1: Rev Med Interne 2002 Dec;23(12):1043
[Article in French]
Levesque H.
Service de medecine interne, hopital de Boisguillaume, CHU, 76031 cedex, Rouen,
France
PMID: 12504248 [PubMed - in process]
2: Surg Radiol Anat 2002 Dec;24(5):302-7
The synovial fold of the humeroradial joint: anatomical and histological
features, and clinical relevance in lateral epicondylalgia of the elbow.
Duparc F, Putz R, Michot C, Muller JM, Freger P.
Laboratoire d'Anatomie, Faculte de Medecine Pharmacie de Rouen, 22, boulevard
Gambetta, 76183 Rouen cedex, France, Fabrice.Duparc@chu-rouen.fr
The synovial fold of the humeroradial joint is known, and sometimes considered
as a meniscus that could be injured by chronic repeated trauma related to
pronation and supination. The aims of this study were to determine the gross
anatomy and histological structure of this fold, and to clarify its
participation in the painful lateral syndromes of the elbow. Fifty elbows from
adult cadavers were dissected. The capsule of the humeroradial part of the elbow
joint was resected with the annular ligament. The presence of a synovial fold,
and its location relative to the cranial edge of the annular ligament divided
into five sectors (ventral, ventrolateral, lateral, laterodorsal and dorsal)
were noted; morphological parameters such as thickness, width and length were
measured. The histological examination determined the structure of the folds.
Five synovial folds were resected during surgery for epicondylalgia in five
patients who suffered from pain precisely at the level of the joint between the
capitulum and the fovea radialis, and were also examined. A fold was present in
43 cases, and in two cases two folds were seen at the deep side of the junction
between the capsule and the annular ligament. The most frequent positions were:
dorsal ( n=11), laterodorsal and dorsal ( n=6;), lateral to dorsal ( n=5),
lateral ( n=5), ventral ( n=4) and circular ( n=4). The mean length was 21.4 mm
(range from 9-51 mm). The mean width was 2.9 mm (range 1-10 mm), and the mean
maximal thickness 1.7 mm (range 1-4 mm). The histological study showed two types
of folds: a rigid structure, with oriented fibrous tissue, triangular with a
peripheral capsular base, covered on its two sides and along the free edge by a
synovial layer; and a pliable structure, formed of two synovial layers that
surrounded a thin fatty tissue, with a villous appearance of the free edge. No
fibromyxoid structure, as in a real meniscus, was observed. Some nerve fibers
were seen in the folds. The five folds resected in operated patients were
hypertrophic, and showed an increased number of nerve fibers, along the capsule
but also close to the synovial layer. Some painful syndromes of the lateral side
of the elbow are not related to tendinitis or to posterior interosseous nerve
compression, but have an intra-articular origin. This study showed that the
synovial fold is not a meniscus, and may be involved in the etiology of lateral
epicondylalgia. The French version of this article is available in the form of
electronic supplementary material and can be obtained by using the Springer Link
server located at http://dx.doi.org/10.1007/s00276-002-0055-0
PMID: 12497221 [PubMed - in process]
3: Ann Surg 2003 Jan;237(1):52-6
Artificial anal sphincter in severe fecal incontinence: outcome of prospective
experience with 37 patients in one institution.
Michot F, Costaglioli B, Leroi AM, Denis P.
Digestive Tract Research Group, Rouen University Hospital, France.
francis.michot@chu-rouen.fr
OBJECTIVE: To evaluate the outcome of artificial anal sphincter implantation for
severe fecal incontinence in 37 consecutive patients operated on in a single
institution from 1993 through 2001. SUMMARY BACKGROUND DATA: Implantation of an
artificial anal sphincter is proposed in severe fecal incontinence when local
treatment is unsuitable or has failed. The results of this technique have not
been determined yet, and its place among the various operative procedures is
still debated. METHODS: Artificial anal sphincters were implanted in 37 patients
from 1993 through 2001. All patients had complete fecal incontinence and had
failed to respond to medical treatment. Median duration of incontinence was 16
years. The causes of incontinence were sphincter disruption (19 patients),
hereditary malformations (2 patients), and neurologic disease (16 patients). Six
patients had had previous surgery for fecal incontinence. Assessment was made by
physical examination (anal continence, rectal emptying) and anorectal manometry.
RESULTS: In the first 12 patients, six devices had to be removed (50%); the
cause of failure was found in all cases, and this allowed contraindications to
be defined. Among the next 25 patients, 23 had an uncomplicated postoperative
follow-up, and 5 developed seven complications: control pump change (n = 3),
balloon migration (n = 1), and major rectal emptying difficulties in patients
with obstructive internal rectal procidentia (n = 2). The artificial anal
sphincter had to be removed definitively in three cases, representing the
failure rate of this technique in the authors' experience (12%); two other
devices had to be removed temporarily and the patients are awaiting
reimplantation. In this latter group of 25 patients, 80% have an activated
sphincter: continence for liquid stool is normal in 78.9%, continence for gas in
63.1%. Seven patients have rectal emptying difficulties, minor in five and major
in two. Manometric studies showed mean pressures of 110 and 37 cm H(2)O with
closed and open sphincter, respectively, with a mean duration of artificial
sphincter opening of 128 seconds. CONCLUSIONS: The long-term functional outcome
of artificial anal sphincter implantation for severe fecal incontinence is
satisfactory; adequate sphincter function is recovered and the definitive
removal rate is low. Good results are directly related to careful patient
selection and appropriate surgical and perioperative management after a learning
curve of the surgical team.
Publication Types:
Evaluation Studies
PMID: 12496530 [PubMed - indexed for MEDLINE]
4: Behav Brain Res 2003 Jan 6;138(1):71-9
Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning,
exploration, anxiety, and motor coordination.
Lalonde R, Qian S, Strazielle C.
Universite de Rouen, Faculte de Medecine et de Pharmacie, 22 bld Gambetta,
INSERM EPI 9906, Batiment de Recherche, Salle 1D18, 76183 Cedex, Rouen, France
The functional consequence of the PS1-A246E mutation was assessed in transgenic
mice on a background lacking the endogenous PS1 gene. These mice have elevated
concentrations of A-beta protein (Abeta(42)) in the absence of plaque formation.
By comparison to a mixed background strain (50% B6, 25% SJl, 25% 129Sv)
controlled for age and gender, PS1-A246E transgenic mice displayed disinhibitory
tendencies, as indicated by increased entries and duration in the open arms of
the elevated plus-maze. Despite normal spontaneous alternation rates in a
T-maze, latencies before responding were higher in PS1-A246E transgenic mice
than controls. Moreover, the PS1-A246E transgenic mice fell more often from two
stationary beams, but not from the coat-hanger and the rotorod. By contrast,
ambulation in an automated photocell chamber and in an open-field was not
affected. Nor was acquisition of place learning in the Morris water maze task.
These results indicate that elevated Abeta(42) levels were insufficient for
causing spatial defects but caused disinhibition, psychomotor slowing, and loss
of motor skills in this model of familial Alzheimer's disease.
PMID: 12493631 [PubMed - in process]
5: Br J Anaesth 2003 Jan;90(1):108-9
Sub-Tenon's infiltration using bupivacaine 0.5% decreases acute postoperative
pain and opioid requirement after posterior segment surgery.
Calenda E, Muraine M, Brasseur G.
Publication Types:
Clinical Trial
Letter
Randomized Controlled Trial
PMID: 12488397 [PubMed - indexed for MEDLINE]
6: Rev Stomatol Chir Maxillofac 2002 Jun;103(3):164-9
[Obstructive sleep apnea syndrome: medical treatment]
[Article in French]
Muir JF, Portier F.
Service de Pneumologie et Unite d'Exploration des Troubles Respiratoires du
Sommeil, CHU Rouen, Hopital de Bois-Guillaume. jean-francois.muir@chu-rouen.fr
Medical management of patients with obstructive sleep apnea syndrome (OSAS)
implies a multidisciplinary organization. Dietary advice is always needed
because the great majority of these patients are significantly overweight.
Drinking alcoholic beverages before bedtime and smoking must be advised against.
Re-learning good sleeping habits is also necessary for certain patients with a
chronic disorder. In patients with a mild to moderate OSAS, or whose diagnostic
tracing demonstrates position-related respiratory events, it may be useful to
avoid dorsal decubitus when sleeping. Sedatives should of course be totally
avoided. Drug treatment for OSAS has generally been disappointing, but new
serotoninergic receptor antagonists offer new possibilities. Medical management
of associated conditions such as hypothyroidism must also be an integral part of
the long term treatment of OSAS. The gold standard treatment remains continuous
nocturnal positive pressure ventilation with proven efficacy largely
demonstrated in several controlled trials showing often spectacular response
within days. Prescription is guided by the intensity of the clinical diurnal and
nocturnal symptoms, better results being obtained in patients with a high index
of respiratory events. For patients with mild to moderate disease (index < 30)
or for patients with severe disease who do not tolerate positive pressure
ventilation, surgery or a mandibular advancement device should be considered.
Publication Types:
Review
Review, Tutorial
PMID: 12486890 [PubMed - indexed for MEDLINE]
7: J Invest Dermatol 2002 Dec;119(6):1379-87
Endothelial dysfunction in murine model of systemic sclerosis: tight-skin mice
1.
Marie I, Beny JL.
Department of Zoology and Animal Biology, University of Geneva, Sciences III, 30
Quai Ernest Ansermet, 1211 Geneva 4, Switzerland. Isabelle.marie@chu-rouen.fr
We conducted this study to analyze endothelial cell function within intact
thoracic aorta of the systemic sclerosis murine model, the heterozygous
tight-skin mice 1: (i) assessing the distribution and activation intensity of
endothelial cells, responsive to endothelium-dependent vasodilators
(acetylcholine, adenosine triphosphate, bradykinin, and substance P) and
Iloprost, using laser line confocal microscopy in combination with two Ca2+
fluorescent dyes; (ii) evaluating en-dothelium-dependent vasodilator- and
Iloprostinduced relaxation, using isometric tension measurement; and (iii)
investigating the role of nitric oxide in mediating relaxation to acetylcholine
and adenosine triphosphate. The number of activated endothelial cells was
significantly lower in heterozygous tight-skin mice 1, compared with controls,
for adenosine triphosphate and Iloprost. Maximal increase of Ca2+ fluorescence
intensity ratio in activated endothelial cells was decreased for adenosine
triphosphate, bradykinin, and Iloprost, in heterozygous tight-skin mice 1.
Adenosine triphosphate- and Iloprost-mediated aortic relaxation was further
impaired in heterozygous tight-skin mice 1. Finally, aortic relaxation to
acetylcholine and adenosine triphosphate was markedly decreased by nitric oxide
synthase inhibitor in heterozygous tight-skin mice 1. This study suggests that
endothelial cell receptors for endothelium-dependent vasodilators and Iloprost
may not be homogeneously distributed or continuously expressed in thoracic aorta
of heterozygous tight-skin mice 1, resulting in endothelium-dependent
vasodilatation dysfunction. Moreover, because endothelium-dependent relaxation
was highly dependent on nitric oxide release in heterozygous tight-skin mice 1,
endothelium-dependent relaxation may differ from that of controls by increased
production of nitric oxide. In turn, in heterozygous tight-skin mice 1, the
resulting elevated nitric oxide levels may contribute to nitric oxide-mediated
free radical endothelial cytotoxicity, although endothelium impairment may be
related to other factors, particularly: Fbn-1 gene mutation and transforming
growth factor-beta.
PMID: 12485443 [PubMed - indexed for MEDLINE]
8: Gastroenterol Clin Biol 2002 Nov;26(11):1047-50
[Juvenile polyposis coli. The usefulness of a genetic study and the role of
surgical treatment]
[Article in French]
Teniere P, Songne K, Frebourg T, Moguelet P, Foulatier O, Michot F, Le Pessot F,
Le Blanc I, Scotte M.
Service de Chirurgie Generale et Digestive, Hopital Charles Nicolle, 1, rue de
Germont, 76031 Rouen Cedex. Paul.Teniere@chu-rouen.fr
We report two cases of familial juvenile polyposis coli. SMAD4 gene mutation was
found in our two patients, leading to the definite diagnosis. Colonic cancer
occurred in the first patient. Long-term outcome was favorable after colectomy.
In the second patient, prophylactic total colectomy was performed. Rectal
bleeding, diarrhea, stomach obstruction and vomiting developed during the
follow-up. Proctectomy, distal partial gastrectomy and total gastrectomy were
successively performed.
PMID: 12483142 [PubMed - indexed for MEDLINE]
9: Respir Care Clin N Am 2002 Sep;8(3):405-18, vi
Evaluation of candidates for long-term ventilation.
Muir JF, Cuvelier A.
Service de Pneumologie et Unite de Ventilation non invasive, Centre
Hospitalo-Universitaire, Rouen, 76031, France. Jean-Francois.Muir@chu-rouen.fr
This article considers the evaluation of patients prior to institution of
long-term ventilation (LTV). LTV has evolved from a concept of necessity
ventilation to a more satisfactory approach of preventive LTV, enabled by the
impressive development of noninvasive mechanical ventilation (NIV). Due to its
convenience and efficacy, and its safety compared with invasive ventilation, NIV
has rapidly gained popularity among patients with chronic respiratory failure
(CRF) requiring intermittent ventilatory assistance. Evaluation of candidates
for LTV involves clinical and laboratory evaluations and sleep monitoring. It
includes consideration of the etiology of CRF, be it restrictive lung disease,
chronic obstructive pulmonary disease, obesity or other cause, and considers the
feasibility of LTV as well as its desirability.
Publication Types:
Review
Review, Tutorial
PMID: 12481964 [PubMed - indexed for MEDLINE]
10: C R Biol 2002 Sep;325(9):917-25
Quasi-periodic behaviour in a model for the lithium-induced, electrical
oscillations of frog skin.
Letellier C, Lassalles JP, Norris V, Ripoll C, Thellier M.
CORIA, universite de Rouen, av. de l'Universite, BP 12, 76801
Saint-Etienne-du-Rouvray, France.
The fact that oscillations can be induced in studies of the maintenance of the
electrical potential of frog skin by addition of lithium allowed evaluation of
several parameters fundamental to the functioning of the system in vivo (e.g.
relative volumes of internal compartments, characteristic times of ionic
exchanges between compartments). A realistic model was thus proposed under the
form of a set of ordinary differential equations. In the past, numerical
simulations using such a model reproduced the periodic experimental oscillations
and was able to provide an explanation for the global synchronised oscillations
of the whole skin. In that paper, new numerical simulations reproduce the
non-periodic oscillations which were observed two decades ago, but not
reproduced by the model. Moreover, the dynamical process under which all the
local oscillators are synchronised is explained in terms of a tangent
bifurcation.
Publication Types:
Review
Review, Tutorial
PMID: 12481685 [PubMed - indexed for MEDLINE]
11: Rev Med Interne 2002 Nov;23 Suppl 4:449s-458s
[The interferons: pharmacology, mechanism of action, tolerance and side effects]
[Article in French]
Arnaud P.
Departement de pharmacie, CHU de Rouen-hopital Charles-Nicolle, 1, rue de
Germont, 76031 Rouen, France. philippe.arnaud@chu-rouen.fr
BACKGROUND: Interferons are a recombinant form of endogenous interferon. By
inducing the release of intracellular enzymes such as 2'5' oligoadenylate
synthetase and double stranded RNA dependent protein kinase, the drug causes
degradation of viral messenger RNA and inhibits protein synthesis. MAIN POINTS:
Interferons are cytokines efficient in the treatment of infections diseases.
Three main types are described as alpha, beta and gamma depending on their
antigenic specificity. They have antiviral activity, antiproliferative and
immunomodulation properties in response to a viral infection or other enzyme
inducers. Furthermore, they increase expression of major histo-compatible
complex antigens, increase natural killer and cytotoxic T cell activity,
cytokine induction and production of endogenous interferon. Adverse effects
frequently occur but are generally wild and reversible at current dosages. The
pharmacokinetics of interferons have been fairly well described. The decline in
serum concentrations is rapid after intravenous administration. The volume of
distribution approximates 20-60% of bodyweight. Terminal elimination half lives
range from 4-16 hrs, 1-2 hrs and 25-35 min for alpha, beta, gamma respectively.
Intra-muscular and subcutaneous administration of interferons alpha and beta
results in protracted but fairly good absorption > 80% for interferon alpha to
70% for interferon gamma. Pegylated interferon safety and pharmacodynamic
profiles were comparable. Pegylated interferon demonstrated delayed clearance
compared with non-pegylated interferon, consistent with once-weekly
administration. The severity of adverse effects is dose dependent. Most patients
treated have an influenza like syndrome within 2-8 hrs of drug administration.
Other effects such as fatigue, lethargy, anorexia are usually dose limiting.
Neuropsychiatric reactions may also become dose limiting. Interferon induced the
formation of serum neutralizing antibodies in approximately 10-20% of treated
patients. PERSPECTIVES: The development of pegylated forms, a greater
understanding of action mechanisms, and the combination with other therapies
should reinforce the place of interferons in the therapeutic arsenal.
Publication Types:
Review
Review, Tutorial
PMID: 12481400 [PubMed - indexed for MEDLINE]
12: Rev Med Interne 2002 Nov;23 Suppl 4:447s-448s
[Interferons: cytokines usually used as drugs]
[Article in French]
Levesque H.
Publication Types:
Editorial
PMID: 12481399 [PubMed - indexed for MEDLINE]
13: Plant Physiol 2002 Dec;130(4):1754-63
Rapid structural phenotyping of plant cell wall mutants by enzymatic
oligosaccharide fingerprinting.
Lerouxel O, Choo TS, Seveno M, Usadel B, Faye L, Lerouge P, Pauly M.
Centre National de la Recherche Scientifique Unite Mixte de Recherche 6037,
Institute Federative de Recherche Multidisciplinaire sur les Peptides 23,
University of Rouen, 76821 Mont Saint Aignan, France.
Various biochemical, chemical, and microspectroscopic methods have been
developed throughout the years for the screening and identification of mutants
with altered cell wall structure. However, these procedures fail to provide the
insight into structural aspects of the cell wall polymers. In this paper, we
present various methods for rapidly screening Arabidopsis cell wall mutants. The
enzymatic fingerprinting procedures using high-performance
anion-exchange-pulsed-amperometric detection liquid chromatography,
fluorophore-assisted carbohydrate electrophoresis, and matrix-assisted
laser-desorption ionization time of flight (MALDI-TOF) mass spectrometry (MS)
were exemplified by the structural analysis of the hemicellulose xyloglucan. All
three techniques are able to identify structural alterations of wall xyloglucans
in mur1, mur2, and mur3, which in comparison with the wild type have side chain
defects in their xyloglucan structure. The quickest analysis was provided by
MALDI-TOF MS. Although MALDI-TOF MS per se is not quantitative, it is possible
to reproducibly obtain relative abundance information of the various
oligosaccharides present in the extract. The lack of absolute quantitation by
MALDI-TOF MS was compensated for with a xyloglucan-specific endoglucanase and
simple colorimetric assay. In view of the potential for mass screening using
MALDI-TOF MS, a PERL-based program was developed to process the spectra obtained
from MALDI-TOF MS automatically. Outliers can be identified very rapidly
according to a set of defined parameters based on data collected from the
wild-type plants. The methods presented here can easily be adopted for the
analysis of other wall polysaccharides. MALDI-TOF MS offers a powerful tool to
screen and identify cell wall mutants rapidly and efficiently and, more
importantly, is able to give initial insights into the structural composition
and/or modification that occurs in these mutants.
PMID: 12481058 [PubMed - in process]
14: J Urol 2003 Jan;169(1):270-1
Renal chromophobe cell carcinoma and paraneoplastic linear IgA bullous
dermatosis.
Benoit Corven C, Khalaf A, Courville P, Sibert L, Gobet F, Joly P.
Department of Dermatology, Rouen University Hospital-Charles Nicolle, Rouen,
France.
PMID: 12478155 [PubMed - indexed for MEDLINE]
15: Joint Bone Spine 2002 Oct;69(5):499-501
Septic arthritis due to Actinomyces naeslundii: report of a case.
Lequerre T, Nouvellon M, Kraznowska K, Bruno MC, Vittecoq O, Mejjad O, Daragon
A, Le Loet X.
Rheumatology Department, Rouen University Hospital Charles-Nicolle, Unit INSERM
519, IFR 23, 76000 Rouen cedex 76031, France.
In a man with osteoarthritis of the knee, Actinomyces naeslundii septic
arthritis developed after intra-articular injection of hyaluronate. Actinomyces
is an anaerobic Gram-positive rod. The outcome was favorable after treatment
with two antibiotics and arthroscopy. The nature of the organism and its
location to a joint are unusual features of this case, which illustrates the
need to search for a septic complication before accepting a diagnosis of
inflammation related to hyaluronate injection.
PMID: 12477236 [PubMed - in process]
16: Rev Mal Respir 2002 Oct;19(5 Pt 1):627-32
[Respiratory tract infections in the elderly living in institutions: prevention]
[Article in French]
Chassagne P, Bentot-Levasseur C, Druesne L, Bercoff E, Doucet J.
Service de Medecine Interne - Geriatrique, CHU Rouen, Rouen, France.
philippe.chassagne@chu-rouen.fr
Pneumonia amongst elderly people living in institutions is common and is a
frequent cause of mortality and hospital admission. It is important to
distinguish between prevention of viral pneumonia, which primarily consists of
influenza vaccination programmes, and prevention of bacterial pneumonia.
Prevention of influenza infection in institutions requires the vaccination of as
many as possible of both residents and caregivers. In the event of a declared
epidemic then amantadine can be used to reduce the severity of, and complication
rate of, influenza infection. The indications for giving this therapy need to be
balanced against potential side-effects, especially neurological ones. For the
prevention of bacterial pneumonia risk factors such as immobility or impaired
swallowing should be first identified and dealt with as necessary.
Anti-pneumoncoccal vaccination may be considered, but on current evidence, the
value of systematic vaccination of residents has not yet been established.
PMID: 12473949 [PubMed - indexed for MEDLINE]
17: Circulation 2002 Dec 10;106(24):3006-8
Percutaneous transcatheter implantation of an aortic valve prosthesis for
calcific aortic stenosis: first human case description.
Cribier A, Eltchaninoff H, Bash A, Borenstein N, Tron C, Bauer F, Derumeaux G,
Anselme F, Laborde F, Leon MB.
Department of Cardiology, Charles Nicolle Hospital, University of Rouen, Rouen,
France. Alain.Cribier@chu-rouen.fr
BACKGROUND: The design of a percutaneous implantable prosthetic heart valve has
become an important area for investigation. A percutaneously implanted heart
valve (PHV) composed of 3 bovine pericardial leaflets mounted within a
balloon-expandable stent was developed. After ex vivo testing and animal
implantation studies, the first human implantation was performed in a
57-year-old man with calcific aortic stenosis, cardiogenic shock, subacute leg
ischemia, and other associated noncardiac diseases. Valve replacement had been
declined for this patient, and balloon valvuloplasty had been performed with
nonsustained results. METHODS AND RESULTS: With the use of an antegrade
transseptal approach, the PHV was successfully implanted within the diseased
native aortic valve, with accurate and stable PHV positioning, no impairment of
the coronary artery blood flow or of the mitral valve function, and a mild
paravalvular aortic regurgitation. Immediately and at 48 hours after
implantation, valve function was excellent, resulting in marked hemodynamic
improvement. Over a follow-up period of 4 months, the valvular function remained
satisfactory as assessed by sequential transesophageal echocardiography, and
there was no recurrence of heart failure. However, severe noncardiac
complications occurred, including a progressive worsening of the leg ischemia,
leading to leg amputation with lack of healing, infection, and death 17 weeks
after PHV implantation. CONCLUSIONS: Nonsurgical implantation of a prosthetic
heart valve can be successfully achieved with immediate and midterm hemodynamic
and clinical improvement. After further device modifications, additional
durability tests, and confirmatory clinical implantations, PHV might become an
important therapeutic alternative for the treatment of selected patients with
nonsurgical aortic stenosis.
PMID: 12473543 [PubMed - indexed for MEDLINE]
18: J Radiol 2002 Nov;83(11):1773-4
[Imaging of a foreign body in the submandibular space]
[Article in French]
Charron F, Callonnec F, Thiebot J, Dacher JN.
Radiologie Generale, CHU de Rouen, 1, Rue de Germont, 76031 Rouen France.
Foreign bodies in the oral cavity are infrequent in children. In spite of a
negative clinical exploration, US and CT showed the suction cup of a
rubber-tipped dart in the left submandibular space of a 3 year-old child.
Surgery could be guided by these investigations.
PMID: 12469016 [PubMed - indexed for MEDLINE]
19: Proc AMIA Symp 2002;:954-8
An Assessment of the Visibility of MeSH-Indexed Medical Web Catalogs through
Search Engines.
Zweigenbaum P, Darmoni SJ, Grabar N, Douyere M, Benichou J.
Service d'Informatique Medicale/DSI, Assistance Publique - Hopitaux de Paris,
Paris Cedex 13 75634, FRANCE,.
Manually indexed Internet health catalogs such as CliniWeb or CISMeF provide
resources for retrieving high-quality health information. Users of these
quality-controlled subject gateways are most often referred to them by general
search engines such as Google, AltaVista, etc. This raises several questions,
among which the following: what is the relative visibility of medical Internet
catalogs through search engines? This study addresses this issue by measuring
and comparing the visibility of six major, MeSH-indexed health catalogs through
four different search engines (AltaVista, Google, Lycos, Northern Light) in two
languages (English and French). Over half a million queries were sent to the
search engines; for most of these search engines, according to our measures at
the time the queries were sent, the most visible catalog for English MeSH terms
was CliniWeb and the most visible one for French MeSH terms was CISMeF.
PMID: 12463965 [PubMed - in process]
20: Rev Stomatol Chir Maxillofac 2002 Nov;103(5):304-6
[Difficult diagnosis for a lingual ulceration. Wegener granulamotosis]
[Article in French]
Chen N, Francois A, Moguelet P, Peron JM.
Service de Chirurgie Maxillo-Faciale et Stomatologie (Pr JM. Peron), Hopital
Charles Nicolle, CHU Rouen, 76031 Rouen Cedex.
Making the correct diagnosis for a lingual ulceration can be difficult. We
present the case of a 55-year-old man, alcooholic and smoker who presented with
a single lingual ulceration. The initial diagnosis suggested a cell-squamed
carcinoma but histological examination revealed a Wegener Granulomatosis.
Wegener Granulomatosis in the oral cavity is found in 6-13% of cases but rarely
primary sign of the disease. The authors review differential diagnosis that
should be taken into consideration when presented with similar lesion.
PMID: 12461467 [PubMed - in process]
