer O, Koch-Nolte F, Haag F.
Inserm U905, 76183, Rouen, France, sahil.adriouch@univ-rouen.fr.
The cytolytic P2X7 purinoceptor is widely expressed on leukocytes and has sparked
interest because of its key role in the activation of the inflammasome, the
release of the pro-inflammatory cytokine IL-1beta and cell death. We report here
the functional characterisation of a R276A gain-of-function mutant analysed for
its capacities to induce membrane depolarisation, calcium influx and opening of a
large membrane pore permeable to YO-PRO-1. Our results highlight the particular
sensitivity of R276A mutant to low micromolar adenosine triphosphate (ATP)
concentrations, which possibly reflect an increased affinity for its ligands, and
a slower closing kinetics of the receptor channel. Our findings support the
notion that evolutionary pressures maintain the low sensitivity of P2X7 to ATP.
We also believe that the R276A mutant described here may be useful for the
generation of new animal models with exacerbated P2X7 functions that will serve
to better characterise its role in inflammation and in immune responses.
PMID: 19234763 [PubMed - in process]
27: J Plast Reconstr Aesthet Surg. 2009 Jun;62(6):742-6. Epub 2008 Dec 23.
Polymorphous low-grade adenocarcinoma: a review regarding an unusual presentation
as infected odontogenic cyst.
Geha H, François A, Boland F, Drikes S, Peron J.
Service de Chirurgie Maxillo-faciale et Stomatologie, CHU Rouen, France.
chirface@free.fr
The World Health Organisation (WHO) classified polymorphous low-grade
adenocarcinoma (PLGA) in 1990 as a low-grade malignancy; ICD-O 8525/3 being the
assigned international code. It has been frequently described as occurring in
hard- or soft-palate accessory salivary glands: some cases being described in the
tongue and in major salivary glands. We present an extensive literature review
about PLGA and the most common diagnostic pitfalls. We also report the first case
where it was seen surrounding an impacted maxillary tooth and discuss it in
regard to our review.
Publication Types:
Case Reports
Review
PMID: 19109086 [PubMed - indexed for MEDLINE]
28: Dysphagia. 2009 Jun;24(2):204-10. Epub 2008 Oct 28.
Poststroke dysphagia rehabilitation by repetitive transcranial magnetic
stimulation: a noncontrolled pilot study.
Verin E, Leroi AM.
Service de Physiologie Digestive, Urinaire, Respiratoire et Sportive, CHU de
ROUEN, 1 rue de Germont, 76031, Rouen Cedex, France. eric.verin@chu-rouen.fr
Poststroke dysphagia is frequent and significantly increases patient mortality.
In two thirds of cases there is a spontaneous improvement in a few weeks, but in
the other third, oropharyngeal dysphagia persists. Repetitive transcranial
magnetic stimulation (rTMS) is known to excite or inhibit cortical neurons,
depending on stimulation frequency. The aim of this noncontrolled pilot study was
to assess the feasibility and the effects of 1-Hz rTMS, known to have an
inhibitory effect, on poststroke dysphagia. Seven patients (3 females, age = 65
+/- 10 years), with poststroke dysphagia due to hemispheric or subhemispheric
stroke more than 6 months earlier (56 +/- 50 months) diagnosed by
videofluoroscopy, participated in the study. rTMS at 1 Hz was applied for 20 min
per day every day for 5 days to the healthy hemisphere to decrease transcallosal
inhibition. The evaluation was performed using the dysphagia handicap index and
videofluoroscopy. The dysphagia handicap index demonstrated that the patients had
mild oropharyngeal dysphagia. Initially, the score was 43 +/- 9 of a possible 120
which decreased to 30 +/- 7 (p < 0.05) after rTMS. After rTMS, there was an
improvement of swallowing coordination, with a decrease in swallow reaction time
for liquids (p = 0.0506) and paste (p < 0.01), although oral transit time,
pharyngeal transit time, and laryngeal closure duration were not modified.
Aspiration score significantly decreased for liquids (p < 0.05) and residue score
decreased for paste (p < 0.05). This pilot study demonstrated that rTMS is
feasible in poststroke dysphagia and improves swallowing coordination. Our
results now need to be confirmed by a randomized controlled study with a larger
patient population.
PMID: 18956227 [PubMed - in process]
29: Rev Neurol (Paris). 2009 Jun-Jul;165(6-7):601-4. Epub 2008 Oct 23.
[An aphasic reader.]
[Article in French]
Thery-Langlois C, Amossé C, Lefaucheur R, Bioux S, Gérardin E, Hannequin D,
Martinaud O.
Service de neurologie, hôpital Charles-Nicolle, centre hospitalier universitaire
de Rouen, 1, rue de Germont, 76031 Rouen, France.
Nonsemantic reading is the capacity to read without understanding by impairment
of the lexical-semantic pathway. We report the case of a female steno secretary
with nonsemantic reading capacity associated with severe aphasia caused by a left
hemisphere ischemic stroke in Broca's area. Arguments in favor of a right
hemisphere contribution to the reading ability are presented.
Publication Types:
English Abstract
PMID: 18950824 [PubMed - in process]
