1. Rev Stomatol Chir Maxillofac. 2010 Mar 26. [Epub ahead of print]
[Polymorphous low-grade adenocarcinoma of the maxilla simulating an odontogenic
cyst.]
[Article in French]
Geha H, Boland FX, Francois A, Tardif A, Peron JM.
Service de chirurgie maxillofaciale et stomatologie, CHU de Rouen, 1, rue de
Germont, 76000 Rouen, France.
INTRODUCTION: In 1990, the WHO classified Polymorphous Low Grade Adenocarcinoma
as a low-grade malignant tumor of the minor salivary glands. This tumor often
originates from the hard or soft palate minor salivary glands. We report the
first case revealed as an infected maxillary odontogenic cyst around an impacted
tooth. CASE REPORT: A 50-year-old female presented 20 months ago with a bulging,
painful oral mass in the right superior vestibule. The diagnosis was infected
odontogenic cyst associated with an impacted canine tooth. A course of oral
antibiotics was given and cyst enucleation and tooth extraction were performed 6
days later. Ameloblastoma was suggested on macroscopic findings; nevertheless,
the pathologic end diagnosis was Polymorphic Low-Grade Adenocarcinoma of minor
salivary gland origin. After negative carcinological screening, wide surgical
resection was performed. Postoperative external radiotherapy was applied to the
operated area as well as to cervical lymph node areas. DISCUSSION: Most of the
565 published cases concern a palatine location. Even though wide surgical
resection is sufficient, external radiotherapy may be used on a case-by-case
basis. Copyright © 2010. Published by Elsevier Masson SAS.
PMID: 20347466 [PubMed - as supplied by publisher]
2. Eur J Cardiothorac Surg. 2010 Mar 23. [Epub ahead of print]
Aortic valve replacement after percutaneous valvuloplasty - an approach in
otherwise inoperable patients.
Doguet F, Godin M, Lebreton G, Eltchaninoff H, Cribier A, Bessou JP, Litzler PY.
Department of Thoracic and Cardiovascular Surgery, Rouen University Hospital and
University of Rouen, Rouen, France.
Objectives: Cardiac surgery can relieve symptoms and improve the prognosis of
patients with aortic stenosis. However, surgery-related morbidity and mortality
are high when severe cardiac or extracardiac factors co-exist. We report the
outcome of percutaneous balloon aortic valvuloplasty (BAV) as a bridge to aortic
valve replacement (AVR) in temporarily inoperable patients in our institution.
Methods: All patients who, between January 2002 and December 2006, underwent a
bridging percutaneous BAV and had an AVR performed 8-14 weeks later, were
included in the study. Clinical and investigational data were collected
retrospectively from the patients' files. Follow-up was performed by telephonic
interview. Results: Twenty-five patients were included in the analysis (median
age 71.9 years). Operative risk decreased from 18.6% before BAV to less than 13%
before AVR, according to the logistical European System for Cardiac Operative
Risk Evaluation (EuroSCORE). Median ejection fraction (EF) was 40% before
dilation compared with 44% after BAV. The necessity for BAV included acute
pulmonary oedema (8%), cardiac failure (64%), cardiogenic shock (16%), syncope
(8%) and EF<10% (4%). Complications included low output (28%), renal failure
(20%), septic shock (4%) and cerebrovascular accident (8%). One postoperative
hospital death was observed. The median length of stay in the intensive care unit
(ICU) was 44 days, and the median total hospital stay was 10 days. Conclusions:
BAV used as a bridging procedure to improve cardiovascular function prior to AVR
is an interesting therapeutic approach in patients with aortic stenosis and
haemodynamic failure. The postoperative course after AVR was also improved in our
patients. Copyright © 2010 European Association for Cardio-Thoracic Surgery.
Published by Elsevier B.V. All rights reserved.
PMID: 20338774 [PubMed - as supplied by publisher]
3. Surg Radiol Anat. 2010 Mar;32(3):277-84. Epub 2010 Feb 21.
Anatomical basis of the suprascapular nerve entrapment, and clinical relevance of
the supraspinatus fascia.
Duparc F, Coquerel D, Ozeel J, Noyon M, Gerometta A, Michot C.
Laboratory of Anatomy, Faculty of Medicine, Rouen University, 22 Boulevard
Gambetta, 76183-1, Rouen, France. fabrice.duparc@univ-rouen.fr
INTRODUCTION: The entrapment of the suprascapular nerve (SSN) is commonly
considered at the level of the suprascapular notch and more rarely in the
spinoglenoid notch. Recent per-operative findings showed a compression of the SSN
along its course in the supraspinatus fossa. The removal of a fascia for
releasing the nerve between the suprascapular notch and spinoglenoid notch led us
to purchase an anatomical study. MATERIALS AND METHODS: 30 cadaver shoulders have
been dissected. The morphological features about the suprascapular notch, the
supraspinatus fascia, and the spinoglenoid notch have been observed. Histological
studies of the fascia and the spinoglenoid ligament have been performed.
Morphometric parameters such as shape of the suprascapular notch, diameters of
the SSN before and after the suprascapular notch, distance between the two
notches, length of the course of the SSN into the supraspinatus fossa, diameters
of the spinoglenoid notch have been measured. RESULTS: The shape of the
suprascapular notch could be seen as "U"- or "V" as previously reported. The
fascia was quite constant (completely identified in 29 shoulders) and was the
lateral extension of the supraspinatus fascia. The SSN coursed between the bone
and the fascia and was surrounded by fat tissue. This fascia was thickened at the
level of the spinoglenoid notch and joined the infraspinatus fascia. The
spinoglenoid ligament was seen in 28 shoulders. DISCUSSION AND CONCLUSION: In
pathologic and post-trauma conditions, the fascia can be retracted or thickened
and the SSN may be entrapped along its course in the supraspinatus fossa, between
the suprascapular notch and the spinoglenoid notch and without any compression in
any notch. These anatomical data lead us to consider that a tunnel syndrome may
concern the SSN.
PMID: 20309668 [PubMed - in process]
4. Nephrol Dial Transplant. 2010 Mar 17. [Epub ahead of print]
A 50% reduction in cyclosporine exposure in stable renal transplant recipients:
renal function benefits.
Etienne I, Toupance O, Bénichou J, Thierry A, Al Najjar A, Hurault de Ligny B, Le
Meur Y, Westeel PF, Marquet P, François A, Hellot MF, Godin M.
1Department of Nephrology, Rouen University Hospital, and Inserm CIC 0204,
Institute of Biomedical Research, University of Rouen, Rouen, France.
BACKGROUND: Although cyclosporine maintenance therapy reduces the risk of acute
rejection and increases short-term graft survival in renal transplant recipients,
its associated nephrotoxicity increases the risk of chronic graft dysfunction.
The dose that allows an optimal risk-to-benefit ratio has not been established.
METHODS: This multicentre study enrolled stable renal allograft recipients
receiving cyclosporine and mycophenolate mofetil without corticosteroids in their
second year post-transplant. Patients were randomized to a cyclosporine dose
targeted to a standard area under the concentration-time curve (AUC)(0-12 h)
(usual exposure, n = 104) or 50% of the study standard AUC(0-12 h) (low exposure,
n = 108) using a three-point pharmacokinetic sampling. The primary endpoint was
the percentage of patients with treatment failure at 24 months (graft loss/acute
rejection/nephrotoxicity/>15% serum creatinine level increase). RESULTS:
Treatment failure was reported in 37 out of 101 (37%) patients in the
usual-exposure and 19 out of 106 (18%) patients in the low-exposure groups (P =
0.003). Mean estimated glomerular filtration rate decreased from baseline to 2
years with usual exposure and increased with low exposure (P < 0.001). Mean
systolic and diastolic blood pressures were lower with low exposure (P = 0.03 and
P = 0.008, respectively). CONCLUSION: In renal transplant recipients receiving
maintenance therapy without corticosteroids, a minimization strategy using
three-point pharmacokinetic sampling to reduce and maintain cyclosporine exposure
to 50% of the usual levels is safe and reduces the risk of graft dysfunction.
PMID: 20299336 [PubMed - as supplied by publisher]
5. J Clin Microbiol. 2010 Mar 17. [Epub ahead of print]
Should blood cultures be performed in patients with acute prostatitis?
Etienne M, Pestel-Caron M, Chapuzet C, Bourgeois I, Chavanet P, Caron F.
Department of Infectious Diseases, GRAM EA 2656, IFRMP23, Rouen University
Hospital, F-76031 Rouen, France; Department of Microbiology, GRAM EA 2656,
IFRMP23, Rouen University Hospital, F-76031 Rouen, France; Department of
Infectious Diseases, Rouen University Hospital, F-76031 Rouen, France; Department
of Infectious Diseases, Dijon University Hospital, F-21000 Dijon, France.
Diagnostic and prognostic values of blood cultures (BC) were evaluated in 347
acute prostatitis inpatients. BC were positive for 21 % of patients and
contributed to the microbiological diagnosis in 5 %. Fever duration, length of
hospitalization, use of antibiotic combination, antibiotic duration, and urine
bacterial titers increased when BC were positive.
PMID: 20237098 [PubMed - as supplied by publisher]
6. Colorectal Dis. 2010 Mar 10. [Epub ahead of print]
PREDICTIVE FACTORS FOR SUCCESSFUL SACRAL NERVE STIMULATION IN THE TREATMENT OF
FAECAL INCONTINENCE: RESULTS OF TRIAL STIMULATION IN 200 PATIENTS.
Gallas S, Michot F, Faucheron JL, Meurette G, Lehur PA, Barth X, Damon H, Mion F,
Rullier E, Zerbib F, Sielezneff I, Ouassi M, Orsoni P, Desfourneaux V, Siproudhis
L, Mathonnet M, Menard JF, Leroi AM.
ADEN EA 3234/IFR MP 23, Rouen University Hospital, France.
ABSTRACT Objective: Sacral nerve stimulation (SNS) has a place in the treatment
algorithm for faecal incontinence (FI). However, after implantation, 15 to 30% of
patients with FI fail to respond for unknown reasons. We investigated the effect
of SNS on continence and quality of life and tried to identify specific
predictive factors of the success of permanent SNS in the treatment of FI.
Method: 200 consecutive patients (6 men; median age=60; range 16-81) underwent
permanent implantation for FI. The severity of FI was evaluated by the Cleveland
Clinic score. Quality of life (QOL) was evaluated by the French version of the
American Society of Colon and Rectal Surgeons (ASCRS) quality-of-life
questionnaire (FIQL). All patients underwent a preoperative evaluation. After
permanent implantation, severity and QOL scores were reevaluated after 6 and 12
months and then once a year. Results: The severity scores were significantly
reduced during SNS (p=0.001). QOL improved in all domains. At the 6 month
follow-up, the clinical outcome of the permanent implant was not affected by age,
gender, duration of symptoms, QOL, main causes of FI, anorectal manometry or
endoanal ultrasound results. Only loose stool consistency (p= 0.01), persistent
FI even though diarrhea was controlled by medical treatment (p= 0.004) and low
stimulation intensity (p=0.02) were associated with improved short-term outcome.
Multivariate analysis confirmed that loose stool consistency and low stimulation
intensity were related to a good outcome. Conclusion: Stool consistency and low
stimulation intensity have been identified as predictive factors for the
short-term outcome of SNS.
PMID: 20236144 [PubMed - as supplied by publisher]
7. Ear Nose Throat J. 2010 Mar;89(3):132-9.
Nasolacrimal duct oncocytoma: an unusual cause of chronic epiphora.
Delas B, Bertrand M, Babin E, François A, Marie JP, Dehesdin D, Choussy O.
Department of Otolaryngology-Head and Neck Surgery, Rouen University Hospital,
Rouen, France.
Epiphora has traditionally fallen under the purview of ophthalmologists. However,
owing to the development of endoscopic dacryocystorhinostomy, this condition has
been increasingly observed in otolaryngologic practice. We report the case of a
woman with a 4-month history of right epiphora and dacryocystitis. Nasal
endoscopy revealed the presence of a tumor at the inferior meatus.
Histopathologic examination of a biopsy specimen identified the tumor as an
oncocytoma. Surgical excision via a lateral rhinotomy approach was performed. At
3 years postoperatively, the patient was disease-free. Lacrimal sac and
nasolacrimal duct tumors are rare, but they should be considered as a possible
etiology in patients with acquired epiphora because most of these tumors are
malignant.
PMID: 20229479 [PubMed - in process]
8. Transplantation. 2010 Mar 10. [Epub ahead of print]
Cost-Effectiveness Analysis of Individualized Mycophenolate Mofetil Dosing in
Kidney Transplant Patients in the APOMYGRE Trial.
Rousseau A, Laroche ML, Venisse N, Loichot-Roselmac C, Turcant A, Hoizey G,
Compagnon P, Hary L, Debruyne D, Saivin S, Jacqz-Aigrain E, Buchler M, Villeneuve
C, Vergnenègre A, Le Meur Y, Marquet P.
1INSERM UMR-S850, Limoges, France. 2Department of Pharmocology-Toxicology, CHU
Limoges, Limoges, France. 3Faculty of Medicine, Laboratory of Pharmacology, Univ
Limoges, Limoges, France. 4Faculty of Pharmacy, Department of Biomathematics,
Univ Limoges, Limoges, France. 5Department of Pharmacokinetics and Toxicology,
CHU Poitiers, France. 6Pôle de Pharmacie Pharmacologie, Hôpital Civil,
Strasbourg, France. 7Department of Pharmacology-Toxicology, CHU Angers, France.
8Department of Pharmacology-Toxicology, CHU Reims, France. 9Institut de Biologie
Clinique, Service de pharmacologie, CHU Rouen, France. 10Department of
Pharmacology-Toxicology, CHU Amiens, France. 11Department of
Pharmacology-Toxicology, CHU Caen, France. 12Department of Pharmacology, CHU
Toulouse, France. 13Department of Pediatric Pharmacology and Pharmacogenetics,
CIC Inserm 9202, Hôpital Robert-Debré, Paris, France. 14Service de Néphrologie et
d'Immunologie Clinique, Université François Rabelais, Tours, France. 15Department
of Medical Information, CHU Limoges, France. 16Department of
Nephrology-Transplantation, CHU Limoges, France.
BACKGROUND.: In the prospective, randomized, multicenter APOMYGRE trial conducted
in France, concentration-controlled mycophenolate mofetil (MMF) dosing based on
mycophenolic acid (MPA) exposure significantly reduced the treatment failure and
acute rejection during the first posttransplantation year compared with
fixed-dose MMF. This analysis investigated the cost effectiveness of dose
individualization. METHOD.: The study included 65 patients per group
(intent-to-treat population). Treatment failure (primary efficacy endpoint) was
defined as death, graft loss, acute rejection, or MMF discontinuation because of
adverse effects. Data on hospitalizations, drugs prescribed, physicians' fees,
laboratory expenses, ambulatory visits, and transportation were retrieved. Costs
were calculated from the French National Health System perspective. RESULTS.: The
mean (95% confidence interval) total yearly cost per patient was &OV0556;47,477
(&OV0556;43,933; &OV0556;51,020) in the concentration-controlled group and
&OV0556;46,783 (&OV0556;44,152; &OV0556;49,414) in the fixed-dose group (P=0.7).
The observed incremental cost-effectiveness ratio was &OV0556;3757 per treatment
failure (Purchasing Power Parities United States/France: $4129). Hospitalization
and drug costs accounted for approximately 50% and 25% of total costs,
respectively. The cost for MPA area under the concentration-time curve and dose
calculation was &OV0556;452 per patient, less than 1% of the total cost.
CONCLUSION.: In the APOMYGRE trial, therapeutic MPA monitoring using a limited
sampling strategy reduced the risk of treatment failure and acute rejection in
renal allograft recipients during the first 12 months posttransplantation, at
neutral cost.
PMID: 20224514 [PubMed - as supplied by publisher]
9. Gastroenterol Clin Biol. 2010 Mar 8. [Epub ahead of print]
Outcome of primary tumor in patients with synchronous stage IV colon or rectal
cancer: So much the same yet so different.
Tougeron D, Paillot B, Michel P.
Digestive Oncology Unit, Department of Gastroenterology, Rouen University
Hospital, 1, rue de Germont, 76031 Rouen cedex 01, France.
PMID: 20219303 [PubMed - as supplied by publisher]
10. Leuk Lymphoma. 2010 Mar 10. [Epub ahead of print]
Miescher cheilitis and myelomonocytic leukemia: a fortuitous association or a
rare paraneoplastic syndrome?
Lemasle E, Jardin F, Duval AB, Courville P, Buchonnet G, Callat MP, Stamatoullas
A, Tilly H.
Hematology, Centre Henri Becquerel, Rouen, France.
PMID: 20218814 [PubMed - as supplied by publisher]
11. J Plast Reconstr Aesthet Surg. 2010 Mar 2. [Epub ahead of print]
Necrotizing pyoderma gangrenosum: an unusual differential diagnosis of
necrotizing fasciitis.
Ayestaray B, Dudrap E, Chartaux E, Verdier E, Joly P.
Department of orthopaedic and plastic surgery, Rouen University Hospital, Rouen,
France.
PMID: 20202917 [PubMed - as supplied by publisher]
12. Compr Psychiatry. 2010 Mar-Apr;51(2):106-9. Epub 2009 May 5.
Prenatal exposure to tobacco and risk for schizophrenia: a retrospective
epidemiological study.
Baguelin-Pinaud A, Robert S, Ménard JF, Thibaut F.
Department of Psychiatry, Rouen University Hospital, Rouen 76031, France.
INTRODUCTION: In animal studies, long-term prenatal nicotinic exposure alters the
development of dopaminergic neurons. To determine whether prenatal smoking
exposure was associated with schizophrenia, using a retrospective design study,
we compared the prevalence of tobacco use during pregnancy in mothers of subjects
with and without schizophrenia. METHODS: One hundred patients with schizophrenia,
100 nonschizophrenic-matched subjects, and their respective mothers were
interviewed. The prevalence of smoking was measured in these individuals as well
as in their respective mothers during the pregnancy. RESULTS: Patients with
schizophrenia smoked more often compared with controls (73% vs 57%). In contrast,
the prevalence of smoking during pregnancy did not differ between the groups of
mothers. Indeed, the amount of tobacco used was significantly lower in mothers of
patients with schizophrenia vs mothers of nonpsychotic subjects. CONCLUSION: This
study did not show any association between prenatal tobacco exposure and further
development of schizophrenia. Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 20152288 [PubMed - in process]
13. Hypertension. 2010 Mar;55(3):674-80. Epub 2010 Jan 18.
Arterial stiffness is regulated by nitric oxide and endothelium-derived
hyperpolarizing factor during changes in blood flow in humans.
Bellien J, Favre J, Iacob M, Gao J, Thuillez C, Richard V, Joannidès R.
Department of Pharmacology, Rouen University Hospital and Institut National de la
Sante et de la Recherche Medicale U644, Rouen Medical School, Institut Federatif
de Recherche Multidisciplinaire sur les Peptides 23, Institute for Biomedical
Research, University of Rouen, Rouen, France.
Comment in:
Hypertension. 2010 Mar;55(3):612-3.
Cytochrome-derived epoxyeicosatrienoic acids may be important endothelium-derived
hyperpolarizing factors, opening calcium-activated potassium channels, but their
involvement in the regulation of arterial stiffness during changes in blood flow
in humans is unknown. In healthy volunteers, we measured arterial pressure,
radial artery diameter, wall thickness, and flow (NIUS02) during hand skin
heating in the presence of saline or inhibitors of NO synthase
(N(G)-monomethyl-L-arginine), calcium-activated potassium channels
(tetraethylammonium), and cytochrome epoxygenases (fluconazole). Arterial
compliance and elastic modulus were calculated and fitted as functions of midwall
stress to suppress the confounding influence of geometric changes. Under saline
infusion, heating induced an upward shift of the compliance-midwall stress curve
and a downward shift of the modulus-midwall stress curve demonstrating a decrease
in arterial tone and stiffness when blood flow increases. These shifts were
reduced by N(G)-monomethyl-L-arginine and abolished by the combinations of
N(G)-monomethyl-L-arginine+tetraethylammonium and N(G)-monomethyl
arginine+fluconazole. In parallel, in isolated mice coronary arteries,
fluconazole and tetraethylammonium reduced the relaxations to acetylcholine.
However, fluconazole did not affect the relaxations to the openers of
calcium-activated potassium channels of small- and intermediate-conductance NS309
and of large-conductance NS1619 excluding a direct effect on these channels.
Moreover, tetraethylammonium reduced the relaxations to NS1619 but not to NS309,
suggesting that the endothelium-derived hyperpolarizing factor involved mainly
acts on large-conductance calcium-activated potassium channels. These results
show in humans that, during flow variations, arterial stiffness is regulated by
the endothelium through the release of both NO and cytochrome-related
endothelium-derived hyperpolarizing factor.
PMID: 20083732 [PubMed - indexed for MEDLINE]
14. Antimicrob Agents Chemother. 2010 Mar;54(3):1315-8. Epub 2010 Jan 4.
Evaluation of new thiazolide/thiadiazolide derivatives reveals nitro
group-independent efficacy against in vitro development of Cryptosporidium
parvum.
Gargala G, Le Goff L, Ballet JJ, Favennec L, Stachulski AV, Rossignol JF.
Parasitology Department, Rouen University Hospital and UPRES-EA 4311-IFRMP 23,
University of Rouen, Rouen, France. gilles.gargala@univ-rouen.fr
Thirty-nine new thiazolide/thiadiazolide compounds were compared with the
nitrothiazole nitazoxanide for activity against Cryptosporidium parvum
development in HCT-8 cells. Twenty-seven agents exerted > or =90% inhibition.
Agents with a lower 50% inhibitory concentration (IC(50)) than nitazoxanide were
either NO(2) or halogen 5 substituted on the thiazole moiety. Other 5
substitutions such as methyl, C(3)H(7), C(6)H(11), H, SO(2)CH(3), and SCH(3)
negatively impacted activity. Five-substituted deacetylated analogues exhibited
higher IC(50)s than their acetylated counterparts.
Halogeno-thiazolide/thiadiazolides may provide valuable nitro-free alternatives
to nitazoxanide.
PMCID: PMC2825981 [Available on 2010/9/1]
PMID: 20047919 [PubMed - in process]
15. Int J Gynaecol Obstet. 2010 Mar;108(3):249. Epub 2009 Nov 26.
Fertility after pelvic arterial embolization, stepwise uterine devascularization,
hypogastric artery ligation, and B-Lynch suture to control postpartum hemorrhage.
Sentilhes L, Gromez A, Marpeau L.
Department of Obstetrics and Gynecology, Rouen University Hospital, Charles
Nicolle, Rouen, France. loicsentilhes@hotmail.com
PMID: 19944415 [PubMed - in process]
16. Biol Blood Marrow Transplant. 2010 Mar;16(3):430-4. Epub 2009 Oct 31.
Reduced frequency of regulatory T cells in peripheral blood stem cell compared to
bone marrow transplantations.
Blache C, Chauvin JM, Marie-Cardine A, Contentin N, Pommier P, Dedreux I,
François S, Jacquot S, Bastit D, Boyer O.
INSERM U905, Faculte de Medecine, 22 Boulevard Gambetta, Rouen, France.
Peripheral blood stem cell transplantation (PBSCT) is an alternative to bone
marrow transplantation (BMT). Although CD4(+)CD25(+)CD127(lo) regulatory T cells
(Tregs) have been shown to play important roles in the control of T cell
reactivity, the Treg contents of both graft types have not been analyzed
comparatively to date. We report herein that Treg frequencies are significantly
reduced in PBSC compared to BM transplants. Furthermore, most Tregs from PBSC
transplants are CD62L(lo), a phenotype reported to have poor suppressor activity.
Both granulocyte-colony stimulating factor (G-CSF) administration and
leukapheresis were found to contribute to the loss of CD62L(+) Tregs. Although
higher T cell numbers are infused in PBSCT than in BMT, it is possible that the
reduced Treg content of PBSC transplants may represent 1 factor contributing to
the higher risk of GVHD reported after PBSCT. Copyright (c) 2010 American Society
for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights
reserved.
PMID: 19883775 [PubMed - in process]
17. Inflamm Bowel Dis. 2010 Mar;16(3):518-24.
Potential for amino acids supplementation during inflammatory bowel diseases.
Coëffier M, Marion-Letellier R, Déchelotte P.
Appareil Digestif Environnement Nutrition (ADEN EA4311), Institute for Biomedical
Research, European Institute for Peptide Research (IFRMP 23), Rouen University
and Rouen University Hospital, Rouen, France. moise.coeffier@univ-rouen.fr
The pathophysiology of inflammatory bowel diseases (IBDs) is multifactorial and
involves interactions of gut luminal content with mucosal barrier and especially
immune cells. Malnutrition is a frequent issue during IBD flares, especially in
Crohn's disease (CD) patients, and nutritional support is frequently used to
treat malnutrition but also in an attempt to modulate intestinal inflammation.
The use of oral or enteral nutrition intervention in IBDs may be effective, alone
or in combination with drugs, to achieve and maintain remission. However,
standard diets are less effective than new-generation biotherapies and could be
improved by supplementation with specific immunomodulatory amino acids.
Experimental studies evaluating glutamine, the preferential substrate for
enterocytes, are promising. Some clinical studies with oral glutamine in CD are
until now disappointing, but new formulations and targeting could enhance
glutamine efficacy at the site of mucosal lesions. The role of arginine, involved
in nitric oxide and polyamines synthesis, still remains debated. However, the
effects of these amino acids in IBD have been poorly documented in humans. Other
candidates like glycine, cysteine, histidine, or taurine should also be evaluated
in the future.
PMID: 19572337 [PubMed - in process]
18. Eur Psychiatry. 2010 Mar;25(2):75-9. Epub 2009 Jun 21.
The Emotional Stroop task: A comparison between schizophrenic subjects and
controls.
Demily C, Attala N, Fouldrin G, Czernecki V, Ménard JF, Lamy S, Dubois B, Thibaut
F.
INSERM U, Rouen University Hospital Charles Nicolle, France.
The colour-word Emotional Stroop task (ES task) has been proposed to assess the
interferences between emotion and attention. Using this task, first, we examined
how attention (using reaction times) can be modified by emotionally relevant
words in schizophrenics as compared with controls as a function of the emotional
significance of the word; second, we tested the assumption that schizophrenics
with the most negative symptoms will show higher impairment in relationship to
negative emotional words. In general, schizophrenics were slower to react. In
both groups, mean reaction times were slower for emotional as compared with
neutral words. No significant differences were observed between negative and
positive words either in schizophrenics (n=21) or in controls (n=20). Even in the
most negative schizophrenic patients, there were no differences between negative
and positive words. There were no significant interactions between type of
stimulus and any clinical variables (PANSS negative or non negative
categorization, etc.). Also, there were no statistically significant correlations
between reaction times and neuroleptic dosage or anhedonia scores. In conclusion,
schizophrenia patients showed the same degree of interference from emotional
words as compared with controls. Moreover, patients with a higher level of
negative symptoms did not differently experience positive and negative words.
2009 Elsevier Masson SAS. All rights reserved.
PMID: 19541456 [PubMed - in process]
19. Rev Med Interne. 2010 Mar;31(3):238-40. Epub 2009 Mar 28.
[Subcutaneous calcifications and dysmorphic syndrome]
[Article in French]
Avenel G, Bernet J, Lahaxe L, Lévesque H, Marie I.
Département de médecine interne, CHU de Rouen, France.
PMID: 19329231 [PubMed - in process]
