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2020


Abstract: In the context of the COVID-19 pandemic, wearing a face mask has become usual and ubiquitous, in both hospitals and community. However, the general public is consuming surgical or filtering face piece (FFP) masks irrespective of their specificity, leading to global supply shortage for the most exposed persons, which are healthcare workers. This underlines the urgent need to clarify the indications of the different categories of mask, in order to rationalize their use. The study herein specifies the French position for the rational use of respiratory protective equipment for healthcare workers.
BibTeX:
@article{Lepelletier2020,
  author = {Lepelletier, Didier and Grandbastien, Bruno and Romano-Bertrand, Sara and Aho, Serge and Chidiac, Christian and Géhanno, Jean-François and Chauvin, Franck and {French Society for Hospital Hygiene and the High Council for Public Health}},
  title = {What face mask for what use in the context of {COVID}-19 pandemic? {The} {French} guidelines},
  month = {April},
  journal = {The Journal of Hospital Infection},
  year = {2020},
  doi = {10.1016/j.jhin.2020.04.036}
}

Abstract: Background: With the continuous expansion of available biomedical data, efficient and effective information retrieval has become of utmost importance. Semantic expansion of queries using synonyms may improve information retrieval.
Objective: The aim of this study was to automatically construct and evaluate expanded PubMed queries of the form "preferred term"[MH] OR "preferred term"[TIAB] OR "synonym 1"[TIAB] OR "synonym 2"[TIAB] OR …, for each of the 28,313 Medical Subject Heading (MeSH) descriptors, by using different semantic expansion strategies. We sought to propose an innovative method that could automatically evaluate these strategies, based on the three main metrics used in information science (precision, recall, and F-measure).
Methods: Three semantic expansion strategies were assessed. They differed by the synonyms used to build the queries as follows: MeSH synonyms, Unified Medical Language System (UMLS) mappings, and custom mappings (Catalogue et Index des Sites Médicaux de langue Française [CISMeF]). The precision, recall, and F-measure metrics were automatically computed for the three strategies and for the standard automatic term mapping (ATM) of PubMed. The method to automatically compute the metrics involved computing the number of all relevant citations (A), using National Library of Medicine indexing as the gold standard ("preferred term"[MH]), the number of citations retrieved by the added terms ("synonym 1"[TIAB] OR "synonym 2"[TIAB] OR …) (B), and the number of relevant citations retrieved by the added terms (combining the previous two queries with an "AND" operator) (C). It was possible to programmatically compute the metrics for each strategy using each of the 28,313 MeSH descriptors as a "preferred term," corresponding to 239,724 different queries built and sent to the PubMed application program interface. The four search strategies were ranked and compared for each metric.
Results: ATM had the worst performance for all three metrics among the four strategies. The MeSH strategy had the best mean precision (51%, SD 23%). The UMLS strategy had the best recall and F-measure (41%, SD 31% and 36%, SD 24%, respectively). CISMeF had the second best recall and F-measure (40%, SD 31% and 35%, SD 24%, respectively). However, considering a cutoff of 5%, CISMeF had better precision than UMLS for 1180 descriptors, better recall for 793 descriptors, and better F-measure for 678 descriptors.
Conclusions: This study highlights the importance of using semantic expansion strategies to improve information retrieval. However, the performances of a given strategy, relatively to another, varied greatly depending on the MeSH descriptor. These results confirm there is no ideal search strategy for all descriptors. Different semantic expansions should be used depending on the descriptor and the user's objectives. Thus, we developed an interface that allows users to input a descriptor and then proposes the best semantic expansion to maximize the three main metrics (precision, recall, and F-measure).
BibTeX:
@article{Massonnaud2018,
  author = {Massonnaud, Clément R and Kerdelhué, Gaetan and Grosjean, Julien and Lelong, Romain and Griffon, Nicolas and Darmoni, Stefan J},
  title = {Identification of the Best Semantic Expansion to Query PubMed Through Automatic Performance Assessment of Four Search Strategies on All Medical Subject Heading Descriptors: Comparative Study},
  month = {June},
  journal = {JMIR Medical Informatics},
  year = {2020},
  volume = {8},
  number = {6},
  pages = {e12799},
  url = {https://medinform.jmir.org/2020/6/e12799/},
  doi = {10.2196/12799}
}

Abstract: Screening and management of frail elderly patients is essential in general practice.
OBJECTIVE: This study aims to describe and evaluate the knowledge about frailty, its screening tests and management in a population of general practice interns.
METHOD: A prospective, descriptive and mono-centric study using an online survey was conducted. The 2018's promotion of general practice interns in Rouen's University participated. Evaluation of the general knowledge (e.g diagnostic criteria) and specific knowledge (e.g ranking different conditions such as: undernourishment leading to asthenia) and management algorithm (e.g to address the patient for geriatric evaluation) Results: 90 questionnaires were analyzed. Ten interns (11 stated to know at least one screening test or to know a set of 4 major frailty criteria. Thirty four interns knew at least 4 frailty criteria (major or minor) and 46 interns had partial knowledge. Fried's phenotype was the most known. Seventy-five interns (83 stated to know the frailty syndrome. However, 88% of the interns had little knowledge about its pathophysiology. Concerning frailty management, 78% (70 interns) stated to know how to screen frailty and prescribe first line treatments. Thirty-one among them knew how to reassess initial treatment if failure. In 59 interns (65, identifying frailty would have led to a geriatric consultation. Seventy-nine interns (87 were favorable to go through further training on frailty.
CONCLUSION: These general practice interns were able to identify frailty criterion but, in contrast, global understanding of the syndrome was missing. Further training about this topic seems to be necessary.
BibTeX:
@article{Piedallu2020,
  author = {Piedallu, Jean-Baptiste and Lorenzo-Villalba, Noël and Chassagne, Philippe and Schuers, Mathieu and Zulfiqar, Abrar-Ahmad},
  title = {Frailty syndrome: evaluation of its knowledge and screening tools by general medicine interns},
  month = {March},
  journal = {Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement},
  year = {2020},
  volume = {18},
  number = {1},
  pages = {53--62},
  doi = {10.1684/pnv.2019.0840}
}

Abstract: Background: Unstructured data from electronic health record is a gold mine. Doc’EDS is a pre-screening tool based on textual and semantic analysis. The system provides an easy-to-use interface to search documents in French. The aim of this study is to present the tools and to provide a formal ...
BibTeX:
@article{Pressat-Laffouilhere2020,
  author = {Thibaut Pressat-Laffouilhère and Pierre Balayé and Badisse Dahamna and Romain Lelong and Kévin Billey and Stéfan Jacques Darmoni and Julien Grosjean},
  title = {Evaluation of {Doc}’{EDS}: {A} {French} {Semantic} {Search} {Tool} to {Query} {Health} {Documents} from {A} {Clinical} {Data} {Warehouse}},
  month = {September},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2020},
  note = {This preprint is under consideration at BMC Medical Informatics and Decision Making.},
  url = {https://www.researchsquare.com/article/rs-59497/v1},
  doi = {10.21203/rs.3.rs-59497/v1}
}

Abstract: BACKGROUND: The definition and the treatment of male urinary tract infections (UTIs) are imprecise. This study aims to determine the frequency of male UTIs in consultations of general practice, the diagnostic approach and the prescribed treatments.
METHODS: We extracted the consultations of male patients, aged 18 years or more, during the period 2012-17 with the International Classification of Primary Care, version 2 codes for UTIs or associated symptoms from PRIMEGE/MEDISEPT databases of primary care. For eligible consultations in which all symptoms or codes were consistent with male UTIs, we identified patient history, prescribed treatments, antibiotic duration, clinical conditions, additional examinations and bacteriological results of urine culture.
RESULTS: Our study included 610 consultations with 396 male patients (mean age 62.5 years). Male UTIs accounted for 0.097% of visits and 1.44 visits per physician per year. The UTIs most commonly identified were: undifferentiated (52, prostatitis (36, cystitis (8.5 and pyelonephritis (3.5. Fever was recorded in 14% of consultations. Urine dipstick test was done in 1.8% of consultations. Urine culture was positive for Escherichia coli in 50.4% of bacteriological tests. Fluoroquinolones were the most prescribed antibiotics (64.9, followed by beta-lactams (17.4, trimethoprim-sulfamethoxazole (11.9 and nitrofurantoin (2.6.
CONCLUSIONS: Male UTIs are rare in general practice and have different presentations. The definition of male UTIs needs to be specified by prospective studies. Diagnostic evidence of male cystitis may reduce the duration of antibiotic therapy and spare critical antibiotics.
BibTeX:
@article{Soudais2020,
  author = {Soudais, Benjamin and Lacroix-Hugues, Virginie and Meunier, François and Gillibert, André and Darmon, David and Schuers, Matthieu},
  title = {Diagnosis and management of male urinary tract infections: a need for new guidelines. {Study} from a {French} general practice electronic database},
  month = {December},
  journal = {Family Practice},
  year = {2020},
  doi = {10.1093/fampra/cmaa136}
}

Abstract: Résumé
But
En deux décennies, la télédermatologie est devenue une des applications les plus développées de la télémédecine. Son déploiement nécessite d’être accompagné par des évaluations de qualité. Pour réaliser ces évaluations, des indicateurs précis et mesurables doivent être définis. L’objectif de cette étude était d’identifier de manière exhaustive les indicateurs permettant d’évaluer les procédures de télédermatologie et d’évaluer leur pertinence et leurs résultats.
Méthodes
Revue systématique de la littérature conduite sur MEDLINE via PubMed jusqu’en septembre 2017, à partir d’une requête comportant les termes MeSH suivants : « telemedicine », « dermatology », « quality improvement ».
Résultats
La requête a identifié 372 articles, dont 127 ont été retenus. Quatorze indicateurs ont été identifiés et répartis en quatre catégories : indicateurs de processus, de qualité, de coût et de satisfaction. La fiabilité diagnostique de la télédermatologie était l’indicateur le plus souvent évalué (49 études). Elle était globalement bonne comparée à la consultation conventionnelle. Les coûts étaient généralement moindres. Les résultats de certains indicateurs étaient difficiles à comparer et donc à généraliser du fait de l’absence d’instrument de mesure validé, notamment pour la satisfaction.
Conclusion
La télédermatologie est un outil prometteur. Sa mise en place doit s’adapter aux différents besoins des territoires et être réfléchie avec les patients et les différents professionnels de santé concernés. Son évaluation devra également être spécifique à chaque terrain et se baser sur des indicateurs standardisés.
Summary
Aim
Over the last two decades teledermatology has become one of the most widely used applications in telemedicine. Wide-ranging medico-economic evaluations are necessary to facilitate its deployment. “Accurate and measurable” indicators must be defined in order to enable high-quality assessments to be performed. The objective of this study is to identify all indicators allowing evaluation of teledermatology procedures and to assess the relevance and results thereof.
Materials and methods
A literature search until September 2017 was conducted in PubMed using the following MeSH search terms: “telemedicine”, “dermatology” and “quality improvement”.
Results
The search identified 372 articles, of which 127 were included. Fourteen indicators were identified and split into 4 categories: processes indicators, quality indicators, cost indicators and satisfaction indicators. Reliability of diagnosis was the most widely evaluated indicator (49 studies). It was good overall compared to conventional consultations. Costs were generally reduced. Due to the absence of a validated measuring tool, it was difficult to compare the results for certain indicators, particularly satisfaction, and thus to make any generalizations.
Conclusion
Teledermatology is a promising tool. Its deployment must be adapted to the various needs in the field and achievement of this goal requires consultation with patients and with the different healthcare professionals involved. Its evaluation must also be specific to each terrain and must employ standardized measuring instruments.
BibTeX:
@article{Ridard2020,
  author = {Ridard, E. and Secember, H. and Carvalho-Lallement, P. and Schuers, M.},
  title = {Indicateurs en télédermatologie : une revue de la littérature},
  month = {July},
  journal = {Annales de Dermatologie et de Vénéréologie},
  year = {2020},
  url = {http://www.sciencedirect.com/science/article/pii/S0151963820302702},
  doi = {10.1016/j.annder.2020.01.024}
}

Abstract: INTRODUCTION: Return to work after cancer is a determinant of patients quality of life. The aims were to describe return-to-work interventions applied in a French University Hospital and to assess its effectiveness in achieving a successful return to work.
METHODS: A return-to-work questionnaire was sent to 153 patients who were accompanied by a multidisciplinary return-to-work after cancer consultation.
RESULTS: hundred and twenty-one patients answered the return-to-work questionnaire. Analysis of the questionnaire found an overall rate of return to work of 50% two years after the cancer diagnosis. The rate was significantly higher in patients who had received individual psychological support for returning to work (P=0.04) and higher, but not significantly, in patients who had a consultation with the company physician during their period of sick-leave (P=0.08). Participating in support groups and performing the required actions for the recognition of handicapped worker status were not factors associated with return to work.
DISCUSSION: An individual psychological support for returning to work and a consultation with the company physician during the period of sick-leave should be systematically recommended for patients suffering from cancer. Participating in support groups and recognition of handicapped worker status should be recommended on a case-by-case basis.
BibTeX:
@article{Rollin2020,
  author = {Rollin, Laétitia and De Blasi, Geraldine and Boucher, Line and Bouteyre, Evelyne and Gehanno, Jean-François},
  title = {Return-to-work support in cancer patients: {Which} methodology?},
  month = {February},
  journal = {Bulletin Du Cancer},
  year = {2020},
  volume = {107},
  number = {2},
  pages = {200--208},
  doi = {10.1016/j.bulcan.2019.10.006}
}

Abstract: A lexical method was used to map ICD-11 to the terminologies included in the HeTOP server. About half of ICD-11 codes (47.76 were mapped to at least one concept. The developed tool reached a global precision of 0.98 and a recall of 0.66. Lexical methods are powerful methods to map health terminologies. Supervised and manual mapping is still necessary to complete the mapping.
BibTeX:
@article{Grosjean2020,
  author = {Grosjean, Julien and Billey, Kévin and Charlet, Jean and Darmoni, Stefan J.},
  title = {Manual {Evaluation} of the {Automatic} {Mapping} of {International} {Classification} of {Diseases} ({ICD})-11 (in {French}).},
  month = {June},
  journal = {Studies in health technology and informatics},
  year = {2020},
  volume = {270},
  pages = {1335--1336},
  note = {Place: Netherlands},
  url = {http://ebooks.iospress.nl/volume/digital-personalized-health-and-medicine-proceedings-of-mie-2020},
  doi = {10.3233/SHTI200429}
}

BibTeX:
@article{Deroualle2020,
  author = {Deroualle, T. and Dominique, S. and Darmoni, S. and Grosjean, J. and Monti, F. and Lequerré, T. and Vittecoq, O.},
  title = {Les formes rhumatologiques de la sarcoïdose sont associées à un risque accru de développer une spondyloarthrite : résultats d’une étude cas-témoins monocentrique rétrospective},
  month = {December},
  journal = {Revue du rhumatisme},
  year = {2020},
  volume = {87},
  pages = {A98--A99},
  note = {Publisher: Paris : Elsevier},
  url = {https://www.lissa.fr/fr/rep/articles/EL_S1169833020303641},
  doi = {10.1016/j.rhum.2020.10.170}
}

Abstract: Résumé
La crise inédite du Covid-19 a fait apparaitre le besoin de recenser et de diffuser des supports didactiques thérapeutiques à destination des patients (auto-rééducation) en complément des séances, notamment dans le cadre du télésoin. Kinedoc, la banque documentaire francophone, a collaboré avec le D2IM du CHU de Rouen pour créer ce nouveau type de documents en adaptant le moteur de recherche du CISMeF qui recense déjà des publications similaires dans d’autres domaines. Désormais, il sera possible de trouver et de télécharger dans Kinedoc des brochures thérapeutiques dont le Collège de la Masso-Kinésithérapie (CMK) aura préalablement validé la conformité. Chaque société savante, association ou kinésithérapeute/physiothérapeute peut proposer de partager ses « brochures pédagogiques pour le patient », en les envoyant par courriel à cette adresse : secretariat@college-mk.org.
With this unprecedented Covid-19 crisis, appeared the need to draw up a list and to spread pedagogical and therapeutic media for patients (self-rehabilitation), in addition to sessions, particularly in "telehealth". Kinedoc, a French database, collaborated with the D2IM of Rouen’s university hospital to create this new type of documents, adjusting CISMeF’s search engine, which has already listed similar publications in other fields. From now on, it will be possible to find and download in Kinedoc therapeutic brochures certified by the "Collège de la Masso-Kinésithérapie" (CMK). Every academic society, association or physiotherapist can suggest sharing its "pedagogical brochures for patients" by sending them to this address: secretariat@college-mk.org.
BibTeX:
@article{Kerdelhue2020,
  author = {Kerdelhué, Gaétan and Grosjean, Julien and Lejeune, Emeline and Letord, Catherine and Darmoni, Stéfan and Oviève, Jean-Marc and Martin, Laurélyne and Gedda, Michel},
  title = {Kinedoc, {CISMeF} et {COVID}-19: la nécessité de référencer les brochures pédagogiques pour le patient},
  month = {May},
  journal = {Kinésithérapie, la Revue},
  year = {2020},
  url = {http://www.sciencedirect.com/science/article/pii/S1779012320301790},
  doi = {10.1016/j.kine.2020.05.010}
}

BibTeX:
@unpublished{Kiem2020,
  author = {Kiem, C{\'e}cile Tran and Massonnaud, Cl{\'e}ment and Levy-Bruhl, Daniel and Poletto, Chiara and Colizza, Vittoria and Bosetti, Paolo and Gabet, Am{\'e}lie and Olie, Val{\'e}rie and Zanetti, Laura and Bo{\"e}lle, Pierre-Yves and Crepey, Pascal and Cauchemez, Simon},
  title = {{Evaluation des strat{\'e}gies vaccinales COVID-19 avec un mod{\`e}le math{\'e}matique populationnel}},
  month = {December},
  school = {{Haute Autorit{\'e} de Sant{\'e} ; Institut Pasteur Paris ; Sant{\'e} publique France}},
  year = {2020},
  note = {working paper or preprint},
  url = {https://hal-pasteur.archives-ouvertes.fr/pasteur-03087143}
}

BibTeX:
@article{Trost2020,
  author = {Trost, Olivier and Crampon, Frédéric and Prum, Grégoire and Trouilloud, Pierre and Duparc, Fabrice},
  title = {A plea to remove the word "condyle" from the international anatomical nomenclature},
  month = {January},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2020},
  volume = {42},
  number = {1},
  pages = {95--96},
  doi = {10.1007/s00276-019-02296-7}
}

2019


Abstract: PURPOSE: Nasomaxillary fractures can be mistaken for fractures confined to the nasal bones, resulting in inappropriate treatments that jeopardize patient outcomes. Our purpose here was to provide information on nasomaxillary fractures via a retrospective study and literature review. MATERIAL AND METHODS: We retrospectively collected clinical, computed tomography (CT), therapeutic, and outcome data in consecutive patients managed for unilateral impacted nasomaxillary fractures at our centre over a 5-year period (2013-2017). Long-term outcomes were further assessed by administering scoring tools for subjectively assessed cosmesis, nasal obstruction, and pain during a telephone interview. RESULTS: The 11 included patients had a mean age of 33.4 years. The clinical manifestations included nasal asymmetry in all 11 patients and infra-orbital rim step-off deformity in 9 patients. Consistent CT findings were involvement of the nasal bone, canine pillar, and anterior maxillary bone; and presence of blood within the maxillary sinus. The treatment in 8 patients consisted in open reduction and internal fixation via the intraoral approach, with or without an added infra-orbital approach; 1 patient was managed by endonasal reduction and 2 patients declined reduction. Almost 1 year after surgery, the cosmetic outcome was good (mean score, 22/25) and few patients reported nasal obstruction (mean score, 3.6/20) or pain (mean score, 1.6/10). CONCLUSION: Nasomaxillary fracture is a specific entity that must be differentiated from nasal bone fracture. Open reduction and internal fixation via the intraoral approach, with an added infra-orbital approach if needed, provides good outcomes.
BibTeX:
@article{Adnot2019a,
  author = {Adnot, J. and Desbarats, C. and Joly, L.-M. and Trost, O.},
  title = {Nasomaxillary fracture: Retrospective review of 11 consecutive patients and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  volume = {120},
  number = {6},
  pages = {534--539},
  doi = {10.1016/j.jormas.2019.03.003}
}

Abstract: Dental rehabilitation raises specific challenges in patients with mandibular fibrous dysplasia. We report the 2-year post-operative outcomes on the normal and affected sides in a 64-year-old female with focal left mandibular fibrous dysplasia and bilateral posterior edentulism. On the left, bone shaving of the lesion to restore sufficient vertical height was followed by the insertion of two dental implants. Three dental implants were inserted into the normal bone on the right. Dental prostheses were added 6 months later. Two years after the first procedure, no complications had been recorded and the patient reported similar high satisfaction for both sides. This comparison of outcomes of dental implants inserted into dysplastic versus normal bone in the same patient suggests that dental implants may constitute a valid option for managing edentulism in selected patients with fibrous dysplasia, provided appropriate precautions are taken.
BibTeX:
@article{Adnot2019,
  author = {Adnot, J. and Moizan, H. and Trost, O.},
  title = {Dental implants in a patient with left mandibular fibrous dysplasia: Two-year outcomes on the normal and affected sides},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  volume = {120},
  number = {6},
  pages = {575--578},
  doi = {10.1016/j.jormas.2019.02.005}
}

Abstract: BACKGROUND: Extracting concepts from biomedical texts is a key to support many advanced applications such as biomedical information retrieval. However, in clinical notes Named Entity Recognition (NER) has to deal with various types of errors such as spelling errors, grammatical errors, truncated sentences, and non-standard abbreviations. Moreover, in numerous countries, NER is challenged by the availability of many resources originally developed and only suitable for English texts. This paper presents the Cimind system, a multilingual system dedicated to named entity recognition in medical texts based on a phonetic similarity measure. METHODS: Cimind performs entity recognition by combining phonetic recognition using the DM phonetic algorithm to deal with spelling errors and string similarity measures. Three main steps are processed to identify terms in a controlled vocabulary: normalization, candidate selection by phonetic similarity and candidate ranking. RESULTS: Cimind was evaluated in the 2016 and 2017 editions of the CLEF eHealth challenge in the CepiDC/CDC tasks. In 2017, it obtained on each corpus the following results: English dataset: 83.9% P, 78.3% R, 81.0% F1; French raw dataset: 85.7% P, 68.9% R, 76.4% F1; French aligned dataset: 83.5% P, 77.5% R, 80.4% F1. It ranked first in French and fourth in English in officials runs.
BibTeX:
@article{Cabot2019,
  author = {Cabot, Chloe and Darmoni, Stefan and Soualmia, Lina F.},
  title = {Cimind: {A} phonetic-based tool for multilingual named entity recognition in biomedical texts.},
  month = {June},
  journal = {Journal of biomedical informatics},
  year = {2019},
  volume = {94},
  pages = {103176},
  doi = {10.1016/j.jbi.2019.103176}
}

Abstract: PURPOSE: The objective of this study was to record the descriptive and metric anatomical characteristics of the thyrohyoid nerve with the aim of rerouting it in a selective laryngeal reinnervation procedure. METHODS: An anatomical study was performed on ten formalin-embalmed cadavers. The origin of the thyrohyoid nerve and the superior root of the ansa cervicalis, the location of the thyrohyoid nerve ending in the thyrohyoid muscle, and the recurrent laryngeal nerve were established. Then, a rerouting of the thyrohyoid nerve was performed. We measured the length of thyrohyoid nerve, the distance between the thyrohyoid nerve ending and the recurrent laryngeal nerve at the horizontal level of the cricothyroid joint before and after the rerouting, and the distance between the origin of the thyrohyoid nerve and the superior root of the ansa cervicalis. RESULTS: The thyrohyoid nerve was identified on both sides in all the cases. The average length of the thyrohyoid nerve was 27 mm. The end of the thyrohyoid nerve was found in 100% of the cases at the upper outer quarter of the thyrohyoid muscle. After the rerouting, an average reduction of 30% of the distance between the end of the thyroid nerve and the recurrent laryngeal nerve at the horizontal level of the cricothyroid joint was measured. CONCLUSION: The rerouting of the thyrohyoid nerve provided a reduction in the length of the nerve graft in laryngeal reinnervation. Moreover, the constancy of the thyrohyoid nerve and its characteristics make it a valuable anatomical base for laryngeal reinnervation and laryngeal innervated allotransplantation.
BibTeX:
@article{Crampon2019,
  author = {Crampon, Frédéric and Duparc, Fabrice and Trost, Olivier and Marie, Jean-Paul},
  title = {Selective laryngeal reinnervation: can rerouting of the thyrohyoid nerve simplify the procedure by avoiding the use of a nerve graft?},
  month = {February},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2019},
  volume = {41},
  number = {2},
  pages = {145--150},
  doi = {10.1007/s00276-018-2117-y}
}

Abstract: INTRODUCTION: Guidelines concerning the follow-up of subjects occupationally exposed to lung carcinogens, published in France in 2015, recommended the setting up of a trial of low-dose chest CT lung cancer screening in subjects at high risk of lung cancer. OBJECTIVE: To evaluate the organisation of low-dose chest CT lung cancer screening in subjects occupationally exposed to lung carcinogens and at high risk of lung cancer. METHODS AND ANALYSIS: This trial will be conducted in eight French departments by six specialised reference centres (SRCs) in occupational health. In view of the exploratory nature of this trial, it is proposed to test initially the feasibility and acceptability over the first 2 years in only two SRCs then in four other SRCs to evaluate the organisation. The target population is current or former smokers with more than 30 pack-years (who have quit smoking for less than 15 years), currently or previously exposed to International Agency for Research on Cancer group 1 lung carcinogens, and between the ages of 55 and 74 years. The trial will be conducted in the following steps: (1) identification of subjects by a screening invitation letter; (2) evaluation of occupational exposure to lung carcinogens; (3) evaluation of the lung cancer risk level and verification of eligibility; (4) screening procedure: annual chest CT scans performed by specialised centres and (5) follow-up of CT scan abnormalities. ETHICS AND DISSEMINATION: This protocol study has been approved by the French Committee for the Protection of Persons. The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings. TRIAL REGISTRATION NUMBER: NCT03562052; Pre-results.
BibTeX:
@article{Delva2019,
  author = {Delva, Fleur and Laurent, François and Paris, Christophe and Belacel, Milia and Brochard, Patrick and Bylicki, Olivier and Chouaïd, Christos and Clin, Benedicte and Dewitte, Jean-Dominique and Le Denmat, Véronique and Gehanno, Jean-François and Lacourt, Aude and Margery, Jacques and Verdun-Esquer, Catherine and Mathoulin-Pélissier, Simone and Pairon, Jean-Claude},
  title = {LUCSO-1-French pilot study of LUng Cancer Screening with low-dose computed tomography in a smokers population exposed to Occupational lung carcinogens: study protocol},
  journal = {BMJ open},
  year = {2019},
  volume = {9},
  number = {3},
  pages = {e025026},
  doi = {10.1136/bmjopen-2018-025026}
}

Abstract: Background: Word embedding technologies are now used in a wide range of applications. However, no formal evaluation and comparison have been made on models produced by the three most famous implementations (Word2Vec, GloVe and FastText).
Objective: The goal of this study is to compare embedding implementations on a corpus of documents produced in a working context, by health professionals.
Methods: Models have been trained on documents coming from the Rouen university hospital. This data is not structured and cover a wide range of documents produced in a clinic (discharge summary, prescriptions ...). Four evaluation tasks have been defined (cosine similarity, odd one, mathematical operations and human formal evaluation) and applied on each model.
Results: Word2Vec had the highest score for three of the four tasks (mathematical operations, odd one similarity and human validation), particularly regarding the Skip-Gram architecture.
Conclusions: Even if this implementation had the best rate, each model has its own qualities and defects, like the training time which is very short for GloVe or morphosyntaxic similarity conservation observed with FastText. Models and test sets produced by this study will be the first publicly available through a graphical interface to help advance French biomedical research.
BibTeX:
@article{Dynomant2019,
  author = {Dynomant, Emeric and Lelong, Romain and Dahamna, Badisse and Massonaud, Clément and Kerdelhué, Gaétan and Grosjean, Julien and Canu, Stéphane and Darmoni, Stefan J},
  title = {Word embedding for {French} natural language in healthcare: a comparative study},
  month = {April},
  journal = {JMIR Medical Informatics},
  year = {2019},
  pages = {30},
  doi = {10.2196/12310}
}

Abstract: BACKGROUND: Clinical research is mostly conducted among hospitalized patients, which restricts the generalizability of research results. The involvement of GPs in research has been consistently highlighted as a factor associated with successful study recruitment. OBJECTIVES: To assess GPs' motivations and willingness to participate in primary care research as investigators and to identify factors associated with their willingness. METHODS: We conducted an observational, cross-sectional study in Normandy, France, with a self-questionnaire sent to 3002 GPs. We collected data on GPs' socio-demographic characteristics, their experiences and their expectations regarding research, and their reasons for non-participation. RESULTS: Overall, 489 questionnaires were collected. Two hundred and forty-six GPs (50.3%) were interested in participating in clinical research as investigators. The two main conditions for participation as investigators were the relevance of the study topic for clinical practice (80.5%) and the feedback of study results (80.1%). The two main reasons for non-participation were lack of time (79.4%) and administrative burden (43.6%). Age between 27 and 34 years (adjusted odds ratio [AOR] = 2.86, P = 0.004) and GP trainer status (AOR = 2.41, P < 0.001) were associated with willingness to participate in primary care research. Age between 60 and 70 years (AOR = 0.53, P = 0.03) and locum status (AOR = 0.40, P = 0.04) were associated with non-participation in research. CONCLUSIONS: Based on our results, we were able to establish a profile of GPs willing to participate in primary care research as investigators. GPs' involvement should be based on their preferred areas of research. Different incentives such as a dedicated clinical research nurse or financial support could also be considered.
BibTeX:
@article{FerrandDevouge2019,
  author = {Ferrand Devouge, Eglantine and Biard, Morgane and Beuzeboc, Jean and Tavolacci, Marie-Pierre and Schuers, Matthieu},
  title = {Motivations and willingness of general practitioners in France to participate in primary care research as investigators},
  journal = {Family Practice},
  year = {2019},
  volume = {36},
  number = {5},
  pages = {552--559},
  doi = {10.1093/fampra/cmy126}
}

Abstract: BACKGROUND: Childhood obesity (CO) has become a true epidemic and a subject of increasing publications. The aim of this study was to assess if the number of publications in that field increases over time in proportion to the epidemic, and also according to socioeconomic factors.
METHODS: A PubMed search was carried out to extract articles related to CO published between 1945 and 2017. Data were downloaded from PubMed and processed through a dedicated parser. Socioeconomic data were collected from international organizations.
RESULTS: Overall, 36,554 articles were retrieved among 3329 journals, one-third of them being concentrated in 44 journals. The annual growth rate of publications on CO was on average 11.6% per year between 1990 and 2016, whereas the growth rate of articles on pediatrics or of the total articles indexed in MEDLINE was 2.6% and 4.4 respectively. The most productive countries were the United States (37.80, the United Kingdom (6.24, and Italy (4.56. There was a significant relationship between publications on CO in a country and prevalence of CO in that country (p = 0.002) and between evolution of the number of publications and evolution of the Human Development Index (p = 0.01). Following exponential growth, CO publications reached a plateau in 2013, whereas publications targeted on obesity in infants continue to increase.
CONCLUSIONS: Research on CO has risen markedly in the last two decades, with a higher growth rate than biomedical research overall, as a result of the worldwide obesity epidemic and also due to specific socioeconomic factors.
BibTeX:
@article{Gehanno2019,
  author = {Gehanno, Jean-Francois and Gehanno, Bogna and Schuers, Mathieu and Grosjean, Julien and Rollin, Laetitia},
  title = {Analysis of {Publication} {Trends} in {Childhood} {Obesity} {Research} in {PubMed} {Since} 1945},
  month = {March},
  journal = {Childhood Obesity (Print)},
  year = {2019},
  doi = {10.1089/chi.2018.0276}
}

Abstract: INTRODUCTION: The pharmaceutical record system (PRS) is a French nationwide centralized electronic database shared among all community pharmacists listing all drugs dispensed by community pharmacists in the last four months. The objective of this study, the Medication Assessment Through Real time Information eXchange - Distributed Pharmaceutical Record System (MATRIX - DPRS) study, was to assess the clinical impact of the PRS upon granting access to physicians in three hospital specialties: anesthesiology, emergency medicine and geriatrics. MATERIAL AND METHODS: A multicenter prospective study was conducted in six hospital departments, two per specialty. Participating physicians noted medication information found exclusively in the pharmaceutical record (PR) of each patient unavailable elsewhere and any diagnostic or therapeutic management changes resulting from the PR information. The primary objective was to assess the proportion of diagnostic or therapeutic management changes attributable to the PR among patients who had an accessible PR. RESULTS: The inclusion level ranged from 1.1 to 30% in the six departments. The rate of diagnostic or therapeutic management changes was highest in geriatrics (n = 31/67; 46.3% 95% Confidence IntervaI (CI): 34.0-58.9 and lowest in anesthesiology (n = 36/227; 15.9% 95% CI: 11.4-21.3. Emergency medicine was intermediate (n = 5/22; 22.7% 95% CI: 7.8-45.4. CONCLUSION: Although the inclusion rate and statistical precision were low, these findings suggest that the information contained in the PRS is useful and may result in modifying patient management in a sizeable proportion of patients. This opens the prospect of evaluating other hospital specialties, as well as primary and secondary care settings.
BibTeX:
@article{Gillibert2019,
  author = {Gillibert, Andre and Griffon, Nicolas and Schuers, Matthieu and Hardy, Kristell and Elmerini, Amine and Letord, Catherine and Staccini, Pascal and Darmoni, Stefan J. and Benichou, Jacques},
  title = {Impact on medical practice of accessing pharmaceutical records},
  month = {January},
  journal = {International journal of medical informatics},
  year = {2019},
  volume = {121},
  pages = {58--63},
  doi = {10.1016/j.ijmedinf.2018.09.010}
}

Abstract: INTRODUCTION: La classification internationale des soins primaires, deuxième version (CISP-2) alignée sur la classification internationale des maladie dixième révision (CIM-10) est un standard pour le recueil épidémiologique en soins primaires. La CISP-2 convient aussi pour identifier les thèmes cliniques dont discutent les médecins de famille. Les domaines contextuels de connaissances spécifiques à la médecine de famille et aux Soins Primaires comme les structures, la gestion, les catégories de patients, les méthodes de recherche, les aspects éthiques ou environnementaux ne sont pas standardisés et reflètent le plus souvent des vues d'experts. METHODES: une méthode de recherche qualitative, appliquée à l'analyse de plusieurs congrès de médecine de famille a permis d'identifier, en plus des items cliniques, un ensemble de concepts contextuels abordés par les médecins de famille lors de leurs échanges pendant les congrès. Assemblés sous forme hiérarchique, ces concepts ont trouvé leur place au côté de la CISP-2, sous le nom de Q-codes version 2.5, sur le serveur sémantique multilingue multi-terminologique du Département d'Information et d'Informatique médicale (D2IM) de l'Université de Rouen, France. Les deux classifications sont éditées sous le sigle 3CGP pour Core Content Classification of General Practice. Ce serveur d'accès libre permet de consulter la CISP-2 en 22 langues et les Q-codes en dix langues. RESULTATS: le résultat de l'utilisation conjointe de ces deux classifications, comme descripteurs dans des congrès, pour identifier des concepts dans des textes, ou indexer la littérature grise en médecine de famille et soins primaires est présenté ici dans différentes utilisations pilotes. La validité et la généralisabilité de 3CGP semble bonne au vu des traductions déjà réalisées par des collègues du monde entier et de l'applicabilité de la méthode des deux côtés de l'Atlantique. Toute fois la reproductibilité et la variation inter-codeurs restent encore à tester pour les Q-codes. La question de la maintenance reste posée. CONCLUSION: grâce à cette méthode, on peut mettre en évidence l'extension conceptuelle, la complexité et la dynamique du métier de médecin généraliste et de famille et de médecin de soins primaires.
BibTeX:
@article{Jamoulle2019,
  author = {Jamoulle, Marc and Augusto, Daniel Knupp and Pizzanelli, Miguel and Tavares, Ariana De Oliveira and Resnick, Melissa and Grosjean, Julien and Darmoni, Stefan},
  title = {Une base de connaissance multilingue et dynamique en ligne pour la médecine générale et les soins primaires},
  journal = {Pan African Medical Journal},
  year = {2019},
  volume = {32},
  url = {http://www.panafrican-med-journal.com/content/article/32/66/full/},
  doi = {10.11604/pamj.2019.32.66.15952}
}

Abstract: Background: The huge amount of clinical, administrative and demographic data recorded and maintained by hospitals can be consistently aggregated into Health Data Warehouses (HDWs) with a uniform data model. In 2017, Rouen University Hospital (RUH) initiated the design of a Semantic Health Data Warehouse (SHDW) enabling both semantic description and retrieval of health information.
Objective: Our objectives were: first, to present a proof of concept of this SHDW, based on the data of 250,000 patients from RUH and second, to assess its ability to assist health professionals to select patients in a clinical trials context.
Methods: The SHDW relies on three distinct semantic layers: (a) a Terminology and Ontology (T&O) portal, (b) a Semantic Annotator and (c) a Semantic Search Engine and a Not Only SQL (NoSQL) layer to enhance data access performances. The system adopts an entity-centered vision which contrasts with the usually patient-centered vision adopted by existing systems such as Informatics for Integrating Biology and the Bedside (i2b2). This vision notably provides generic search capabilities able to express data requirements in terms of the whole set of interconnected conceptual entities that compose health information. We assessed the ability of the system to assist the search for 95 inclusion and exclusion criteria originating from five randomly chosen Clinical Trials from RUH.
Results: The system succeeded in fully automating 39.19% of the criteria and was efficiently used as a pre-screening tool for 72.97% of them.
Conclusions: The semantic aspect of the system combined with its generic entity-centered vision enables the processing of a large range of clinical questions. However, an important part of health information remains in Clinical Narratives and we are currently investigating novel approaches (deep learning) to enhance the semantic annotation of those unstructured data.
BibTeX:
@article{Lelong2019,
  author = {Lelong, Romain and Soualmia, Lina F and Grosjean, Julien and Taalba, Mehdi and Darmoni, SJ},
  title = {Building a {Semantic} {Health} {Data} {Warehouse}: {Evaluation} of a search tool in {Clinical} trials},
  journal = {JMIR Medical Informatics},
  year = {2019},
  pages = {30},
  doi = {10.2196/13917}
}

BibTeX:
@article{Maquet2019,
  author = {Maquet, C. and Evrard, M. and Kerbrat, J.-B. and Bastien, A.-V. and Adnot, J. and Trost, O.},
  title = {A case of severe facial palsy following bimaxillary osteotomy: It is time to update the pre-surgery patient fact sheet},
  month = {September},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2019},
  doi = {10.1016/j.jormas.2019.08.013}
}

Abstract: BACKGROUND:
PubMed is one of the most important basic tools to access medical literature. Semantic query expansion using synonyms can improve retrieval efficacy.
OBJECTIVE:
The objective was to evaluate the performance of three semantic query expansion strategies.
METHODS:
Queries were built for forty MeSH descriptors using three semantic expansion strategies (MeSH synonyms, UMLS mappings, and mappings created by the CISMeF team), then sent to PubMed. To evaluate expansion performances for each query, the first twenty citations were selected, and their relevance were judged by three independent evaluators based on the title and abstract.
RESULTS:
Queries built with the UMLS expansion provided new citations with a slightly higher mean precision (74.19%) than with the CISMeF expansion (70.28%), although the difference was not significant. Inter-rater agreement was 0.28. Results varied greatly depending on the descriptor selected.
DISCUSSION:
The number of citations retrieved by the three strategies and their precision varied greatly according to the descriptor. This heterogeneity could be explained by the quality of the synonyms. Optimal use of these different expansions would be through various combinations of UMLS and CISMeF intersections or unions.
CONCLUSION:
Information retrieval tools should propose different semantic expansions depending on the descriptor and the search objectives.
BibTeX:
@article{Massonaud2019,
  author = {Clément Massonaud and Romain Lelong and Gaétan Kerdelhué and Emeline Lejeune and Julien Grosjean and Nicolas Griffon and Stéfan Darmoni},
  title = {Performance evaluation of three semantic expansions to query PubMed},
  journal = {Health Information and Libraries Journal},
  year = {2019},
  doi = {10.1111/hir.12291}
}

Abstract: BACKGROUND: Despite growing access to effective therapies, asthma control still needs improvement. Many non-drug factors, such as allergens, air pollutants and stress also affect asthma control and patient quality of life, but an overview of the effectiveness of non-drug interventions on asthma control was lacking.
OBJECTIVES: To identify non-drug interventions likely to improve asthma control.
METHODS: A systematic review of the available literature in Medline and the Cochrane Library was conducted in March 2017, without any time limit. Initial searching identified 884 potentially relevant clinical trial reports, literature reviews and meta-analyses, which were screened for inclusion using criteria of quality, relevance, and reporting outcomes based on asthma control.
RESULTS: Eighty-two publications met the inclusion criteria. In general, the quality of the studies was low. Patient education programmes (22 studies) significantly improved asthma control. Multifaceted interventions (10 studies), which combined patient education programmes with decreasing exposure to indoor allergens and pollutants, significantly improved asthma control based on clinically relevant outcomes. Renovating homes to reduce exposure to allergens and indoor pollutants improved control (two studies). Air filtration systems (five studies) were effective, especially in children exposed to second-hand smoke. Most measures attempting to reduce exposure to dust mites were ineffective (five studies). Dietary interventions (eight studies) were ineffective. Promoting physical activity (five studies) tended to yield positive results, but the results did not attain significance.
CONCLUSION: Twenty-six interventions were effective in asthma control. Simultaneously combining several action plans, each focusing on different aspects of asthma management, seems most likely to be effective.
BibTeX:
@article{Schuers2019,
  author = {Schuers, Matthieu and Chapron, Anthony and Guihard, Hugo and Bouchez, Tiphanie and Darmon, David},
  title = {Impact of non-drug therapies on asthma control: {A} systematic review of the literature},
  month = {March},
  journal = {The European Journal of General Practice},
  year = {2019},
  pages = {1--12},
  doi = {10.1080/13814788.2019.1574742}
}

Abstract: INTRODUCTION:
Research in family medicine is necessary to improve the quality of care. The number of publications in general medicine remains low. Databases from Electronic Medical Records can increase the number of these publications. These data must be coded to be used pertinently. The objective of this study was to assess the quality of semantic annotation by a multi-terminological concept extractor within a corpus of family medicine consultations.
METHOD:
Consultation data in French from 25 general practitioners were automatically annotated using 28 different terminologies. The data extracted were classified into three groups: reasons for consulting, observations and consultation results. The first evaluation led to a correction phase of the tool which led to a second evaluation. For each evaluation, the precision, recall and F-measure were quantified. Then, the inter- and intra-terminological coverage of each terminology was assessed.
RESULTS:
Nearly 15,000 automatic annotations were manually evaluated. The mean values for the second evaluation of precision, recall and F-measure were 0.85, 0.83 and 0.84 respectively. The most common terminologies used were SNOMED CT, SNOMED 3.5 and NClt. The terminologies with the best intra-terminological coverage were ICPC-2, DRC and CISMeF Meta-Terms.
CONCLUSION:
A multi-terminological concepts extractor can be used for the automatic annotation of consultation data in family medicine. Integrating such a tool into general practitioners' business software would be a solution to the lack of routine coding. Developing the use of a single terminology specific to family medicine could improve coding, facilitate semantic interoperability and the communication of relevant information.
BibTeX:
@article{Siefridt2019,
  author = {Charlotte Siefridt and Julien Grosjean and Tatiana Lefebvre and Laetitia Rollin and Stéfan Darmoni and Matthieu Schuers},
  title = {Evaluation of automatic annotation by a multi-terminological concepts extractor within a corpus of data from family medicine consultations},
  journal = {International Journal of Medical Informatics},
  year = {2019},
  doi = {10.1016/j.ijmedinf.2019.104009}
}

BibTeX:
@article{Desbarats2019,
  author = {Desbarats, C. and Adnot, J. and Bastien, A. V. and Trost, O.},
  title = {Histiocytose langerhansienne révélée par un désordre de l’appareil manducateur : rapport d’un cas et revue de la littérature des atteintes crâniofaciales.},
  month = {August},
  journal = {La Revue de médecine interne},
  year = {2019},
  url = {https://www.lissa.fr/fr/rep/articles/31474430},
  doi = {10.1016/j.revmed.2019.08.005}
}

Abstract: Lyme borreliosis is transmitted en France by the tick Ixodes ricinus, endemic in metropolitan France. In the absence of vaccine licensed for use in humans, primary prevention mostly relies on mechanical protection (clothes covering most parts of the body) that may be completed by chemical protection (repulsives). Secondary prevention relies on early detection of ticks after exposure, and mechanical extraction. There is currently no situation in France when prophylactic antibiotics would be recommended. The incidence of Lyme borreliosis in France, estimated through a network of general practitioners (réseau Sentinelles), and nationwide coding system for hospital stays, has not significantly changed between 2009 and 2017, with a mean incidence estimated at 53 cases/100,000 inhabitants/year, leading to 1.3 hospital admission/100,000 inhabitants/year. Other tick-borne diseases are much more seldom in France: tick-borne encephalitis (around 20 cases/year), spotted-fever rickettsiosis (primarily mediterranean spotted fever, around 10 cases/year), tularemia (50-100 cases/year, of which 20% are transmitted by ticks), human granulocytic anaplasmosis (<10 cases/year), and babesiosis (<5 cases/year). The main circumstances of diagnosis for Lyme borreliosis are cutaneous manifestations (primarily erythema migrans, much more rarely borrelial lymphocytoma and atrophic chronic acrodermatitis), neurological (<15% of cases, mostly meningoradiculitis and cranial nerve palsy, especially facial nerve) and rheumatologic (mostly knee monoarthritis, with recurrences). Cardiac and ophtalmologic manifestations are very rarely encountered.
BibTeX:
@article{Figoni2019,
  author = {Figoni, J. and Chirouze, C. and Hansmann, Y. and Lemogne, C. and Hentgen, V. and Saunier, A. and Bouiller, K. and Gehanno, J. F. and Rabaud, C. and Perrot, S. and Caumes, E. and Eldin, C. and de Broucker, T. and Jaulhac, B. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Gocko, X. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J. P. and Degeilh, B. and Partouche, H. and Lenormand, C. and Sotto, A. and Raffetin, A. and Monsuez, J. J. and Michel, C. and Boulanger, N. and Cathebras, P. and Tattevin, P. and endorsed by scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {318--334},
  doi = {10.1016/j.medmal.2019.04.381}
}

Abstract: BACKGROUND: In France, complex cases of occupational disease (OD) are submitted to regional committees who are in charge of accepting, or rejecting, the claim. Their mean annual acceptance rate varies from one region to another, which may reflect differences in the cases, or discrepancies between committees. The objective of this study was to assess the comparability of the decisions of the committees on the basis of standardized cases.
METHODS: Three experienced occupational physicians specialized in OD were asked to develop 28 clinical cases representative of claims for compensation usually seen in these committees. The cases, in the form of short vignettes, were submitted to the 18 French regional committees, asking if they would recognise each case as an OD.
RESULTS: All committees participated. The acceptance rate (recognition of the case as an OD) varied, ranging from 18% to 70%. All the committees took the same decision for only 7 out of the 28 cases, but half accepted and half refused for 3 cases. For 10 cases, one quarter of the committees gave a decision different than the other 75%. The highest discordance rates were observed for the cases concerning musculoskeletal disorders and asbestos related diseases.
CONCLUSION: The committees take very different decisions in terms of recognition of OD, especially for the most frequently compensated OD in France, i.e. musculoskeletal disorders and asbestos related diseases. This is a major source of injustice for the employees who seek compensation and there is a need to develop methods to harmonize decisions between committees.
BibTeX:
@article{Gehanno2019b,
  author = {Gehanno, J.-F. and Letalon, S. and Gislard, A. and Rollin, L.},
  title = {Inequities in occupational diseases recognition in {France}},
  month = {July},
  journal = {Revue D'epidemiologie Et De Sante Publique},
  year = {2019},
  volume = {67},
  number = {4},
  pages = {247--252},
  doi = {10.1016/j.respe.2019.04.054}
}

BibTeX:
@article{Gocko2019,
  author = {Gocko, X. and Lenormand, C. and Lemogne, C. and Bouiller, K. and Gehanno, J.-F. and Rabaud, C. and Perrot, S. and Eldin, C. and de Broucker, T. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Sobas, C. and Jaulhac, B. and Figoni, J. and Chirouze, C. and Hansmann, Y. and Hentgen, V. and Caumes, E. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J.-P. and Degeilh, B. and Partouche, H. and Saunier, A. and Sotto, A. and Raffetin, A. and Monsuez, J.-J. and Michel, C. and Boulanger, N. and Cathebras, P. and Tattevin, P. and endorsed by the following scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {296--317},
  doi = {10.1016/j.medmal.2019.05.006}
}

Abstract: The serodiagnosis of Lyme borreliosis is based on a two-tier strategy: a screening test using an immunoenzymatic technique (ELISA), followed if positive by a confirmatory test with a western blot technique for its better specificity. Lyme serology has poor sensitivity (30-40%) for erythema migrans and should not be performed. The seroconversion occurs after approximately 6 weeks, with IgG detection (sensitivity and specificity both>90%). Serological follow-up is not recommended as therapeutic success is defined by clinical criteria only. For neuroborreliosis, it is recommended to simultaneously perform ELISA tests in samples of blood and cerebrospinal fluid to test for intrathecal synthesis of Lyme antibodies. Given the continuum between early localized and disseminated borreliosis, and the efficacy of doxycycline for the treatment of neuroborreliosis, doxycycline is preferred as the first-line regimen of erythema migrans (duration, 14 days; alternative: amoxicillin) and neuroborreliosis (duration, 14 days if early, 21 days if late; alternative: ceftriaxone). Treatment of articular manifestations of Lyme borreliosis is based on doxycycline, ceftriaxone, or amoxicillin for 28 days. Patients with persistent symptoms after appropriate treatment of Lyme borreliosis should not be prescribed repeated or prolonged antibacterial treatment. Some patients present with persistent and pleomorphic symptoms after documented or suspected Lyme borreliosis. Another condition is eventually diagnosed in 80% of them.
BibTeX:
@article{Jaulhac2019,
  author = {Jaulhac, B. and Saunier, A. and Caumes, E. and Bouiller, K. and Gehanno, J. F. and Rabaud, C. and Perrot, S. and Eldin, C. and de Broucker, T. and Roblot, F. and Toubiana, J. and Sellal, F. and Vuillemet, F. and Sordet, C. and Fantin, B. and Lina, G. and Sobas, C. and Gocko, X. and Figoni, J. and Chirouze, C. and Hansmann, Y. and Hentgen, V. and Cathebras, P. and Dieudonné, M. and Picone, O. and Bodaghi, B. and Gangneux, J. P. and Degeilh, B. and Partouche, H. and Lenormand, C. and Sotto, A. and Raffetin, A. and Monsuez, J. J. and Michel, C. and Boulanger, N. and Lemogne, C. and Tattevin, P. and endorsed by scientific societies},
  title = {Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies (II). Biological diagnosis, treatment, persistent symptoms after documented or suspected Lyme borreliosis},
  month = {August},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  volume = {49},
  number = {5},
  pages = {335--346},
  doi = {10.1016/j.medmal.2019.05.001}
}

Abstract: Objectifs : L’objectif principal de cette étude était de décrire la méthodologie de redressement utilisée dans le cadre de l’observatoire « Évolution et relations en santé au travail » (Évrest). Les objectifs secondaires étaient, d’une part, d’apprécier l’ampleur des écarts entre les estimations brutes et pondérées et, d’autre part, de vérifier que le décalage de deux années dans la disponibilité des données de référence utilisées n’impactait pas substantiellement les estimations produites.
Méthodes : L’étude a porté sur les données recueillies en 2013 et 2014 (n = 26 227). Le redressement a comporté deux étapes : 1) la prise en compte de la probabilité de participation de chaque salarié ; 2) le calage sur marges pour corriger les éventuelles distorsions de l’échantillon par rapport au champ de l’enquête, les données de référence utilisées provenant des déclarations annuelles de données sociales (DADS) des années 2014 et 2012. L’impact du redressement a été analysé sur les 60 variables du questionnaire par l’étude des écarts entre les pourcentages bruts et pondérés.
Résultats : Au total, 90 % des écarts observés entre estimations brutes et pondérées étaient compris entre – 2,0 % et + 2,0 % avec les DADS 2014, 83 % avec les DADS 2012. L’estimation brute la plus surestimée concernait le travail à temps plein et celle la plus sous-estimée, le contact avec le public. L’impact d’un décalage de deux années des données de référence était faible, quelle que soit la variable étudiée.
Conclusion : Une méthodologie de redressement pour l’observatoire Évrest a été définie et mise en œuvre, permettant d’extrapoler les résultats à l’ensemble des salariés du champ de l’enquête.
BibTeX:
@article{Leroyer2019,
  author = {Leroyer, Ariane and Murcia, Marie and Chastang, Jean-François and Rollin, Laétitia and Volkoff, Serge and Molinié, Anne-Françoise and Niedhammer, Isabelle},
  title = {Méthodologie de redressement des données nationales de l’enquête Évrest},
  journal = {Sante Publique},
  year = {2019},
  volume = {Vol. 31},
  number = {5},
  pages = {645--655},
  url = {https://www.cairn.info/revue-sante-publique-2019-5-page-645.htm},
  doi = {10.3917/spub.195.0645}
}

Abstract: Compensation for occupational pulmonary diseases requires the establishment of guidelines based on standardized and objective criteria, in order to provide compensation that is as fair as possible to patients who suffer from them. A review of the elements necessary for the examination of an individual file was carried out by a working group. It is accepted that respiratory functional exploration is the key element in assessing the level of permanent disability in all of these conditions, with the exception of thoracic malignancies. Guiding scales have been developed for the respiratory impairment of three types of conditions: occupational asthma, thoracic malignancy, and other respiratory diseases. Additional criteria for increasing the permanent disability level are also proposed in order to take into account professional prejudice, in particular the possibility or not of continuing the occupational activity, in the same job or after changing to another. For certain respiratory diseases, a periodic reassessment of the initially attributed permanent disability level is recommended as well as the initial one at the time of definitive cessation of occupational activity.
BibTeX:
@article{Pairon2019,
  author = {Pairon, J.-C. and Azoury, H. and Catto, M. and Dalphin, J.-C. and Gehanno, J.-F. and Housset, B. and L'huillier, J.-P. and Serveau, S. and Straus, C.},
  title = {Comment évaluer en 2019 les taux d’incapacité permanente des pathologies professionnelles pulmonaires ?},
  month = {March},
  journal = {Revue Des Maladies Respiratoires},
  year = {2019},
  volume = {36},
  number = {3},
  pages = {307--325},
  doi = {10.1016/j.rmr.2018.07.007}
}

Abstract: OBJECTIVES: To conduct an audit of vaccination practices against pertussis in maternity wards to assess immunization practices targeting women, knowledge and awareness among health professionals and their involvement in the vaccination process, and to estimate their vaccine coverage. MATERIALS AND METHODS: 2017 cross-sectional descriptive survey using a data collection sheet of immunization practices targeting women and an anonymous questionnaire for health professionals whose vaccine coverage had been documented by the occupational health service. RESULTS: Five public maternity wards participated: one had a vaccination policy for women; 426 of 822 health professionals completed the questionnaire, 76% (from 50% of all residents to 83% of nurses) declared their vaccination status as up to date. Staff files in occupational health services showed that 69% of 822 health professionals received at least one vaccine booster during adulthood (57% less than 10 years before the survey); documented vaccination coverage rates ranged from 75% for residents to 91% for senior physicians. Occupational physicians and family physicians respectively performed 41% and 34% of vaccinations. While knowledge regarding vaccines was good, only 47% of health professionals declared prescribing them and 18% declared administering the anti-pertussis vaccine "often" or "very often". CONCLUSIONS: Updated data is needed to confirm the reported increase as participating centers are not representative of all birth centers. The active role of health professionals in vaccination-based pertussis prevention needs to be reinforced.
BibTeX:
@article{Pellissier2019,
  author = {Pellissier, G. and Lolom, I. and Cairati, N. and Cherifi, C. and Amiel-Taieb, C. and Farbos, S. and Caillaud, V. and Gaudelus, J. and Gozlan, C. and Pinquier, D. and Gehanno, J. F. and Luton, D. and Bouvet, E. and Abiteboul, D.},
  title = {Maternity staff immunization coverage against pertussis and maternal vaccination practices: Results of a 2017 cross-sectional survey in five public maternity hospitals},
  month = {July},
  journal = {Medecine Et Maladies Infectieuses},
  year = {2019},
  doi = {10.1016/j.medmal.2019.07.009}
}

Abstract: Return to work is a public health priority which led the French Health Authority to publish recommendations about "return to work and health: prevention of exclusion from work". The aim of this article is to present a literature review of return to work after cancer. Studies about medium-term and long-term effects of cancer are sparse. They suggest worker durable effects. Factors associated with return to work are linked to the patient characteristics, to characteristics of the illness and the treatment, to the workplace and to the help provided to the patient during the return to work process. A specific plan for returning to work in 3 phases (situation comprehension, identification of negative and positive factors for returning to work, implementation of measures concerning the patient, the workplace and the coordination between return to work actors) should be built for each patient, involving the worker, the occupational practitioner, the general and specialist practitioners.
BibTeX:
@article{Rollin2019a,
  author = {Rollin, Laétitia and Fantoni-Quinton, Sophie and Petit, Audrey and Baumann, Camille and Petitprez, Karine and Gehanno, Jean-François and Fassier, Jean-Baptiste},
  title = {Maintien en emploi des patients atteints de cancer},
  month = {November},
  journal = {Bulletin Du Cancer},
  year = {2019},
  volume = {106},
  number = {11},
  pages = {1039--1049},
  doi = {10.1016/j.bulcan.2019.08.008}
}

Abstract: Even if, English is generally used for international communication, it is essential to keep in mind that research is running at the local level by local teams generally communicating in their local/national language. Bearing these in mind, the "European Federation for Medical Informatics Working Group on Health Informatics for Inter-regional Cooperation" has as one of its objectives, to develop a multilingual dictionary focusing on Health Informatics as a collaboration tool allowing improving international and more particularly European cooperation. This dictionary is implemented as a part of HeTOP (Health Terminology/Ontology Portal) which is currently integrating more than 70 terminologies and ontologies in 32 languages. The EFMI Dictionary main aims are helping medical librarians, translators, academic and industrial researchers understanding better one another and supporting students self-learning.
BibTeX:
@inproceedings{Benis2019,
  author = {Benis, Arriel and Crisan-Vida, Mihaela and Stoicu-Tivadar, Lacramioara and Darmoni, Stefan},
  title = {A {Multi}-{Lingual} {Dictionary} for {Health} {Informatics} as an {International} {Cooperation} {Pillar}.},
  booktitle = {ICIMTH 2019, the 17th International Conference on Informatics, Management and Technology in Healthcare},
  month = {July},
  journal = {Studies in health technology and informatics},
  year = {2019},
  volume = {262},
  pages = {31--34},
  doi = {10.3233/SHTI190009}
}

Abstract: The ApiAppS ongoing project aims to provide physicians with a decision support system for the prescription / recommendation of mHealth technologies. We describe the context and the components of the project which includes: 1) a technical part on modelling and implementing the decision support system, and 2) a psychosocial investigation part designed to have a better knowledge of general practitioners (GPs) and patients' expectations, beliefs and practices.
BibTeX:
@inproceedings{Dufour2019,
  author = {Dufour, Jean-Charles and Grosjean, Julien and Darmoni, Stefan and Yasini, Mobin and Marchand, Guillaume and Simon, Christian and Sarradon-Eck, Aline and Préau, Marie and Darmon, David and Schuers, Matthieu and Hassanaly, Parina and Giorgi, Roch},
  title = {{ApiAppS}: {A} {Project} to {Study} and {Help} {Practitioners} in {Recommending} {mHealth} {Apps} and {Devices} to {Their} {Patients}},
  booktitle = {MEDINFO 2019: Health and Wellbeing e-Networks for All},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2019},
  volume = {264},
  pages = {1919--1920},
  doi = {10.3233/SHTI190713}
}

Abstract: Structuring raw medical documents with ontology mapping is now the next step for medical intelligence. Deep learning models take as input mathematically embedded information, such as encoded texts. To do so, word embedding methods can represent every word from a text as a fixed-length vector. A formal evaluation of three word embedding methods has been performed on raw medical documents. The data corresponds to more than 12M diverse documents produced in the Rouen hospital (drug prescriptions, discharge and surgery summaries, inter-services letters, etc.). Automatic and manual validation demonstrates that Word2Vec based on the skip-gram architecture had the best rate on three out of four accuracy tests. This model will now be used as the first layer of an AI-based semantic annotator.
BibTeX:
@inproceedings{Dynomant2019a,
  author = {Dynomant, Emeric and Lelong, Romain and Dahamna, Badisse and Massonnaud, Clément and Kerdelhué, Gaëtan and Grosjean, Julien and Canu, Stéphane and Darmoni, Stéfan},
  title = {Word {Embedding} for {French} {Natural} {Language} in {Healthcare}: {A} {Comparative} {Study}},
  booktitle = {MEDINFO 2019: Health and Wellbeing e-Networks for All},
  month = {August},
  journal = {Studies in Health Technology and Informatics},
  year = {2019},
  volume = {264},
  pages = {118--122},
  doi = {10.3233/SHTI190195}
}

Abstract: Information science is a fast-changing field, and medical librarians need to develop their roles to meet the users’new requirements. The professional development becomes a major challenge, not only regarding the core activities, but also in the way librarians and users can learn in a more innovative way. In order to invent new tools for training, a group of librarians with different backgrounds decided to create a game inspired by the “Bucket ofdoom”, which is described as a “Card game that meets storytelling with a sprinkling of comedy”. This adapted version for health libraries will face players with real professional situations. To overcome each challenge and have fun, librarians must use their experience and imagination with a high dose of creativity and humour.
BibTeX:
@article{AliciaGomez-Sanchez2019,
  author = {{Alicia Gómez-Sánchez} and {Gaétan Kerdelhue} and {Rebeca Isabel-Gómez} and {Mar González-Cantalejo} and {Pablo Iriarte} and {Floriane Muller}},
  title = {Health libraries: sharing through gaming},
  month = {September},
  journal = {Journal of EAHIL},
  year = {2019},
  volume = {15},
  number = {3},
  pages = {8-11},
  url = {http://ojs.eahil.eu/ojs/index.php/JEAHIL/article/view/329},
  doi = {10.32384/jeahil15329}
}

Abstract: Il n’existe pas de standard universellement accepté pour nommer les médicaments. L’identification du médicament a fait l’objet de nombreux travaux de normalisation. Notre objectif est de définir un modèle formel du médicament en français pour lier les différentes entités manipulables autour du médicament. Ce modèle formel vise un double sous-objectif : (a) créer et instancier une ontologie formelle du médicament ; (b) créer une terminologie du médicament, intégrable dans un serveur de terminologies. À terme, ces ressources seront des outils puissants pour, notamment, supporter la recherche d’information dans des bases de médicaments ou des entrepôts de données. Ils seront mis librement à disposition de la communauté.
BibTeX:
@inproceedings{Grosjean2019,
  author = {Julien Grosjean and Catherine Letord and Jean Charlet and Xavier Aimé and Loane Danès and Julien Rio and Ilan Zana and Stéfan J Darmoni and Catherine Duclos},
  title = {Un modèle sémantique d’identification du médicament en France},
  booktitle = {Atelier IA \& Santé},
  address = {Toulouse},
  month = {Juillet},
  year = {2019}
}

Abstract: Introduction
Les technologies de l’information et de la communication ont permis la naissance du web 2.0, caractérisé par la mise en place et l’utilisation de nouveaux outils collaboratifs de communication tels que les blogs, les wikis, les fils RSS et les réseaux sociaux. En s’appropriant ces outils, une médecine participative basée sur le partage d’informations et d’expériences entre professionnels, patients et tout acteur de la santé s’est développée. Depuis juin 2012, une communauté médicale échange sur Twitter avec le hashtag DocTocToc et contribue à la naissance de la e-santé sur ce réseau social. L’objectif de cette étude est d’analyser les principales thématiques des demandes effectuées via le hashtag DocTocToc par les médecins généralistes entre juin 2012 et mars 2017.
Méthodes
Une collecte de données par une méthode de « web scraping » a permis de constituer un corpus de tweets dont les auteurs ont été identifiés manuellement afin de procéder à un échantillonnage, de façon à ne conserver que les tweets émis par les médecins généralistes. Une étape de prétraitement a permis de transformer les formes potentiellement non reconnues par les logiciels de traitement du langage naturel. Le corpus a été appréhendé à l’aide de deux approches : une approche lexicale via le logiciel Iramuteq® et une indexation terminologique par l’extracteur de concepts multi-terminologiques (ECMT) du Catalogue et index des sites médicaux francophones (CISMeF).
Résultats
Sur les 12 716 tweets recueillis, 7366 étaient rédigés par des médecins généralistes et ont été analysés. L’approche lexicale détermine deux grands mondes lexicaux représentés sous forme de dendrogramme, l’un en lien avec les demandes médico administratives relatives à la gestion du cabinet et à la prise en charge sociale du patient, l’autre en lien avec les demandes d’ordre purement médicales. La méthode d’indexation terminologique met en évidence les spécialités médicales pourvoyeuses de demandes de télé-expertise : gynécologie, neurologie, infectiologie, pédiatrie, cardiologie, dermatologie ; et permet de les croiser avec l’objectif de la demande : diagnostic, thérapeutique.
Conclusion
Sur Twitter®, le hashtag DocTocToc est utilisé par les médecins généralistes comme un espace de partage informel d’informations en matière de santé mais aussi de gestion de problèmes administratifs et sociaux. Le DocsTocToc se présente comme un groupe d’échange de pratique à grande échelle ou le médecin compte sur l’avis de ses pairs.(Fig. 1)
BibTeX:
@article{Salles2019,
  author = {Salles, A. and Dufour, J. and Hassanaly, P. and Michel, P. and Cabot, C. and Grosjean, J.},
  title = {Analyse du discours médical sur {Twitter}®. Étude d’un corpus de tweets émis par des médecins généralistes entre juin 2012 et mars 2017 et contenant le hashtag \#{DocTocToc}},
  month = {May},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2019},
  series = {{EPICLIN} 2019},
  volume = {67},
  pages = {S152--S153},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762019301993},
  doi = {10.1016/j.respe.2019.03.027}
}

Abstract: PubMed is the biggest and most used bibliographic database worldwide, hosting more than 26M biomedical publications. One of its useful features is the "similar articles" section, allowing the end-user to find scientific articles linked to the consulted document in term of context. The aim of this study is to analyze whether it is possible to replace the statistic model PubMed Related Articles (pmra) with a document embedding method. Doc2Vec algorithm was used to train models allowing to vectorize documents. Six of its parameters were optimised by following a grid-search strategy to train more than 1,900 models. Parameters combination leading to the best accuracy was used to train models on abstracts from the PubMed database. Four evaluations tasks were defined to determine what does or does not influence the proximity between documents for both Doc2Vec and pmra. The two different Doc2Vec architectures have different abilities to link documents about a common context. The terminological indexing, words and stems contents of linked documents are highly similar between pmra and Doc2Vec PV-DBOW architecture. These algorithms are also more likely to bring closer documents having a similar size. In contrary, the manual evaluation shows much better results for the pmra algorithm. While the pmra algorithm links documents by explicitly using terminological indexing in its formula, Doc2Vec does not need a prior indexing. It can infer relations between documents sharing a similar indexing, without any knowledge about them, particularly regarding the PV-DBOW architecture. In contrary, the human evaluation, without any clear agreement between evaluators, implies future studies to better understand this difference between PV-DBOW and pmra algorithm.
BibTeX:
@article{Dynomant2019b,
  author = {Dynomant, Emeric and Darmoni, Stéfan J. and Lejeune, Émeline and Kerdelhué, Gaëtan and Leroy, Jean-Philippe and Lequertier, Vincent and Canu, Stéphane and Grosjean, Julien},
  title = {Doc2Vec on the {PubMed} corpus: study of a new approach to generate related articles},
  month = {November},
  journal = {arXiv:1911.11698 [cs]},
  year = {2019},
  note = {arXiv: 1911.11698},
  url = {http://arxiv.org/abs/1911.11698}
}

BibTeX:
@article{Trost2019,
  author = {Trost, Olivier and Micoud, Stéphane and Duparc, Fabrice},
  title = {Comments about the article "A Crouzon syndrome from the classic period of Maya civilization?" The art historian's point of view},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2019},
  volume = {41},
  number = {12},
  pages = {1529--1530},
  doi = {10.1016/j.jormas.2019.08.013}
}

Abstract: Les données cliniques sont produites par différents professionnels de santé, dans divers lieux et sous diverses formes dans le cadre de la pratique de la médecine. Elles présentent par conséquent une hétérogénéité à la fois au niveau de leur nature et de leur structure mais également une volumétrie particulièrement importante et qualifiable de massive. Le travail réalisé dans le cadre de cette thèse s’attache à proposer une méthode de recherche d’information efficace au sein de ce type de données complexes et massives. L’accès aux données cliniques se heurte en premier lieu à la nécessité de modéliser l’informationclinique. Ceci peut notamment être réalisé au sein du dossier patient informatisé ou, dans une plus large mesure, au sein d’entrepôts de données. Je propose dans ce mémoire unepreuve de concept d’un moteur de recherche permettant d’accéder à l’information contenue au sein de l’entrepôt de données de santé sémantique du Centre Hospitalier Universitaire de Rouen. Grâce à un modèle de données générique, cet entrepôt adopte une vision de l’information assimilable à un graphe de données rendant possible la modélisation de cette information tout en préservant sa complexité conceptuelle. Afin de fournir des fonctionnalités de recherche adaptées à cette représentation générique, un langage de requêtes permettant l’accès à l’information clinique par le biais des diverses entités qui la composent a été développé et implémenté dans le cadre de cette thèse. En second lieu, la massivité des données cliniques constitue un défi technique majeur entravant la mise en oeuvre d’une recherche d’information efficace. L’implémentation initiale de la preuve de concept sur un système de gestion de base de données relationnel a permis d’objectiver les limites de ces derniers en terme de performances. Une migration vers un système NoSQL orienté clé-valeur a été réalisée. Bien qu’offrant de bonnes performances d’accès atomique aux données, cette migration a également nécessité des développements annexes et la définition d’une architecture matérielle et applicative propice à la mise en oeuvre des fonctionnalités de recherche et d’accès aux données. Enfin, l’apport de ce travail dans le contexte plus général de l’entrepôt de données de santé sémantique du CHU de Rouen a été évalué. La preuve de concept proposée dans ce travail a ainsi été exploitée pour accéder aux descriptions sémantiques afin de répondre à des critères d’inclusion et d’exclusion de patients dans des études cliniques. Dans cette évaluation, une réponse totale ou partielle a pu être apportée à 72,97% des critères. De plus, la généricité de l’outil a également permis de l’exploiter dans d’autres contextes tels que la recherche d’information documentaire et bibliographique en santé.
BibTeX:
@phdthesis{Lelong2019a,
  author = {Romain Lelong},
  title = {Accès sémantique aux données massives et hétérogènes en santé},
  month = {June},
  school = {Normandie Université},
  year = {2019},
  url = {https://tel.archives-ouvertes.fr/tel-02287217}
}

2018


Abstract: INTRODUCTION: Oral metastases from hepatocellular carcinoma (HCC) are very rare, and predominate in the mandible. We report an exceptional case of maxillary metastasis revealing HCC. CASE REPORT: A 56-year-old man with a previous medical history of alcohol abuse presented to our department with a 3-week evolving oral mass. Physical examination showed a left maxillary tumor. The biopsy revealed a HCC and a multi-metastatic HCC with portal thrombosis and a pulmonary embolism was discovered following a CT-scan. A state of advanced malnutrition contraindicated sorafenib chemotherapy. Thus, external irradiation was proposed, without success. The patient subsequently died 50 days later. DISCUSSION: Maxillary HCC metastases are extremely rare. The average age of HCC jaw metastases appearance in patients has been reported to be approximately 57 years, men are more affected than women are, and the mean life expectancy is 12 months following the diagnosis. These patients require palliative treatment. Local recurrences occur very early after possible surgery, and expose the patient to life-threatening bleeding.
BibTeX:
@article{Adnot2018,
  author = {Adnot, J. and Gemival, P. and Trost, O.},
  title = {Maxillary metastasis from a hepatocellular carcinoma: Report of an uncommon presentation and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2018},
  volume = {119},
  number = {6},
  pages = {503--505},
  doi = {10.1016/j.jormas.2018.07.001}
}

Abstract: BACKGROUND: General practice became an academic discipline quite recently in many western countries. In France, junior lecturer work is specified in a three-part mandate: medical work in general practice, teaching in the university, and research. Since 2007, 130 junior lecturers have been appointed in general practice. The aim of the creation of junior lecturer status was to align general practice with other specialties and to develop research and education in primary care.
OBJECTIVES: To describe the healthcare, teaching and research undertaken by junior lecturers in general practice, practising in October 2014.
METHODS: A cross-sectional multicentre study using an online self-administered questionnaire on the cohort composed of all the junior lecturers in general practice with open questions and the qualitative analysis of written verbatim accounts.
RESULTS: Of the 95 junior lecturers practising at the date of the study, 75 (79 responded; average age 32 years; gender ratio (F/M) 2.4:1. They spent five, two and three half-days per week respectively in healthcare, teaching and research. The healthcare activity was predominantly carried out in the community (73. Thirty-nine per cent worked as part of a multi-professional team taking on 50 consultations per week. Most of the educational work involved lecturing and mentoring students specializing in general practice (median 86 hours per year). Research output increased during the fellowship. Research topics were varied and relevant to the disciplinary field.
CONCLUSION: During the fellowship, the balancing, and even the reinforcement, of healthcare and research contributions were accompanied by a significant investment in educational provision.
BibTeX:
@article{Barais2018,
  author = {Barais, Marie and Laporte, Catherine and Schuers, Matthieu and Saint-Lary, Olivier and Frappé, Paul and Dibao-Dina, Clarisse and Darmon, David and Bouchez, Tiphanie and Gelly, Julien},
  title = {Cross-sectional multicentre study on the cohort of all the {French} junior lecturers in general practice},
  month = {December},
  journal = {The European Journal of General Practice},
  year = {2018},
  volume = {24},
  number = {1},
  pages = {99--105},
  doi = {10.1080/13814788.2017.1422176}
}

Abstract: Background: The Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) have recognized social media as a new data source to strengthen their activities regarding drug safety. Objective: Our objective in the ADR-PRISM project was to provide text mining and visualization tools to explore a corpus of posts extracted from social media. We evaluated this approach on a corpus of 21 million posts from five patient forums, and conducted a qualitative analysis of the data available on methylphenidate in this corpus. Methods: We applied text mining methods based on named entity recognition and relation extraction in the corpus, followed by signal detection using proportional reporting ratio (PRR). We also used topic modelling based on the Correlated Topic Model to obtain the list of thematics in the corpus and classify the messages based on their topics. Results: We automatically identified 3443 posts about methylphenidate published between 2007 and 2016, among which 61 adverse drug reactions (ADR) were automatically detected. Two pharmacovigilance experts evaluated manually the quality of automatic identification, and a f-measure of 0.57 was reached. Patient’s reports were mainly neuro-psychiatric effects. Applying PRR, 67% of the ADRs were signals, including most of the neuro-psychiatric symptoms but also palpitations. Topic modelling showed that the most represented topics were related to Childhood and Treatment initiation, but also Side effects. Cases of misuse were also identified in this corpus, including recreational use and abuse. Conclusion: Named entity recognition combined with signal detection and topic modelling have demonstrated their complementarity in mining social media data. An in-depth analysis focused on methylphenidate showed that this approach was able to detect potential signals and to provide better understanding of patients’ behaviors regarding drugs, including misuse.
BibTeX:
@article{Chen2018,
  author = {Chen, Xiaoyi and Faviez, Carole and Schuck, Stéphane and Lillo-Le-Louët, Agnès and Texier, Nathalie and Dahamna, Badisse and Huot, Charles and Foulquié, Pierre and Pereira, Suzanne and Leroux, Vincent and Karapetiantz, Pierre and Guenegou-Arnoux, Armelle and Katsahian, Sandrine and Bousquet, Cédric and Burgun, Anita},
  title = {Mining Patients' Narratives in Social Media for Pharmacovigilance: Adverse Effects and Misuse of Methylphenidate},
  journal = {Frontiers in Pharmacology},
  year = {2018},
  volume = {9},
  url = {https://www.frontiersin.org/articles/10.3389/fphar.2018.00541/full},
  doi = {10.3389/fphar.2018.00541}
}

Abstract: BACKGROUND: While documentation of clinical aspects of General Practice/Family Medicine (GP/FM) is assured by the International Classification of Primary Care (ICPC), there is no taxonomy for the professional aspects (context and management) of GP/FM. OBJECTIVES: To present the development, dissemination, applications, and resulting face validity of the Q-Codes taxonomy specifically designed to describe contextual features of GP/FM, proposed as an extension to the ICPC. DEVELOPMENT: The Q-Codes taxonomy was developed from Lamberts' seminal idea for indexing contextual content (1987) by a multi-disciplinary team of knowledge engineers, linguists and general practitioners, through a qualitative and iterative analysis of 1702 abstracts from six GP/FM conferences using Atlas.ti software. A total of 182 concepts, called Q-Codes, representing professional aspects of GP/FM were identified and organized in a taxonomy. Dissemination: The taxonomy is published as an online terminological resource, using semantic web techniques and web ontology language (OWL) ( http://www.hetop.eu/Q ). Each Q-Code is identified with a unique resource identifier (URI), and provided with preferred terms, and scope notes in ten languages (Portuguese, Spanish, English, French, Dutch, Korean, Vietnamese, Turkish, Georgian, German) and search filters for MEDLINE and web searches. APPLICATIONS: This taxonomy has already been used to support queries in bibliographic databases (e.g., MEDLINE), to facilitate indexing of grey literature in GP/FM as congress abstracts, master theses, websites and as an educational tool in vocational teaching, Conclusions: The rapidly growing list of practical applications provides face-validity for the usefulness of this freely available new terminological resource.
BibTeX:
@article{Jamoulle2018,
  author = {Jamoulle, Marc and Resnick, Melissa and Grosjean, Julien and Ittoo, Ashwin and Cardillo, Elena and Vander Stichele, Robert and Darmoni, Stefan and Vanmeerbeek, Marc},
  title = {Development, dissemination, and applications of a new terminological resource, the {Q}-{Code} taxonomy for professional aspects of general practice/family medicine},
  month = {December},
  journal = {The European journal of general practice},
  year = {2018},
  volume = {24},
  number = {1},
  pages = {68--73},
  url = {https://www.ncbi.nlm.nih.gov/pubmed/29243572},
  doi = {10.1080/13814788.2017.1404986}
}

Abstract: PURPOSE: Microsurgical reconstruction in a vessel-depleted neck is a challenge due to the lack of reliable vessels in or nearby the host site. The use of the internal thoracic pedicle (ITP) by rib section or sparring is a limited option due to the small length of the pedicle of some flaps. However, in cardiac surgery, the internal thoracic artery (ITA) is widely used for myocardial revascularization, providing a long and versatile pedicle. We aimed at determining precise anatomical bases for the use of the ITP, approached by sternotomy and rerouted in the neck, as recipient vessels for free-flap facial reconstructions. METHODS: We performed a descriptive single centre anatomical study on 20 formalin-embalmed cadavers. The ITP was harvested on both sides from the emergence of the artery under the brachiocephalic vein to its terminal division. The level reached by the ITP in the cervicofacial area was described. Distal arterial and venous diameters, pedicle length and other parameters were measured. RESULTS: In at least 85% of the cases, the ITP reached the mandibular angle. The mean diameter at the distal extremity for the ITA was 2.36 ± 0.15, and 2.48 ± 0.19 mm for the committing vein. The mean length of the ITP was 177.3 mm. CONCLUSION: Rerouting the ITP towards the cervicofacial area could provide a reliable pedicle for free-flap reconstructions in patients with a vessel-depleted neck but it should be limited to selected patients. This novel solution for situations where current techniques are unfeasible warrants further clinical research.
BibTeX:
@article{Morel2018,
  author = {Morel, François and Crampon, Frédéric and Adnot, Jérôme and Litzler, Pierre-Yves and Duparc, Fabrice and Trost, Olivier},
  title = {Rerouting the internal thoracic pedicle: a novel solution for maxillofacial reconstruction in vessel-depleted situations? A preliminary anatomic study},
  month = {August},
  journal = {Surgical and radiologic anatomy: SRA},
  year = {2018},
  volume = {40},
  number = {8},
  pages = {911--916},
  doi = {10.1007/s00276-017-1965-1}
}

Abstract: BACKGROUND: Unstructured health documents (e.g. discharge summaries) represent an important and unavoidable source of information.
METHODS: A semantic annotator identified all the concepts present in the health documents from the clinical data warehouse of the Rouen University Hospital.
RESULTS: 2,087,784,055 annotations were generated from a corpus of about 11.9 million documents with an average of 175 annotations per document. SNOMED CT, NCIt and MeSH were the top 3 terminologies that reported the most annotation.
DISCUSSION: As expected, the most general terminologies with the most translated concepts were those with the most concepts identified.
BibTeX:
@article{Ndangang2018,
  author = {Ndangang, Marie and Grosjean, Julien and Lelong, Romain and Dahamna, Badisse and Kergourlay, Ivan and Griffon, Nicolas and Darmoni, Stéfan J.},
  title = {Terminology {Coverage} from {Semantic} {Annotated} {Health} {Documents}},
  journal = {Studies in Health Technology and Informatics},
  year = {2018},
  volume = {255},
  pages = {20--24},
  doi = {10.3233/978-1-61499-921-8-20}
}

Abstract: Background: Burnout is a common occurrence among GPs, decreasing quality of and access to care and impacting both physician and patient health. The link between burnout and low medical density has never been studied.
Objectives: This study aimed to assess the prevalence of burnout and its related factors, including low medical density, among GPs.
Method: We conducted a cross-sectional survey. A self-administered questionnaire was sent to all of the 1632 GPs in Normandy, France, in September 2015. The Maslach Burnout Inventory was used to assess the three burnout dimensions: emotional exhaustion (EE), depersonalization (DP) and low personal accomplishment (PA).
Results: In all, 501 GPs sent back their questionnaire (response rate: 30.7; 487 questionnaires were analysed. Burnout had been experienced by 43.3% of the physicians in the sample. Nearly 24% of the respondents scored high EE, 27.3% scored high DP, and 13.3% scored low PA. Low medical density [odds ratios (OR): 2.16 (1.31-3.54)], and intent to quit [OR: 4.40 (2.59-7.47)] were strongly linked to the three burnout dimensions. Burnout was not linked with quantitative workload.
Conclusion: Burnout among GPs was common. Low medical density and intent to quit were strong predictors of burnout. Given the current medical demographic crisis, these results highlight the relationship between burnout and medical shortage. Qualitative workload may have a more significant influence on burnout than quantitative workload. Recruiting more GPs is necessary, but may prove insufficient in fighting burnout. Preventive and curative actions are required, especially in areas with low medical density.
BibTeX:
@article{Picquendar2018,
  author = {Picquendar, Guillaume and Guedon, Antoine and Moulinet, Fanny and Schuers, Matthieu},
  title = {Influence of medical shortage on {GP} burnout: a cross-sectional study},
  month = {September},
  journal = {Family Practice},
  year = {2018},
  doi = {10.1093/fampra/cmy080}
}

Abstract: Objective
There is a growing interest in using natural language processing (NLP) for healthcare-associated infections (HAIs) monitoring. A French project consortium, SYNODOS, developed a NLP solution for detecting medical events in electronic medical records for epidemiological purposes. The objective of this study was to evaluate the performance of the SYNODOS data processing chain for detecting HAIs in clinical documents.
Materials and methods
The collection of textual records in these hospitals was carried out between October 2009 and December 2010 in three French University hospitals (Lyon, Rouen and Nice). The following medical specialties were included in the study: digestive surgery, neurosurgery, orthopedic surgery, adult intensive-care units. Reference Standard surveillance was compared with the results of automatic detection using NLP. Sensitivity on 56 HAI cases and specificity on 57 non-HAI cases were calculated.
Results
The accuracy rate was 84% (n = 95/113). The overall sensitivity of automatic detection of HAIs was 83.9% (CI 95 71.7–92.4) and the specificity was 84.2% (CI 95 72.1–92.5). The sensitivity varies from one specialty to the other, from 69.2% (CI 95 38.6–90.9) for intensive care to 93.3% (CI 95 68.1–99.8) for orthopedic surgery. The manual review of classification errors showed that the most frequent cause was an inaccurate temporal labeling of medical events, which is an important factor for HAI detection.
Conclusion
This study confirmed the feasibility of using NLP for the HAI detection in hospital facilities. Automatic HAI detection algorithms could offer better surveillance standardization for hospital comparisons.
BibTeX:
@article{Tvardik2018,
  author = {Tvardik, Nastassia and Kergourlay, Ivan and Bittar, André and Segond, Frédérique and Darmoni, Stefan and Metzger, Marie-Hélène},
  title = {Accuracy of using natural language processing methods for identifying healthcare-associated infections},
  month = {September},
  journal = {International Journal of Medical Informatics},
  year = {2018},
  volume = {117},
  pages = {96--102},
  url = {http://www.sciencedirect.com/science/article/pii/S1386505618304362},
  doi = {10.1016/j.ijmedinf.2018.06.002}
}

BibTeX:
@article{Lacroix-Hugues2018,
  author = {Lacroix-Hugues, V. and Schuers, M. and Pradier, C. and Staccini, P. and Letrilliart, L. and Darmon, D.},
  title = {Utilisation des enregistrements médicaux électroniques dans le cadre du projet {PRIMEGE} {PACA}},
  month = {May},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2018},
  number = {143},
  pages = {197--203},
  url = {https://www.lissa.fr/fr/rep/articles/AA_1015780242018143197203utilla}
}

Abstract: Les infections urinaires masculines (IUM) sont un continuum allant des formes cliniques paucisymptomatiques (« cystite-like » dans la littérature anglo-saxonne) à la prostatite et à l’urosepsis sévère. La bandelette urinaire positive pour leucocytes et/ou nitrites conforte la suspicion clinique mais ne dispense pas de l’examen cytobactériologique des urines. En présence de fièvre, d’une mauvaise tolérance, d’une rétention aiguë d’urine, le traitement doit être introduit sans tarder. Les IUM paucisymptomatiques doivent être documentées et les patients réévalués. Le caractère fruste
permet de décaler si possible l’introduction d’une antibiothérapie. La ciprofloxacine et la lévofloxacine sont les traitements de référence pour une durée de 14 jours quelle que soit l’intensité de l’IUM. L’ofloxacine ne doit plus être prescrite de façon probabiliste en raison d’une augmentation des résistances en soins premiers.
BibTeX:
@article{Soudais2018,
  author = {Soudais, B and Schuers, M and Lefebvre, E and Etienne, M and Pellerin, L},
  title = {Infections urinaires masculines en soins primaires},
  month = {October},
  journal = {exercer, la revue française de médecine générale},
  year = {2018},
  number = {146},
  pages = {368--73},
  url = {https://www.exercer.fr/numero/146/page/368/}
}

BibTeX:
@inproceedings{Douze2018,
  author = {Douze, L and Kerdelhue, G and Grosjean, J and Schiro, J and Pelayo, S and Marcilly, R},
  title = {Search engines in medicine: the need to involve healthcare professional end users},
  booktitle = {MIE},
  year = {2018}
}

BibTeX:
@inproceedings{Lelong2018,
  author = {Romain Lelong and Lina F. Soualmia and Saoussen Sakji and Badisse Dahamna and Stéfan Darmoni},
  title = {NoSQL technology in order to support Semantic Health Search Engine},
  booktitle = {MIE 2018},
  year = {2018}
}

Abstract: La base de données bibliographiques LiSSa (Littérature scientifique en santé) (www.lissa.fr) référence plus d'un million d'articles francophones et vise à les rendre plus visibles à l'heure où la place de la langue française pour ces publications est de plus en plus discutée. La base a été créée à l'aide de multiples sources de données publiques et privées et la contribution de plusieurs éditeurs. Le moteur de recherche peut être interrogé simplement et apporter des résultats pertinents. Un formulaire de recherche avancée et des options spécifiques permettent également de mener des recherches plus complexes. Des fonctionnalités d'exportations et d'alertes sont également disponibles pour manipuler facilement les références et être tenu informé.
BibTeX:
@article{Kerdelhue2018,
  author = {Gaétan Kerdelhué and Jean-Francois Gehanno and Julien Grosjean and Stéfan Darmoni},
  title = {La base de données bibliographiques LiSSa (Littérature scientifique en santé) : intérêt et utilisation pour la santé au travail},
  journal = {Références en Santé au Travail},
  year = {2018},
  number = {154},
  pages = {115-119},
  url = {http://www.rst-sante-travail.fr/rst/pages-article/ArticleRST.html?ref=RST.TM%2046}
}

2017


Abstract: The purpose of this anatomic study was to compare the retraction force necessary to expose the mandibular neck in the Risdon and the high cervical anteroparotid transmasseteric (HAT) approaches. An anatomic study was performed on 18 formalin-embalmed cadavers. We performed a Risdon approach on the left side, and an HAT approach on the right side in all the cases. The subjects were placed in a normative frame and the force necessary to maintain a satisfactory exposure of the condyle was measured with a system of cables, pulleys, and mechanical dynamometer. The statistical comparison between the two sides was carried out using the Wilcoxon signed-rank test for paired series. In all the cases, the region of interest was exposed as in the operating room. In the Risdon approach, the mean force was 32 Newtons (4-47). In the HAT approach, the mean force was 19 Newtons (4-33). The difference was statistically significant (p < 0.001). The age, gender, and duration of conservation had no influence on the retraction force. In the HAT approach, the retraction of the soft tissues was significantly lower than in the Risdon approach. This study gave an additional explanation to the remarkable safety of the HAT approach. Our results were in favor of the generalization of this technique.
BibTeX:
@article{Adnot2017,
  author = {Adnot, Jérôme and Feuss, Aliosha and Duparc, Fabrice and Trost, Olivier},
  title = {Retraction force necessary to expose the mandibular neck in Risdon and high cervical anteroparotid transmasseteric approaches: an anatomic comparative study.},
  month = {April},
  journal = {Surgical and radiologic anatomy : SRA},
  year = {2017},
  doi = {10.1007/s00276-017-1853-8}
}

Abstract: The authors report the case of a 43-year-old woman who underwent endodontic treatment of the right second mandibular molar with substantial extrusion of endodontic material into the mandibular canal. The patient presented at the Department of Oral and Maxillofacial Surgery with a persistent total anaesthesia of the lower lip and chin after two months. 2D panoramic view and 3D CT-scan examination highlighted the overfilling into the mandibular canal with a more than 50% stenosis of the canal and a consequently significant compression of the dental pedicle. A surgical decompression of the inferior alveolar nerve was performed through an inferior vestibular approach, using PiezoSurgery®. The tooth was conserved. After a period of 8days, paraesthesia of the lower lip and chin appeared. Thermoalgic sensitivity was recovered at 1month. At 3months postoperatively, the patient had recovered protopathic and epicritic sensitivity. Dental prosthetic rehabilitation was finally achieved one year postoperatively. The authors discuss the physiopathology of nervous injuries during dental procedures, and further strategies in the case of persistent neurologic disorders.
BibTeX:
@article{Bastien2017,
  author = {Bastien, A.-V. and Adnot, J. and Moizan, H. and Calenda, É. and Trost, O.},
  title = {Secondary surgical decompression of the inferior alveolar nerve after overfilling of endodontic sealer into the mandibular canal: Case report and literature review},
  month = {December},
  journal = {Journal of Stomatology, Oral and Maxillofacial Surgery},
  year = {2017},
  volume = {118},
  number = {6},
  pages = {389--392},
  doi = {10.1016/j.jormas.2017.09.001}
}

Abstract: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Classical Pharmacovigilance process is limited by underreporting which justifies the current interest in new knowledge sources such as social media. The Adverse Drug Reactions from Patient Reports in Social Media (ADR-PRISM) project aims to extract ADRs reported by patients in these media. We identified 5 major challenges to overcome to operationalize the analysis of patient posts: (1) variable quality of information on social media, (2) guarantee of data privacy, (3) response to pharmacovigilance expert expectations, (4) identification of relevant information within Web pages, and (5) robust and evolutive architecture. This article aims to describe the current state of advancement of the ADR-PRISM project by focusing on the solutions we have chosen to address these 5 major challenges. In this article, we propose methods and describe the advancement of this project on several aspects: (1) a quality driven approach for selecting relevant social media for the extraction of knowledge on potential ADRs, (2) an assessment of ethical issues and French regulation for the analysis of data on social media, (3) an analysis of pharmacovigilance expert requirements when reviewing patient posts on the Internet, (4) an extraction method based on natural language processing, pattern based matching, and selection of relevant medical concepts in reference terminologies, and (5) specifications of a component-based architecture for the monitoring system. Considering the 5 major challenges, we (1) selected a set of 21 validated criteria for selecting social media to support the extraction of potential ADRs, (2) proposed solutions to guarantee data privacy of patients posting on Internet, (3) took into account pharmacovigilance expert requirements with use case diagrams and scenarios, (4) built domain-specific knowledge resources embeding a lexicon, morphological rules, context rules, semantic rules, syntactic rules, and post-analysis processing, and (5) proposed a component-based architecture that allows storage of big data and accessibility to third-party applications through Web services. We demonstrated the feasibility of implementing a component-based architecture that allows collection of patient posts on the Internet, near real-time processing of those posts including annotation, and storage in big data structures. In the next steps, we will evaluate the posts identified by the system in social media to clarify the interest and relevance of such approach to improve conventional pharmacovigilance processes based on spontaneous reporting.
BibTeX:
@article{Bousquet2017,
  author = {Bousquet, Cedric and Dahamna, Badisse and Guillemin-Lanne, Sylvie and Darmoni, Stefan J and Faviez, Carole and Huot, Charles and Katsahian, Sandrine and Leroux, Vincent and Pereira, Suzanne and Richard, Christophe and Schück, Stéphane and Souvignet, Julien and Lillo-Le Louët, Agnès and Texier, Nathalie},
  title = {The Adverse Drug Reactions from Patient Reports in Social Media Project: Five Major Challenges to Overcome to Operationalize Analysis and Efficiently Support Pharmacovigilance Process.},
  month = {September},
  journal = {JMIR research protocols},
  year = {2017},
  volume = {6},
  pages = {e179},
  doi = {10.2196/resprot.6463}
}

Abstract: Introduction
In January 2015, Rouen University Hospital’s information system experienced serious issues. It was necessary to rapidly switch from the computerized provider order entry (CPOE) system towards a paper-based order entry (PBOE) system. This was an opportunity to evaluate prescriber opinion on the two provider order entry (POE) systems.
Methods
All residents were asked to fill an augmented version of the POE satisfaction and usage survey for both POE systems. The results were compared to identify the strengths and weaknesses of each system.
Results
Fifty-one respondents had used the CPOE system and the PBOE system. Overall, satisfaction was higher with PBOE than CPOE (odds ratio (OR) = 3.74; p < 0.001). Usability (OR = 4.00; p < 0.001), reliability (OR = 8.54; p < 0.001), time consumption (OR = 0.50; p < 0.05 – survey statement was formulated negatively), and communication with nurses (OR = 14.27; p < 0.0001) reached statistically better agreement. The more experience with CPOE the more residents were disillusioned with the reliability (OR = 6.55; p < 0.01), the usability (OR = 5.68; p < 0.01) and the patient safety (OR = 0.27; p < 0.05 – survey statement was formulated negatively) of CPOE. Although safety issues were reported for both systems, the causes were different; PBOE imposed frequent rewriting of the order while CPOE lack of usability might be unsafe. Another important issue with both POE systems was time consumption.
Conclusion
Residents did not report any increase in safety issues with the rapid switch from CPOE to PBOE. They even seemed more satisfied with the rollback to paper, which remains a possible degraded mode in case of health information technology collapse.
BibTeX:
@article{Griffon2017,
  author = {Griffon, N. and Schuers, M. and Joulakian, M. and Bubenheim, M. and Leroy, J.-P. and Darmoni, S. J.},
  title = {Physician satisfaction with transition from {CPOE} to paper-based prescription},
  month = {July},
  journal = {International Journal of Medical Informatics},
  year = {2017},
  volume = {103},
  pages = {42--48},
  url = {http://www.ijmijournal.com/article/S1386-5056(17)30085-0/abstract},
  doi = {10.1016/j.ijmedinf.2017.04.007}
}

Abstract: This case control study assessed: the relationship of systemic sclerosis (SSc) related to exposure to heavy metals, the risk of SSc related to occupational exposure in male and female patients. From 2005 to 2008, 100 patients with a definite diagnosis of SSc were included in the study; 3 age, gender, and smoking habits matched controls were selected for each patient. All SSc patients and controls underwent detection and quantification of heavy metal traces in hair samples, using multi-element inductively coupled plasma mass spectrometry (ICP-MS). SSc patients exhibited higher median levels of the following metals: antimony (p=0.001), cadmium (p=0.0003), lead (p=0.02), mercury (p=0.02), molybdenum (p=0.04), palladium (p<0.001) and zinc (p=0.0003). A marked association between SSc and occupational exposure was further found for: 1) antimony (p=0.008) and platinum (p=0.04) in male patients; and 2) antimony (p=0.02), cadmium (p=0.001), lead (p=0.03), mercury (p=0.03), palladium (p=0.0003) and zinc (p=0.0001) in female patients CONCLUSION: The results show the impact of occupational risk factors in the development of SSc for: antimony, cadmium, lead, mercury, molybdenum, palladium and zinc. Thus, occupational exposure should be systematically checked in all SSc patients at diagnosis. Finally, the association between SSc and occupational exposure may be variable according to patients" gender.
BibTeX:
@article{Marie2017,
  author = {Marie, I and Gehanno, J-F and Bubenheim, M and Duval-Modeste, A-B and Joly, P and Dominique, S and Bravard, P and Noël, D and Cailleux, A-F and Weber, J and Lagoutte, P and Benichou, J and Levesque, H and Goullé, J-P},
  title = {Systemic sclerosis and exposure to heavy metals: A case control study of 100 patients and 300 controls.},
  month = {January},
  journal = {Autoimmunity reviews},
  year = {2017},
  doi = {10.1016/j.autrev.2017.01.004}
}

Abstract: MEDLINE is the most widely used medical bibliographic database in the world. Most of its citations are in English and this can be an obstacle for some researchers to access the information the database contains. We created a multilingual query builder to facilitate access to the PubMed subset using a language other than English. The aim of our study was to assess the impact of this multilingual query builder on the quality of PubMed queries for non-native English speaking physicians and medical researchers. A randomised controlled study was conducted among French speaking general practice residents. We designed a multi-lingual query builder to facilitate information retrieval, based on available MeSH translations and providing users with both an interface and a controlled vocabulary in their own language. Participating residents were randomly allocated either the French or the English version of the query builder. They were asked to translate 12 short medical questions into MeSH queries. The main outcome was the quality of the query. Two librarians blind to the arm independently evaluated each query, using a modified published classification that differentiated eight types of errors. Twenty residents used the French version of the query builder and 22 used the English version. 492 queries were analysed. There were significantly more perfect queries in the French group vs. the English group (respectively 37.9% vs. 17.9%; p < 0.01). It took significantly more time for the members of the English group than the members of the French group to build each query, respectively 194 sec vs. 128 sec; p < 0.01. This multi-lingual query builder is an effective tool to improve the quality of PubMed queries in particular for researchers whose first language is not English.
BibTeX:
@article{Schuers2017,
  author = {Schuers, Matthieu and Joulakian, Mher and Kerdelhué, Gaetan and Segas, Léa and Grosjean, Julien and Darmoni, Stéfan J and Griffon, Nicolas},
  title = {Lost in translation? A multilingual Query Builder improves the quality of PubMed queries: a randomised controlled trial.},
  month = {July},
  journal = {BMC medical informatics and decision making},
  year = {2017},
  volume = {17},
  pages = {94},
  doi = {10.1186/s12911-017-0490-9}
}

Abstract: Metopism (complete persistence of the metopic suture in adults) is a rare but not exceptional variation of the calvaria. Hypoplasia or aplasia of the frontal sinus may be associated without evident correlation. Nevertheless, a misdiagnosis of these variations may have clinical consequences, especially in a traumatic context. The aim of this paper was to report a case of metopism associated with a unilateral aplasia of the left frontal sinus, originally illustrated with 3D image fusion volume rendering reconstructions.
BibTeX:
@article{Eliezer2017,
  author = {Eliezer, M. and Crampon, F. and Adnot, J. and Duparc, F. and Trost, O.},
  title = {Représentation tridimensionnelle originale d’un cas de métopisme associé à une agénésie unilatérale complète du sinus frontal gauche : intérêt clinique et revue de la littérature},
  month = {May},
  journal = {Morphologie: Bulletin De l'Association Des Anatomistes},
  year = {2017},
  doi = {10.1016/j.morpho.2017.04.004}
}

Abstract: Introduction Les publications scientifiques en français sont de plus en plus éclipsées par les publications en langue anglaise, notamment dans les bases de données bibliographiques internationales. Il s’agit pourtant de ressources potentiellement utiles pour beaucoup de professionnels médicaux et paramédicaux. Objectifs L’objectif de cet article est de présenter un nouvel outil, LiSSa pour « Littérature Scientifique en Santé », qui vise à agréger l’ensemble de la littérature médicale en français, ainsi que les premières étapes de sa conception. Méthodes L’agrégation de différentes bases de données requiert l’harmonisation des métadonnées et l’adaptation du modèle de données. Une évaluation ergonomique préliminaire a été réalisée. Résultats Les données de PubMed et d’Elsevier-Masson ont été intégrées, permettant la mise à disposition d’une base de données bibliographique riche de 869 834 références. Concernant les données postérieures à 2000, LiSSa regroupe 300 988 références, dont 81 239 avec le résumé en français et 209 610 avec un lien vers le texte intégral (dont 15 838 en accès gratuit). L’évaluation ergonomique a confirmé l’intérêt des professionnels de santé pour cet outil et a permis d’aboutir à l’actuelle version de LiSSa qui dispose d’outils de filtre et d’exportation classiques pour ce genre d’outil, ainsi que de liens contextuels vers PubMed et vers le Catalogue et Index des Sites Médicaux en langue Française. Conclusion : LiSSa est gratuitement disponible à l’URL suivante: http://www.lissa.fr .
BibTeX:
@article{Griffon2017a,
  author = {Griffon, N. and Rollin, L. and Schuers, M. and Douze, L. and Rodriguez, D. and Delerue, D. and Dutoit, D. and Dahamna, B. and Kerdelhué, G. and Grosjean, J. and Gehanno, JF. and Darmoni, SJ.},
  title = {{LiSSa}, {Littérature} {Scientifique} en {Santé} : une base de données bibliographique en français},
  journal = {Pratique Neurologique - FMC},
  year = {2017},
  volume = {8},
  number = {4},
  pages = {204-247},
  doi = {10.1016/j.praneu.2017.06.008}
}

BibTeX:
@article{Griffon2016c,
  author = {Griffon, Nicolas and Schuers, Matthieu and Kerdelhué, Gaétan and Grosjean, Julien and Darmoni, Stéfan},
  title = {Littérature scientifique en santé ({LiSSa}) : une base de données bibliographiques en français},
  journal = {La Revue Du Praticien},
  year = {2017},
  volume = {67},
  number = {2},
  pages = {134-138}
}

BibTeX:
@article{Siedlecki2017,
  author = {Siedlecki, C. and Griffon, N. and Kerdelhué, G.},
  title = {Thèmes et tendances des publications en médecine générale dans {PubMed}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2017},
  number = {130},
  pages = {70--1},
  url = {http://www.lissa.fr/fr/rep/articles/EX_130_70}
}

Abstract: Extracting concepts from medical texts is a key to support many advanced applications in medical information retrieval. Entity recognition in French texts is moreover challenged by the availability of many resources originally developed for English texts. This paper proposes an evaluation of the terminology coverage in a corpus of 50,000 French articles extracted from the bibliographic database LiSSa. This corpus was automatically indexed with 32 health terminologies, published in French or translated. Then, the terminologies providing the best coverage of these documents were determined. The results show that major resources such as the NCI and SNOMED CT thesauri achieve the largest annotation of the corpus while specific French resources prove to be valuable assets.
BibTeX:
@article{Cabot2017,
  author = {Cabot, Chloé and Soualmia, Lina F and Grosjean, Julien and Griffon, Nicolas and Darmoni, Stéfan J},
  title = {Evaluation of the Terminology Coverage in the French Corpus LiSSa.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {126--130},
  doi = {10.3233/978-1-61499-753-5-126}
}

BibTeX:
@inproceedings{Chebil2017,
  author = {Wiem Chebil and Lina Fatima Soualmia and Mohamed Nazih Omri and St{\'{e}}fan Jacques Darmoni},
  title = {Indexing biomedical documents with Bayesian networks and terminologies},
  booktitle = {12th International Conference on Intelligent Systems and Knowledge Engineering, {ISKE} 2017, Nanjing, China, November 24-26, 2017},
  year = {2017},
  pages = {1--6},
  url = {https://doi.org/10.1109/ISKE.2017.8258745},
  doi = {10.1109/ISKE.2017.8258745}
}

Abstract: Suspected adverse drug reactions (ADR) reported by patients through social media can be a complementary source to current pharmacovigilance systems. However, the performance of text mining tools applied to social media to discover ADRs needs to be evaluated. In this paper, we introduce the approach developed to mine ADR from French social media. A protocol of evaluation is highlighted, which includes a detailed sample size determination and corpus constitution. Our text mining approach provided very encouraging preliminary results with F-measures of 0.94, 0.81 and 0.70 for recognition of drugs, symptoms and ADRs respectively, thus this approach is promising for downstream pharmacovigilance analysis.
BibTeX:
@inproceedings{Chen2017,
  author = {Chen, C and Deldossi, M and Aboukhamis, R and Faviez, C and Dahamna, B and Karapetiantz, P and Guenegou-Arnoux, A and Girardeau, Y and Guillemin-Lanne, S and Lillo-Le-Louët, A and Texier, N and Burgun, A and Katsahian, S},
  title = {Mining adverse drug reactions in social media with named entity recognition and semantic methods},
  booktitle = {Medinfo},
  year = {2017},
  note = {Accepted}
}

Abstract: The hereby proposed terminology called "Q-Codes" can be defined as an extension of the International Classification of Primary Care (ICPC-2). It deals with non-clinical concepts that are relevant in General Practice/Family Medicine (GP/FM). This terminology is a good way to put an emphasis on underestimated topics such as Teaching, Patient issues or Ethics. It aims at indexing GP/FM documents such as congress abstracts and theses to get a more comprehensive view about the GP/FM domain. The 182 identified Q-Codes have been very precisely defined by a college of experts (physicians and terminologists) from twelve countries. The result is available on the Health Terminology/Ontology Portal (http://www.hetop.org/Q) and formatted in OWL-2 for further semantic considerations and will be used to index the 2016 WONCA World congress communications.
BibTeX:
@article{Jamoulle2017,
  author = {Jamoulle, Marc and Grosjean, Julien and Resnick, Melissa and Ittoo, Ashwin and Treuherz, Arthur and Vander Stichele, Robert and Cardillo, Elena and Darmoni, Stéfan J and Shamenek, Frank S and Vanmeerbeek, Marc},
  title = {A Terminology in General Practice/Family Medicine to Represent Non-Clinical Aspects for Various Usages: The Q-Codes.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {471--475}
}

BibTeX:
@inproceedings{Jamoulle2017a,
  author = {Jamoulle, Marc and Resnick, Melissa and Ittoo, Ashwin and Vander Stichele, Robert and Cardillo, Elena and Grosjean, Julien and Darmoni, Stefan and Vanmeerbeek, Marc},
  title = {Indexing grey multilingual literature in {General} {Practice} in the era of {Semantic} {Web}},
  booktitle = {Nineteenth International Conference on Grey Literature Public Awareness and Access to Grey Literature},
  address = {Rome, Italy},
  month = {October},
  journal = {The Grey Journal},
  year = {2017},
  url = {https://orbi.uliege.be/handle/2268/210490}
}

Abstract: While the digitization of medical documents has greatly expanded during the past decade, health information retrieval has become a great challenge to address many issues in medical research. Information retrieval in electronic health records (EHR) should also reduce the difficult tasks of manual information retrieval from records in paper format or computer. The aim of this article was to present the features of a semantic search engine implemented in EHRs. A flexible, scalable and entity-oriented query language tool is proposed. The program is designed to retrieve and visualize data which can support any Conceptual Data Model. The search engine deals with structured and unstructured data, for a sole patient from a caregiver perspective, and for a number of patients (e.g. epidemiology). Several types of queries on a test database containing 2,000 anonymized patients EHRs (i.e. approximately 200,000 records) were tested. These queries were able to accurately treat symbolic, textual, numerical and chronological data.
BibTeX:
@article{Lelong2017,
  author = {Lelong, Romain and Soualmia, Lina and Dahamna, Badisse and Griffon, Nicolas and Darmoni, Stéfan J},
  title = {Querying EHRs with a Semantic and Entity-Oriented Query Language.},
  journal = {Studies in health technology and informatics},
  year = {2017},
  volume = {235},
  pages = {121--125},
  doi = {10.3233/978-1-61499-753-5-121}
}

Abstract: The emergence of electronic health records has highlighted the need for semantic standards for representation of observations in laboratory medicine. Two such standards are LOINC, with a focus on detailed encoding of lab tests, and SNOMED CT, which is more general, including the representation of qualitative and ordinal test results. In this paper we will discuss how lab observation entries can be represented using SNOMED CT. We use resources provided by the Regenstrief Institute and SNOMED International collaboration, which formalize LOINC terms as SNOMED CT post-coordinated expressions. We demonstrate the benefits brought by SNOMED CT to classify lab tests. We then propose a SNOMED CT based model for lab observation entries aligned with the BioTopLite2 (BTL2) upper level ontology. We provide examples showing how a model designed with no ontological foundation can produce misleading interpretations of inferred observation results. Our solution based on a BTL2 conformant formal interpretation of SNOMED CT concepts allows representing lab test without creating unintended models. We argue in favour of an ontologically explicit bridge between compositional clinical terminologies, in order to safely use their formal representations in intelligent systems.
BibTeX:
@inproceedings{Mary2017,
  author = {Mary, Mélissa and Soualmia, Lina F. and Gansel, Xavier and Darmoni, Stéfan and Karlsson, Daniel and Schulz, Stefan},
  title = {Ontological {Representation} of {Laboratory} {Test} {Observables}: {Challenges} and {Perspectives} in the {SNOMED} {CT} {Observable} {Entity} {Model} {Adoption}},
  booktitle = {Artificial {Intelligence} in {Medicine}},
  month = {June},
  publisher = {Springer, Cham},
  year = {2017},
  series = {Lecture {Notes} in {Computer} {Science}},
  pages = {14--23},
  url = {https://link.springer.com/chapter/10.1007/978-3-319-59758-4_2},
  doi = {10.1007/978-3-319-59758-4_2}
}

BibTeX:
@inproceedings{Merabti2017,
  author = {Merabti, T and Grosjean, J and Darmoni, SJ},
  title = {MT@HeTOP: The Mapping and Translation tool based on the Health multi-terminology portal HeTOP},
  booktitle = {ISHIC2017 2nd International Saudi Health Informatics Conference},
  address = {Riyadh, Kingdom of Saudi of Arabia},
  month = {March},
  year = {2017}
}

BibTeX:
@inproceedings{Lelong2017a,
  author = {Romain Lelong and Lina Soualmia and Saoussen Sakji and Badisse Dahamna and Stéfan Darmoni},
  title = {Une technologie NoSQL au service de moteur de recherche en Santé},
  booktitle = {4ème édition du Symposium sur l'Ingénierie de l'Information Médicale},
  address = {Toulouse},
  month = {Novembre},
  year = {2017}
}

BibTeX:
@article{Perrin2017,
  author = {Helene Perrin and Marion Denorme and Julien Grosjean and OMICtools community and Emeric Dynomant and Vincent J. Henry and Fabien Pichon and Stefan Darmoni and Arnaud Desfeux and Bruno J. Gonzalez},
  title = {OMICtools: a community-driven search engine for biological data analysis},
  journal = {CoRR},
  year = {2017},
  volume = {abs/1707.03659},
  url = {http://arxiv.org/abs/1707.03659}
}

BibTeX:
@phdthesis{Cabot2017a,
  author = {Chloé Cabot},
  title = {Recherche d'information clinomique au sein du Dossier Patient Informatisé : modélisation, implantation et évaluation},
  school = {Université de Rouen},
  year = {2017}
}

2016


BibTeX:
@article{Bouvry2016,
  author = {Bouvry, C. and Tvardik, N. and Kergourlay, I. and Bittar, A. and Arnod-Prin, P. and Segond, F. and Dini, L. and Darmoni, S. and Metzger, M.H.},
  title = {The {SYNODOS} {Project}: {System} for the {Normalization} and {Organization} of {Textual} {Medical} {Data} for {Observation} in {Healthcare}},
  month = {April},
  journal = {IRBM},
  year = {2016},
  volume = {37},
  number = {2},
  pages = {109--115},
  url = {http://linkinghub.elsevier.com/retrieve/pii/S1959031816300045},
  doi = {10.1016/j.irbm.2016.03.002}
}

Abstract: In this article, we propose a new approach for indexing biomedical
documents based on a possibilistic network that carries out partial
matching between documents and biomedical vocabulary. The main contribution
of our approach is to deal with the imprecision and uncertainty of
the indexing task using possibility theory. We enhance estimation
of the similarity between a document and a given concept using the
two measures of possibility and necessity. Possibility estimates
the extent to which a document is not similar to the concept. The
second measure can provide confirmation that the document is similar
to the concept. Our contribution also reduces the limitation of partial
matching. Although the latter allows extracting from the document
other variants of terms than those in dictionaries, it also generates
irrelevant information. Our objective is to filter the index using
the knowledge provided by the Unified Medical Language System®. Experiments
were carried out on different corpora, showing encouraging results
(the improvement rate is +26.37% in terms of main average precision
when compared with the baseline).
BibTeX:
@article{Chebil2014,
  author = {Chebil, Wiem and Soualmia, Lina Fatima and Omri, Mohamed Nazih and Darmoni, Stéfan Jacques},
  title = {Indexing biomedical documents with a possibilistic network},
  month = {April},
  journal = {Journal of the Association for Information Science and Technology},
  year = {2016},
  volume = {67},
  number = {4},
  pages = {928-941},
  url = {http://onlinelibrary.wiley.com/doi/10.1002/asi.23435/abstract},
  doi = {10.1002/asi.23435}
}

Abstract: BACKGROUND: Health care workers (HCWs) are considered to be at higher
risk of tuberculosis (TB) than the general population. However, a
decreasing incidence in the general population as well as improvement
in preventive measures in hospitals has reduced the risk for HCWs.
AIMS: To quantify the actual incidence of TB in nurses and health
care assistants in a low-incidence country. METHODS: We performed
a retrospective study of 80 hospitals throughout France, employing
233389 health care staff (physicians excluded). We calculated the
number of pulmonary TB cases over 3 years (700166 person-years) and
the total number of staff members in each job category (nurses, health
care assistants, administrative staff) in each hospital, to calculate
the incidence. RESULTS: Overall, the incidence rate varied between
1.27 and 6/100000 for administrative staff and nurses, respectively
(non-significant difference). The incidence varied according to the
geographical area. However, the incidence in nurses and health care
assistants was not different from the general population (7.5/100000).
CONCLUSIONS: In a low-incidence country, such as France, the implementation
of measures to prevent occupational TB among HCWs has been effective.
These preventive measures should be maintained but medical follow-up
could be revised.
BibTeX:
@article{Gehanno2016a,
  author = {Gehanno, J.-F. and Abiteboul, D. and Rollin, L.},
  title = {Incidence of tuberculosis among nurses and health care assistants in {France}.},
  month = {September},
  journal = {Occupational medicine (Oxford, England)},
  year = {2016},
  doi = {10.1093/occmed/kqw138}
}

Abstract: Despite international initiatives like Orphanet, it remains difficult
to find up-to-date information about rare diseases. The aim of this
study is to propose an exhaustive set of queries for PubMed based
on terminological knowledge and to evaluate it versus the queries
based on expertise provided by the most frequently used resource
in Europe: Orphanet.Four rare disease terminologies (MeSH, OMIM,
HPO and HRDO) were manually mapped to each other permitting the automatic
creation of expended terminological queries for rare diseases. For
30 rare diseases, 30 citations retrieved by Orphanet expert query
and/or query based on terminological knowledge were assessed for
relevance by two independent reviewers unaware of the query's origin.
An adjudication procedure was used to resolve any discrepancy. Precision,
relative recall and F-measure were all computed.For each Orphanet
rare disease (n = 8982), there was a corresponding terminological
query, in contrast with only 2284 queries provided by Orphanet. Only
553 citations were evaluated due to queries with 0 or only a few
hits. There were no significant differences between the Orpha query
and terminological query in terms of precision, respectively 0.61
vs 0.52 (p = 0.13). Nevertheless, terminological queries retrieved
more citations more often than Orpha queries (0.57 vs. 0.33; p = 0.01).
Interestingly, Orpha queries seemed to retrieve older citations than
terminological queries (p < 0.0001).The terminological queries proposed
in this study are now currently available for all rare diseases.
They may be a useful tool for both precision or recall oriented literature
search.
BibTeX:
@article{Griffon2016a,
  author = {Griffon, N. and Schuers, M. and Dhombres, F. and Merabti, T. and Kerdelhué, G. and Rollin, L. and Darmoni, S. J.},
  title = {Searching for rare diseases in PubMed: a blind comparison of Orphanet expert query and query based on terminological knowledge.},
  journal = {BMC Med Inform Decis Mak},
  school = {S, 75006, Paris, France; Univ Paris 13, Sorbonne Paris Cité, LIMICS (UMR_S 1142), 93430, Villetaneuse, France.},
  year = {2016},
  volume = {16},
  number = {1},
  pages = {101},
  url = {http://dx.doi.org/10.1186/s12911-016-0333-0},
  doi = {10.1186/s12911-016-0333-0}
}

Abstract: Background Physicians are increasingly encouraged to practice evidence-based
medicine (EBM), and their decisions require evidence based on valid
research. Existing literature shows a mismatch between general practitioners’
(GPs) information needs and evidence available online. The aim of
this study was to explore the attitudes and behavior of residents
in general medicine and GPs when seeking medical information online.
Methods Five focus groups (FGs) involving residents in general medicine
and GPs were conducted between October 2013 and January 2014. The
overall number of participants recruited was 35. The focus group
discussion guide focused on participants’ experiences in searching
for health information on the Internet, perceived barriers and possible
solutions for improving the quality of their own search processes.
Descriptive analysis was performed by three researchers. Results
Participants described a wide range of research topics, covering
all general medicine core competencies, and especially patient-oriented
topics. They used a limited list of websites. Participants were not
confident about their ability to assess the quality of the information
they found. Their assessment of data quality was based on intuition,
and they mainly sought concordance with their existing knowledge.
The way the data were exposed was considered very important. Participants
were looking for information that was directly linked to their clinical
practice. Information seeking processes varied among participants.
They felt they had not mastered query building for conducting searches,
and were aware of the impact this shortcoming had on the quality
of their search for information. Conclusions Residents in general
medicine and GPs understood the importance of EBM and the need for
objective and reliable information. The present study highlights
the difficulties in identifying this kind of information, and suggests
ideas for improvement. Available search tools should change in order
to fill the gap with real-world clinical practice, for example by
integrating a patient-centred approach.
BibTeX:
@article{Schuers2016,
  author = {Schuers, Matthieu and Griffon, Nicolas and Kerdelhue, Gaëtan and Foubert, Quentin and Mercier, Alain and Darmoni, Stéfan J.},
  title = {Behavior and attitudes of residents and general practitioners in searching for health information: {From} intention to practice},
  month = {May},
  journal = {International Journal of Medical Informatics},
  year = {2016},
  volume = {89},
  pages = {9--14},
  url = {http://www.sciencedirect.com/science/article/pii/S1386505616300235},
  doi = {10.1016/j.ijmedinf.2016.02.003}
}

Abstract: OBJECTIVES: To summarize excellent current research in the field of
Knowledge Representation and Management (KRM) within the health and
medical care domain. METHOD: We provide a synopsis of the 2016 IMIA
selected articles as well as a related synthetic overview of the
current and future field activities. A first step of the selection
was performed through MEDLINE querying with a list of MeSH descriptors
completed by a list of terms adapted to the KRM section. The second
step of the selection was completed by the two section editors who
separately evaluated the set of 1,432 articles. The third step of
the selection consisted of a collective work that merged the evaluation
results to retain 15 articles for peer-review. RESULTS: The selection
and evaluation process of this Yearbook's section on Knowledge Representation
and Management has yielded four excellent and interesting articles
regarding semantic interoperability for health care by gathering
heterogeneous sources (knowledge and data) and auditing ontologies.
In the first article, the authors present a solution based on standards
and Semantic Web technologies to access distributed and heterogeneous
datasets in the domain of breast cancer clinical trials. The second
article describes a knowledge-based recommendation system that relies
on ontologies and Semantic Web rules in the context of chronic diseases
dietary. The third article is related to concept-recognition and
text-mining to derive common human diseases model and a phenotypic
network of common diseases. In the fourth article, the authors highlight
the need for auditing the SNOMED CT. They propose to use a crowdbased
method for ontology engineering. CONCLUSIONS: The current research
activities further illustrate the continuous convergence of Knowledge
Representation and Medical Informatics, with a focus this year on
dedicated tools and methods to advance clinical care by proposing
solutions to cope with the problem of semantic interoperability.
Indeed, there is a need for powerful tools able to manage and interpret
complex, large-scale and distributed datasets and knowledge bases,
but also a need for user-friendly tools developed for the clinicians
in their daily practice.
BibTeX:
@article{Soualmia2016,
  author = {Soualmia, L. F. and Charlet, J.},
  title = {Efficient {Results} in {Semantic} {Interoperability} for {Health} {Care}. {Findings} from the {Section} on {Knowledge} {Representation} and {Management}},
  month = {November},
  journal = {Yearbook of Medical Informatics},
  year = {2016},
  number = {1},
  pages = {184--187},
  doi = {10.15265/IY-2016-051}
}

Abstract: OBJECTIVES: Summarize excellent current research published in 2015
in the field of Public Health and Epidemiology Informatics. METHODS:
The complete 2015 literature concerning public health and epidemiology
informatics has been searched in PubMed and Web of Science, and the
returned references were reviewed by the two section editors to select
14 candidate best papers. These papers were then peer-reviewed by
external reviewers to allow the editorial team an enlightened selection
of the best papers. RESULTS: Among the 1,272 references retrieved
from PubMed and Web of Science, three were finally selected as best
papers. The first one presents a language agnostic approach for epidemic
event detection in news articles. The second paper describes a system
using big health data gathered by a statewide system to forecast
emergency department visits. The last paper proposes a rather original
approach that uses machine learning to solve the old issue of outbreak
detection and prediction. CONCLUSIONS: The increasing availability
of data, now directly from health systems, will probably lead to
a boom in public health surveillance systems and in large-scale epidemiologic
studies.
BibTeX:
@article{Toubiana2016,
  author = {Toubiana, L. and Griffon, N.},
  title = {Some {Innovative} {Approaches} for {Public} {Health} and {Epidemiology} {Informatics}},
  month = {November},
  journal = {Yearbook of Medical Informatics},
  year = {2016},
  number = {1},
  pages = {247--250},
  doi = {10.15265/IY-2016-047}
}

Abstract: Introduction et objectifs Cancers Pro Doc et Cancers Pro Actu sont
deux outils documentaires sur la prévention des cancers professionnels,
mis en place en 2013 par l’Institut national du cancer (INCa) et
ses partenaires, et qui comptent, fin 2015, plus de 1200 abonnés.
Après ces trois ans d’existence, le comité éditorial a souhaité réaliser
une enquête auprès des abonnés pour évaluer la pertinence et l’utilisation
de ces deux outils et permettre d’identifier des pistes d’amélioration.
Ces deux outils ont pour objectif de faciliter la recherche documentaire
de l’ensemble des professionnels de la santé au travail et de contribuer
à une diffusion plus large des informations parues dans ce domaine.
Cancers Pro Actu, bulletin de veille trimestriel, présente une sélection
d’outils et de supports d’aide à la pratique récemment parus et accessibles
gratuitement sur Internet. Cancers Pro Doc est une base de ressources
documentaires qui répertorie les documents pérennes de Cancers Pro
Actu et dispose d’un moteur de recherche avancée. Méthode et résultats
attendus La communication présentera les premiers enseignements d’une
enquête de satisfaction qui sera réalisée durant le premier semestre 2016 auprès
des abonnés de Cancers Pro Actu et des utilisateurs de Cancers Pro
Doc. L’enquête s’appuiera sur un questionnaire en ligne, puis sur
des entretiens plus approfondis avec des professionnels volontaires.
Par ailleurs, les données de consultation du bulletin de veille et
du site internet seront analysées. Nous disposerons ainsi de données
concernant les habitudes de lecture des utilisateurs, leurs pratiques
en matière de recherches documentaires et leurs perceptions vis-à-vis
des outils mis à disposition. Conclusion L’ensemble des résultats
collectés permettra d’identifier les évolutions nécessaires pour
améliorer Cancers Pro Doc et Cancers Pro Actu et répondre au mieux
aux attentes des abonnés et des lecteurs potentiels. Cette démarche
s’intègre dans une réflexion initiée en 2010 par l’INCa et un ensemble
d’acteurs de la santé au travail sur la circulation de l’information
sur la prévention des cancers professionnels et les possibilités
de l’améliorer.
Review: @articlechen_mining_2018,
title = Mining Patients' Narratives in Social Media for Pharmacovigilance: Adverse Effects and Misuse of Methylphenidate,
volume = 9,
issn = 1663-9812,
url = https://www.frontiersin.org/articles/10.3389/fphar.2018.00541/full,
doi = 10.3389/fphar.2018.00541,
shorttitle = Mining Patients' Narratives in Social Media for Pharmacovigilance,
abstract = Background: The Food and Drug Administration (FDA) in the United States and the European Medicines Agency (EMA) have recognized social media as a new data source to strengthen their activities regarding drug safety. Objective: Our objective in the ADR-PRISM project was to provide text mining and visualization tools to explore a corpus of posts extracted from social media. We evaluated this approach on a corpus of 21 million posts from five patient forums, and conducted a qualitative analysis of the data available on methylphenidate in this corpus. Methods: We applied text mining methods based on named entity recognition and relation extraction in the corpus, followed by signal detection using proportional reporting ratio (PRR). We also used topic modelling based on the Correlated Topic Model to obtain the list of thematics in the corpus and classify the messages based on their topics. Results: We automatically identified 3443 posts about methylphenidate published between 2007 and 2016, among which 61 adverse drug reactions (ADR) were automatically detected. Two pharmacovigilance experts evaluated manually the quality of automatic identification, and a f-measure of 0.57 was reached. Patient’s reports were mainly neuro-psychiatric effects. Applying PRR, 67% of the ADRs were signals, including most of the neuro-psychiatric symptoms but also palpitations. Topic modelling showed that the most represented topics were related to Childhood and Treatment initiation, but also Side effects. Cases of misuse were also identified in this corpus, including recreational use and abuse. Conclusion: Named entity recognition combined with signal detection and topic modelling have demonstrated their complementarity in mining social media data. An in-depth analysis focused on methylphenidate showed that this approach was able to detect potential signals and to provide better understanding of patients’ behaviors regarding drugs, including misuse.,
journaltitle = Frontiers in Pharmacology,
shortjournal = Front. Pharmacol.,
author = Chen, Xiaoyi and Faviez, Carole and Schuck, Stéphane and Lillo-Le-Louët, Agnès and Texier, Nathalie and Dahamna, Badisse and Huot, Charles and Foulquié, Pierre and Pereira, Suzanne and Leroux, Vincent and Karapetiantz, Pierre and Guenegou-Arnoux, Armelle and Katsahian, Sandrine and Bousquet, Cédric and Burgun, Anita,
urldate = 2018-06-13,
date = 2018,
keywords = Data Mining, drug misuse, Drug-Related Side Effects and Adverse Reactions, Methylphenidate, Natural Language Processing, Pharmacovigilance, Social Media
BibTeX:
@article{Chauvet2016,
  author = {Chauvet, Claire and Jordan, Philippe and Bijaoui, Annie and Delepine, Anne and Fontaine, Bernard and Gehanno, Jean-François and Haberer, Michel and Hasni-Pichard, Helene},
  title = {Cancers {Pro} {Doc} et cancers {Pro} {Actu}. {Premiers} enseignements d’une enquête de lectorat},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {502--502},
  doi = {10.1016/j.admp.2016.03.341}
}

Abstract: Contexte Les différents facteurs ayant un impact sur le retour au
travail des patients atteints d’hémopathies malignes sont peu documentés.
Objectif Décrire et analyser les modalités de reprise et les déterminants
de la réussite ou de l’échec du maintien à l’emploi ou d’une réinsertion
professionnelle des patients atteints d’une hémopathie maligne. Méthode
Étude pilote médico-sociale observationnelle, non randomisée. Inclusion
des sujets atteints d’une hémopathie maligne dans le département
du Calvados, dont le diagnostic a été effectué entre le 1 er janvier
et le 31 décembre 2010, âgés de 18 à 55 ans au moment du diagnostic,
grâce aux données du registre des hémopathies malignes de Basse-Normandie.
Un auto-questionnaire de recueil d’informations propre à l’étude
et des questionnaires validés d’anxiété-dépression, de qualité de
vie et de fatigue ont été adressés aux patients inclus. Principaux
résultats Sur les 144 questionnaires envoyés, 72 questionnaires ont
été recueillis et 20 refus ont été signifiés. La population de l’étude
était constituée de 54 % d’hommes et de 46 % de femmes, avec une
moyenne d’âge de 49,8 ans. Seuls 60 % des sujets déclaraient avoir
bénéficié d’un arrêt de travail suite à la découverte de leur maladie
et la durée moyenne de celui-ci était de 21 mois. À la date de réception
des questionnaires, la majorité des sujets (85  n’était plus en
arrêt de travail. Parmi les sujets ayant bénéficié d’un arrêt de
travail, 47 % des sujets déclaraient avoir rencontré leur médecin
du travail en visite de pré-reprise. La majorité des sujets avait
repris une activité professionnelle dans la même entreprise qu’avant
le diagnostic (77 , avec le même type de contrat de travail (95 ,
et au même poste de travail (77 . La majorité des sujets de l’étude
(79  déclarait n’avoir bénéficié d’aucun aménagement de ses conditions
de travail et 31 % des sujets déclaraient avoir constaté un impact
négatif de leur maladie sur les conditions de reprise de leur activité
professionnelle. Les conditions de reprise du travail étaient considérées
comme suffisamment anticipées pour 56 % seulement des sujets, « pas
du tout » pour 13 % des sujets. Une minorité de sujets (29,5 
déclarait avoir l’impression de travailler « moins bien qu’avant »
la découverte de leur maladie, et 23 % déclaraient s’être sentis
pénalisés dans leur travail à cause de leur maladie. Conclusion Les
données riches recueillies dans le cadre de cette étude pilote et
le taux de réponse satisfaisant permettent d’envisager la réalisation
d’une étude multicentrique, incluant des sujets atteints d’une hémopathie
maligne en Basse-Normandie, Haute-Normandie, dans la zone de proximité
de Lille et dans la Somme.
BibTeX:
@article{Clin2016,
  author = {Clin, Bénédicte and Heutte, Natacha and Troussard, Xavier and Boulanger, Mathilde and Damaj, Ganghi-Laurent and Cornet, Edouard and Bouvier, Véronique and Guizard, Anne-Valérie and Fantoni-Quinton, Sophie and Leroyer, Ariane and Rollin, Laetitia and Doutrellot, Catherine and Launoy, Guy},
  title = {Analyse des déterminants médico-sociaux du maintien en emploi des patients atteints d’une hémopathie maligne (protocole {ADAMENTINE}). {Résultats} de l’étude pilote},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {383--383},
  doi = {10.1016/j.admp.2016.03.054}
}

Abstract: Introduction et méthode Cette étude a pour objectif de repérer les
facteurs de vulnérabilité face à la reprise du travail après un cancer.
Elle porte sur 77 sujets répartis en deux groupes (33 sujets qui
reprennent le travail sans accompagnement et 44 sujets qui s’adressent
à la consultation pluridisciplinaire d’aide à la reprise du travail
après un cancer du CHU de Rouen). Les caractéristiques psychologiques,
médicales, sociales et professionnelles des sujets non consultants
et des sujets consultants sont comparées. Résultats Des facteurs
de vulnérabilité étaient significativement plus souvent présents
chez les sujets consultants : – plus faible sentiment de contrôle
face aux événements traumatisants vécus (questionnaire EVE, Ferreri
et Vacher) ; – plus faible score moyen d’esprit combatif (Mac 44,
Cayrou et Dickès) ; – valeurs liées à la vie professionnelle plus
affectées par la maladie (échelle de valeurs, Fischer) ; – anticipation
d’une moindre compréhension de la part de l’entourage familial face
à la reprise du travail (questionnaire créé pour les besoins de l’étude) ;
– âge inférieur au moment du diagnostic de cancer ; – perte d’emploi
plus fréquente suite au diagnostic. Les taux de reprise du travail
sont de 73 % pour les non consultants et de 66 % pour les consultants.
Le test de Chi 2 ( χ 2 = 0,4086) n’indique pas de différence significative
( p = 0,52) entre les deux groupes. Chez les sujets ayant repris
une activité professionnelle, les délais moyens entre le diagnostic
et la reprise (en mois) sont de 17,54 ± 13,35 pour les sujets consultants
et de 16,78 ± 10,33 pour les non consultants. Le test- t ne montre
pas de différence significative ( p = 0,41) concernant le délai écoulé
entre le diagnostic de cancer et la reprise du travail entre les
sujets des deux groupes. Conclusion Les facteurs de vulnérabilité,
plus souvent présents dans le groupe des sujets ayant consulté, n’ont
pas eu d’incidence sur le taux de reprise du travail et le délai
moyen entre le diagnostic de cancer et la reprise. L’accompagnement
de la consultation d’aide à la reprise du travail a probablement
favorisé une forme de résilience et l’autonomie psychique chez ces
sujets face au retour à l’emploi. Cet accompagnement pourrait faire
émerger des ressources pour faire face à une vulnérabilité durable
dans la vie professionnelle. Les sujets non consultants présentent
des caractéristiques plutôt favorables à la reprise du travail, mais
des difficultés pèsent sur la vie professionnelle après le diagnostic
de cancer. Nous pouvons nous interroger sur le devenir et le vécu
de la reprise du travail, à moyen ou long terme, et sur la valeur
de ces ressources qui pourraient être moins opérantes dans une temporalité
et un contexte différents.
BibTeX:
@article{DeBlasi2016,
  author = {De Blasi, Géraldine and Bouteyre, Evelyne and Gehanno, Jean-François and Rollin, Laetitia},
  title = {Facteurs de vulnérabilité et résilience face à la reprise du travail après un cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {386--387},
  doi = {10.1016/j.admp.2016.03.064}
}

Abstract: La prévention de l’acquisition d’une infection par un soignant constitue
le cœur de métier des professionnels de la lutte contre les infections
associées aux soins et des professionnels de la santé au travail
car : – une infection acquise par un soignant au cours de son activité
dans un établissement de santé (ES) est une infection nosocomiale ;
– un soignant atteint d’une maladie contagieuse peut participer à
la diffusion épidémique de celle-ci dans l’ES ; – une infection chez
un soignant peut conduire, lorsqu’elle est grave et/ou contagieuse
à un arrêt de travail de ce soignant, arrêt de nature à déstabiliser
le fonctionnement du service. La vaccination du personnel de santé
(PS) est une des missions importantes des services de santé au travail.
La vaccination est un moyen de prévention primaire efficace ayant
permis de diminuer, de contrôler, voire d’éradiquer de nombreuses
maladies infectieuses à prévention vaccinale assurant la protection
des populations. Ainsi, la promotion de la vaccination par une politique
vaccinale volontariste représente un enjeu majeur de santé publique.
Pour guider les pratiques, des recommandations vaccinales existent
dont certaines concernent spécifiquement les PS et autres personnels
en contact avec des sujets à risque dans les domaines de la santé
et du médico-social. Malgré ces recommandations, hormis quelques
travaux ayant montré que si les PS étaient globalement bien couverts
par les vaccinations obligatoires, ils étaient en revanche très insuffisamment
couverts par les vaccinations recommandées, les données de couverture
vaccinale (CV) chez le PS ne sont pas nombreuses en France. En 2013,
une action nationale prioritaire d’évaluation et de suivi de la CV
dans les ES a été suggérée, proposition reprise dans les orientations
du Propias 2015. Pour cette raison, le choix a été fait de déployer
le carnet de vaccination électronique (CVE) de MesVaccins.net (association
loi 1901 à but non lucratif). Celui-ci est doté d’un système expert
qui : – assure un diagnostic personnalisé, précis et immédiat de
l’état vaccinal de chaque personnel, et fournit une aide à la décision ;
– permet d’être alerté des vaccinations à programmer, avec intégration
en temps réel de l’évolution des recommandations vaccinales ; – informe
des éventuelles données de pharmacovigilance à prendre en compte.
Le réseau national coordonné par le Raisin se donne pour objectif
de déployer cette méthode standardisée de recueil et de suivi des
vaccinations et des conditions d’immunisation du personnel des ES
à partir du CVE de MesVaccins.net. La phase pilote débute en 2016.
Dans un deuxième temps, le dispositif explorera la capacité de générer
chez les soignants des données de CV à différents échelons géographiques.
BibTeX:
@article{Floret2016,
  author = {Floret, Nathalie and Abiteboul, Dominique and Bouvet, Elisabeth and Gehanno, Jean-François and Guthmann, Jean-Paul and Koeck, Jean-Louis and Launay, Odile and Lecieux, Fabienne and L’heriteau, François and Rabaud, Christian and Rolland, Patrick and Touche, Sylvie and Verdun-Esquer, Catherine},
  title = {Réseau de surveillance de la couverture vaccinale et des conditions d’immunisation du personnel des établissements de santé : pourquoi, comment},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {428--429},
  doi = {10.1016/j.admp.2016.03.175}
}

Abstract: Les soignants sont un groupe professionnel à risque d’exposition au
virus grippal, mais ils sont également régulièrement impliqués dans
des cas ou des épidémies de grippe nosocomiale. Tous les soignants,
et pas uniquement ceux en contact avec des patients à risque, devraient
donc bénéficier de la vaccination contre la grippe. Bien que les
vaccins actuellement disponibles aient une efficacité limitée, tant
pour la prévention de la grippe chez les soignants que pour la réduction
de la morbidité ou de la mortalité des patients à risques, leur rapport
bénéfice–risque reste favorable. Toutefois, les réticences sont fortes
et les taux de vaccination des personnels de soins restent faibles,
notamment en France. Il existe une abondante littérature sur les
actions à mettre en œuvre pour améliorer la couverture vaccinale.
Le fait de rendre la vaccination antigrippale obligatoire pour les
soignants est de nature à atteindre cet objectif, mais avec des inconvénients
qui doivent être pris en considération. Enfin, la politique de prévention
ne peut reposer sur la seule vaccination ; il ne faut pas méconnaître
l’importance du respect des précautions standards dans la prévention
des grippes nosocomiales.
BibTeX:
@article{Gehanno2016,
  author = {Gehanno, J.-F. and Rollin, L.},
  title = {Vaccination antigrippale du personnel soignant},
  journal = {Journal des Anti-infectieux},
  year = {2016},
  volume = {18},
  number = {2},
  pages = {79--84},
  doi = {10.1016/j.antinf.2016.02.001}
}

BibTeX:
@article{Griffon2016b,
  author = {Griffon, Nicolas and Schuers, Matthieu and Darmoni, Stefan J.},
  title = {Littérature {Scientifique} en {Santé} ({LiSSa}) : une alternative à l’anglais ?},
  month = {November},
  journal = {La Presse Médicale},
  year = {2016},
  volume = {45},
  number = {11},
  pages = {955--956},
  url = {http://www.sciencedirect.com/science/article/pii/S0755498216303505},
  doi = {10.1016/j.lpm.2016.11.001}
}

Abstract: Les langages iconiques permettent de représenter des concepts par
la combinaison de primitives graphiques (couleurs, pictogrammes...).
Les exemples sont nombreux, des pan- neaux routiers aux icônes des
interfaces utilisateur. Cependant, ces langages n’associent pas de
sémantique logique à leurs icônes, ce qui peut poser divers problèmes
: des combinaisons inconsistantes de primitives graphiques, des interprétations
différentes d’une même icône par deux personnes, des difficultés
à mettre en correspondance les icônes avec des concepts de ressources
termino-ontologiques existantes... Dans cet article, nous proposons
une méthode de formalisation de la sémantique d’un lan- gage iconique
à l’aide d’une ontologie. Cette méthode a initialement été développée
pour le langage iconique VCM (Visualisation des Concepts en Médecine),
qui permet de représenter par des icônes les principaux concepts
médicaux (antécédents, maladies, traitements...). Nous montrons que
cette méthode est généralisable à d’autres langages iconiques en
l’appliquant à la signalisation routière. Nous décrivons quatre applications
de la formalisation du langage : la vérification de la consistance
des icônes constituées, l’alignement semi-automatique des icônes
avec une terminologie médicale, la génération d’un lexique des pictogrammes
et la génération de libellés pour les icônes.
BibTeX:
@article{Lamy2016,
  author = {Lamy, JB and Soualmia, LF and Duclos, C and Venot, A},
  title = {Formalisation de la Sémantique des Langages Iconiques : Méthode à base d’Ontologie et Applications},
  journal = {Revue d’Intelligence Artificielle},
  year = {2016},
  volume = {30},
  number = {5},
  pages = {579-606},
  url = {http://ria.revuesonline.com/article.jsp?articleId=36942},
  doi = {10.3166/RIA.30.579-606}
}

Abstract: Objectif Décrire les risques psycho-sociaux (RPS) et la santé psychique
des différentes catégories du personnel hospitalier, puis étudier
les liens entre les troubles neuropsychiques et ces RPS. Méthode
et matériels La démarche EVREST a été appliquée en 2014, un entretien
médico-professionnel, avec passation du questionnaire EVREST par
une infirmière ou un médecin du travail, a été proposé aux salariés
nés en octobre d’une année paire du centre hospitalier universitaire
de Rouen ( n = 322). Les résultats quantitatifs et qualitatifs des
entretiens ont été analysés selon le groupe professionnel (médical,
soignant ou non médical-non soignant). Une comparaison avec les résultats
nationaux EVREST 2013–2014 des travailleurs français a été effectuée.
Enfin les facteurs associés aux troubles neuropsychiques ont été
étudiés à l’aide d’une régression logistique. Résultats Deux cent
soixante salariés (taux de participation = 81  ont participé.
Les personnels hospitaliers déclaraient des contraintes psychosociales
plus importantes que les autres travailleurs français, en particulier
le personnel médical et le personnel soignant. La proportion de troubles
neuropsychiques définis par l’association « fatigue et anxiété/nervosité
et troubles du sommeil » était plus importante chez le personnel
hospitalier de façon générale par comparaison aux résultats nationaux
(22 % versus 7 , sans différence significative selon le groupe
professionnel. Les facteurs associés significativement à la présence
de troubles neuropsychiques étaient la pression temporelle (OR =
3,5, IC95 1,7–7,6]), l’absence de possibilité d’entraide (OR =
2,3, IC95 1,0–5,3]) et la peur de perdre son emploi (OR = 5,6 IC95 
[1,7–19,2]). Conclusion Les personnels hospitaliers sont exposés
à des risques psycho-sociaux et déclarent des troubles neuropsychiques
dans des proportions élevées par rapport aux autres travailleurs
français. Des liens significatifs entre troubles neuro-psychiques
et certains RPS ont été mis en évidence. Ces éléments et, en particulier
les éléments qualitatifs entendus lors des entretiens, servent de
base pour le développement d’un plan concret de prévention des RPS
au sein de ce CHU.
BibTeX:
@article{Lesueur2016,
  author = {Lesueur, Nicoleta and Leroyer, Ariane and Gehanno, Jean-François and Caillard, Jean-François and Rollin, Laetitia},
  title = {Évaluation du retentissement des risques psychosociaux sur l’état de santé du personnel hospitalier : étude comparative à l’aide de la démarche {EVREST} dans un centre hospitalier universitaire},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {411--411},
  doi = {10.1016/j.admp.2016.03.125}
}

Abstract: Objectifs Décrire l’impact sur l’état de santé physique et psychique
des différents risques psychosociaux (RPS) auxquels sont exposés
les aides à domicile et les techniciennes d’intervention socio-familiale
(TISF), ainsi que proposer des pistes de prévention des RPS pour
les salariés du secteur de service à la personne. Matériel et méthodes
Étude prospective, monocentrique, descriptive, à l’aide du questionnaire
EVREST (Évolutions et relations en santé au travail) proposé en visite
périodique avec le médecin du travail ou lors d’entretien infirmier,
réalisée sur la période du 1 er octobre 2013 au 30 janvier 2015 pour
les aides à domicile et des TISF travaillant dans le cadre d’une
association d’aide à la personne, en Rouen et agglomération. Résultats
Un total de 246 salariés ont été inclus, principalement des femmes
(99 , avec un âge moyen de 44 ans. Plus de la moitié des salariés
travaillaient à temps partiel et un tiers des salariés travaillait
avec une pression temporelle forte. Ce métier était apprécié sur
certains aspects : près de 8 salariés sur 10 déclaraient faire un
travail varié en pleine autonomie, par contre un tiers de la population
ne disposait pas de possibilités d’entraide. La majorité des salariés
rapportaient des contraintes physiques au poste, pénibles pour la
moitié d’entre eux. Malgré une moyenne d’âge assez jeune, la santé
des salariés était plutôt altérée : atteintes du rachis dorsolombaire
(1/3 des salariés), atteints du membre supérieur (20 , troubles
neuropsychiques (9 . Quarante-sept pour cent des salariés déclaraient
avoir été victimes d’incivilités ou d’agressions physiques répétées
au cours de leur carrière. La pression psychologique était significativement
associée à la présence de troubles neuropsychiques. Conclusion Notre
étude met en évidence des contraintes organisationnelles, physiques
et psychosociales chez les travailleurs à domicile. Les troubles
musculo-squelettiques et neuropsychiques sont associés significativement
à la présence de ces contraintes. Un plan de prévention a pu être
proposé à partir de ces constats.
BibTeX:
@article{Lupse2016,
  author = {Lupse, Mihaela and Gehanno, Jean-François and Meyer, Michèle and Rollin, Laetitia},
  title = {Évaluation du retentissement des risques psychosociaux sur l’état de santé des travailleurs à domicile},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {409--410},
  doi = {10.1016/j.admp.2016.03.121}
}

Abstract: Objectifs Étudier le profil de la situation professionnelle des patients
douloureux chroniques ; – évaluer l’impact de la mise en place d’une
consultation spécialisée « Douleur et Travail » sur le maintien dans
l’emploi des patients douloureux chroniques ; – accompagner les patients
douloureux chroniques pour le maintien dans l’emploi et/ou la reprise
d’une activité professionnelle. Le principe de cette consultation
est la non-substitution au médecin du travail du salarié, le but
étant plutôt l’orientation et la reprise de contact avec celui-ci,
en temps utile, avant la reprise du travail. Méthodologie Les sujets
ayant consulté le Centre d’étude et traitement de la douleur de CHU
de Rouen ou la Structure douleur de l’hôpital d’Évreux et répondant
aux critères d’inclusion suivants sont adressés à la consultation :
– patients non salariés ou n’ayant pas une activité professionnelle,
âgés d’au moins 18 ans, atteints d’une pathologie douloureuse chronique
souhaitant le maintien dans l’emploi ou intégrer le monde du travail ;
– patients salariés atteints d’une pathologie douloureuse chronique,
n’ayant pas eu une visite avec leur médecin du travail dans les six
derniers mois. Critères d’exclusion : – visite avec le médecin du
travail dans les 6 derniers mois ou prévue dans le mois qui suit ;
– démarches de reclassement professionnel déjà en cours ; Trois temps
sont prévus : – une consultation avec pour objectif d’évaluer : – le
statut professionnel, – l’incapacité dans la vie (questionnaire SF-12)
et au travail, – la prise de contact ou non avec le médecin du travail
et les démarches effectuées. Un bilan des aptitudes médicales récentes
est réalisé puis orientation vers les acteurs du maintien dans l’emploi :
– entretien téléphonique au bout de 6 semaines pour évaluation de
l’avancement des démarches entreprises ; – une consultation de suivi
à trois mois pour faire le bilan sur l’avancement des démarches et
conseil. Résultats Les résultats présentés lors du congrès concerneront
les patients ayant bénéficié d’une première consultation entre le
01/11/2015 et le 01/03/2016. À la date du 06/01/2016, 21 patients
sont inclus, notre objectif est d’étudier au moins 30 patients sur
la période totale. L’analyse des résultats concernera le profil des
patients inclus ainsi que le nombre des objectifs accomplis après
la première consultation à trois mois.
BibTeX:
@article{Lupse2016a,
  author = {Lupse, Mihaela and Rollin, Laetitia and Gehanno, Jean François and Gislard, Antoine and Pouplin, Sophie},
  title = {Mise en place d’une consultation spécialisée « {Douleur} et {Travail} » au {CHU} de {Rouen}},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {382--382},
  doi = {10.1016/j.admp.2016.03.052}
}

BibTeX:
@article{Melissa2016,
  author = {Mélissa, Mary and Lina, Soualmia and Xavier, Gansel},
  title = {Interopérabilité sémantique entre vocabulaires contrôlés. évaluation de la qualité des alignements sur des données de standards du diagnostic in vitro},
  month = {December},
  journal = {Ingénierie des systèmes d'information},
  year = {2016},
  volume = {21},
  number = {5-6},
  pages = {55--81},
  url = {http://isi.revuesonline.com/article.jsp?articleId=37160},
  doi = {10.3166/isi.21.5-6.55-83}
}

Abstract: Introduction Les allergies professionnelles sont en très forte augmentation
en France. L’asthme professionnel peut être provoqué par divers allergènes,
selon les corps de métiers. Nous allons présenter un cas d’asthme
professionnel à la tulipe, diagnostiqué en consultation pluridisciplinaire
de médecine du travail et allergologie. Méthodes Une femme de 51
ans, fleuriste, était atteinte de toux, dyspnée et rhino-conjonctivite
lors de l’effeuillage de tulipes, mais ne présentait ni altération
de l’état général ni fièvre. Des tests de provocation bronchique
à la tulipe ont été réalisés en milieu hospitalier. Des prick + prick-tests
à la tulipe étaient réalisés avec le pistil, la feuille, l’étamine,
la tige, la sève de la fleur. Ils ont également été réalisés chez
deux témoins sains. Résultats Le test de provocation bronchique à
la métacholine ainsi que celui à l’effeuillage de tulipes étaient
positifs. L’asthme à la tulipe était donc confirmé. Les prick-tests
à la tulipe n’étaient positifs que chez la patiente, confirmant le
mécanisme allergique IgE médié. Cliniquement, l’éviction de la tulipe
par le changement de poste de travail a permis l’amendement complet
de la symptomatologie. Discussion L’asthme professionnel à la tulipe
est peu connu. Seuls quatre autres cas similaires ont été précédemment
décrits dans la littérature. La tulipe est plus connue en dermato
allergologie car son allergène majeur, la tulipaline A, est responsable
d’allergies de contact fréquentes, croisées avec d’autres fleurs.
Conclusion Nous rapportons un cas exceptionnel d’asthme professionnel
à la tulipe chez une fleuriste. Son diagnostic de certitude nécessite
une méthodologie rigoureuse et chronophage, facilitée par le cadre
d’une consultation pluridisciplinaire de médecine du travail et d’allergologie.
BibTeX:
@article{Merault2016,
  author = {Merault, C. and Tetart, F. and Kuntz, A. and Gehanno, J.F. and Joly, P. and Gislard, A.},
  title = {Asthme professionnel allergique aux liliacées : à propos d’un cas},
  journal = {Revue Francaise d'Allergologie},
  year = {2016},
  volume = {56},
  number = {3},
  pages = {298--298},
  doi = {10.1016/j.reval.2016.02.110}
}

Abstract: La reprise du travail est une étape primordiale pour les patients
atteints d’un cancer mais celle-ci peut s’avérer difficile et nécessiter
un accompagnement adapté. Le Centre de consultations de pathologie
professionnelle CHU de Rouen a créé, en 2006, une consultation pluridisciplinaire
d’aide au retour au travail après un cancer. Les objectifs de cette
étude descriptive étaient de présenter cette consultation, de connaître
le ressenti des patients vis-à-vis d’un tel dispositif et d’identifier
des facteurs prédictifs de retour au travail. Nous avons réalisé
l’analyse descriptive des patients vus entre 2006 et 2011, à partir
des dossiers médicaux, puis nous leur avons envoyé un questionnaire
détaillé sur les conditions de reprise du travail, sur la réalisation
des conseils prodigués lors de la consultation et sur l’intérêt de
cette consultation. Cent vingt et un patients ont été inclus, 22 hommes
(18  et 99 femmes (82 . Les localisations cancéreuses les plus
fréquentes étaient le sein et les hémopathies malignes, respectivement
65 % (79/121) et 12 % (14/121). Quatre-vingt-six patients (71 
étaient en rémission. Cent quatre patients (86  étaient salariés
lors du diagnostic dont 84 (69  en CDI. Les démarches médico-sociales
proposées ont eu un taux de réalisation allant de 28 à 72 % selon
les mesures. Soixante-six pour cent ([IC 95 % = 57–75]) des patients
ont repris, tous délais confondus. Vingt-cinq pour cent, soit 20 des
80 patients ayant repris, expriment des difficultés avec leur employeur
et 18 % (14/80) expriment des difficultés avec les collègues. L’analyse
multivariée a retrouvé trois facteurs associés significativement
à la reprise du travail : avoir un contrat à durée indéterminée lors
du diagnostic de cancer OR = 4,7 IC 95 1,4–16,0], cancer non évolutif
OR = 5 IC 95 1,25–25] et avoir bénéficié d’un accompagnement par
le psychologue de la consultation OR = 2,7 IC 95 1,0–6,9]. Les
différents constats de cette étude ont permis d’établir des pistes
d’amélioration pour cette consultation.
BibTeX:
@article{Rollin2016a,
  author = {Rollin, Laetitia and Boucher, Line and de Blasi, Géraldine and Bouteyre, Evelyne and Gislard, Antoine and Gehanno, Jean-François},
  title = {Évaluation d’une consultation pluridisciplinaire d’aide au retour au travail après cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {395--396},
  doi = {10.1016/j.admp.2016.03.086}
}

Abstract: En France, parmi les 350 000 personnes touchées par le cancer chaque
année, environ 100 000 d’entre elles sont en situation d’emploi et
travaillent au moment du diagnostic. La réinsertion professionnelle
après un cancer est un facteur de qualité de vie des patients, mais
également un enjeu de santé publique. Il s’agit d’une priorité soulignée
dans les plans cancers qui se succèdent depuis 2003. L’objectif de
cette communication est de décrire l’état des connaissances actuelles
concernant le maintien dans l’emploi des patients après cancer. La
métaanalyse deffectuée par Menhert en 2011 a retrouvé un taux de
reprise du travail après cancer de 63,5 % avec des extrêmes allant
de 24 à 94 % selon les études. Cette grande hétérogénéité est expliquée
par des facteurs liés à la pathologie (localisation, stades, traitement),
mais également par d’autres facteurs comme le sens du travail, les
conditions de travail, les cadres légaux et les politiques sociales
variables selon les pays. Il est donc intéressant, dans la réflexion
pour l’accompagnement des patients, d’examiner les études françaises.
L’étude de la DREES, menée en France en 2006, a montré que 67 %
des patients actifs lors du diagnostic avaient repris une activité
professionnelle à 2 ans. Ces données ont permis de mettre en évidence
une différence de vitesse dans le processus de retour à l’emploi
selon le genre, les hommes reprenant plus rapidement dans les 6 mois
qui suivent le diagnostic et les femmes reprenant graduellement dans
les 18 mois. L’étude Vican2 a confirmé que les patients atteints
de cancer étaient plus sujets à la perte d’emploi que la population
générale. Elle a également mis en évidence de fortes inégalités dans
la reprise du travail, les personnes les plus vulnérables vis-à-vis
de la perte d’emploi étant celles appartenant aux catégories socio-professionnelles
dites d’exécution, les plus jeunes et les plus âgées, les personnes
mariées, avec un niveau d’étude inférieur au baccalauréat, avec des
contrats précaires, et celles travaillant dans les petites et moyennes
entreprises. Des interventions visant à améliorer les retours à l’emploi
après cancer ont été mises en place dans de nombreux pays. La métaanalyse
de De Boer et al. a montré que seules les interventions pluridisciplinaires
apportent des résultats probants quant au retour à l’emploi. En revanche,
elles ne sont pas plus efficaces que les « soins ordinaires » sur
la qualité de vie des participants. Les études visant à préciser
le contenu le plus approprié de ces interventions pluridisciplinaires
sont à poursuivre.
BibTeX:
@article{Rollin2016,
  author = {Rollin, Laetitia and De Blasi, Geraldine and Gehanno, Jean-François},
  title = {Cancer et trajectoires professionnelles},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2016},
  volume = {77},
  number = {3},
  pages = {495--495},
  doi = {10.1016/j.admp.2016.03.323}
}

Abstract: Few data from primary care settings are available about asthma prevalence. The aim of this study was to evaluate the prevalence of asthma consultations in general practice, and to describe their characteristics. This was a multicenter, cross-sectional national study, conducted in general practice. Investigators were 54 interns from 27 medical schools. Between December 2011 and April 2012, they collected and entered variables specific to each consultation over a period of 20 days from a structured electronic health record using the International classification of primary care (ICPC-2) together with data about their trainer(s). Data were recorded for 20,613 consultations with 45,582 consultation outcomes described. Asthma represented 348 (1.69%) of consultations. The presence of an asthma code was associated with fewer reasons for the consultation, but with more processes of care. Forty-two percent of other consultation results associated with asthma in the same consultation concerned chronic diseases. Our findings suggest that asthma remains underdiagnosed in general practice in France. In order to address this problem, the development of validated diagnostic tools that can be used in general practice settings, and a better access to spirometry, may be directions to explore in future research.
BibTeX:
@article{Schuers2016d,
  author = {Schuers, M and Chopinaud, P-A and Guihard, H and Mercier, A},
  title = {Prévalence des consultations pour asthme en médecine générale},
  month = {November},
  journal = {Revue des maladies respiratoires},
  year = {2016},
  volume = {33},
  pages = {781--788},
  doi = {10.1016/j.rmr.2016.01.005}
}

Abstract: Introduction. En France, à la fin des années 1990, 97 % des infections
respiratoires basses (IRB) prises en charge en soins primaires étaient
traitées par antibiotiques. Il n’existe pas de données récentes décrivant
cette situation avec précision. Objectif. L’objectif de cette étude
était de décrire la prescription d’antibiotiques dans les infections
respiratoires basses en France. Méthode. Une étude observationnelle
auprès de médecins généralistes a été réalisée. Les participants
ont été sélectionnés au sein d’un groupe de 200 médecins exerçant
dans deux régions du nord de la France. Tous les médecins ont été
contactés par mail, et ont complété un questionnaire prospectif sur
tous les patients présentant une bronchite aiguë ou une exacerbation
de BPCO.Résultats. Trente-six médecins généralistes ont recruté 193
patients. Cent patients ont reçu un traitement antibiotique (52 .
Des antibiotiques ont été prescrits chez 46 % des patients présentant
une bronchite aiguë et chez 89 % des patients présentant une exacerbation
de BPCO. Le genre féminin des patients (OR : 2,49 ; IC95 : 1,47-4,24),
la durée de la toux (OR : 5,70 ; IC95 : 1,70-19,23), une température
supérieure à 38,5°C (OR : 30,39 ; IC95 : 3,99-231,60) et le diagnostic
d’exacerbation de BPCO (OR : 8,69 ; IC95 : 1,72-43,86) étaient associés
à une proportion plus élevée de prescription d’antibiotiques, toutes
classes confondues. Conclusion. Ces résultats montrent une diminution
significative de la prescription d’antibiotiques dans les IRB, mais
des efforts restent nécessaires pour améliorer la prise en charge
de ces patients.
BibTeX:
@article{Schuers2016b,
  author = {Schuers, M. and Rossignol, L and Laouénan, C and Le Bel, J and Pasque, A and Guihard, H and Aubert, JP and Aubin Auger, I.},
  title = {Prise en charge des infections respiratoires basses en soins primaires en {France} : une étude transversale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2016},
  number = {127},
  pages = {196--203}
}

Abstract: Position du problème Une expérimentation a été lancée en 2013 pour
évaluer l’impact de la consultation du dossier pharmaceutique dans
les services d’urgences, de gériatrie et d’anesthésie-réanimation
de 55 établissements hospitaliers. L’objectif de cette étude était
d’évaluer l’intérêt et l’utilisabilité du dossier pharmaceutique
auprès des médecins et pharmaciens utilisateurs. Méthodes Un auto-questionnaire
électronique a été envoyé à tous les pharmaciens, anesthésistes-réanimateurs,
gériatres et urgentistes des 55 établissements expérimentateurs du
dossier pharmaceutique. Ce questionnaire évaluait l’utilisabilité
du dossier pharmaceutique via la traduction française de l’échelle
d’utilisabilité des systèmes, ainsi que l’usage du dossier pharmaceutique,
son intérêt et ses limites perçues dans la pratique clinique et la
satisfaction générale vis-à-vis de l’outil. Les questionnaires ont
été collectés de novembre 2014 à janvier 2015. Résultats Quatre-vingt-seize
questionnaires ont été recueillis. Ils concernaient 47 centres hospitaliers,
soit 86 % des 55 établissements expérimentateurs du dossier pharmaceutique.
Le recoupement des réponses a permis d’identifier 36 établissements
au sein desquels le dossier pharmaceutique était actif. Soixante-treize
questionnaires remplis par des praticiens ayant pu expérimenter le
dossier pharmaceutique ont pu être exploités. Parmi les répondants,
on comptait 57 % de pharmaciens (n = 42) et 43 % de médecins (n
= 31), dont 13 gériatres, 11 urgentistes et 7 anesthésistes-réanimateurs.
Le score moyen d’utilisabilité du dossier pharmaceutique était de
62,5 sur 100. Il ne variait ni selon la profession du répondant,
ni selon son ancienneté d’exercice. Il était positivement corrélé
à la fréquence d’utilisation. Plus de la moitié des répondants déclaraient
utiliser rarement, ou jamais, le dossier pharmaceutique. La durée
de la période d’accès aux données du dossier était considérée comme
insuffisante. L’absence de mention des posologies des médicaments
délivrés, le faible nombre de patients disposant de leur carte d’assurance
maladie et le faible nombre de patients ayant un dossier pharmaceutique
ouvert constituaient les principaux obstacles à une plus grande utilisation
du dossier pharmaceutique. Conclusion Deux ans après le début de
l’expérimentation visant à élargir l’accès au dossier pharmaceutique
à des professionnels médicaux, les premiers éléments d’évaluation
sont encourageants. Il reste nécessaire d’évaluer les conséquences
de l’accès au dossier pharmaceutique pour les médecins.
BibTeX:
@article{Schuers2016a,
  author = {Schuers, M. and Timsit, M. and Gillibert, A. and Fred, A. and Griffon, N. and Bénichou, J. and Darmoni, S.J. and Staccini, P.},
  title = {Intérêt et utilisabilité du dossier pharmaceutique en pratique médicale. {Enquête} auprès de médecins et pharmaciens hospitaliers (étude {MATRIX})},
  month = {September},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2016},
  volume = {64},
  number = {4},
  pages = {229--236},
  url = {http://linkinghub.elsevier.com/retrieve/pii/S0398762016302905},
  doi = {10.1016/j.respe.2016.05.001}
}

BibTeX:
@article{Cabot2016,
  author = {Cabot, Chloé and Lelong, Romain and Grosjean, Julien and Soualmia, Lina F. and Darmoni, Stéfan J.},
  title = {Retrieving Clinical and Omic Data from Electronic Health Records.},
  journal = {Stud Health Technol Inform},
  school = {TIBS, LITIS EA 4108, Rouen, France.},
  year = {2016},
  volume = {221},
  pages = {115},
  url = {https://www.researchgate.net/profile/Lina_Soualmia/publication/280066101_Integrating_and_Retrieving_Clinical_and_Omic_Data_in_Electronic_Health_Records/links/55a7a47408aeceb8cad65695.pdf}
}

BibTeX:
@inproceedings{Cabot2016a,
  author = {Cabot, C and Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {SIBM at CLEF eHealth Evaluation Lab 2016: Extracting Concepts in French Medical Texts with ECMT and CIMIND},
  booktitle = {2016 Conference and Labs of the Evaluation Forum, CLEF},
  year = {2016},
  pages = {47-60},
  url = {http://ceur-ws.org/Vol-1609/16090047.pdf}
}

BibTeX:
@inproceedings{Gomez-Sanchez2016,
  author = {Gómez-Sánchez, AF and González-Cantalejo, M and Kerdelhué, G and Iriarte, P and Isabel-Gómez, R},
  title = {Evaluating the information retrieval quality and methodological accuracy of Systematic Reviews and Meta-analysis on congenital malformations (2004-2014)},
  booktitle = {EAHIL},
  year = {2016}
}

BibTeX:
@inproceedings{Lelong2016,
  author = {Lelong, R and Cabot, C and Soualmia, LF and Darmoni, SJ},
  title = {Semantic Search Engine to Query into Electronic Health Records with a Multiple-Layer Query Language},
  booktitle = {MEDIR workshop},
  year = {2016},
  url = {http://medir2016.imag.fr/data/MEDIR_2016_paper_8.pdf}
}

BibTeX:
@inproceedings{Cabot2016b,
  author = {Cabot, Chlo{\'e} and Soualmia, Lina F and Dahamna, Badisse and Darmoni, St{\'e}fan J},
  title = {ECMT : Indexation multi-terminologique de documents biom{\'e}dicaux},
  booktitle = {1er Forum Franco-Qu{\'e}b{\'e}cois d'Innovation en Sant{\'e}, Polytechnique Montr{\'e}al},
  year = {2016}
}

BibTeX:
@inproceedings{Henry2016,
  author = {Henry, V and Soualmia, LF and Grosjean, J and Desfeux, A and Darmoni, SJ and Gonzalez, B},
  title = {OMIConto : une Ressource Termino-Ontologique pour la Qualification et l’Indexation des Outils d’Analyse en Sciences Omiques},
  booktitle = {Actes du 2ème Atelier Intelligence Artificielle \& Santé@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  pages = {43-50},
  url = {https://ic2016.sciencesconf.org/conference/ic2016/pages/IA_Sante.pdf}
}

Abstract: Objectif L’objectif de notre étude était de montrer la faisabilité
du recueil de données et de montrer des exemples d’utilisation en
décrivant les principaux motifs de recours ainsi que les principales
classes thérapeutiques prescrites. Méthode Nous avons utilisé les
enregistrements médicaux électroniques (consultations de 2012 à 2015)
de 11 médecins généralistes volontaires recrutés parmi les maîtres
de stage du département de médecine générale de l’université de Nice
Sophia-Antipolis. Certains motifs de consultation ont été codés par
les médecins en utilisant la CISP-2. Les motifs restants ont été
codés a posteriori en utilisant l’extracteur de concepts multiterminologique
(ECMT) développé par l’équipe CISMeF. Résultats Sur 174 212 consultations,
103 571 motifs de consultations ont été renseignés (soit 0,59 motifs
par consultation) ; 16 224 (15,7  comportent un code CISP2 renseigné
par le médecin et 6875 motifs ont été codés a posteriori aboutissant
à un total de 80 099 motifs codés (77,3 .
BibTeX:
@article{Lacroix-Hugues2016,
  author = {Lacroix-Hugues, V. and Darmon, D. and Schuers, M. and Touboul, P. and Pradier, C.},
  title = {Création d’une base de données en médecine générale – projet pilote {PRIMEGE} {PACA}},
  month = {December},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2016},
  series = {8e {Colloque} de {Données} de santé en vie réelle, {Paris}, 2 juin 2016},
  volume = {64, Supplement 6},
  pages = {S301},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762016307374},
  doi = {10.1016/j.respe.2016.10.032}
}

BibTeX:
@inproceedings{Mary2016,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Interopérabilité Sémantique dans le Domaine du Diagnostic in vitro},
  booktitle = {Actes du 2ème Atelier Intelligence Artificielle \& Santé@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  note = {In press}
}

BibTeX:
@inproceedings{Mary2016a,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Évaluation de la Qualité des Liens Sémantiques entre Vocabulaires Contrôlés},
  booktitle = {Actes de l'Atelier SoWeDo (des Sources Ouvertes au Web de Données)@Ingénierie des Connaissances},
  address = {Montpellier, France},
  year = {2016},
  url = {https://ic2016.sciencesconf.org/conference/ic2016/pages/SoWeDo_V2.pdf}
}

BibTeX:
@inproceedings{Mary2016d,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Projection des Propriétés d’une Ontologie pour la Classification d’une Ressource Terminologique},
  booktitle = {Actes des 6èmes Journées Francophones sur les Ontologies (JFO)},
  address = {Bordeaux, France},
  year = {2016},
  note = {in press.}
}

BibTeX:
@inproceedings{Siedlecki2016,
  author = {Clémence Siedlecki and Nicolas Griffon and Gaétan Kerdelhué and Julien Grosjean and Benoit Thirion and Marc Jamoulle and Stéfan Darmoni and Matthieu Schuers},
  title = {Thèmes et tendances de recherche en médecine générale : analyse de la littérature extraite de PubMed},
  booktitle = {Congrès du CNGE},
  year = {2016}
}

BibTeX:
@inproceedings{Griffon2016,
  author = {Griffon, N and Rollin, L and Schuers, M and Dhombres, F and Loiseau, S and Douze, L and Marcilly, R and Chabot, O and Delerue, D and Dutoit, D and Dahamna, B and Kerdelhué, G and Grosjean, J and Gehanno, JF and Darmoni, SJ},
  title = {Une base de données bibliographiques en français pour la Littérature Scientifique en Santé : LiSSa},
  booktitle = {JFIM},
  year = {2016}
}

BibTeX:
@inproceedings{Kerdelhue2016,
  author = {Kerdelhué, G and Grosjean, J},
  title = {A tool to design complex bibliographic queries in your own language},
  booktitle = {EAHIL},
  year = {2016}
}

BibTeX:
@inproceedings{Mary2016b,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Interopérabilité Sémantique dans le Domaine du Diagnostic in vitro : Évaluation d’Algorithmes sur LOINC et l’Ontologie SNOMED CT},
  booktitle = {Actes des 27èmes Journées Francophones d'Ingénierie des Connaissances (IC)},
  address = {Montpellier, France},
  year = {2016}
}

BibTeX:
@inproceedings{Mary2016e,
  author = {Mary, M and Soualmia, LF and Gansel, X},
  title = {Usability and Improvement of Existing Alignments: the LOINC-SNOMED CT Case Study},
  booktitle = {20th International Conference on Knowledge Engineering and Knowledge Management, EKAW},
  address = {Bologna, Italy},
  year = {2016}
}

2015


Abstract: Objectives: An important barrier to electronic healthcare information
exchanges (HIE) is the lack of interoperability between information
systems especially on the semantic level. In the scope of the ANR
(Agence Nationale pour la Recherche)/TeRSan (Terminology and Data
Elements Repositories for Healthcare Interoperability) project, we
propose to set and use a semantic interoperability platform, based
on semantic web technologies, in order to facilitate standardized
healthcare information exchanges between heterogeneous Electronic
Healthcare Records (EHRs) in different care settings.

Material and methods: The platform is a standard-based expressive
and scalable semantic interoperability framework. It includes centrally
managed Common Data Elements bounded to international/national reference
terminologies such as ICD10, CCAM, SNOMED CT, ICD-O, LOINC and PathLex.
It offers semantic services such as dynamic mappings between reference
and local terminologies.

Results: A pilot implementation of semantic services was developed
and evaluated within an HIE prototype in telepathology for remote
expert advice. The semantic services developed for transcoding local
terms into reference terms take into account the type of message
and the exchange context defined within standard-based integration
profiles.

Conclusion: The TeRSan platform is an innovative semantic interoperability
framework that (1) provides standard-based semantic services applicable
to any HIE infrastructure and (2) preserves the use of local terminologies
and local models by end users (health professionals' priority).
BibTeX:
@article{Aime2015,
  author = {Aimé, X. and Traore, L. and Chniti, A. and Sadou, E. and Ouagne, D. and Charlet, J. and Jaulent, M. -C. and Darmoni, S. and Griffon, N. and Amardeilh, F. and Bascarane, L. and Lepage, E. and Daniel, C.},
  title = {Semantic interoperability platform for {Healthcare} {Information} {Exchange}},
  month = {March},
  journal = {IRBM},
  year = {2015},
  series = {{ANR} {TECSAN} 2015},
  volume = {36},
  number = {2},
  pages = {62--69},
  url = {http://www.sciencedirect.com/science/article/pii/S195903181500024X},
  doi = {10.1016/j.irbm.2015.01.003}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A comprehensive review of medical informatics
literature was performed to select some of the most interesting papers
of KRM published in 2014.Four articles were selected, two focused
on annotation and information retrieval using an ontology. The two
others focused mainly on ontologies, one dealing with the usage of
a temporal ontology in order to analyze the content of narrative
document, one describing a methodology for building multilingual
ontologies.Semantic models began to show their efficiency, coupled
with annotation tools.
BibTeX:
@article{Charlet2015,
  author = {Charlet, J. and Darmoni, S. J.},
  title = {Knowledge Representation and Management. From Ontology to Annotation. Findings from the Yearbook 2015 Section on Knowledge Representation and Management.},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {Dr Jean Charlet, LIMICS - INSERM U1142, Campus des Cordeliers, 15, rue de l'école de médecine, 75006 Paris, France, Tél. +33 1 44 27 91 09, E-mail: Jean.Charlet@upmc.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {134--136},
  url = {http://dx.doi.org/10.15265/IY-2015-038},
  doi = {10.15265/IY-2015-038}
}

Abstract: Objective: This part II article about the ‘words of prevention’ presents
in a terminological way the content of ten current concepts used
in the prevention domain which are closely linked to quaternary prevention:
(1) overinformation, (2) overdiagnosis, (3) medically unexplained
symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening,
(7) overtreatment, (8) shared decision making, (9) deprescribing,
and (10) disease mongering. Methods: with the support of the laboratory
team of the University of Rouen, France, which is dedicated to medical
terminology and semantic relationships, it was possible to utilize
a graphic user interface (called DBGUI) allowing the construction
of links for each of chosen terms, and making automatic links to
MeSH, if any. Those concepts are analyzed in their environment in
current literature, as well as in their MeSH counterparts, if any,
and related semantic online terminologies. Results and Discussion:
The rules in terminological development aspire to cover the whole
field of a concept and in the meantime, it helps to avoid the noise
due to proxy and not exactly related issues. This refers to exhaustivity
and specificity in information retrieval. Our finds show that referring
to MeSH only in information retrieval in General Practice/Family
medicine can induce much noise and poor adequacy to the subject investigated.
Conclusion: Gathering concepts in specially prepared terminologies
for further development of ontologies is a necessity to enter in
the semantic web area and the era of distributed data.
BibTeX:
@article{Jamoulle2015,
  author = {Jamoulle, Marc and Gavilan, Enrique and Cardoso, Raquel Val and Mariño, Maria Ana and Pizzanelli, Miguel and Grosjean, Julien and Darmoni, Stefan},
  title = {The words of prevention, part {II}: ten terms in the realm of quaternary prevention},
  month = {April},
  journal = {Revista Brasileira de Medicina de Família e Comunidade},
  year = {2015},
  volume = {10},
  number = {35},
  pages = {1-11},
  url = {http://orbi.ulg.ac.be/handle/2268/176757}
}

Abstract: New tools in data management have emerged in the last decade, which
are going to revolutionize electronic health records and health information
systems. Family practitioners are the first, main and continuous
contact with the patient. They are the source and endpoint of the
circle of information, generated by judicious medical documentation
and smart secondary use of medical data. This article is an introduction
to health terminologies, ontologies, semantic data, and linked open
data, all expressions used by computer scientists, preparing themselves
for the next step: semantic web for health care data.
BibTeX:
@article{Jamoulle2015b,
  author = {Jamoulle, Marc and Stichele, Vander and H, Robert and Cardillo, Elena and Roumier, Joseph and Grosjean, Julien and Darmoni, Stefan},
  title = {Semantic {Web} and the {Future} of {Health} {Care} {Data} in {Family} {Practice}},
  month = {December},
  journal = {Merit Research Journal of Medicine and Medical Sciences},
  year = {2015},
  volume = {3},
  number = {12},
  pages = {586-594},
  url = {http://orbi.ulg.ac.be/handle/2268/189292}
}

Abstract: Systemic sclerosis (SSc) has a complex pathogenesis. Although, there
is a growing evidence that environmental factors have an impact on
alterations and modulation of epigenetic determinants, resulting
in SSc onset and progression. A marked correlation has thus been
found between SSc onset and occupational exposure to crystalline
silica and the following organic solvents: white spirit, aromatic
solvents, chlorinated solvents, trichloroethylene, and ketones; the
risk associated with high cumulative exposure to silica and organic
solvents further appears to be strongly increased in SSc. Altogether,
occupational exposure should be systematically checked in all SSc
patients at diagnosis, as (1) exposed patients seem to develop more
severe forms of SSc and (2) the identification of the occupational
agents will allow its interruption, which may lead to potential improvement
of SSc outcome. By contrast, based on current published data, there
is insufficient evidence that exposure to other chemical agents (including
notably pesticides as well as personal care such as silicone and
hair dye), physical agents (ionizing radiation, ultraviolet radiation,
electric and magnetic fields), and biological agents (infections
and diet, foods, and dietary contaminants) is a causative factor
of SSc. Further investigations are still warranted to identify other
environmental factors that may be associated with SSc onset and progression.
BibTeX:
@article{Marie2015a,
  author = {Marie, Isabelle and Gehanno, Jean-Francois},
  title = {Environmental risk factors of systemic sclerosis.},
  month = {September},
  journal = {Seminars in immunopathology},
  year = {2015},
  volume = {37},
  number = {5},
  pages = {463--473},
  doi = {10.1007/s00281-015-0507-3}
}

Abstract: BACKGROUND: Occupational exposure is reported as playing a substantial
causative role in systemic sclerosis (SSc). OBJECTIVE: We sought
to compare the characteristics of SSc in patients with and without
occupational exposure to crystalline silica/solvents. METHODS: In
all, 142 patients with SSc were enrolled in this prospective study.
An expert committee performed blind evaluation of occupational exposure
to crystalline silica/solvents. RESULTS: Patients exposed to crystalline
silica more often exhibited: diffuse cutaneous SSc (P = .02), digital
ulcers (P = .05), interstitial lung disease (P = .0004), myocardial
dysfunction (P = .006), and cancer (P = .06). Patients exposed to
solvents more frequently developed: diffuse cutaneous SSc (P = .001),
digital ulcers (P = .01), interstitial lung disease (P = .02), myocardial
dysfunction (P = .04), and cancer (P = .003); in addition, these
patients were more frequently anti-Scl 70 positive and anticentromere
negative. Under multivariate analysis, significant factors for SSc
associated with exposure to silica/solvents were: male gender (odds
ratio 19.31, 95% confidence interval 15.34-69.86), cancer (odds
ratio 5.97, 95% confidence interval 1.55-23.01), and digital ulcers
(odds ratio 2.42, 95% confidence interval 1.05-5.56). LIMITATIONS:
The cohort originated from a single geographic region. CONCLUSION:
Occupational exposure to crystalline silica/solvents is correlated
with more severe forms of SSc characterized by: diffuse cutaneous
involvement, interstitial lung disease, general microangiopathy (digital
ulcers and myocardial dysfunction), and association with cancer.
Occupational exposure should be systematically checked in all patients
with SSc, as exposed patients seem to develop more severe forms of
SSc.
BibTeX:
@article{Marie2015,
  author = {Marie, Isabelle and Menard, Jean-Francois and Duval-Modeste, Anne-Benedicte and Joly, Pascal and Dominique, Stephane and Bravard, Pierre and Noel, David and Gehanno, Jean-Francois and Bubenheim, Michael and Benichou, Jacques and Levesque, Herve},
  title = {Association of occupational exposure with features of systemic sclerosis.},
  month = {March},
  journal = {Journal of the American Academy of Dermatology},
  year = {2015},
  volume = {72},
  number = {3},
  pages = {456--464},
  doi = {10.1016/j.jaad.2014.11.027}
}

Abstract: Though there are common variations of the internal jugular vein (IJV),
fenestrations are extremely rare. The lateral branch of the accessory
nerve classically goes through the fenestration. We report a case
of an empty fenestration of the IJV that was discovered during clearance
of cervical lymph nodes. Original operative and radiographic images
are shown.
BibTeX:
@article{Pegot2015,
  author = {Pegot, Alexandre and Guichard, Benjamin and Peron, Jean-Marc and Trost, Olivier},
  title = {Empty fenestration of the internal jugular vein: a rare phenomenon.},
  month = {January},
  journal = {The British journal of oral \& maxillofacial surgery},
  year = {2015},
  volume = {53},
  number = {1},
  pages = {78--80},
  doi = {10.1016/j.bjoms.2014.09.005}
}

BibTeX:
@article{Rollin2015,
  author = {Rollin, L and Griffon, N and Darmoni, SJ and Gehanno, JF},
  title = {Influence of author's affiliation and funding sources on the results of cohort studies on occupational cancer},
  month = {March},
  journal = {American Journal of Industrial Medicine},
  year = {2015},
  volume = {59},
  number = {3},
  pages = {221–226},
  doi = {10.1002/ajim.22549}
}

Abstract: To summarize excellent current research in the field of Bioinformatics
and Translational Informatics with application in the health domain
and clinical care.We provide a synopsis of the articles selected
for the IMIA Yearbook 2015, from which we attempt to derive a synthetic
overview of current and future activities in the field. As last year,
a first step of selection was performed by querying MEDLINE with
a list of MeSH descriptors completed by a list of terms adapted to
the section. Each section editor has evaluated separately the set
of 1,594 articles and the evaluation results were merged for retaining
15 articles for peer-review.The selection and evaluation process
of this Yearbook's section on Bioinformatics and Translational Informatics
yielded four excellent articles regarding data management and genome
medicine that are mainly tool-based papers. In the first article,
the authors present PPISURV a tool for uncovering the role of specific
genes in cancer survival outcome. The second article describes the
classifier PredictSNP which combines six performing tools for predicting
disease-related mutations. In the third article, by presenting a
high-coverage map of the human proteome using high resolution mass
spectrometry, the authors highlight the need for using mass spectrometry
to complement genome annotation. The fourth article is also related
to patient survival and decision support. The authors present datamining
methods of large-scale datasets of past transplants. The objective
is to identify chances of survival.The current research activities
still attest the continuous convergence of Bioinformatics and Medical
Informatics, with a focus this year on dedicated tools and methods
to advance clinical care. Indeed, there is a need for powerful tools
for managing and interpreting complex, large-scale genomic and biological
datasets, but also a need for user-friendly tools developed for the
clinicians in their daily practice. All the recent research and development
efforts contribute to the challenge of impacting clinically the obtained
results towards a personalized medicine.
BibTeX:
@article{Soualmia2015b,
  author = {Soualmia, L. F. and Lecroq, T.},
  title = {Bioinformatics Methods and Tools to Advance Clinical Care. Findings from the Yearbook 2015 Section on Bioinformatics and Translational Informatics.},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = { Health, 1, rue de Germont, Cour Leschevin porte 21, 76031 Rouen Cedex, France, Tel : +33 232 885 869, E-mail: Lina.Soualmia@chu-rouen.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {170--173},
  url = {http://dx.doi.org/10.15265/IY-2015-026},
  doi = {10.15265/IY-2015-026}
}

BibTeX:
@article{Toubiana2015,
  author = {Toubiana, L. and Griffon, N.},
  title = {Modelling, Simulation and Social Network Data: What's New for Public Health and Epidemiology Informatics?},
  month = {Aug},
  journal = {Yearb Med Inform},
  school = {, 15, rue de l'École de Médecine, 75006 Paris, France, Tel: +33 1 44 27 91 97, E-mail: Laurent.toubiana@inserm.fr.},
  year = {2015},
  volume = {10},
  number = {1},
  pages = {216--219},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587051/pdf/ymi-10-0216.pdf},
  doi = {10.15265/IY-2015-031}
}

Abstract: In April 2013, the Strategic Advisory Group of Experts (SAGE) on immunization stated that a single dose of yellow fever (YF) vaccine is sufficient in the general population to confer a lifelong protection against YF. When the period of validity of the International Certificate of Vaccination (ICV) will be extended to a lifetime in June 2016, no booster dose will be needed. The objective of this prospective study was to determine the potential impact of the SAGE recommendations on the vaccination activity of our travel clinics. We showed that among 1,037 subjects seen in our three travel clinics for a YF vaccination in 2013, about 32.3% went for a booster dose that is no longer useful according to the SAGE. A drop in vaccination activity has to be expected by travel clinics in the next years, and changes in daily exercise have to be anticipated, as YF vaccination is a large part of the regular work of many healthcare providers specialized in travel medicine.
BibTeX:
@article{Wyplosz2015,
  author = {Wyplosz, Benjamin and Leroy, Jean-Philippe and Derradji, Ouda and Consigny, Paul-Henri},
  title = {No booster dose for yellow fever vaccination: what are the consequences for the activity of vaccination in travel clinics?},
  journal = {Journal of travel medicine},
  year = {2015},
  volume = {22},
  pages = {140--141},
  doi = {10.1111/jtm.12173}
}

Abstract: Intérêts de la spirométrie en soins primairesLa spirométrie est une
exploration de la fonction respiratoire réalisable en cabinet de
médecine générale. Elle permet de diagnostiquer un trouble ventilatoire
obstructif (TVO), de mesurer sa sévérité et de suivre son évolution
avec ou sans traitement. Elle donne également des arguments en faveur
d’un trouble ventilatoire restrictif (TVR) permettant de proposer
des explorations spécialisées complémentaires. Les professionnels
de santé de soins primaires utilisent la spirométrie principalement
pour le diagnostic et le suivi de l’asthme et de la bronchopneumopathie
chronique obstructive (BPCO). La spirométrie fait partie de la démarche
diagnostique face à un patient symptomatique (toux ou expectoration
chroniques, dyspnée, sibilants).Asthme et BPCO : deux maladies prévalentes
En France, 9 % des enfants et 6 % des adultes sont asthmatiques1.
Diagnostiquer l’asthme permet d’instaurer le traitement médicamenteux
recommandé afin d’améliorer les symptômes, la qualité de vie, la
fréquence des exacerbations et la mortalité2.
BibTeX:
@article{Bouchez2015,
  author = {Bouchez, T and Chapron, A and Guihard, H and Thebault, JL and Schuers, M. and Darmon, D},
  title = {La spirométrie en cabinet de médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {120},
  pages = {176--81}
}

BibTeX:
@article{Crampon2015,
  author = {Crampon, F. and Eliezer, M. and Choussy, O. and Hardy, H. and Trost, O.},
  title = {A pathognomonic {CT} of the parotid gland.},
  month = {February},
  journal = {Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale},
  year = {2015},
  volume = {116},
  number = {1},
  pages = {e1--2},
  doi = {10.1016/j.revsto.2014.10.001}
}

Abstract: L’objectif attribué par la loi aux services de santé au travail est
d’éviter toute altération de la santé des travailleurs du fait de
leur travail mais également de contribuer au maintien dans l’emploi
des travailleurs. À cette fin, les services de santé au travail conduisent,
entre autres, des actions de surveillance systématique de la santé,
dans une optique de dépistage pour des pathologies en lien avec le
travail ou pouvant avoir un retentissement sur le travail. Nous laisserons
de côté la surveillance médicale renforcée, qui fait l’objet de recommandations
spécifiques. Dans le cadre d’un suivi de santé non motivé par une
exposition à des facteurs de risques professionnels, la question
posée est celle de l’intérêt d’un examen clinique régulier, assorti
ou non d’examens paracliniques. Si la littérature est limitée dans
le domaine de la santé au travail, elle est abondante dans le champ
de la santé publique et permet d’affirmer que ce type de suivi systématique
n’apporte pas de bénéfice mesurable en termes de limitation de la
mortalité ou de la morbidité, globale, cardiovasculaire ou par cancer
[1] . Il n’est de plus pas dénué d’effets secondaires, auxquels il
faut ajouter le risque d’exclusion propre à la santé au travail.
Il convient toutefois de souligner que l’intérêt de ce type de rendez-vous
de santé régulier n’a pas été évalué en termes de maintien de la
relation, ou de la confiance, entre le patient/salarié et le médecin.
L’intérêt d’un dépistage étant lié à la fréquence de la maladie dans
la population qui bénéficie du dépistage, il peut être plus important
dans certains groupes exposés à des nuisances professionnelles. On
peut ainsi citer deux exemples ayant fait l’objet de recommandations
récentes de la part de la Société française de médecine du travail.
Chez les sujets exposés à des allergènes, il est recommandé de procéder
au dépistage de la rhinite professionnelle en particulier pendant
l’apprentissage ou les deux premières années d’exposition [2] . Chez
les travailleurs postés et/ou de nuit, il est recommandé de dépister
une privation chronique de sommeil et des épisodes de somnolence
ainsi que de mesurer le poids et la tension de façon annuelle [3]
. Il est intéressant de noter que ces dépistages reposent principalement
sur l’interrogatoire, et peuvent donc impliquer l’infirmier de santé
au travail. Le rendez-vous de santé servant de support au dépistage
peut également être l’occasion d’une information sur les risques
professionnels, comme cela a été proposé récemment chez les salariés
exposés à de la manutention manuelle de charges [4] . Enfin, la notion
de dépistage peut également être élargie aux conditions de travail
et aux expositio...
BibTeX:
@article{Gehanno2015,
  author = {Gehanno, J.F. and Larchevesque, J.Y.},
  title = {État des connaissances sur les dépistages en santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2015},
  volume = {76},
  number = {4},
  pages = {407--407},
  doi = {10.1016/j.admp.2015.04.042}
}

Abstract: Contexte. Depuis 2007, 130 chefs de clinique de médecine générale
ont été nommés et 13 d’entre eux sont devenus maîtres de conférences
des universités par la voie du concours. La création de la soussection
53-03 propre à la médecine générale en mars 2015 paraissait une occasion
pertinente de décrire l’activité des chefs de clinique.Objectif.
Décrire les activités de soins, d’enseignement et de recherche des
chefs de clinique de médecine générale en activité en octobre 2014.Méthode.
Enquête descriptive par questionnaire auto-administré en ligne. Les
activités de soins, d’enseignement et de recherche ont été décrites
: organisation, contenu, formation, satisfaction et perspectives.Résultats.
Parmi les 95 chefs de clinique de médecine générale en poste à la
date de l’étude, 75 (79 ont répondu : âge moyen 32 ans ; sex-ratio
F/H 2,4. Ils consacraient respectivement un nombre médian de 5, 2
et 3 demi-journées par semaine aux activités de soins, d’enseignement
et de recherche. L’activité de soins était majoritairement libérale
(73 – dont 39 % en structure pluriprofessionnelle – à raison
de 50 consultations par semaine. Le nombre de patients les ayant
déclarés médecin traitant augmentait significativement au cours du
clinicat. L’activité d’enseignement concernait surtout le troisième
cycle (médiane : 86 heures par an). Un tiers des chefs de clinique
étaient maîtres de stage des universités. L’activité de recherche
augmentait significativement au cours du clinicat. La majorité des
chefs de clinique avaient une formation à la recherche et un projet
en cours (45 % au sein d’une unité labellisée). Les thématiques
de recherche étaient en rapport avec le champ disciplinaire.Conclusion.
Au cours du clinicat, la stabilisation – voire le renforcement –
des activités de soins et de recherche s’accompagne d’un investissement
marqué dans l’activité d’enseignement. Cette dynamique doit se poursuivre,
pour un rôle de plus en plus modélisant de l’enseignant-chercheur
en médecine générale.
BibTeX:
@article{Laporte2015,
  author = {Laporte, C. and Barais, M and Bouchez, T and Darmon, D and Dibao-Dina, C. and Frappé, P. and Saint-Lary, O. and Schuers, M. and Gelly, J.},
  title = {Activité des chefs de clinique en médecine générale},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {122},
  pages = {283--94}
}

BibTeX:
@article{Leroy2015,
  author = {Leroy, Jean-Philippe},
  title = {Vaccin contre la fièvre jaune : une protection à vie ?},
  month = {October},
  journal = {La Revue du praticien},
  year = {2015},
  volume = {65},
  pages = {1015--1017}
}

Abstract: Dans le domaine de la santé au travail, de très nombreuses situations
sont à l’origine de conflits éthiques. À titre d’exemple, les adaptations
ou les maintiens dans l’emploi pour des problèmes de santé font intervenir
non seulement les employeurs et leurs employés mais également les
médecins du travail dont les déterminations d’aptitude médicale au
poste ont des conséquences socioprofessionnelles majeures. Si on
remonte à sa création, depuis 1946, la réglementation française relative
à la santé au travail a fait l’objet de multiples modifications.
À ce titre, en 2012, une nouvelle réforme de la médecine du travail
a été à l’origine d’une réapparition de questionnements de pratiques
chez les personnes impliquées par ces changements. Aussi, par l’intermédiaire
d’un recueil de situations réelles, nous avons voulu apporter un
regard pluridisciplinaire sur les dilemmes éthiques encore plus mis
en lumière par cette évolution réglementaire dans un monde du travail
qui traverse actuellement une période économique tendue.
BibTeX:
@article{Lodde2015,
  author = {Loddé, B. and Gehanno, J.-F. and Jousset, D. and Pougnet, R. and Durand-Moreau, Q. and Dewitte, J.-D.},
  title = {Conflits éthiques en {Santé} au {Travail} : quelques particularités de la réglementation française opposées à des difficultés pratiques de mises en œuvre},
  journal = {Ethique et Sante},
  year = {2015},
  volume = {12},
  number = {2},
  pages = {138--144},
  doi = {10.1016/j.etiqe.2014.12.001}
}

Abstract: Il n’existe pas à l’heure actuelle de réel consensus concernant les
modalités du dépistage du risque de mort subite d’origine cardiovasculaire
chez les sportifs de moins de 35 ans. La question de l’adjonction
systématique d’un électrocardiogramme fait notamment débat. D’un
côté, l’électrocardiogramme vient apporter de la validité à un examen
physique qui en manque cruellement. L’expérience italienne, la plus
connue, montre aussi des résultats spectaculaires. Entre 1979 et
2004, l’incidence des morts subites chez les sportifs a chuté de
près de 90 %. D’un autre côté, l’incidence des morts subites chez
les jeunes sportifs en France est très faible, de l’ordre de 0,5
à 1 cas pour 100 000 personnes par an, soit moins de 50 cas annuels.
De plus, la réalisation systématique d’un ECG, même interprété par
un professionnel expérimenté, expose à un taux significatif de faux
positifs. Cette faible spécificité n’est pas sans conséquences pour
le patient. Enfin, l’implémentation d’un programme de dépistage systématique
du risque de mort subite par électrocardiogramme en France engendrerait
des coûts majeurs, en termes d’équipement, de formation des professionnels
et d’honoraires. À ce jour, il ne semble pas exister suffisamment
de données permettant de justifier l’ajout systématique de l’ECG
à la procédure de dépistage du risque de mort subite chez le jeune
sportif.
BibTeX:
@article{Quibel2015,
  author = {Quibel, T and Valy, G and Schuers, M.},
  title = {Dépistage du risque de mort subite chez le sportif : quelle place pour l’{ECG} ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2015},
  number = {119},
  pages = {77--82}
}

Abstract: Contexte Afin d’aider les patients atteints de cancer à reprendre
le travail, une plateforme multidisciplinaire médico-socio-psychologique
d’aide à la reprise du travail après un cancer a été créée en 2006 en
Haute-Normandie. Objectifs Décrire l’organisation et les retours
de cette plateforme. Méthode Les 3 intervenants ont fait part de
leurs observations. Les caractéristiques des consultants, les conseils
apportés et le devenir des patients ont été analysés via l’étude
des dossiers et un questionnaire complété par le patient. Résultats
Cent cinquante patients, atteints principalement de cancer du sein
(64 , ont consulté pour des problématiques de maintien dans l’emploi
(3/4) ou de recherche d’emploi (1/4). Le taux de reprise, évalué
à partir de questionnaires adressés aux patients en 2011, était de
64 % (IC 95 % = 54–73), en moyenne 7 mois (IC 95 % = 5–9) après
la 1 re  consultation de reprise du travail. Quatre-vingt-treize
pour cent des patients estimaient que la plateforme leur avait été
utile. Cette plateforme permet une transition entre les milieux de
soins et du travail, oriente le patient vers le bon interlocuteur
compte tenu de la situation et apporte des conseils spécifiques adaptés
à la pathologie ainsi qu’un avis spécialisé à des patients n’en bénéficiant
pas habituellement.
BibTeX:
@article{Rollin2015a,
  author = {Rollin, Lætitia and De Blasi, Géraldine and Boucher, Line and Gehanno, Jean-François},
  title = {Intérêts d’une consultation spécialisée d’aide à la reprise du travail après cancer},
  journal = {Bulletin du cancer},
  year = {2015},
  volume = {102},
  number = {2},
  pages = {182--189},
  doi = {10.1016/j.bulcan.2014.06.001}
}

BibTeX:
@inproceedings{Cabot2015a,
  author = {Cabot, Chlo{\'e} and Soualmia, Lina F and Grosjean, Julien and Lelong, Romain and Darmoni, St{\'e}fan J},
  title = {Integrating and Retrieving Clinical and Omic Data in Electronic Health Records},
  booktitle = {7th International Workshop on Knowledge Representation for Health Care (KRH4C) and 8th International Workshop on Process-oriented Information Systems in Healthcare (ProHealth)},
  year = {2015},
  pages = {154-159},
  url = {https://www.researchgate.net/profile/Lina_Soualmia/publication/280066101_Integrating_and_Retrieving_Clinical_and_Omic_Data_in_Electronic_Health_Records/links/55a7a47408aeceb8cad65695.pdf}
}

BibTeX:
@inproceedings{Chebil2015,
  author = {Chebil, W and Soualmia, LF and Omri, MN and Darmoni, SJ},
  title = {Biomedical Concepts Extraction with a Possibilistic Network and a Vector Space Model},
  booktitle = {15th Conference on Artificial Intelligence in MEdicine, AIME'15},
  year = {2015},
  series = {Lecture Notes in Artificial Intelligence},
  volume = {9105},
  pages = {227-231},
  doi = {10.1007/978-3-319-19551-3_29}
}

Abstract: The use of watermarking in the protection of medical relational databases
requires that the introduced distortion does not hinder records interpretation.
In this paper, we present the preliminary results of a watermarked
data quality evaluation protocol developed so as to analyze the perception
the practitioner has of the watermark. These results show that some
attributes are more appropriate for watermarking than others and
also that incoherent or unlikely records resulting from careless
watermarking are easily identified by an expert.
BibTeX:
@inproceedings{Franco-Contreras2015,
  author = {Franco-Contreras, Javier and Coatrieux, Gouenou and Massari, Philippe and Darmoni, Stefan and Cuppens-Boulahia, Nora and Cuppens, Frédéric and Roux, Christian},
  title = {Data quality evaluation in medical database watermarking.},
  booktitle = {MIE 2015},
  journal = {Stud Health Technol Inform},
  school = {Institut Mines-TELECOM, Mines Saint-Étienne, Saint-Étienne, 62362 France.},
  year = {2015},
  volume = {210},
  pages = {276--280}
}

BibTeX:
@inproceedings{Grouin2015a,
  author = {Grouin, C and Griffon, N and Névéol, A},
  title = {Is it possible to recover personal health information from an automatically de-identified corpus of French EHRs?},
  booktitle = {Proc of LOUHI - the Sixth International Workshop on Health Text Mining and Information Analysis},
  address = {Lisbon, Portugal},
  year = {2015}
}

Abstract: Suspected adverse drug reactions (ADR) reported by patients through
social media can be a complementary tool to already existing ADRs
signal detection processes. However, several studies have shown that
the quality of medical information published online varies drastically
whatever the health topic addressed. The aim of this study is to
use an existing rating tool on a set of social network web sites
in order to assess the capabilities of these tools to guide experts
for selecting the most adapted social network web site to mine ADRs.First,
we reviewed and rated 132 Internet forums and social networks according
to three major criteria: the number of visits, the notoriety of the
forum and the number of messages posted in relation with health and
drug therapy. Second, the pharmacist reviewed the topic-oriented
message boards with a small number of drug names to ensure that they
were not off topic. Six experts have been chosen to assess the selected
internet forums using a French scoring tool: Net scoring. Three different
scores and the agreement between experts according to each set of
scores using weighted kappa pooled using mean have been computed.Three
internet forums were chosen at the end of the selection step. Some
criteria get high score (scores 3-4) no matter the website evaluated
like accessibility (45-46) or design (34-36), at the opposite some
criteria always have bad scores like quantitative (40-42) and ethical
aspect (43-44), hyperlinks actualization (30-33). Kappa were positives
but very small which corresponds to a weak agreement between experts.The
personal opinion of the expert seems to have a major impact, undermining
the relevance of the criterion. Our future work is to collect results
given by this evaluation grid and proposes a new scoring tool for
Internet social networks assessment.
BibTeX:
@inproceedings{Katsahian2015,
  author = {Katsahian, Sandrine and {Simond Moreau}, Erica and Leprovost, Damien and Lardon, Jeremy and Bousquet, Cedric and Kerdelhué, Gaétan and Abdellaoui, Redhouane and Texier, Nathalie and Burgun, Anita and Boussadi, Abdelali and Faviez, Carole},
  title = {Evaluation of Internet Social Networks using Net scoring Tool: A Case Study in Adverse Drug Reaction Mining.},
  booktitle = {MIE 2015},
  journal = {Stud Health Technol Inform},
  school = {Kappa Santé, Paris, France.},
  year = {2015},
  volume = {210},
  pages = {526--530}
}

BibTeX:
@inproceedings{Merabti2015,
  author = {Merabti, T and Lelong, R and Darmoni, SJ},
  title = {InfoRoute: the CISMeF Context-specific Search Algorithm},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {544-8}
}

Abstract: Consequences of the computerization of laboratory and radiology information
system (LIS and RIS) are not well documented. The aim of this study
was to evaluate the impact of computerization of LIS and RIS of four
hospitals on performance and quality of care. The study was divided
into three phases. First, the subprocesses and information flows
of LIS and RIS were described. Then, a literature review was performed
in order to identify the indicators used to assess the impact of
computerization. Finally, comparisons were made between 2 hospitals.
Using the initial framework, each partner described its process mapping
concerning LIS and RIS. The review identified a wide panel of indicators.
Only 41 were useful to assess the impact of information systems.
For each two by two comparison, lists of relevant indicators have
been selected from the identified indicators and according to the
process mapping comparison. Two by two comparisons have to be completed.
Eventually, these indicators may be integrated in the quality process
of hospital information systems.
BibTeX:
@inproceedings{Schuers2015a,
  author = {Schuers, M and Joulakian, M and Griffon, N and Pachéco, J and Périgard, C and Lepage, E and Watbled, L and Massari, P and Darmoni, SJ},
  title = {Quality indicators from laboratory and radiology information systems},
  booktitle = {MEDINFO},
  journal = {Studies in Health Technology and Informatics},
  year = {2015},
  volume = {216},
  pages = {212-6},
  note = {PREPS EVAL-SI},
  doi = {10.3233/978-1-61499-564-7-212}
}

BibTeX:
@inproceedings{Soualmia2015a,
  author = {Soualmia, LF and Cabot, C and Dahamna, B and Darmoni, SJ},
  title = {SIBM at CLEF e-Health Evaluation Lab 2015},
  booktitle = {proceedings of CLEF 2015 - Conference and Labs of the Evaluation Forum},
  year = {2015},
  series = {CEUR Workshop Proceedings},
  volume = {1391},
  url = {http://ceur-ws.org/Vol-1391/125-CR.pdf}
}

Abstract: In this paper, a method based on pre-defined patterns, which rewrites
natural language queries into a multi-layer, flexible, scalable and
object-oriented query language, is presented. The method has been
conceived to assist physicians in their search for clinical information
in an Electronic Health Records system. Indeed, the query language
of the system being difficult to handle for physicians, this method
allows querying using natural language vs. using dedicated object-oriented
query language. The information extraction method that has been developed
can be seen as a named entity recognition system based on regular
expressions that tags pieces of the query. The patterns are constructed
recursively from the initial natural language query and from atomic
patterns that correspond to the entities, the relationships and the
constraints of the underlying model representing Electronic Health
Records. Further evaluation is needed, but the preliminary results
obtained by testing a set of natural language queries are very encouraging.
BibTeX:
@inproceedings{Soualmia2015,
  author = {Soualmia, LF and Lelong, R and Dahamna, B and Darmoni, SJ},
  title = {Rewriting Natural Language Queries Using Patterns},
  booktitle = {proceedings of MRMD},
  publisher = {Springer-Verlag},
  year = {2015},
  series = {Lecture Notes in Computer Science},
  volume = {9059},
  pages = {40-53},
  doi = {10.1007/978-3-319-24471-6_4}
}

BibTeX:
@inproceedings{Cabot2015,
  author = {Cabot, C and Soualmia, LF and Darmoni, SJ},
  title = {Intégration de données cliniques et omiques pour la recherche d’information dans le Dossier Patient Informatisé},
  booktitle = {Actes des 26èmes Journées Francophones d’Ingénierie des Connaissances (IC), associées à la Plateforme de l’Association Française pour l’Intelligence Artificielle},
  address = {Rennes, France},
  year = {2015},
  pages = {183-193},
  url = {https://hal.archives-ouvertes.fr/hal-01179292/}
}

BibTeX:
@inproceedings{Grouin2015,
  author = {Grouin, C and Griffon, N and Névéol, A},
  title = {Étude des risques de réidentification des patients à partir d'un corpus désidentifié de comptes-rendus cliniques en français},
  booktitle = {Atelier ETeRNAL Ethique et TRaitemeNt Automatique des Langues},
  address = {Caen, France},
  month = {Juin},
  year = {2015},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/pdf/Giquel2013.pdf}
}

BibTeX:
@inproceedings{Lelong2015a,
  author = {Lelong, R and Cabot, C and Merabti, T and Grosjean, J and Joulakian, M and Griffon, N and Dahamna, B and Massari, P and Darmoni, SJ},
  title = {Information Retrieval in Electronic Health Records Using a Multiple Layer Query Language},
  booktitle = {RITS},
  year = {2015},
  note = {projet RAVEL ANR TecSan}
}

BibTeX:
@inproceedings{Gicquel2015,
  author = {Gicquel, Q and Tvardik, N and Bouvry, C and Kergourlay, I and Bittar, A and Segond, F and Darmoni, SJ and Metzger, MH},
  title = {Annotation methods to develop and evaluate an expert system based on natural langage processing in electronic medical records},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {1067},
  doi = {10.3233/978-1-61499-564-7-1067}
}

BibTeX:
@inproceedings{Henry2015,
  author = {Henry, V and Grosjean, J and Soualmia, LF and Bandrowski, A and Gonzalez, B and Darmoni, SJ and Desfeux, A},
  title = {OMIC-Onto : une ressource pour l'indexation et la recherche d'outils omiques},
  booktitle = {Actes des Journées Ouvertes en Bioinformatique, Informatique et Mathématiques (JOBIM)},
  address = {Clermont-Ferrand, France},
  month = {Juillet},
  year = {2015}
}

Abstract: ICPC is available in the HeTOP cross-lingual terminology portal (URL:
www.hetop.eu) [1] in 19 languages, mostly European (e.g. Spanish,
Portuguese) but also in Japanese or Mandarin. The HeTOP interface
has been also translated in 10 languages, including by Wonca colleagues
(in Turkish, Vietnamese and Romanian). This is very important for
non-English speakers to access a health Web site in his/her native
language. Thanks to a partial manual mapping between ICPC2 and MeSH,
it is now also possible to query PubMed from 20% of ICPC2 codes.
This task is time consuming as in lot of cases, the mapping is 1
to N (one ICPC code generates several MeSH terms; e.g. the ICPC term
"diverticular disease" is mapped to two MeSH terms " diverticulosis,
colonic" and " diverticulitis". HeTOP currently contains 56 health
terminologies and ontologies (only 17 are included in UMLS as most
of them are French terminologies), 1,951,834 concepts, 6,636,000
terms, 8,023,181 relations and 1,340,855 relations. Overall, HeTOP
contains 108 millions of SPARQL triplets. These figures underlines
the possible application of the so called "health big data". Overall,
the number of distinct UMLS concepts with at least one French translation
in UMLS (MeSH, MedDRA, WHOART, ICPC) is 45,405 vs. 317,539 in HeTOP.
1. Grosjean, J; Merabti, T; Griffon, N; Dahamna, B & Darmoni, SJ.
Teaching medicine with a terminology/ontology portal. Stud Health
Technol Inform 2012:180;949-53.
BibTeX:
@inproceedings{Jamoulle2015a,
  author = {Jamoulle, Marc and Pizzanelli, Miguel and Grosjean, Julien and Kerdelhue, Gaetan and Darmoni, Stefan},
  title = {International {Classification} of {Primary} {Care} in a cross-lingual terminology portal},
  month = {March},
  year = {2015},
  note = {Best Poster Award},
  url = {http://orbi.ulg.ac.be/handle/2268/179499}
}

BibTeX:
@inproceedings{Kerdelhue2015,
  author = {Kerdelhué, G and Grosjean, J and Darmoni, SJ \& le consortium du projet BDBfr},
  title = {LiSSa : Une nouvelle base de données de la littérature Scientifique en Santé en langue française},
  booktitle = {7ème journée ITS / 2ème journée innovation},
  address = {Montpellier, France},
  month = {Décembre},
  year = {2015},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2015/12/ITS_poster_2015_lissa.pdf}
}

BibTeX:
@inproceedings{Merabti2015a,
  author = {Merabti, T and Grosjean, J and Rodrigues, JM and Darmoni, SJ},
  title = {Translating ICD-11 into French using lexical-based approach: a preliminary study},
  booktitle = {Studies in Health Technology and Informatics MEDINFO},
  year = {2015},
  volume = {216},
  pages = {1036}
}

BibTeX:
@inproceedings{Schuers2015,
  author = {Schuers, M},
  title = {Interroger Medline en français : c'est possible !},
  booktitle = {CMGF Paris},
  year = {2015}
}

BibTeX:
@inproceedings{Schuers2015b,
  author = {Schuers, M and Griffon, N and Kerdelhué, G and Grosjean, J and Darmoni, SJ},
  title = {Évaluation de l'association entre langue et qualité des requêtes pour la recherche bibliographique: essai randomisé},
  booktitle = {4ème journée de l'IRIB},
  address = {Rouen, France},
  year = {2015}
}

Abstract: Electronic medical records (EHR) are a very important source of information
for secondary use as epidemiological analysis and health services
evaluation. The normalisation of the medical terms extracted from
medical documents is an essential step of the preprocessing. Its
quality partly depends on the medical terminologies available in
the corresponding language. The objective of this presentation is
to highlight the terminology needs for optimizing the data analysis
of medical documents in the context of care pathway evaluation.
BibTeX:
@inproceedings{Tvardik2015,
  author = {Tvardik, N and Bouvry, C and Kergoulay, I and Darmoni, SJ and Metzger, M},
  title = {The terminology needs for evaluation of care pathways},
  booktitle = {WHO - family of international classifications network annual meeting 2015},
  month = {October},
  year = {2015}
}

Abstract: Studies on the impact of a Health Information Technology seldom consider
socio-technical characteristics of the work system in which the technology
is implemented. Yet those dimensions may act as hidden variables
that could explain the inconsistency of impact studies' results in
terms of performance, quality and satisfaction. This paper reports
on the identification of those variables in the discharge letter
(DL) process. Human Factors experts performed an analysis of the
work system of the DL process in 17 medical units. The DL process
is composed of three sub-processes running with work system differing
according to the distribution of tasks, the technology implemented
and the work organization. Hidden variables identified are: verification
by the physician, technology's integration, number of editing cycles,
physicians' preferences etc. Those variables can be collected automatically
or by questionnaire. Statistical analyses will have to be performed
to know which variable explain impact indicators.
BibTeX:
@article{Watbled2015,
  author = {Watbled, Ludivine and Beuscart-Zephir, Marie-Catherine and Guerlinger, Sandra and Douze, Laura and Lepage, Eric and Darmoni, Stéfan J. and Marcilly, Romaric},
  title = {Work System Characteristics Impacting the Performance and Quality of the Discharge Letter Process.},
  journal = {Stud Health Technol Inform},
  school = {INSERM CIC-IT 1403, Lille; Univ Lille Nord de France ; CHU Lille ; UDSL EA 2694 ; F-59000 Lille, France.},
  year = {2015},
  volume = {218},
  pages = {145--150},
  note = {PREPS EVAL-SI},
  doi = {10.3233/978-1-61499-574-6-145}
}

2014


Abstract: This qualitative pilot exploratory study focuses on support groups
for vocational rehabilitation after cancer implemented in a French
and innovative multidisciplinary department of "Return to Work after
a Cancer." Sixty-three patients were invited to participate to constitute
two support groups of 20 participants. Questionnaires are sent to
assess their benefit according to the participants' point of view.
For 58% of participants, support groups helped the return to work,
and for 70% it provided personal, family, and relational support.
Support groups are a relevant response to expectations and specific
issues of patients experiencing return to work after cancer.
BibTeX:
@article{DeBlasi2014,
  author = {De Blasi, G. and Bouteyre, E. and Bretteville, J. and Boucher, L. and Rollin, L.},
  title = {Multidisciplinary department of "{Return} to {Work} {After} a {Cancer}": a {French} experience of support groups for vocational rehabilitation.},
  journal = {Journal of psychosocial oncology},
  year = {2014},
  volume = {32},
  number = {1},
  pages = {74--93},
  doi = {10.1080/07347332.2013.855961}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A comprehensive review of medical informatics
literature was performed to select some of the most interesting papers
of KRM and natural language processing (NLP) published in 2013.Four
articles were selected, one focuses on Electronic Health Record (EHR)
interoperability for clinical pathway personalization based on structured
data. The other three focus on NLP (corpus creation, de-identification,
and co-reference resolution) and highlight the increase in NLP tools
performances.NLP tools are close to being seriously concurrent to
humans in some annotation tasks. Their use could increase drastically
the amount of data usable for meaningful use of EHR.
BibTeX:
@article{Griffon2014c,
  author = {Griffon, N. and Charlet, J. and Darmoni, S. J.},
  title = {Managing free text for secondary use of health data.},
  journal = {Yearb Med Inform},
  year = {2014},
  volume = {9},
  number = {1},
  pages = {167--169},
  url = {http://dx.doi.org/10.15265/IY-2014-0037},
  doi = {10.15265/IY-2014-0037}
}

Abstract: BACKGROUND AND OBJECTIVE: Doc'CISMeF (DC) is a semantic search engine
used to find resources in CISMeF-BP, a quality controlled health
gateway, which gathers guidelines available on the internet in French.
Visualization of Concepts in Medicine (VCM) is an iconic language
that may ease information retrieval tasks. This study aimed to describe
the creation and evaluation of an interface integrating VCM in DC
in order to make this search engine much easier to use.

METHODS: Focus groups were organized to suggest ways to enhance information
retrieval tasks using VCM in DC. A VCM interface was created and
improved using the ergonomic evaluation approach. 20 physicians were
recruited to compare the VCM interface with the non-VCM one. Each
evaluator answered two different clinical scenarios in each interface.
The ability and time taken to select a relevant resource were recorded
and compared. A usability analysis was performed using the System
Usability Scale (SUS).

RESULTS: The VCM interface contains a filter based on icons, and icons
describing each resource according to focus group recommendations.
Some ergonomic issues were resolved before evaluation. Use of VCM
significantly increased the success of information retrieval tasks
(OR=11; 95% CI 1.4 to 507). Nonetheless, it took significantly more
time to find a relevant resource with VCM interface (101 vs 65 s;
p=0.02). SUS revealed 'good' usability with an average score of 74/100.

CONCLUSIONS: VCM was successfully implemented in DC as an option.
It increased the success rate of information retrieval tasks, despite
requiring slightly more time, and was well accepted by end-users.
BibTeX:
@article{Griffon2014a,
  author = {Griffon, N and Kerdelhué, G and Hamek, S and Hassler, S and Boog, C and Lamy, JB and Duclos, C and Venot, A and Darmoni, SJ},
  title = {Design and usability study of an iconic user interface to ease information retrieval of medical guidelines},
  month = {March},
  journal = {Journal of the American Medical Informatics Association},
  year = {2014},
  volume = {21},
  number = {e2},
  pages = {e270-277},
  doi = {10.1136/amiajnl-2012-001548}
}

BibTeX:
@article{Griffon2014,
  author = {Griffon, N and Kerdelhué, G and Soualmia, LF and Merabti, T and Grosjean, J and Lamy, JB and Venot, A and Duclos, C and Darmoni, SJ},
  title = {Evaluating alignment quality between iconic language and reference terminologies using similarity metrics},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2014},
  volume = {14},
  pages = {17},
  doi = {10.1186/1472-6947-14-17}
}

BibTeX:
@article{Griffon2014d,
  author = {Griffon, N and Schuers, M and Soualmia, LF and Grosjean, J and Kerdelhué, G and Kergoulay, I and Dahamna, B and Darmoni, SJ},
  title = {A Search Engine to Access PubMed Monolingual Subsets: Proof of Concept - Evaluation in French},
  month = {December},
  journal = {J Med Internet Res},
  year = {2014},
  volume = {16},
  number = {12},
  pages = {e271},
  doi = {doi:10.2196/jmir.3836}
}

Abstract: Anatomical variations of the stylohyoid apparatus are frequent. Two
types can occur: an elongation of the stylohyoid ligament, from a
long styloid process to a complete ossified structure connecting
the skull base to the lesser horn of the hyoid bone, or the existence
of supernumerary bones in the stylohyoid fibrous matrix, which sometimes
resembles phalanges. These variations are in the majority of cases
bilateral and symmetrical. The authors report the case of a 43-year-old
male patient who presented with an unusual unilateral complete ossification
of the stylohyoid apparatus, associated with vertebral and laryngeal
calcifications. Original latest generation CT scan and three-dimensional
MRI imagery are provided to illustrate this rare case.
BibTeX:
@article{Hardy2014,
  author = {Hardy, Hubert and Guichard, Benjamin and Eliezer, Mickael and Choussy, Olivier and Peron, Jean-Marc and Trost, Olivier},
  title = {Unilateral complete articulated ossification of the stylohyoid apparatus: case report and review of the literature.},
  month = {November},
  journal = {Surgical and radiologic anatomy : SRA},
  year = {2014},
  volume = {36},
  number = {9},
  pages = {941--945},
  doi = {10.1007/s00276-014-1328-0}
}

BibTeX:
@article{Lamy2014a,
  author = {Lamy, J. -B and Séroussi, B. and Griffon, N. and Kerdelhué, G. and Jaulent, M. -C and Bouaud, J.},
  title = {Toward a Formalization of the Process to Select {IMIA} Yearbook Best Papers},
  journal = {Methods of Information in Medicine},
  year = {2014},
  volume = {54},
  number = {2},
  pages = {135-144},
  url = {http://www.schattauer.de/en/magazine/subject-areas/journals-a-z/methods/contents/preprint-online/november-14-2014/issue/special/manuscript/23692/show.html},
  doi = {10.3414/ME14-01-0031}
}

BibTeX:
@inproceedings{Lecroq2014,
  author = {Lecroq, T. and Soualmia, L. F.},
  title = {Managing Large-Scale Genomic Datasets and Translation into Clinical Practice:},
  booktitle = {IMIA Yearbook},
  year = {2014},
  volume = {9},
  number = {1},
  pages = {212--214},
  url = {http://www.schattauer.de/index.php?id=1214&doi=10.15265/IY-2014-0039},
  doi = {10.15265/IY-2014-0039}
}

Abstract: Systemic sclerosis (SSc) has complex pathogenesis and likely multifactorial
causes. Environmental exposures have been suggested to play a role
in SSc pathogenesis, including occupational exposure to pollutants
and chemicals as well as use of drugs leading to modulation of immune
response. Thus, this case-control study aimed to assess: the relationship
between SSc and occupational exposure; and the risk of SSc related
to occupational exposure in male and female patients.From 2005 to
2008, 100 patients with a definite diagnosis of SSc were included
in the study; 3 age, gender, and smoking habits matched controls
were selected for each patient. A committee of experts evaluated
blindly occupational exposure to crystalline silica, white spirit,
organic solvents, ketones, welding fumes, epoxy resins, and pesticides;
an occupational exposure score was calculated for all subjects. Our
findings were compared with previous data in the literature.Increased
ORs for SSc were found for: crystalline silica (p<0.0001), white
spirit (p<0.0001), aromatic solvents (p=0.0002), chlorinated solvents
(p=0.014), trichlorethylene (p=0.044), ketones (p=0.002) and welding
fumes (p=0.021). Elevated risk associated with high final cumulative
score in SSc was observed for: crystalline silica, white spirit,
chlorinated solvents, trichlorethylene, aromatic solvents, any type
of solvents, ketones and welding fumes. A marked association between
SSc and occupational exposure was further found for: 1) crystalline
silica, chlorinated solvents, trichloroethylene, white spirit, ketones
and welding fumes in male patients; and 2) white spirit, aromatic
solvents, any type of solvent and ketones in female patients. Finally,
we did not find an association between SSc and: 1) the use of drugs
that have been speculated to play a role in SSc onset (anorexigens,
pentazocine, bromocriptine, l-tryptophan); 2) implants - that are
prosthesis, silicone implants, and contact lenses; and 3) dyeing
hair. In the literature, SSc has been associated with occupational
exposure to silica and solvents, while the association between SSc
and specific organic solvents and welding fumes has been anecdotally
reported.The following occupational factors have an impact in the
development of SSc: crystalline silica, white spirit, aromatic solvents,
chlorinated solvents, trichlorethylene, ketones and welding fumes.
The risk of SSc appears to be markedly associated with high cumulative
exposure. Finally, the association between SSc and occupational exposure
may be variable according to gender.
BibTeX:
@article{Marie2014,
  author = {Marie, I. and Gehanno, J-F. and Bubenheim, M. and Duval-Modeste, A-B. and Joly, P. and Dominique, S. and Bravard, P. and Noël, D. and Cailleux, A-F. and Weber, J. and Lagoutte, P. and Benichou, J. and Levesque, H.},
  title = {Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature.},
  month = {Feb},
  journal = {Autoimmun Rev},
  school = {Department of Internal Medicine, CHU Rouen, Rouen, France; INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France. Electronic address: isabelle.marie@chu-rouen.fr.},
  year = {2014},
  volume = {13},
  number = {2},
  pages = {151--156},
  url = {http://dx.doi.org/10.1016/j.autrev.2013.10.002},
  doi = {10.1016/j.autrev.2013.10.002}
}

Abstract: BACKGROUND: The frequency of antidepressant (ADs) prescription is
high, with general practitioners (GPs) responsible for about 80%
of the prescriptions. Some studies considered prescriptions meet
DSM criteria, while others stress inadequate use. The importance
of biological and psychosocial determinants of GP prescription behaviour
remains little explored. We aimed to describe the importance of these
biological and psychosocial determinants and their weight in the
daily practice of GPs'. METHODS: During a week chosen at random,
28 GPs collected the AD prescriptions made within the previous six
months, regardless of the reason for the patient contact. Bio psychosocial
and AD treatment characteristics were recorded for all patients.
In a random sample of 50 patients, patient characteristics were assessed
via a structured face-to-face interview with the GP. RESULTS: The
frequency of AD prescription was 8.90% [3.94 -17.02]. The GPs initiated
65.6% [60.1-70.8] of the prescriptions. The rate of AD prescription
for non-psychiatric conditions was 18%. Patients had from 1 to 9
conditions, showing a high level of multi-morbidity. There was a
strong influence of past medical history and contextual problems,
such as work related problems. CONCLUSION: AD prescription is related
to complex contextual situations and multi-morbid patients. GPs use
a bio psycho social approach, rather than a purely biological assessment.
Awareness of these influences could improve prescription by GPs.
BibTeX:
@article{Mercier2014,
  author = {Mercier, Alain and Auger-Aubin, Isabelle and Lebeau, Jean-Pierre and Schuers, Matthieu and Boulet, Pascal and Van Royen, Paul and Peremans, Lieve},
  title = {Why do general practitioners prescribe antidepressants to their patients? {A} pilot study.},
  journal = {BioPsychoSocial medicine},
  year = {2014},
  volume = {8},
  pages = {17},
  doi = {10.1186/1751-0759-8-17}
}

BibTeX:
@article{Morel2014,
  author = {Morel, F. and Peron, J.-M. and Trost, O.},
  title = {A plea for the systematic preservation of the deltopectoralis ({Bakamjian}) flap in pectoralis major flap harvesting.},
  month = {September},
  journal = {International journal of oral and maxillofacial surgery},
  year = {2014},
  volume = {43},
  number = {9},
  pages = {1169},
  doi = {10.1016/j.ijom.2014.05.012}
}

BibTeX:
@article{Trost2014,
  author = {Trost, Olivier and Peron, Jean-Marc},
  title = {Regarding unilateral nasomaxillary buttress fractures.},
  month = {November},
  journal = {Journal of plastic, reconstructive \& aesthetic surgery : JPRAS},
  year = {2014},
  volume = {67},
  number = {11},
  pages = {e278--279},
  doi = {10.1016/j.bjps.2014.07.012}
}

Abstract: RésuméObjectif Medline/PubMed est la base documentaire la plus
utilisée dans le domaine de la santé. L’objectif de ce travail était
de proposer une nouvelle méthode générique pour limiter une requête
quelconque effectuée en utilisant PubMed en utilisant le facteur
d’impact « relatif », en se limitant aux catégories A et B du score
SIGAPS, c’est-à-dire, aux « meilleurs articles » au sens du facteur
d’impact. Matériel et méthodes Nous avons utilisé le corpus complet
de PubMed comme référence, puis dix pathologies fréquentes en termes
d’indexation dans PubMed, et les citations de quatre prix Nobel.
Le facteur d’impact relatif (FIR) est calculé par discipline médicale
défini dans le Journal Citation Reports. Les deux requêtes incluant
les journaux de catégorie A (ou A ou B) ont pu être ajoutées à une
requête quelconque de PubMed, ce qui était un élément central en
termes de faisabilité. Résultats Le filtre par la catégorie A de
SIGAPS est plus large que celui des Core Clinical Journals (CCJ)
en sélectionnant 15,6 % du corpus de PubMed versus 8,6 % pour
le CCJ. Le temps de réponse sur l’ensemble du corpus de PubMed
est inférieur à deux secondes. Dans cinq pathologies sur dix, le
filtre FIR est plus efficace que le filtre CCJ. Pour les quatre
prix Nobel, le filtre FIR est beaucoup plus efficace que le filtre
FIR. Conclusion L’étude de faisabilité d’utiliser le facteur d’impact
relatif comme filtre d’une requête quelconque de Medline/PubMed
est positive. AbstractBackground Medline/PubMed is the most frequently
used medical bibliographic research database. The aim of this study
was to propose a new generic method to limit any Medline/PubMed
query based on the relative impact factor and the A &amp; B categories
of the SIGAPS score. Material and methods The entire PubMed corpus
was used for the feasibility study, then ten frequent diseases in
terms of PubMed indexing and the citations of four Nobel prize
winners. The relative impact factor (RIF) was calculated by medical
specialty defined in Journal Citation Reports. The two queries, which
included all the journals in category A (or A OR B), were added
to any Medline/PubMed query as a central point of the feasibility
study. Results Limitation using the SIGAPS category A was larger
than the when using the Core Clinical Journals (CCJ): 15.65% of
PubMed corpus vs 8.64% for CCJ. The response time of this limit
applied to the entire PubMed corpus was less than two seconds.
For five diseases out of ten, limiting the citations with the RIF
was more effective than with the CCJ. For the four Nobel prize
winners, limiting the citations with the RIF was more effective
than the CCJ. Conclusion The feasibility study to apply a new filter
based on the relative impact factor on any Medline/PubMed query
was positive.
BibTeX:
@article{Avillach2014,
  author = {Avillach, P. and Kerdelhué, G. and Devos, P. and Maisonneuve, H. and Darmoni, S. J.},
  title = {Limiter une requête Medline/{PubMed} aux articles publiés dans les revues les plus citées de chaque discipline},
  journal = {Revue d'Épidémiologie et de Santé Publique},
  year = {2014},
  volume = {62},
  number = {6},
  pages = {361-365},
  url = {http://www.sciencedirect.com/science/article/pii/S0398762014007081},
  doi = {10.1016/j.respe.2014.09.008}
}

BibTeX:
@article{Chauvet2014,
  author = {Chauvet, C. and Jordan, P. and Bijaoui, A. and Delepine, A. and Fontaine, B. and Gehanno, J.F. and Hasni Pichard, H. and Haberer, M. and Bousquet, P.J. and Bessette, D.},
  title = {Diffusion numérique de l’information sur la prévention des cancers professionnels : exemple de l’élaboration d’un bulletin de veille (cancers pro actu) et d’une base de ressources (cancers pro doc) (institut national du cancer)},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2014},
  volume = {75},
  number = {3},
  pages = {S38--S38},
  doi = {10.1016/j.admp.2014.03.123}
}

Abstract: Nous proposons dans cet article une nouvelle approche d’indexation
de documents biomédicaux basée sur les réseaux possibilistes permettant
de les apparier partiellement aux termes du thésaurus MeSH (Medical
Subject Headings). La principale contribution de notre approche est
le traitement de l’imprécision et de l’incertitude liée à la tâche
d’indexation à travers l’utilisation de la théorie des possibilités.
En effet, nous proposons d’améliorer l’estimation de la pertinence
d’un document étant donné un concept en utilisant deux mesures :
la possibilité et la nécessité. La possibilité estime le degré de
rejet d’un document non pertinent étant donné un concept. La nécessité
de la pertinence d’un document évalue dans quelle mesure un document
est pertinent pour le concept. De plus, notre approche permet de
réduire les limites de l’appariement partiel qui génère de l’information
inutile, bien que ce type d’appariement permette de trouver dans
le document d’autres variantes du vocabulaire contrôlé. Pour ce faire,
nous proposons de filtrer l’index en utilisant les connaissances
fournies par l’UMLS (Unified Medical Langage System). Filtrer l’index
permet de ne garder que les concepts pertinents parmi ceux ayant
un sous-ensemble de leurs mots dans le document. Les expérimentations
réalisées sur les deux corpus OSHUMED et CISMeF ont montré des résultats
encourageants.
BibTeX:
@article{Chebil2014a,
  author = {Chebil, W and Soualmia, LF and Omri, M and Darmoni, SJ},
  title = {Extraction possibiliste de concepts MeSH à partir de documents biomédicaux},
  journal = {Revue d’Intelligence Artificielle},
  year = {2014},
  volume = {28},
  number = {6},
  pages = {729-752},
  url = {http://ria.revuesonline.com/article.jsp?articleId=20003},
  doi = {10.3166/ria.28.729-752}
}

BibTeX:
@article{Darmoni2014,
  author = {Darmoni, Stefan and Griffon, Nicolas and Massari, Philippe},
  title = {Les systèmes d'aide à la décision médicale},
  month = {November},
  journal = {Annales des Mines - Réalités industrielles},
  year = {2014},
  volume = {2014},
  number = {4},
  pages = {47--50},
  url = {http://www.cairn.info/article.php?ID_ARTICLE=RINDU_144_0047},
  doi = {10.3917/rindu.144.0047}
}

Abstract: Buts de l’étude Le lambeau antébrachial radial composite est une option
thérapeutique pour les grandes pertes de substances traumatiques
ou cancérologiques de la face. Or ce lambeau a souvent été critiqué
pour sa réserve osseuse jugée inadéquate et insuffisante pour reconstruire
des pertes de substances osseuses, ou pour la réhabilitation prothétique
implanto-portée. En outre, une morbidité élevée du site donneur est
souvent déplorée. Le but de ce travail anatomoradiologique était
d’étudier la vascularisation du lambeau antébrachial radial composite,
et en particulier de sa baguette osseuse. Matériel et méthodes Une
étude anatomoradiologique a été réalisée sur sept avant-bras prélevés
sur des cadavres frais. Après lavage des vaisseaux par injection
intra-artérielle d’un mélange d’eau et d’acétate de potassium, une
préparation par injection intra-artérielle d’un mélange d’oxyde de
plomb rouge et de gélatine était pratiquée. Après recongélation,
une étude tomodensitométrique des pièces anatomiques ainsi préparées
était réalisée. Dans un second temps, les lambeaux antébrachiaux
composites étaient prélevés, puis analysés par examen microscannographique
(NanoSPECT-CT Bioscan ® , voxel 220 microns). Les branches collatérales
cutanées et osseuses issues de l’artère radiale étaient comptées
et localisées en trois tiers (supérieur, moyen et inférieur). Résultats
Une artère nourricière diaphysaire principale radiale était mise
en évidence dans les sept dissections : le foramen nourricier se
situait à la face antéromédiale du radius, entre 45 et 65 % de sa
longueur. Un système vasculaire périosté dense était mis en évidence,
alimenté par une à quatre branches musculopériostées et une à six
artères fascio-périostées. L’étude des lambeaux a au total mis en
évidence en moyenne cinq branches radiales à destinée osseuse et
12 branches perforantes pour la palette cutanée. Conclusion Les résultats
de cette étude préclinique suggéraient qu’il était possible de prélever
avec une grande sécurité vasculaire une baguette osseuse radiale
allant jusqu’à 16 cm, sans tenir compte de la morbidité du site donneur
qui reste une limite majeure de ce lambeau. L’approche anatomoradiologique
(tomodensitométrie conventionnelle et microscanner) permettait une
étude fine de la microvascularisation tissulaire, aisément applicable
aux lambeaux, et ouvrant un champ de recherches original dans le
domaine de la chirurgie réparatrice.
BibTeX:
@article{DeTaddeo2014,
  author = {De Taddéo, A. and Collin, B. and Hardy, H. and Guichard, B. and Trouilloud, P. and Trost, O.},
  title = {Peut-on prélever une grande baguette osseuse radiale dans le lambeau antébrachial radial composite ? Étude radio-anatomique et microscannographique originale},
  journal = {Annales de chirurgie plastique et esthétique},
  year = {2014},
  volume = {59},
  number = {3},
  pages = {170--176},
  doi = {10.1016/j.anplas.2013.12.005}
}

Abstract: L’objectif attribué par la loi aux services de santé au travail est
d’éviter toute altération de la santé des travailleurs du fait de
leur travail mais également de contribuer au maintien dans l’emploi
des travailleurs. À cette fin, les services de santé au travail conduisent,
entre autres, des actions de surveillance systématique de la santé,
dans une optique de dépistage pour des pathologies en lien avec le
travail ou pouvant avoir un retentissement sur le travail. Nous laisserons
de coté la surveillance médicale renforcée, qui fait l’objet de recommandations
spécifiques. Dans le cadre d’un suivi de santé non motivé par une
exposition à des facteurs de risques professionnels, la question
posée est celle de l’intérêt d’un examen clinique régulier, assorti
ou non d’examens para-cliniques. Si la littérature est limitée dans
le domaine de la santé au travail, elle est abondante dans le champ
de la santé publique et permet d’affirmer que ce type de suivi systématique
n’apporte pas de bénéfice mesurable en terme de limitation de la
mortalité ou de la morbidité, globale, cardiovasculaire ou par cancer
[1] . Il n’est de plus pas dénué d’effets secondaires, auxquels il
faut ajouter le risque d’exclusion propre à la santé au travail.
Il convient toutefois souligner que l’intérêt de ce type de rendez-vous
de santé régulier n’a pas été évalué en terme de maintien de la relation
ou de la confiance, entre le patient/salarié et le médecin. L’intérêt
d’un dépistage étant lié à la fréquence de la maladie dans la population
qui bénéficie du dépistage, il peut être plus important dans certains
groupes exposés à des nuisances professionnelles. On peut ainsi citer
deux exemples ayant fait l’objet de recommandations récentes de la
part de la Société française de médecine du travail. Chez les sujets
exposés à des allergènes, il est recommandé de procéder au dépistage
de la rhinite professionnelle en particulier pendant l’apprentissage
ou les deux premières années d’exposition [2] Chez les travailleurs
postés et/ou de nuit, il est recommandé de dépister une privation
chronique de sommeil et des épisodes de somnolence ainsi que de mesurer
le poids et la tension de façon annuelle [3] Il est intéressant de
noter que ces dépistages reposent principalement sur l’interrogatoire,
et peuvent donc impliquer l’infirmier de santé au travail. Le rendez
vous de santé servant de support au dépistage peut également être
l’occasion d’une information sur les risques professionnels, comme
cela a été proposé récemment chez les salariés exposés à de la manutention
manuelle de charges [4] Enfin, la notion de dépistage peut également
être élargie aux conditions de travail et aux expositions professionnelles.
Cela peut être r...
BibTeX:
@article{Gehanno2014a,
  author = {Gehanno, J.-F. and Teissier, P. and Soulat, J.-M.},
  title = {État des connaissances sur les dépistages en santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2014},
  volume = {75},
  number = {5},
  pages = {513--514},
  doi = {10.1016/j.admp.2014.07.010}
}

Abstract: Introduction et but de l’étude Le travail posté et particulièrement
le travail de nuit engendre des perturbations au niveau des rythmes
biologiques des salariés exposés pouvant être à l’origine de troubles
du sommeil, de troubles digestifs et de troubles nutritionnels, notamment
avec l’apparition d’un surpoids. L’objectif de cette étude était
double : Evaluer la prévalence des troubles nutritionnels au sein
du personnel de nuit du CHU de Rouen (notamment la surcharge pondérale
et les TCA) et repérer les facteurs associés à la présence d’un TCA
chez les travailleurs de nuit afin de mettre en place une prise en
charge spécifique et adaptée au sein du CHU de Rouen. Matériel et
méthodes Un questionnaire anonyme a été distribué à l’ensemble des
agents travaillant de nuit au sein du CHU de Rouen. Plusieurs critères
ont été pris en compte : des critères socio-démographiques (age,
sexe, fonction) des critères nutritionnels (pratique d’une activité
physique, indice de masse corporelle (IMC), existence de grignotage,
d’hyperphagie, antécédents de régime, prise de poids depuis le début
du travail de nuit, et dépistage des TCA (questionnaire SCOFF)),
des critères concernant le statut tabagique et le sommeil (Echelle
EPWORTH). Résultats et Analyse statistique Au total, 325 agents de
nuit ont répondu au questionnaire soit un taux de réponse de 47 %.
Plus de 9 agents sur 10 (91,5 étaient de sexe féminin et près
de la moitié des agents était des infirmières (49 . Nos résultats
retrouvent une prévalence de la surcharge pondérale de 33,3 % (n
= 115) et une prévalence des TCA (SCOFF positif) de 15,5 % (n =
54). Un agent sur cinq (20,6 n = 72) présentait un score d’EPWORTH
évoca-teur de syndrome des apnées du sommeil. Après analyse par régression
logistique multivariée, les facteurs associées significativement
à un risque de TCA étaient d’avoir un score d’EPWORTH élevé (ORa
= 2,13), avoir eu recours à des régimes amaigrissants (ORa = 2,51),
ne pas pratiquer d’activité physique (OR a = 3,61), et avoir pris
du poids depuis le début du travail de nuit (ORa = 1,25). Prés des
trois-quarts des agents ayant un problème de poids ou un risque de
TCA ont exprimé un intérêt pour la mise en place d’une aide diététique.
Conclusion Ce travail retrouve une prévalence du surpoids comparable
aux données de la littérature. La prévalence des personnes à risque
de TCA a été étudié pour la première fois et s’élève à plus de 15
%. Ce risque est particulièrement augmenté en cas de sédentarité,
de prise de poids depuis le travail de nuit, d’antécédents de régime
et de risque de syndrome des apnées du sommeil. Sur les bases de
ce travail, la mise en place d’une consultation diététique spécialisée
pour les agents de nuit paraît opportune et est en cours d’expérimentation.
BibTeX:
@article{Grigioni2014,
  author = {Grigioni, S. and Pascal, E. and Horlaville, M. and Dechelotte, P. and Gehanno, J.F. and Folope, V.},
  title = {P043: {Prévalence} de la surcharge pondérale et des troubles du comportement alimentaire ({TCA}) chez les soignants travaillant de nuit : Étude chez 325 agents du {CHU} de {Rouen}},
  journal = {Nutrition clinique et métabolisme},
  year = {2014},
  volume = {28},
  pages = {S90--S90},
  doi = {10.1016/S0985-0562(14)70686-7}
}

Abstract: Contexte. La filière universitaire de médecine générale (FUMG) est
née en 2004 avec la création du diplôme d’études spécialisées (DES)
de médecine générale (MG). Les premiers chefs de clinique des universités
(CCU) ont été nommés en 2007. Cette étude a eu pour objectif de décrire
leur statut, leur devenir et leurs perspectives de carrière.Méthode.
Suivi longitudinal de la cohorte des CCU, complété par un questionnaire
envoyé en novembre 2013.Résultats. Sur les 126 CCU de MG nommés depuis
2007, 80 étaient en poste lors de l’étude (chiffre en stagnation
depuis 2010). Quarante-six avaient fini leur clinicat : 4 (9
avaient été nommés maîtres de conférences des universités (MCU),
8 (17 , maîtres de conférences associés (MCA), 10 (22 chefs
de clinique associés (CCA), 13 (27 étaient chargés d’enseignement
(CE) ou maîtres de stage des universités (MSU), et 11 (24 avaient
quitté la FUMG. 109 CCU (87 ont répondu au questionnaire. Parmi
les 68 CCU répondants en poste lors de l’étude, 33 (48 envisageaient
de passer le concours de MCU, 14 (20 de devenir MCA et 18 (26
de faire de la recherche ou de l’enseignement. Parmi les 41 anciens
CCU répondants, 21 (51 avaient accès à un poste d’enseignant-chercheur
de type CCA, MCA ou MCU. Vingt n’ont pas eu accès à ce type de poste.
Parmi eux, 12 ont invoqué des freins divers : manque de soutien de
leur département de médecine générale (DMG), charge de travail nécessaire,
manque de lisibilité sur l’avenir, épuisement professionnel.Discussion.
Les CCU de MG représentent 5 % de l’ensemble des CCU alors qu’ils
participent à l’encadrement pédagogique de 50 % des internes de
médecine en France. La structuration de la FUMG se fera avec une
volonté politique forte et une dynamique soutenue des DMG.
BibTeX:
@article{Laporte2014,
  author = {Laporte, C. and Darmon, D and Gelly, J. and Bonnet, P. and Bouchez, T and Schuers, M.},
  title = {Chefs de clinique des universités : que sont-ils devenus ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2014},
  number = {116},
  pages = {275--9}
}

Abstract: Contexte. En France, peu de données permettent d’avoir une vue d’ensemble
des motifs de recours aux soins et des problèmes de santé en soins
primaires. Les données des quelques opérateurs privés existants sont
peu accessibles.Objectif. Décrire le protocole et les principaux
résultats de l’étude ECOGEN en termes de distribution des motifs
et des résultats de consultation.Méthodes. Étude transversale nationale
multicentrique réalisée en patientèle de médecine générale. Les investigateurs
étaient 54 internes de 27 facultés de médecine, en stage supervisé
de niveau 1 chez 128 maîtres de stage universitaires. Ils ont été
formés à la structuration du dossier médical informatisé et à l’utilisation
de la Classification internationale des soins primaires (CISP-2).
Ils ont recueilli et saisi des variables spécifiques à chaque consultation
sur une période de 20 jours répartis entre décembre 2011 et avril
2012, ainsi que des variables relatives à leur(s) maître(s) de stage.Résultats.
Les données de consultation ont été enregistrées pour 20 613 consultations.
Chaque consultation comportait en moyenne 2,6 motifs de consultation,
2,2 résultats de consultation, et 4,7 procédures de soins. Chaque
résultat de consultation était ainsi associé à 1,2 motif de consultation
et à 2,1 procédures de soins. Le résultat de consultation le plus
fréquent correspondait à des situations de prévention (11 % des
résultats de consultation), suivi des facteurs de risque cardiovasculaires
: hypertension artérielle non compliquée (7 , dyslipidémie (3,7
, diabète (2,4 . Le motif de consultation le plus fréquent
était la demande de renouvellement de traitement médicamenteux (21,3
, devant le suivi d’un problème de santé (5,7 et la discussion
de résultats d’examens (4 .Conclusion. L’étude ECOGEN atteste
de la diversité et de la continuité des soins du médecin généraliste.
Celui-ci est le véritable partenaire de ses patients, au service
de la préservation et l’amélioration de leur santé.
BibTeX:
@article{Letrilliart2014,
  author = {Letrilliart, L. and Supper, I and Schuers, M. and Darmon, D and Boulet, P and Favre, M and Guerin, MH and Mercier, A.},
  title = {{ECOGEN} : étude des Éléments de la {COnsultation} en médecine {GENérale}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2014},
  number = {114},
  pages = {148--57}
}

BibTeX:
@article{Marie2014b,
  author = {Marie, I. and Duval-Modeste, A.-B. and Joly, P. and Menard, J.-F. and Dominique, S. and Bravard, P. and Noël, D. and Gehanno, J.-F. and Benichou, J. and Levesque, H.},
  title = {Influence des facteurs professionnels sur les caractéristiques de la sclérodermie systémique},
  journal = {La Revue de médecine interne},
  year = {2014},
  volume = {35},
  pages = {A72--A72},
  doi = {10.1016/j.revmed.2014.03.089}
}

BibTeX:
@article{Pegot2014,
  author = {Pégot, A. and Pinson, C. and Guichard, B. and Hardy, H. and Péron, J.-M. and Trost, O.},
  title = {Fenestration de la veine jugulaire interne gauche : à propos d’un cas atypique},
  journal = {Morphologie : bulletin de l'Association des anatomistes},
  year = {2014},
  volume = {98},
  number = {322},
  pages = {113--113},
  doi = {10.1016/j.morpho.2014.04.039}
}

BibTeX:
@article{Trost2014b,
  author = {Trost, Olivier},
  title = {Un histoséminaire de pathologie buccale et stomatologique pour éviter au pathologiste de tomber sur une dent},
  journal = {Annales de pathologie},
  year = {2014},
  volume = {34},
  number = {3},
  pages = {169--170},
  doi = {10.1016/j.annpat.2014.04.012}
}

Abstract: La désignation des structures anatomiques exige une rigueur absolue,
aussi bien en pratique clinique quotidienne qu’en recherche et en
enseignement. La nomenclature anatomique internationale utilise le
latin. En France, une nomenclature anatomique francisée peine à être
adoptée en pratique clinique. Les principes de cette nomenclature
sont la suppression systématique des noms propres, le respect des
définitions de l’anatomie générale et la francisation des termes
latins. Malgré une grande rigueur, quelques termes restent inappropriés,
car ils induisent des confusions ou des imprécisions. De plus, ce
langage d’utilisation internationale est moins aisé à manier au quotidien
par les cliniciens. Le but de cet article était de rappeler le vocabulaire
anatomique utile en chirurgie orale et maxillo-faciale, et de justifier
son emploi en clinique, en recherche et en pédagogie.
BibTeX:
@article{Trost2014a,
  author = {Trost, O. and Hardy, H. and Péron, J.-M. and Trouilloud, P.},
  title = {Nomenclature anatomique utile en chirurgie orale et maxillo-faciale},
  journal = {Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale},
  year = {2014},
  volume = {115},
  number = {5},
  pages = {287--292},
  doi = {10.1016/j.revsto.2014.09.002}
}

Abstract: Les mélanomes mandibulaires, primitifs ou métastatiques, sont extrêmement
rares. Nous rapportons le cas original d’une femme de 55 ans traitée
16 ans auparavant d’un mélanome cutané, et présentant un volumineux
mélanome achromique mandibulaire : métastase très tardive et de nature
histologique différente du mélanome cutané, ou mélanome muqueux achromique
primitif métachrone ?
BibTeX:
@article{Vierne2014,
  author = {Vierne, C. and Hardy, H. and Guichard, B. and Barat, M. and Péron, J-M and Trost, O.},
  title = {Métastase mandibulaire d’un mélanome cutané ou mélanome achromique primitif métachrone de la cavité orale ? À propos d’un cas et revue de la littérature},
  journal = {Annales de chirurgie plastique et esthétique},
  year = {2014},
  volume = {59},
  number = {4},
  pages = {276--9},
  doi = {10.1016/j.anplas.2014.01.002}
}

BibTeX:
@inproceedings{Cabot2014,
  author = {Cabot, C and Grosjean, J and Lelong, R and Lefebvre, A and Lecroq, T and Soualmia, LF and Darmoni, SJ},
  title = {Omic Data Modelling for Information Retrieval},
  booktitle = {Proceedings of the 2nd International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO},
  year = {2014},
  url = {http://iwbbio.ugr.es/2014/papers/IWBBIO_2014_paper_50.pdf}
}

BibTeX:
@inproceedings{Chniti2014a,
  author = {Chniti, Amina and Traore, Lamine and Hussain, Sajjad and Griffon, Nicolas and Darmoni, Stefan and Charlet, Jean and Sadou, Eric and Ouagne, David and Lepage, Eric and Daniel, Christel},
  title = {A Semantic Interoperability Framework for Facilitating Cross-Hospital Exchanges.},
  journal = {Stud Health Technol Inform},
  school = {AP-HP, F-75006, Paris, France.},
  year = {2014},
  volume = {205},
  pages = {1255}
}

BibTeX:
@inproceedings{Dhondt2014,
  author = {D'hondt, E and Grau, B and Darmoni, S and Névéol, A and Schuers, M and Zweigenbaum, P},
  title = {LIMSI @ 2014 Clinical Decision Support Track},
  booktitle = {TREC Working Notes},
  year = {2014},
  url = {https://perso.limsi.fr/neveol/DhondtTREC2014WorkingNotes.pdf}
}

BibTeX:
@inproceedings{Gicquel2014,
  author = {Gicquel, Q and Kergoulay, I and Gerbier-Colomban, S and Chariout, S and Bittar, A and Segond, F and Darmoni, SJ and Metzger, MH},
  title = {Annotation methods to develop and evaluate an expert system based on natural language processing in electronic medical records},
  booktitle = {MIE},
  year = {2014},
  url = {http://person.hst.aau.dk/ska/MIE2014/Slides/S12/ID074.pdf}
}

BibTeX:
@inproceedings{Griffon2014b,
  author = {Griffon, N and Merabti, T and Cormont, S and Tariel-Laurent, S and Massari, P and Lepage, E and Chniti, A and Daniel, C and Darmoni, SJ},
  title = {Preservation of Information in Terminology Transcoding},
  booktitle = {Stud Health Technol Inform MIE},
  year = {2014},
  volume = {205},
  pages = {156-160},
  doi = {10.3233/978-1-61499-432-9-156}
}

Abstract: The volume of data in the biomedical field constantly grows. The vast
majority of information retrieval systems are based on controlled
vocabularies and most specifically on terminologies or ontologies
(T/O). These classification structures allow indexing, coding, annotating
various types of documents. In Health, many T/O have been created
for different purposes and it became a problem to find specific concepts
in the multitude of nomenclatures. The NCBO (National Center for
Biomedical Ontologies, Stanford University) BioPortal project and
the CISMeF (Catalogue et Index des Sites M'edicaux de langue Franc¸aise,
Rouen University Hospital) HeTOP portals have been developed to tackle
this issue. While both portals are designed to store and make T/O
available to the community, they are also very different mainly because
of their basic purposes. The present work consists in comparing both
portals and in answering the following question: is it possible to
merge BioPortal and HeTOP into one unique solution to manage T/O
?
BibTeX:
@inproceedings{Grosjean2014,
  author = {Grosjean, J and Soualmia, LF and Bouarech, K and Jonquet, C and Darmoni, SJ},
  title = {Comparing BioPortal and HeTOP: towards a unique biomedical ontology portal ?},
  booktitle = {IWBBIO'14: 2nd International Work-Conference on Bioinformatics and Biomedical Engineering},
  address = {Granada, Spain},
  year = {2014},
  pages = {227–237},
  url = {http://iwbbio.ugr.es/2014/papers/IWBBIO_2014_paper_27.pdf}
}

Abstract: Background: main biomedical information retrieval systems are based
on controlled vocabularies and most specifically on terminologies
or ontologies (T/O). These classification structures allow indexing,
coding, annotating different kind of documents. Many T/O have been
created for different purposes and it became a problem for finding
specific concepts in the multitude of existing nomenclatures. The
NCBO (National Center for Biomedical Ontologies) BioPortal and the
CISMeF (Catalogue et Index des Sites Médicaux de langue Française)
HeTOP projects have been developed to tackle this issue. Objective:
the present work consists in comparing both portals. Methods: we
hereby are proposing a set of criteria to compare bio-ontologies
portals in terms of goals, features, technologies and usability.
Results: BioPortal and HeTOP have been compared based on the given
criteria. While both portals are designed to store and make T/O available
to the community and are sharing many basic features, they differ
on several points mainly because of their basic purposes. Conclusion:
thanks to the comparison criteria, we can assume that a merge between
BioPortal and HeTOP is possible in terms of functionalities. The
main difficulties will be about merging the data repositories and
applying different policies on T/O content.
BibTeX:
@inproceedings{Grosjean2014a,
  author = {Grosjean, Julien and Soualmia, Lina F. and Bouarech, Khedidja and Jonquet, Clément and Darmoni, Stéfan J.},
  title = {An Approach to Compare Bio-Ontologies Portals.},
  journal = {Stud Health Technol Inform},
  school = { TIBS, LITIS EA4108, Rouen University Hospital, France.},
  year = {2014},
  volume = {205},
  pages = {1008--1012}
}

Abstract: In order to identify variations between two or several versions of
Clinical Practice Guidelines, we propose a method based on the detection
of noun phrases. Currently, we are developing a comparison approach
to extract similar and different elements between medical documents
in French in order to identify any significant changes such as new
medical terms or concepts, new treatments etc. In this paper, we
describe a basic initial step for this comparison approach i.e. detecting
noun phrases. This step is based on patterns constructed from six
main medical terminologies used in document indexing. The patterns
are constructed by using a Tree Tagger. To avoid a great number of
generated patterns, the most relevant ones are selected that are
able identify more than 80% of the six terminologies used in this
study. These steps allowed us to obtain a manageable list of 262
patterns which have been evaluated. Using this list of patterns,
708 maximal noun phrases were found, with, 364 correct phrases which
represent a 51.41% precision. However by detecting these phrases
manually, 602 maximal noun phrases were found which represent a 60.47%
recall and therefore a 55.57% F-measure. We attempted to improve
these results by increasing the number of patterns from 262 to 493.
A total of 729 maximal noun phrases were obtained, with 365 which
were correct, and corresponded to a 50.07% precision, 60.63% recall
and 54.85% F-measure.
BibTeX:
@incollection{Merabti2014,
  author = {Merabti, A and Soualmia, LF. and Darmoni, SJ},
  title = {Detecting Noun Phrases in Biomedical Terminologies: The First Step in Managing the Evolution of Knowledge},
  booktitle = {Health Information Science},
  month = {January},
  publisher = {Springer International Publishing},
  year = {2014},
  series = {Lecture Notes in Computer Science},
  number = {8423},
  pages = {109--120},
  doi = {10.1007/978-3-319-06269-3_12}
}

BibTeX:
@inproceedings{NEVEOL14.604,
  author = {Névéol, A and Grosjean, J and Darmoni, SJ and Zweigenbaum, P},
  title = {Language Resources for French in the Biomedical Domain},
  booktitle = {Proceedings of the Ninth International Conference on Language Resources and Evaluation (LREC'14)},
  address = {Reykjavik, Iceland},
  month = {may},
  publisher = {European Language Resources Association (ELRA)},
  year = {2014},
  url = {http://www.lrec-conf.org/proceedings/lrec2014/pdf/604_Paper.pdf}
}

BibTeX:
@inproceedings{Chniti2014,
  author = {Chniti, A and Griffon, N and Traore, L and Hussain, S and Daniel, C},
  title = {Terminologies et référentiels d’interopérabilité sémantique en Santé},
  booktitle = {JFIM},
  year = {2014},
  url = {http://ceur-ws.org/Vol-1379/paper-05.pdf}
}

BibTeX:
@inproceedings{Joulakian2014,
  author = {Joulakian, M and Griffon, N and Schuers, M and Lepage, E and Savoye-Collet, C and Skalli, S and Massari, P and Darmoni, SJ},
  title = {Indicateurs en biologie et en imagerie au sein des systèmes d’information de santé},
  booktitle = {JFIM},
  year = {2014}
}

BibTeX:
@inproceedings{Lamy2014,
  author = {Lamy, JB and Soualmia, LF and Venot, A and Duc},
  title = {Validation de la sémantique d'un langage iconique médical à l'aide d'une ontologie : méthodes et applications},
  booktitle = {Actes des 25° journées francophones d'Ingénierie des Connaissances, IC'14},
  address = {Clermont-Ferrand, France},
  month = {May},
  year = {2014},
  pages = {51-62},
  url = {https://hal.archives-ouvertes.fr/hal-01004802/document}
}

BibTeX:
@inproceedings{Lelong2014,
  author = {Lelong, R and Merabti, T and Grosjean, J and Joulakian, M and Griffon, N and Dahamna, B and Cuggia, M and Pereira, S and Grabar, N and Thiessard, F and Massari, P and Darmoni, SJ},
  title = {Moteur de recherche sémantique au sein du dossier du patient informatisé : langage de requêtes spécifique},
  booktitle = {JFIM},
  year = {2014}
}

BibTeX:
@inproceedings{Metzger2014,
  author = {Metzger, M and Giquel, Q and Rabarijaona, D and Segond, F and Bittar, A and Dini, L and Soualmia, LF and Darmoni, SJ},
  title = {Usage secondaire du dossier médical informatisé à des fins épidémiologiques et d’évaluation de la qualité des soins : le projet SYNODOS},
  booktitle = {Actes des Journées Francophones d’Informatique Médicale (JFIM), Pré-symposium French Special Interest Groupe of International Medical Informatics, (FR SIG IMIA)},
  address = {Fès},
  year = {2014},
  volume = {1379},
  pages = {152–161}
}

Abstract: Le Dossier Patient Informatisé (DPI) constitue une source d’information
pour des applications aussi variées que la recherche médicale, l’aide
à la décision, la médecine factuelle ou la surveillance épidémiologique.
Les publications utilisant l’analyse textuelle pour traiter du dossier
patient sont en progression constante. Bien que donnant de très bons
résultats, une telle approche fait apparaitre un certain nombre de
défis, tels que la nécessité d’intégrer connaissances linguistiques
et connaissances métier. Se basant sur une expérience précédente,
cet article montre comment lier l’analyse linguistique, la représentation
des connaissances, les ontologies médicales et le raisonnement afin
de fournir un système générique permettant d’extraire, de structurer
et d’exploiter l’information provenant des DPIs.
BibTeX:
@inproceedings{Segond2014,
  author = {Segond, F and Ponomareva, A and Rabarijaona, D and Bittar, A and Kergourlay, I and Darmoni, SJ and Gicquel, Q and Metzher, MH},
  title = {Bien représenter pour mieux raisonner : deux approches pour le dossier patient},
  booktitle = {Atelier IC et Santé},
  address = {Clermont Ferrand},
  month = {Mai},
  year = {2014}
}

BibTeX:
@inproceedings{cabot2014b,
  author = {C. Cabot and J. Grosjean and R. Lelong and A. Lefebvre and T. Lecroq and L. F. Soualmia and S. J. Darmoni},
  title = {Integrating omic and clinical data in electronic health records for visualisation and retrieval},
  booktitle = {3ème Journ\'ee Scientifique de l'IRIB},
  address = {Caug\'e, France},
  year = {2014},
  pages = {64}
}

BibTeX:
@inproceedings{Cabot2014a,
  author = {Chloé Cabot and Mélissa Mary and Chadi Saad and Alexandre Renaux and Alexis Bertrand and Amandine Velt and Arnaud Lefebvre and Caroline Bérard and Nicolas Vergne and Hélène Dauchel},
  title = {GC- VC/DGE: a user-friendly web application for Going over Concordance across results from NGS bioinformatics analytic pipelines},
  booktitle = {ECCB 2014},
  address = {Strasbourg, France},
  year = {2014}
}

BibTeX:
@inproceedings{Cabot2014b,
  author = {Chloé Cabot and Mélissa Mary and Chadi Saad and Alexandre Renaux and Alexis Bertrand and Amandine Velt and Arnaud Lefebvre and Caroline Bérard and Nicolas Vergne and Hélène Dauchel},
  title = {GC- VC/DGE: a user-friendly web application for Going over Concordance across results from NGS bioinformatics analytic pipelines},
  booktitle = {3ème Journ\'ee Scientifique de l'IRIB},
  address = {Caug\'e, France},
  year = {2014}
}

BibTeX:
@inproceedings{Kerdelhue2014,
  author = {Kerdelhué, G and Grosjean, J and Darmoni, SJ},
  title = {A PubMed third party for French Language (and possibly others)},
  booktitle = {14th EAHIL Conference},
  year = {2014}
}

BibTeX:
@inproceedings{Lefebvre2014b,
  author = {Arnaud Lefebvre and Alexandra Martins and Karim Labrèche and Vivien Deshaies and Alan Lahure and Pascaline Gaildrat and Hélène Dauchel and C. Cabot and J. Grosjean and R. Lelong and A. Lefebvre and T. Lecroq and L. F. Soualmia and S. J. Darmoni},
  title = {HExoSplice: a bioinformatics software based on overlapping hexamer scores for prediction and stratification of exonic variants altering splicing regulation of human genes},
  booktitle = {3ème Journ\'ee Scientifique de l'IRIB},
  address = {Caug\'e, France},
  year = {2014}
}

BibTeX:
@inproceedings{Mary2014,
  author = {Mary, M and Gansel, X and Soualmia, LF},
  title = {LOINC \& SNOMED-CT: usability and challenges to code identification tests and results for automated in vitro diagnostics systems.},
  booktitle = {13th European Conference on Computational Biology},
  address = {Strasbourg, France},
  month = {September},
  year = {2014}
}

BibTeX:
@inproceedings{Neveol2014,
  author = {Névéol, A and Déleger, L and Burgun, A and D'hondt, E and Griffon, N and Grouin, C and Hamon, T and Lavergne, T and Ligozat, AL and Pham, AD and rabary, C and Tannier, X and Tapi-Nzal, MD and Zweigenbaum, P},
  title = {CABeRneT: Compréhension Automatique de Textes Biomédicaux pour la Recherche Translationnelle},
  booktitle = {forum Digiteo STIC du Campus},
  month = {Décembre},
  year = {2014}
}

Abstract: This chapter explains why it is hard to use medical language in computer
applications and why the computer must adopt the human interpretation
of medical words to avoid misunderstandings linked to ambiguity,
homonymy and synonymy. Terminological resources are specific representations
of medical language for dedicated use in particular health domains.
We describe here the components of terminology (terms, concepts,
relationships between concepts, definitions, constraints). The various
artefacts of terminological resources (e.g. thesaurus, classification,
nomenclature) are defined. We also provide examples of the dedicated
use of terminological resources, such as disease coding, the indexing
of biomedical publications, reasoning in decision support systems
and data entry into electronic medical records. ICD 10, SNOMED
CT, and MeSH are among the terminologies used in the examples.
Alignment methods are described, making it possible to identify equivalent
terms in different terminologies and to bridge different domains
in health. We also present plans for multi-terminological servers,
such as the UMLS (Unified Medical Language Systems), which provide
a key vocabulary linking heterogeneous health terminologies in different
languages.
BibTeX:
@incollection{Duclos2014,
  author = {Duclos, C. and Burgun, A. and Lamy, J. B. and Landais, P. and Rodrigues, J. M. and Soualmia, L. and Zweigenbaum, P.},
  title = {Medical Vocabulary, Terminological Resources and Information Coding in the Health Domain},
  booktitle = {Medical Informatics, e-Health},
  month = {January},
  publisher = {Springer Paris},
  year = {2014},
  series = {Health Informatics},
  pages = {11--41},
  url = {http://link.springer.com/chapter/10.1007/978-2-8178-0478-1_2},
  doi = {10.1007/978-2-8178-0478-1_2}
}

Abstract: This chapter describes the various types of document available via
the Internet for the dissemination of health knowledge. It describes
the process for the publication of scientific articles reporting
the results of research. The concepts of journal impact factor, citation
base and h-index are explained. The Cochrane collaboration for literature
reviews and meta-analysis is described. The goals of national and
international clinical guidelines are explained and examples are
provided of websites providing access to such guidelines. The various
types of training materials available from e-learning platforms for
medical students are described. This chapter also takes into account
drug monographs, which are particularly useful for prescription and
disease knowledge bases. Examples of resources useful to members
of the public are also provided and we describe the methods for accessing
health knowledge, including details of the resource indexing process
and the MeSH thesaurus frequently used for indexing. The quality
of health information on the Internet is also considered and the
principal quality criteria are listed. The HON foundation and certification
are described.
BibTeX:
@incollection{Venot2014,
  author = {Venot, A. and Charlet, J. and Darmoni, S. and Duclos, C. and Dufour, J. C. and Soualmia, L.},
  title = {Management and Dissemination of Health Knowledge},
  booktitle = {Medical Informatics, e-Health},
  month = {January},
  publisher = {Springer Paris},
  year = {2014},
  series = {Health Informatics},
  pages = {43--64},
  url = {http://link.springer.com/chapter/10.1007/978-2-8178-0478-1_3},
  doi = {10.1007/978-2-8178-0478-1_3}
}

BibTeX:
@article{Neveol2014a,
  author = {Névéol, A and Darmoni, SJ and Zweigenbaum, P},
  title = {Les ressources pour le traitement automatique de la langue biomédicale en français: appel à la communauté},
  journal = {Newsletter de l'Association Française d'Informatique Médicale},
  year = {2014},
  url = {http://france-aim.org/aim/sites/default/files/News4_0.pdf}
}

BibTeX:
@phdthesis{Grosjean2014b,
  author = {Julien Grosjean},
  title = {Modélisation, réalisation et évaluation d’un portail Multi-terminologique, Multi-discipline, Multi-lingue (3M) dans le cadre de la Plateforme d’Indexation Régionale (PlaIR)},
  school = {Université de Rouen, École doctorale Sciences Physiques, Mathématiques et de l'Information pour l'Ingénieur},
  year = {2014},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2017/01/thèse_Julien_Grosjean_final.pdf}
}

2013


Abstract: OBJECTIVES: Self-efficacy is defined as a person's beliefs in his
or her abilities to successfully complete a task, and has been shown
to influence student motivation and academic achievement. The purpose
of this study was to evaluate the impact of a new European teaching
module in occupational medicine on undergraduate students' self-efficacy
and knowledge in the subject matter. METHODS: Pre-, in-between, and
posttraining tests were used to assess self-efficacy and knowledge
building of 261 third-year medical students on occupational health
issues. Determinants of self-efficacy and knowledge were also identified.
Repeated measurement data were analyzed with multilevel statistical
procedures. RESULTS: The level of self-efficacy and knowledge in
occupational medicine increased after the training. Students who
frequently attended the lectures scored significantly higher than
sporadic attendees. There was no relation between the level of self-efficacy
and the final knowledge score. CONCLUSIONS: Teaching with the new
occupational medicine module was effective. Lecture attendance is
an important determinant of self-efficacy and performance. Self-efficacy
was not associated with knowledge score. Encouraging classroom participation
may enhance student achievement.
BibTeX:
@article{Braeckman2013a,
  author = {Braeckman, Lutgart and De Clercq, Bart and Janssens, Heidi and Gehanno, Jean-Francois and Bulat, Petar and Pauncu, Elena-Ana and Smits, Paul and van Dijk, Frank and Vanderlinde, Ruben and Valcke, Martin},
  title = {Development and evaluation of a new occupational medicine teaching module to advance self-efficacy and knowledge among medical students.},
  month = {November},
  journal = {Journal of occupational and environmental medicine},
  year = {2013},
  volume = {55},
  number = {11},
  pages = {1276--1280},
  doi = {10.1097/JOM.0b013e3182a50016}
}

Abstract: The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
BibTeX:
@article{Delbos2013,
  author = {Delbos, Valérie and Lemée, Ludovic and Bénichou, Jacques and Berthelot, Gilles and Deghmane, Ala-Eddine and Leroy, Jean-Philippe and Houivet, Estelle and Hong, Eva and Taha, Muhamed-Kheir and Caron, François and B14 STOP study group},
  title = {Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage.},
  month = {September},
  journal = {Vaccine},
  year = {2013},
  volume = {31},
  pages = {4416--4420},
  doi = {10.1016/j.vaccine.2013.06.080}
}

Abstract: The aim of this study performed in Normandy, France, was to analyze the pharyngeal meningococcal carriage at the peak of a clonal meningococcal B outbreak, which was subsequently controlled using an outer membrane vesicle vaccination. This cross-sectional study included randomly selected subjects aged 1-25 years. Carriers and non carriers were compared using unconditional logistic regression. Among the 3,522 volunteers, there were 196 (standardized rate: 6.46 %) Neisseria meningitidis carriers, of which there were only five with the outbreak strain (B:14:P1.7,16/ST-32; standardized rate: 0.18 %). From the multivariate analysis, older age, smoking, higher degree of socialization, and social deprivation appear to favor the carriage of all the strains included. Prior antibiotic treatment up to 12 months before swabbing, even with β-lactam, was protective against carriage. Our data indicate a low overall meningococcal carriage rate with a surprising protective effect of prior antibiotic exposure. The observed low carriage rate of the epidemic strain (B:14:P1.7,16/ST-32) contrasts with the high incidence of invasive meningococcal diseases (IMD) due to this strain. Hence, our data underline the high virulence of the strain and suggest a low level of natural immunity of the population against this strain. Although highly resource-consuming, carriage studies are helpful in guiding the implementation of control measures of IMD, such as mass vaccination or chemoprophylaxis.
BibTeX:
@article{Delbos2013a,
  author = {Delbos, V and Lemée, L and Bénichou, J and Berthelot, G and Taha, M-K and Caron, F and B14 STOP study group},
  title = {Meningococcal carriage during a clonal meningococcal B outbreak in France.},
  month = {November},
  journal = {European journal of clinical microbiology \& infectious diseases : official publication of the European Society of Clinical Microbiology},
  year = {2013},
  volume = {32},
  pages = {1451--1459},
  doi = {10.1007/s10096-013-1897-6}
}

Abstract: In searches for clinical trials and systematic reviews, it is said
that Google Scholar (GS) should never be used in isolation, but
in addition to PubMed, Cochrane, and other trusted sources of information.
We therefore performed a study to assess the coverage of GS specifically
for the studies included in systematic reviews and evaluate if GS
was sensitive enough to be used alone for systematic reviews.
BibTeX:
@article{Gehanno2013,
  author = {Gehanno, JF and Rollin, L and Darmoni, SJ},
  title = {Is the coverage of google scholar enough to be used alone for systematic reviews},
  month = {January},
  journal = {{BMC} Medical Informatics and Decision Making},
  year = {2013},
  volume = {13},
  number = {1},
  pages = {7},
  url = {http://www.biomedcentral.com/1472-6947/13/7/abstract},
  doi = {10.1186/1472-6947-13-7}
}

Abstract: PURPOSE: General practitioners play or should play a role in occupational
medicine (OM), either in diagnosing occupational diseases or in counseling
on return to work. Nevertheless, their training has been reported
to be insufficient in most single country studies. AIMS: The objectives
of this study were to analyze the content and extent of undergraduate
teaching of OM in European medical schools. METHODS: An e-mail questionnaire
survey of the teaching of OM to undergraduates was undertaken from
December 2010 to April 2011 in all medical schools and medical faculties
listed in 27 European countries (n = 305). RESULTS: Among the 305
universities identified, 135 answered to the questionnaire, giving
a response rate of 44 %. The mean number of hours given to formal
instruction in occupational medicine to medical undergraduates was
25.5 h. Nevertheless, this number of hours varied widely between
countries, but also within countries. Overall, 27 % of medical schools
gave their students 10 h of teaching or less, 52 % 20 h or less
and 69 % 30 h or less. Whereas occupational diseases and principles
of prevention were covered in most schools, disability and return
to work were very poorly represented among the topics that were taught
to students. CONCLUSION: Dedicated undergraduate teaching on occupational
health or OM in European medical schools is present in most medical
schools, usually at a low level, but is very variable between and
within countries. Medical schools across Europe are very unequal
to provide qualifying doctors education on the topics they will frequently
come across in their working lives.
BibTeX:
@article{Gehanno2013a,
  author = {Gehanno, J. F. and Bulat, P. and Martinez-Jarreta, B. and Pauncu, E. A. and Popescu, F. and Smits, P B A. and {van Dijk}, F J H. and Braeckman, L.},
  title = {Undergraduate teaching of occupational medicine in European schools of medicine.},
  month = {Apr},
  journal = {Int Arch Occup Environ Health},
  school = {Department of Occupational Medicine, Rouen University Hospital, 1, rue de Germont, 76000, Rouen, France, jean-francois.gehanno@chu-rouen.fr.},
  year = {2013},
  volume = {87},
  number = {4},
  pages = {397-401},
  url = {http://dx.doi.org/10.1007/s00420-013-0878-5},
  doi = {10.1007/s00420-013-0878-5}
}

Abstract: The objective of this study was to ascertain the performance of syndromic
algorithms for the early detection of patients in healthcare facilities
who have potentially transmissible infectious diseases, using computerised
emergency department (ED) data.A retrospective cohort in an 810-bed
University of Lyon hospital in France was analysed. Adults who were
admitted to the ED and hospitalised between June 1, 2007, and March
31, 2010 were included (N=10895). Different algorithms were built
to detect patients with infectious respiratory, cutaneous or gastrointestinal
syndromes. The performance parameters of these algorithms were assessed
with regard to the capacity of our infection-control team to investigate
the detected cases.For respiratory syndromes, the sensitivity of
the detection algorithms was 82.70 and the specificity was 82.37%.
For cutaneous syndromes, the sensitivity of the detection algorithms
was 78.08 and the specificity was 95.93%. For gastrointestinal
syndromes, the sensitivity of the detection algorithms was 79.41
and the specificity was 81.97%.This assessment permitted us to detect
patients with potentially transmissible infectious diseases, while
striking a reasonable balance between true positives and false positives,
for both respiratory and cutaneous syndromes. The algorithms for
gastrointestinal syndromes were not specific enough for routine use,
because they generated a large number of false positives relative
to the number of infected patients. Detection of patients with potentially
transmissible infectious diseases will enable us to take precautions
to prevent transmission as soon as these patients come in contact
with healthcare facilities.
BibTeX:
@article{Gerbier-Colomban2013,
  author = {Gerbier-Colomban, Solweig and Gicquel, Quentin and Millet, Anne-Laure and Riou, Christophe and Grando, Jacqueline and Darmoni, Stefan and Potinet-Pagliaroli, Véronique and Metzger, Marie-Hélène},
  title = {Evaluation of syndromic algorithms for detecting patients with potentially transmissible infectious diseases based on computerised emergency-department data.},
  journal = {BMC Med Inform Decis Mak},
  school = {Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Unité d'hygiène et d'épidémiologie, F-69317 Lyon, France. solweig.gerbier-colomban@chu-lyon.fr.},
  year = {2013},
  volume = {13},
  pages = {101},
  url = {http://dx.doi.org/10.1186/1472-6947-13-101},
  doi = {10.1186/1472-6947-13-101}
}

Abstract: OBJECTIVE: The objective is to represent the Foundational Model of
Anatomy (FMA) in the OWL 2 Web Ontology Language (informally OWL
2), and to use it in a European cross-lingual portal of health terminologies
for indexing and searching Web resources. Formalizing the FMA in
OWL 2 is essential for semantic interoperability, to improve its
design, and to ensure its reliability and correctness, which is particularly
important for medical applications. METHOD AND MATERIAL: The native
FMA was implemented in frames and stored in a MySQL database backend.
The main strength of the method is to leverage OWL 2 expressiveness
and to rely on the naming conventions of the FMA, to make explicit
some implicit semantics, while improving its ontological model and
fixing some errors. Doing so, the semantics (meaning) of the formal
definitions and axioms are anatomically correct. A flexible tool
enables the generation of a new version in OWL 2 at each Protégé
FMA update. While it creates by default a 'standard' version of the
FMA in OWL 2 (FMA-OWL), many options allow for producing other variants
customized to users' applications. Once formalized in OWL 2, it was
possible to use an inference engine to check the ontology and detect
inconsistencies. Next, the FMA-OWL was used to derive a lightweight
FMA terminology for a European cross-lingual portal of terminologies/ontologies
for indexing and searching resources. The transformation is mainly
based on a reification process. RESULT: Complete representations
of the entire FMA in OWL 1 or OWL 2 are now available. The formalization
tool is flexible and easy to use, making it possible to obtain an
OWL 2 version for all existing public FMA. A number of errors were
detected in the native FMA and several patterns of recurrent errors
were identified in the original FMA. This shows how the underlying
OWL 2 ontology is essential to ensure that the lightweight derived
terminology is reliable. The FMA OWL 2 ontology has been applied
to derive an anatomy terminology that is used in a European cross-lingual
portal of health terminologies. This portal is daily used by librarians
to index Web health resources. In August 2011, 6481 out of 81,450
health resources of CISMeF catalog (http://www.chu-rouen.fr/cismef/
- accessed 29.08.12) (7.96 were indexed with at least one FMA
entity. CONCLUSION: The FMA is a central terminology used to index
and search Web resources. To the best of our knowledge, neither a
complete representation of the entire FMA in OWL 2, nor an anatomy
terminology available in a cross-lingual portal, has been developed
to date. The method designed to represent the FMA ontology in OWL
2 presented in this article is general and may be extended to other
ontologies. Using a formal ontology for quality assurance and deriving
a lightweight terminology for biomedical applications is a general
and promising strategy.
BibTeX:
@article{Golbreich2012,
  author = {Golbreich, C and Grosjean, J and Darmoni, SJ},
  title = {The Foundational Model of Anatomy in OWL 2 and its use.},
  month = {Feb},
  journal = {Artif Intell Med},
  school = { University of Versailles Saint-Quentin, 78035 Versailles, France. Electronic address: cgolbrei@gmail.com.},
  year = {2013},
  volume = {57},
  number = {2},
  pages = {119-132},
  url = {http://dx.doi.org/10.1016/j.artmed.2012.11.002},
  doi = {10.1016/j.artmed.2012.11.002}
}

Abstract: To summarize the best papers in the field of Knowledge Representation
and Management (KRM).A synopsis of the four selected articles for
the IMIA Yearbook 2013 KRM section is provided, as well as highlights
of current KRM trends, in particular, of the semantic web in daily
health practice. The manual selection was performed in three stages:
first a set of 3,106 articles, then a second set of 86 articles followed
by a third set of 15 articles, and finally the last set of four chosen
articles.Among the four selected articles (see Table 1), one focuses
on knowledge engineering to prevent adverse drug events; the objective
of the second is to propose mappings between clinical archetypes
and SNOMED CT in the context of clinical practice; the third presents
an ontology to create a question-answering system; the fourth describes
a biomonitoring network based on semantic web technologies.These
four articles clearly indicate that the health semantic web has become
a part of daily practice of health professionals since 2012. In the
review of the second set of 86 articles, the same topics included
in the previous IMIA yearbook remain active research fields: Knowledge
extraction, automatic indexing, information retrieval, natural language
processing, management of health terminologies and ontologies.
BibTeX:
@article{Griffon2013,
  author = {Griffon, N. and Charlet, J. and Darmoni, Sj and , Section Editors for the I. M. I. A Yearbook 2013, Section on Knowledge Representation and Management},
  title = {Knowledge representation and management: towards an integration of a semantic web in daily health practice.},
  journal = {Yearb Med Inform},
  school = {Rouen University Hospital, Department of BioMedical Informatics, 1 rue de Gérmont, 76031 Rouen Cedex, France. E-mail: stefan.darmoni@chu-rouen.fr.},
  year = {2013},
  volume = {8},
  number = {1},
  pages = {155--158}
}

Abstract: To assess the safety and immunogenicity of live attenuated yellow fever (YF) 17D vaccine in adults receiving systemic corticosteroid therapy. All adult travelers on systemic corticosteroid therapy who had received the YF17D vaccine in 24 French vaccination centers were prospectively enrolled and matched with healthy controls (1:2) on age and history of YF17D immunization. Safety was assessed in a self-administered standardized questionnaire within 10 days after immunization. YF-specific neutralizing antibody titers were measured 6 months after vaccination in patients receiving corticosteroids. Between July 2008 and February 2011, 102 vaccine recipients completed the safety study (34 receiving corticosteroids and 68 controls). The median age was 54.9 years (interquartile range [IQR] 45.1-60.3 years) and 45 participants had a history of previous YF17D immunization. The median time receiving corticosteroid therapy was 10 months (IQR 1-67 months) and the prednisone or equivalent dosage was 7 mg/day (IQR 5-20). Main indications were autoimmune diseases (n = 14), rheumatoid arthritis (n = 9), and upper respiratory tract infections (n = 8). No serious adverse event was reported; however, patients receiving corticosteroids reported more frequent moderate/severe local reactions than controls (12% and 2%, respectively; relative risk 8.0, 95% confidence interval 1.4-45.9). All subjects receiving corticosteroids who were tested (n = 20) had neutralizing antibody titers >10 after vaccination. After YF17D immunization, moderate/severe local reactions may be more frequent in patients receiving systemic corticosteroid therapy. Immunogenicity seems satisfactory. Large-scale studies are needed to confirm these results.
BibTeX:
@article{Kerneis2013,
  author = {Kernéis, Solen and Launay, Odile and Ancelle, Thierry and Iordache, Laura and Naneix-Laroche, Véronique and Méchaï, Frédéric and Fehr, Thierry and Leroy, Jean-Philippe and Issartel, Bertrand and Dunand, Jean and van der Vliet, Diane and Wyplosz, Benjamin and Consigny, Paul-Henri and Hanslik, Thomas},
  title = {Safety and immunogenicity of yellow fever 17D vaccine in adults receiving systemic corticosteroid therapy: an observational cohort study.},
  month = {September},
  journal = {Arthritis care \& research},
  year = {2013},
  volume = {65},
  pages = {1522--1528},
  doi = {10.1002/acr.22021}
}

Abstract: To help clinicians read medical texts such as clinical practice guidelines
or drug monographs, we proposed an iconic language called VCM. This
language can use icons to represent the main medical concepts, including
diseases, symptoms, treatments and follow-up procedures, by combining
various pictograms, shapes and colors. However, the semantics of
this language have not been formalized, and users may create inconsistent
icons, e.g. by combining the "tumor" shape and the "sleeping" pictograms
into a "tumor of sleeping" icon.This work aims to represent the VCM
language using DLs and OWL for evaluating its semantics by reasoners,
and in particular for determining inconsistent icons. We designed
an ontology for formalized the semantics of VCM icons using the Protégé
editor and scripts for translating the VCM lexicon in OWL. We evaluated
the ability of the ontology to determine icon consistency for a set
of 100 random icons. The evaluation showed good results for determining
icon consistency, with a high sensitivity. The ontology may also
be useful for the design of mapping between VCM and other medical
terminologies, for generating textual labels for icons, and for developing
user interfaces for creating VCM icons.
BibTeX:
@article{Lamy2012,
  author = {Lamy, Jean-Baptiste and Soualmia, Lina F. and Kerdelhué, Gaëtan and Venot, Alain and Duclos, Catherine},
  title = {Validating the semantics of a medical iconic language using ontological reasoning.},
  month = {Sep},
  journal = {J Biomed Inform},
  school = {BIO (EA3969), UFR SMBH, University Paris 13, Sorbonne Paris Cité, Bobigny, France. Electronic address: jean-baptiste.lamy@univ-paris13.fr.},
  year = {2013},
  volume = {46},
  number = {1},
  pages = {56-67},
  url = {http://dx.doi.org/10.1016/j.jbi.2012.08.006},
  doi = {10.1016/j.jbi.2012.08.006}
}

Abstract: To summarize excellent current research in the field of Bioinformatics
and Translational Informatics with application in the health domain
and evidence-based medicine.We provide a synopsis of the articles
selected for the IMIA Yearbook 2013, from which we attempt to derive
a synthetic overview of current and future activities in the field.
Three steps of selection were performed by querying PubMed and Web
of Science. A first set of 5,549 articles was refined into a second
set of 1,272 articles from which 15 articles were retained for peer-review.The
selection and evaluation process of this Yearbook's section on Bioinformatics
and Translational Informatics yielded four excellent articles regarding
the Human Genome and Medicine. Exploiting genomic data depends on
having the appropriate reference annotation available. In the first
article, the goal of the GENCODE Consortium is to produce and publish
The GENCODE human reference gene set. As a result it is composed
by merged manual and automatic annotations, which are frequently
updated from public experimental databases. The quality of genome
sequencing is platform-dependant. In the second article, a generic
database independent from the sequencing technologies, Huvariome,
can help to identify errors and inconsistencies in sequencing. To
understand complex diseases of patients it will be of great importance
to detect rare gene variants. This is the aim of the third study.
Finally, in the last article, the plasma's DNA of healthy individual
and patients suffering from cancer is compared.The current research
activities attest to the continuous convergence of Bioinformatics
and Medical Informatics for clinical practice. For instance, a direct
use of high throughput sequencing technologies for patients could
aid the diagnosis of complex diseases (such as cancer) without invasive
surgery (such as biopsy) but only with blood analysis. However, ongoing
genomic tests will generate massive amounts of data and will imply
new trends in the near future: "Big Data" and smart health management.
BibTeX:
@article{Lecroq2013,
  author = {Lecroq, T. and Soualmia, L. F. and , Section Editors for the I. M. I. A Yearbook Section on Bioinformatics and Translational Informatics},
  title = {From genome sequencing to bedside. Findings from the section on bioinformatics and translational informatics.},
  journal = {Yearb Med Inform},
  school = { Health, 76821 Mont-Saint-Aignan Cedex, France. E-mail: Thierry.lecroq@univ-rouen.fr.},
  year = {2013},
  volume = {8},
  number = {1},
  pages = {175--177}
}

Abstract: BACKGROUND: Antidepressants (ADs) are commonly prescribed in primary
care and are mostly indicated for depression. According to the literature,
they are now more frequently prescribed for health conditions other
than psychiatric ones. Due to their many indications in a wide range
of medical fields, assessing the appropriateness of AD prescription
seems to be a challenge for GPs. The aim of this study was to review
evidence from guidelines for antidepressant prescription for non-psychiatric
conditions in Primary Care (PC) settings. METHODS: Data were retrieved
from French, English and US guideline databases. Guidelines or reviews
were eligible if keywords regarding 44 non-psychiatric conditions
related to GPs' prescription of ADs were encountered. After excluding
psychiatric and non-primary care conditions, the guidelines were
checked for keywords related to AD use. The latest updated version
of the guidelines was kept. Recent data was searched in the Cochrane
Database of Systematic Reviews and in PubMed for updated reviews
and randomized control trials (RCTs). RESULTS: Seventy-eight documents
were retrieved and were used to assess the level of evidence of a
potential benefit to prescribing an AD. For 15 conditions, there
was a consensus that prescribing an AD was beneficial. For 5 others,
ADs were seen as potentially beneficial. No proof of benefit was
found for 15 conditions and proof of no benefit was found for the
last 9. There were higher levels of evidence for pain conditions,
(neuropathic pain, diabetic painful neuropathy, central neuropathic
pain, migraine, tension-type headaches, and fibromyalgia) incontinence
and irritable bowel syndrome. There were difficulties in summarizing
the data, due to a lack of information on the level of evidence,
and due to variations in efficacy between and among the various classes
of ADs. CONCLUSIONS: Prescription of ADs was found to be beneficial
for many non-psychiatric health conditions regularly encountered
in PC settings. On the whole, the guidelines were heterogeneous,
seemingly due to a lack of trials assessing the role of ADs in treatment
strategies.
BibTeX:
@article{Mercier2013,
  author = {Mercier, Alain and Auger-Aubin, Isabelle and Lebeau, Jean-Pierre and Schuers, Matthieu and Boulet, Pascal and Hermil, Jean-Loup and Van Royen, Paul and Peremans, Lieve},
  title = {Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: an analysis of guidelines and systematic reviews.},
  month = {May},
  journal = {BMC family practice},
  year = {2013},
  volume = {14},
  pages = {55},
  doi = {10.1186/1471-2296-14-55}
}

Abstract: BACKGROUND: Data about perceived needs of workers for information
on occupational hazards or diseases (OHDs) are scarce and the behaviour
of workers seeking information on these matters is not well known.
AIMS: To describe workers' needs and behaviour in seeking information
about OHDs. METHODS: All workers attending for consultation at an
occupational health service in Upper Normandy within 1 week were
invited to fill in an anonymous questionnaire. RESULTS: Of the 2640
workers responding 58% declared a need for information about OHD,
but only 37% actually sought that information. Whereas 82% of workers
mentioned the internet and their general physician (GP) as sources
of information on OHD, only 43% mentioned their occupational physician
(OP). Furthermore, information received from OPs was not considered
more reliable than that from GPs. CONCLUSIONS: Workers report a need
for information about OHDs. Although most of them trust information
given by OPs, they do not use OPs to obtain OHD information, but
instead use less reliable sources such as the internet or their GPs.
BibTeX:
@article{Rollin2013a,
  author = {Rollin, L. and Ladner, J. and Gislard, A. and Monfrin, F. and Larchevesque, J.-Y. and Deslandes, P. and Gehanno, J.-F.},
  title = {Hazard information needs and information seeking in {French} workers.},
  month = {October},
  journal = {Occupational medicine (Oxford, England)},
  year = {2013},
  volume = {63},
  number = {7},
  pages = {473--478},
  doi = {10.1093/occmed/kqt091}
}

BibTeX:
@article{Soualmia2013,
  author = {Soualmia, LF and Sakji, S and Letord, C and Rollin, L and Massari, P and Darmoni, SJ},
  title = {Improving information retrieval with multiple health terminologies in a quality-controlled gateway},
  journal = {BMC Health Information Science and Systems},
  year = {2013},
  pages = {1-8},
  url = {http://www.hissjournal.com/content/1/1/8},
  doi = {10.1186/2047-2501-1-8}
}

BibTeX:
@article{Trost2013,
  author = {Trost, O. and Peron, J.-M.},
  title = {Re: "{Treatment} of low subcondylar fractures--a 5-year retrospective study".},
  month = {December},
  journal = {International journal of oral and maxillofacial surgery},
  year = {2013},
  volume = {42},
  number = {12},
  pages = {1596--1597},
  doi = {10.1016/j.ijom.2013.08.017}
}

BibTeX:
@article{Marie2013,
  author = {Marie, I. and Gehanno, J.F. and Bubenheim, M. and Duval-Modeste, A.B. and Dominique, S. and Joly, P. and Bravard, P. and Noel, D. and Weber, J. and Benichou, J. and Levesque, H.},
  title = {Sclérodermie systémique et facteurs environnementaux : enquête prospective de 100 patients et 300 témoins},
  journal = {La Revue de médecine interne},
  year = {2013},
  volume = {34},
  pages = {A31--A32},
  doi = {10.1016/j.revmed.2013.10.034}
}

BibTeX:
@article{Marie2013a,
  author = {Marie, I. and Gehanno, J.-F. and Bubenheim, M. and Duval-Modeste, A.-B. and Joly, P. and Dominique, S. and Noel, D. and Bravard, P. and Lagoutte, P. and Cailleux, A.-F. and Weber, J. and Levesque, H.},
  title = {Sclérodermie systémique et facteurs environnementaux : enquête prospective cas-témoins},
  journal = {La Revue de médecine interne},
  year = {2013},
  volume = {34},
  pages = {A63--A63},
  doi = {10.1016/j.revmed.2013.03.283}
}

BibTeX:
@article{Pairon2013,
  author = {Pairon, J.C. and Gehanno, J.F. and Paris, C.},
  title = {Le mésusage des substances psychoactives en milieu de travail : un besoin de recommandations pour les acteurs des équipes de santé au travail},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2013},
  volume = {74},
  number = {3},
  pages = {238--239},
  doi = {10.1016/j.admp.2013.04.008}
}

Abstract: This prospective survey, conducted at the Dakar airport from August 18, 2011, to May 8, 2012, asked a sample of travelers living in France and returning there after a stay in Senegal to complete a questionnaire. The aim of the study was to assess the determinants of vaccination coverage against yellow fever. The study included 10 298 travelers, with a median age of 48 years (interquartile range: 27-58); 52% were tourists, and 22% were traveling for business purposes. The measured level of anti-yellow fever vaccination coverage was 39.3%. Vaccination coverage was influenced by the travelers' level of knowledge and their perception of the risk.
BibTeX:
@article{Rapp2013,
  author = {Rapp, C and Fall, K B and Tall, A and Michel, R and Royon, P and de Gentile, L and Leroy, J P and Caumes, E and Bouchaud, O},
  title = {Évaluation de la couverture vaccinale des voyageurs se rendant en zone d'endémicité amarile (Sénégal).},
  month = {May},
  journal = {Medecine et sante tropicales},
  year = {2013},
  volume = {23},
  pages = {236},
  doi = {10.1684/mst.2013.0207}
}

Abstract: Contexte. Depuis le rapport de la Global INItiative for Asthma (GINA)
en 2006, le niveau de contrôle guide la prise en charge des patients
asthmatiques. Cette maladie chronique nécessite une approche globale.
De nombreuses études ont évalué la prise en charge pharmacologique
de la maladie, mais peu ont étudié les mesures non médicamenteuses.Objectif.
Identifier les interventions permettant d’améliorer le contrôle de
l’asthme, en dehors des thérapies médicamenteuses spécifiques validées.Méthode.
Revue systématique de la littérature menée en juin 2013 dans Medline
et la Cochrane Library.Résultats. Les programmes d’éducation thérapeutique
amélioraient significativement le contrôle de l’asthme. Il était
toutefois difficile d’identifier les types de programme les plus
efficaces. La plupart des mesures visant à réduire l’exposition aux
acariens étaient inefficaces. Les systèmes de purification d’air
par filtration semblaient plus efficaces que les systèmes par ioniseur.
La réhabilitation totale ou partielle des logements visant à réduire
l’exposition aux allergènes et polluants intérieurs permettait d’améliorer
le contrôle. Aucune adaptation du régime alimentaire ne s’est révélée
efficace. L’activité physique a montré des résultats encourageants
mais non significatifs. Le traitement du reflux gastro-oesophagien
et la prescription d’antibiotiques au long cours n’ont pas permis
d’améliorer le contrôle de l’asthme. Les interventions psychologiques
ou de physiothérapie n’ont généralement pas fait la preuve de leur
efficacité. Le transfert de la prise en charge du médecin vers une
infirmière n’a pas montré de résultats concluants. La prise en charge
des enfants asthmatiques en milieu scolaire s’est révélée efficace.
Les interventions complexes, qui associaient généralement des programmes
d’éducation thérapeutique à une diminution de l’exposition aux allergènes
et polluants intérieurs, amélioraient significativement le contrôle
de la maladie.Conclusion. Quelques interventions non médicamenteuses
ont prouvé une amélioration du contrôle de l’asthme. Les interventions
complexes qui coordonnent des professionnels de soins primaires autour
du patient semblent les plus efficaces.
BibTeX:
@article{Schuers2013,
  author = {Schuers, M. and Chapron, A and Bouchez, T and Darmon, D},
  title = {Interventions sur les facteurs associés au contrôle de l’asthme : une revue systématique de la littérature},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2013},
  number = {109},
  pages = {224--35}
}

Abstract: ContextePour valider le diplôme d’études spécialisées (DES) de médecine
générale, le département de médecine générale de Rouen a choisi,
en 1997, une approche par objectifs. Il s’est inspiré des évaluations
du Collège des médecins de famille du Canada en développant l’examen
clinique objectif standardisé (ECOS)1. Cet examen oral est organisé
en plusieurs stations de 7 minutes. Chacune propose à l’interne une
situation clinique particulière, avec un objectif précis. L’interne
est face à un patient simulé et un observateur qui l’évalue suivant
une grille d’observation. Chaque situation évalue une ou plusieurs
compétences. L’ensemble permet une évaluation globale des compétences
suivantes : la démarche diagnostique de l’entretien, de l’examen
clinique, paraclinique, les gestes techniques, la prise en charge
thérapeutique et la communication (information du patient, relation
médecin-patient).
BibTeX:
@article{Secret2013,
  author = {Secret, J and Schuers, M.},
  title = {Impact du {SASPAS} sur les performances des internes aux {ECOS}},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2013},
  number = {106 suppl 2},
  pages = {58--9}
}

Abstract: The partial match between biomedical documents and controlled vocabularies
allows to find in the documents more terms variants than those existing
in the dictionaries. However, it generates irrelevant information.
We propose a new approach for indexing biomedical documents with
the Medical Subject Headings (MeSH) thesaurus that aims to overcome
the limitation of the partial match. In fact, our indexing approach
proposes to restrict the stemming process in the step of pretreatment.
The step of the descriptors extraction is based essentially on the
vector space model and combines semantic and statistic methods to
compute a score to estimate the relevance of a descriptor given a
document. The knowledge provided by the Unified Medical Language
System (UMLS) is used then for filtering. The filtering method aims
to keep only relevant descriptors. The experiments of our approach
that have been carried out on the OHSUMED collection, showed very
encouraging results.
BibTeX:
@inproceedings{Chebil2013,
  author = {Chebil, W and Soualmia, LF and Darmoni, SJ},
  title = {BioDI: A new approach to improve Biomedical Documents Indexing},
  booktitle = {Proceedings of the 24th International Conference on Database and Expert Systems Applications, DEXA},
  month = {August},
  publisher = {Springer},
  year = {2013},
  series = {Lecture Notes in Computer Science},
  pages = {78-87},
  doi = {10.1007/978-3-642-40285-2_9}
}

BibTeX:
@inproceedings{Chebil2013a,
  author = {Chebil, W and Soualmia, LF and Darmoni, SJ},
  title = {BNDI:A Bayesian Network for biomedial Documents Indexing with MeSH thesaurus},
  booktitle = {Proceedings of the International Conference on Reasoning and Optimization in Information Systems (ROIS)},
  address = {Hammam- Sousse, Tunisia},
  month = {September},
  year = {2013},
  pages = {134-139}
}

BibTeX:
@inproceedings{Dupuch2013,
  author = {Dupuch, M and Segond, F and Bittar, A and Dini, L and Soualmia, LF and Darmoni, SJ and Gicquel, Q and Metzger, MH},
  title = {Separate the grain from the chaff: make the best use of language and knowledge technologies to model textual medical data extracted from electronic health records},
  booktitle = {Proceedings of the LTC'13 6th Language \& Technology Conference: Human Language Technologies as a Challenge for Computer Science and Linguistics},
  address = {Poznań, Poland},
  month = {December},
  year = {2013}
}

BibTeX:
@inproceedings{Merabti2013b,
  author = {Merabti, A and Soualmia, LF and Darmoni, SJ},
  title = {Aligning bio-terminologies and bio-ontologies lexicons : a preliminary study},
  booktitle = {Proceedings of the 10th International Conference on Terminology and Artificial Intelligence},
  month = {October},
  year = {2013}
}

Abstract: The objective of this study is to evaluate to approaches assisting
the translation of SNOMED CT into French. Two types of approaches
were combined: a concept-based one, which relies on conceptual information
of the UMLS Metathesaurus and a lexical-based one, which relieson
NLP techniques. In addition to the French terminologies (whether
included in UMLS or not). Using the concept-based approach, a set
of 156,157 (39.4 SNOMED CT terms were translated to at least one
French term from UMLS. Expanded to the French terms from UMLS terminologies
translated by CISMeF, 2,548 (+0.7 additional SNOMED CT terms were
translated to at least one French term. Using the lexical-based approach,
a set of 145,737 (36.8 SNOMED CT terms were translated to at least
one French term from HeTOP. The qualitative evaluation showed that
44% of the translations were rated as "relevant". Overall, the two
approaches have provided the translation of 168,750 (42.6 SNOMED
CT terms into French using different bilingual terminological sources
included in UMLS or in HeTOP.
BibTeX:
@inproceedings{Merabti2013a,
  author = {Merabti, T and Soualmia, LF. and Grosjean, J and Letord, C and Darmoni, SJ},
  title = {Assisting the Translation of SNOMED CT into French.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = { TIBS, LITIS EA 4108, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {47--51}
}

BibTeX:
@inproceedings{Darmoni2013,
  author = {Darmoni, SJ and Soualmia, LF and Griffon, N and Grosjean, J and Kerdelhué, G and Kergoulay, I and Thirion, B and Dahamna, B},
  title = {MLPubMed : une base de données bibliographique multi-lingue},
  booktitle = {Colloque RITS},
  year = {2013}
}

BibTeX:
@inproceedings{Darmoni2013a,
  author = {Darmoni, SJ and Soualmia, LF and Griffon, N and Kerdelhué, G and Kergourlay, I and Thirion, B and Dahamna, B},
  title = {MLPubMed : une base de données bibliographique multi-lingue},
  booktitle = {Pré-symposium French Special Interest Group of the International Medical Informatics Association, FR SIG IMIA},
  month = {August},
  year = {2013}
}

BibTeX:
@inproceedings{Giquel2013,
  author = {Giquel, Q and Dini, L and Kergourlay, I and Arnod-Prin, P and Chariout, S and Bittar, A and Soualmia, LF and Guedez, P and Segond, F and Ruhlman, M and Darmoni, SJ and Metzger, M},
  title = {SYstème de Normalisation et d'Organisation de Données médicales textuelles pour l'Observation en Santé (SYNODOS)},
  booktitle = {Pré-symposium French Special Interest Group of the International Medical Informatics Association, FR SIG IMIA},
  month = {August},
  year = {2013}
}

BibTeX:
@inproceedings{Neveol2013,
  author = {Névéol, A and Grouin, C and and Darmoni, SJ and Zweigenbaum, P},
  title = {Dé-identification d’un corpus clinique pour le traitement automatique du français},
  booktitle = {Pré-symposium French Special Interest Group of the International Medical Informatics Association, FR SIG IMIA},
  month = {August},
  year = {2013}
}

Abstract: PubMed contains many articles in languages other than English but
it is difficult to find them using the English version of the Medical
Subject Headings (MeSH) Thesaurus. The aim of this work is to propose
a tool allowing access to a PubMed subset in one language, and to
evaluate its performance. Translations of MeSH were enriched and
gathered in the information system. PubMed subsets in main European
languages were also added in our database, using a dedicated parser.
The CISMeF generic semantic search engine was evaluated on the response
time for simple queries. MeSH descriptors are currently available
in 11 languages in the information system. All the 654,000 PubMed
citations in French were integrated into CISMeF database. None of
the response times exceed the threshold defined for usability (2
seconds). It is now possible to freely access biomedical literature
in French using a tool in French; health professionals and lay people
with a low English language may find it useful. It will be expended
to several European languages: German, Spanish, Norwegian and Portuguese.
BibTeX:
@inproceedings{Darmoni2013b,
  author = {Darmoni, SJ. and Soualmia, LF and Griffon, N and Grosjean, J and Kerdelhué, G and Kergourlay, I and Dahamna, B},
  title = {Multi-lingual Search Engine to Access PubMed Monolingual Subsets: A Feasibility Study.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = { TIBS, LITIS EA 4108, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {966}
}

Abstract: The Human Phenotype Ontology (HPO) is a controlled vocabulary which
provides phenotype data related to genes or diseases. The Health
Terminology/Ontology Portal (HeTOP) is a tool dedicated to both human
beings and computers to access and browse biomedical terminologies
or ontologies (T/O). The objective of this work was to integrate
the HPO into HeTOP in order to enhance both works. This integration
is a success and allows users to search and browse the HPO with a
dedicated interface. Furthermore, the HPO has been enhanced with
the addition of content such as new synonyms, translations, mappings.
Integrating T/O such as the HPO into HeTOP is a benefit to vocabularies
because it allows enrichment of them and it is also a benefit for
HeTOP which provides a better service to both humans and machines.
BibTeX:
@inproceedings{Grosjean2013,
  author = {Grosjean, J and Merabti, T and Soualmia, LF and Letord, C and Charlet, J and Robinson, P and Darmoni, SJ},
  title = {Integrating the Human Phenotype Ontology into HeTOP Terminology-Ontology Server.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = { TIBS, LITIS EA 4108, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {961}
}

BibTeX:
@inproceedings{Merabti2013,
  author = {Merabti, A and Soualmia, LF and Darmoni, SJ},
  title = {Mise en correspondance de terminologies et ontologies biomédicales pour un accès facilité aux connaissances},
  booktitle = {13e Conférence Francophone sur l'Extraction et la Gestion des Connaissances (EGC'13)},
  year = {2013}
}

Abstract: The concept-oriented structure of the MeSH® thesaurus is not yet in
common use. Nevertheless, it has been shown that a concept-based
querying of PubMed may be of interest. To take full advantage of
the concept-oriented structure of MeSH in the information retrieval
tool associated with the CISMeF catalogue, it was necessary to translate
such concepts into French.
BibTeX:
@inproceedings{Soualmia2013a,
  author = {Soualmia, Lina F. and Letord, Catherine and Merabti, Tayeb and Griffon, Nicolas and Manel, Jacques and Darmoni, Stéfan J.},
  title = {Translating MeSH Concepts.},
  booktitle = {MEDINFO 2013 - Proceedings of the 14th World Congress on Medical Informatics},
  journal = {Stud Health Technol Inform},
  school = { CISMeF, Rouen University Hospital, Rouen, France.},
  year = {2013},
  volume = {192},
  pages = {1007}
}

BibTeX:
@phdthesis{griffon2013,
  author = {N. Griffon},
  title = {Modélisation, création et évaluation de flux de terminologies et de terminologies d'interface : application à  la production d'examens complémentaires de biologie et d'imagerie médicale},
  school = {University of Rouen, France},
  year = {2013},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2017/01/Thèse_NG_10-25_these.pdf}
}

BibTeX:
@phdthesis{Rollin2013,
  author = {Laetitia Rollin},
  title = {L’accès à la connaissance et qualité de l’information en santé au travail},
  year = {2013}
}

2012


Abstract: A meningococcal B:14:P1.7,16 outbreak in Normandy (France) was recently controlled using MenBvac, an outer membrane vesicle vaccine previously designed against the B:15:P1.7,16 strain. The further emergence of a new B:14:P1.7,16 outbreak in another district in Normandy led us to explore immunity against B:14:P1.7,16 before and after the MenBvac campaign using a 2+1 (day 0, week 6, month 8) schedule. Children (1-5 years) were sampled before, during and up to one year after vaccination. Serum bactericidal activity against B:14:P1.7,16 was titrated using human complement (hSBA) and immune response was defined by hSBA titer ≥4 as a surrogate for protection. The percentage of hSBA titer ≥4 was 10.8% before vaccination, raised to 84.1% 6 weeks after the completion of the schedule, but declined to 39.7% one year later. This level is lower than the targeted 60% level and suggests only short-term persistence of response against B:14:P1.7,16 using this schedule.
BibTeX:
@article{Caron2012,
  author = {Caron, François and Delbos, Valérie and Houivet, Estelle and Deghmane, Ala-Eddine and Leroy, Jean-Philippe and Hong, Eva and Bénichou, Jacques and Taha, Muhamed-Kheir},
  title = {Evolution of immune response against Neisseria meningitidis B:14:P1.7,16 before and after the outer membrane vesicle vaccine MenBvac.},
  month = {July},
  journal = {Vaccine},
  year = {2012},
  volume = {30},
  pages = {5059--5062},
  doi = {10.1016/j.vaccine.2012.05.051}
}

BibTeX:
@article{Coutant2012a,
  author = {Coutant, S and Cabot, C and Lefebvre, A and Léonard, M and Prieur-Gaston, E and Campion, D and Lecroq, T and Dauchel, H},
  title = {EVA: Exome Variation Analyzer, an efficient and versatile tool for filtering strategies in medical genomics},
  journal = {BMC Bioinformatics},
  year = {2012},
  volume = {13},
  number = {Suppl 14},
  pages = {S9},
  url = {http://www.biomedcentral.com/1471-2105/13/S14/S9},
  doi = {10.1186/1471-2105-13-S14-S9}
}

BibTeX:
@article{Darmoni2012a,
  author = {Darmoni, SJ and Soualmia, LF and Letord, C and Griffon, N and Jaulent, MC and Thirion, B and Névéol, A},
  title = {Improving information retrieval using MeSH Concepts: a test case on rare and chronic diseases},
  journal = {J Med Libr Assoc},
  year = {2012},
  volume = {100},
  number = {3},
  pages = {176-83},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411256/pdf/mlab-100-03-176.pdf},
  doi = {10.3163/1536-5050.100.3.007}
}

BibTeX:
@article{Gehanno2012,
  author = {Gehanno, JF and Rollin, L and Ladner, J and Darmoni, SJ},
  title = {How is Occupational Medicine represented in the major journals in general medicine?},
  month = {June},
  journal = {Occupational and Environmental Medicine},
  year = {2012},
  volume = {69},
  number = {8},
  pages = {603-5},
  doi = {10.1136/oemed-2011-100044}
}

BibTeX:
@article{Gehanno2012a,
  author = {Gehanno, Jean-François and Rollin, Laetitia},
  title = {Influenza vaccination coverage among health professionals before and after the {A(H1N1)} influenza pandemic in France},
  month = {July},
  journal = {Infection control and hospital epidemiology: the official journal of the Society of Hospital Epidemiologists of America},
  year = {2012},
  volume = {33},
  number = {7},
  pages = {757--758},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/22669240},
  doi = {10.1086/666338}
}

Abstract: BACKGROUND: PubMed is the main access to medical literature on the
Internet. In order to enhance the performance of its information
retrieval tools, primarily non-indexed citations, the authors propose
a method: expanding users' queries using Unified Medical Language
System's (UMLS) synonyms i.e. all the terms gathered under one unique
Concept Unique Identifier.

METHODS: This method was evaluated using queries constructed to emphasize
the differences between this new method and the current PubMed automatic
term mapping. Four experts assessed citation relevance.

RESULTS: Using UMLS, we were able to retrieve new citations in 45.5%
of queries, which implies a small increase in recall. The new strategy
led to a heterogeneous 23.7% mean increase in non-indexed citation
retrieved. Of these, 82% have been published less than 4 months earlier.
The overall mean precision was 48.4% but differed according to the
evaluators, ranging from 36.7% to 88.1% (Inter rater agreement was
poor: kappa = 0.34).

CONCLUSIONS: This study highlights the need for specific search tools
for each type of user and use-cases. The proposed strategy may be
useful to retrieve recent scientific advancement.
BibTeX:
@article{Griffon2012,
  author = {Griffon, N and Chebil, W and Rollin, L and Kerdelhue, G and Thirion, B and Gehanno, JF and Darmoni, SJ},
  title = {Performance evaluation of Unified Medical Language System®'s synonyms expansion to query PubMed},
  month = {Feb},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2012},
  volume = {12},
  number = {1},
  pages = {12},
  doi = {10.1186/1472-6947-12-12}
}

Abstract: Objectives: To analyze the attitude of physicians towards alertin
g in CPOE systems in different hospitals in different countries,
addressing various organizational and technical settings and the
view of physicians not currently using a CPOE.Methods: A cross-sectional
quantitative and qualitative questionnaire survey. We invited 2,600
physicians in eleven hospitals from nine countries to participate.
Eight of the hospitals had different CPOE systems in use, and three
of the participating hospitals were not using a CPOE system.Results:
1,018 physicians participated. The general attitude of the physicians
towards CPOE alerting is positive and is found to be mostly independent
of the country, the specific organizational settings in the hospitals
and their personal experience with CPOE systems. Both quantitative
and qualitative results show that the majority of the physicians,
both CPOE-users and non-users, appreciate the benefits of alerting
in CPOE systems on medication safety. However, alerting should
be better adapted to the clinical context and make use of more sophisticated
ways to present alert information. The vast majority of physicians
agree that additional information regarding interactions is useful
on demand. Around half of the respondents see possible alert overload
as a major problem; in this regard, physicians in hospitals with
sophisticated alerting strategies show partly better attitude scores.Conclusions:
Our results indicate that the way alerting information is presented
to the physicians may play a role in their general attitude towards
alerting, and that hospitals with a sophisticated alerting strategy
with less interruptive alerts tend towards more positive attitudes.
This aspect needs to be further investigated in future studies.
BibTeX:
@article{jung_attitude_2012,
  author = {Jung, M and Hoerbst, A and Hackl, W O and Kirrane, F and Borbolla, D and Jaspers, M W M and Oertle, M and Koutkias, V and Ferret, L and Massari, P and Lawton, K and Riedmann, D and Darmoni, S and Maglaveras, N and Lovis, C and Ammenwerth, E},
  title = {Attitude of Physicians Towards Automatic Alerting in Computerized Physician Order Entry Systems. A Comparative International Survey},
  month = {November},
  journal = {Methods of information in medicine},
  year = {2012},
  volume = {52},
  number = {2},
  pages = {99-108},
  doi = {10.3414/ME12-02-0007}
}

Abstract: Background Research on return to work (RTW) is increasing. It is
important to benefit from studies originating from different countries
since certain factors influencing the RTW process are specific
to each country.Aims To compare RTW research in Europe with the
USA and to describe research on RTW in Europe.Methods Medline
was scanned with specific search strings to identify studies concerning
RTW in Europe, in the USA and in the rest of the world. Characteristics
of the European studies were analyzed with two specific tools for
bibliometrics research.Results Four thousand five hundred and twenty-five
studies were identified (1100, 1005 and 2420 coming from Europe,
the USA and the rest of the world, respectively). The European
countries producing the greatest number of research papers standardized
for population of that country were Sweden, the Netherlands, Finland
and Denmark. Sweden was 5.7 times more prolific than the USA. Specialties
covered by the European publications included occupational medicine
(the subject of 66% of the articles), neurology (36, environment
and public health (32, physical medicine and rehabilitation (26
and rheumatology (24.Conclusions There is a worldwide trend
upwards in the number of publications on RTW. Europe recently overtook
the USA in the number of publications per head of population, although
there were large differences in publication rates among the European
countries. The publications of European researchers on RTW are
spread over a wide variety of journals, making access to this research
difficult.
BibTeX:
@article{Rollin2012,
  author = {Rollin, L. and Gehanno, {J.-F.}},
  title = {Research on return to work in European Union countries},
  month = {January},
  journal = {Occupational Medicine},
  year = {2012},
  volume = {62},
  number = {3},
  pages = {210-5},
  url = {http://occmed.oxfordjournals.org/content/early/2012/01/12/occmed.kqr207.abstract},
  doi = {10.1093/occmed/kqr207}
}

BibTeX:
@article{Soualmia2012,
  author = {Soualmia, LF and Prieur-Gaston, E and Moalla, Z and Lecroq, T and Darmoni, SJ},
  title = {Matching health information seekers' queries to medical terms.},
  journal = {BMC Bioinformatics},
  year = {2012},
  volume = {13},
  number = {Suppl 14},
  pages = {S11},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439674/},
  doi = {10.1186/1471-2105-13-S14-S11}
}

BibTeX:
@article{Chebil2012,
  author = {Chebil, W and Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {Indexation automatique de documents en santé : évaluation et analyse de sources d'erreurs},
  journal = {IRBM, Ingénierie et Recherche Biomédicale / IRBM BioMedical Engineering and Research},
  year = {2012},
  volume = {33},
  number = {5-6},
  pages = {316-329},
  doi = {10.1016/j.irbm.2012.10.002}
}

BibTeX:
@article{DeBlasi2012,
  author = {De Blasi, G. and Bouteyre, E. and Rollin, L.},
  title = {Consultation pluridisciplinaire d’aide à la reprise du travail après un cancer : des processus psychologiques en jeu dans la réinsertion professionnelle},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2012},
  volume = {73},
  number = {3},
  pages = {581--581},
  doi = {10.1016/j.admp.2012.03.686}
}

BibTeX:
@article{Gehanno2012f,
  author = {Gehanno, J.-F.},
  title = {L’information sur les dangers et les risques},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2012},
  volume = {73},
  number = {3},
  pages = {504--506},
  doi = {10.1016/j.admp.2012.02.032}
}

BibTeX:
@article{Griffon2012a,
  author = {Griffon, N et Devos, P et Gehanno, JF et Darmoni, SJ},
  title = {Existe-t-il une corrélation entre le score SIGAPS et les publications en français ?},
  month = {Septembre},
  journal = {La Presse Médicale},
  year = {2012},
  volume = {41},
  number = {9},
  pages = {e432–e435},
  doi = {10.1016/j.lpm.2012.03.015}
}

Abstract: Face au patient, le médecin n'a que très peu de temps disponible pour
consulter les informations médicales présentes dans le dossier patient,
les guides de bonnes pratiques ou les moteurs de recherche médicaux.
Une solution à  ce problème consiste à  proposer des outils graphiques
visuels permettant au médecin d'accéder très rapidement à  l'information,
comme le langage iconique Visualisation des connaissances médicales
(VCM) que nous avons proposé, il y a quelques années, pour représenter
à  l'aide d'icônes les principaux concepts médicaux : maladies, risques,
antécédents, traitements, examens... afin de faciliter la lecture
des monographies des médicaments. L'objectif du travail actuel est
d'étendre le langage VCM et de proposer de nouvelles applications
afin de résoudre les problèmes d'accès à  l'information rencontrés
par les médecins. Pour cela, nous avons d'abord analysé les difficultés
que les médecins généralistes et hospitaliers rencontre dans cette
tà¢che, puis nous en avons déduits les applications possibles et
les complémentations nécessaires à  apporter à  VCM. Nous avons
ensuite réalisé des prototypes de ces applications, qui sont en cours
d'évaluation.
BibTeX:
@article{Lamy,
  author = {Lamy, {J.-B.} and {Beuscart-Zéphir}, {M.-C.} and Boog, C. and Darmoni, S. and Favre, M. and Guigue, L. and Hamek, S. and Hassler, S. and Kerdelhué, G. and Leroy, N. and Mitouard, T. and Pereira, S. and Simon, C. and Venot, A. and Duclos, C.},
  title = {Langage iconique et interfaces interactives en médecine : application aux dossiers patients, guides de bonnes pratiques et moteurs de recherche médicaux},
  month = {April},
  journal = {{IRBM}},
  year = {2012},
  volume = {33},
  number = {2},
  pages = {129-136},
  url = {http://www.sciencedirect.com/science/article/pii/S1959031812000176},
  doi = {10.1016/j.irbm.2012.01.016}
}

Abstract: Cet article résume le travail de mise au point d'un outil d'analyse
du contenu textuel de dossiers hospitaliers afin d'y détecter des
indices permettant de suspecter des cas d'infections associées aux
soins. Des mécanismes de traitement de l'anonymat, de la terminologie,
des entités nommées, de la temporalité ont été mis au point, ainsi
qu'une caractérisation opérationnelle des scénarios à  risques. Les
résultats obtenus et les suites envisagées sont décrits dans cet
article.
BibTeX:
@article{Proux,
  author = {Proux, D. and Hagège, C. and Gicquel, Q. and Kergourlay, I. and Pereira, S. and Rondeau, G. and Darmoni, S. and Segond, F. and Metzger, {M.-H.}},
  title = {{ALADIN} : développement d'un outil sémantique d'analyse des documents textuels médicaux pour la détection d'infections associées aux soins},
  month = {April},
  journal = {{IRBM}},
  year = {2012},
  volume = {33},
  number = {2},
  pages = {137-142},
  url = {http://www.sciencedirect.com/science/article/pii/S195903181200019X},
  doi = {10.1016/j.irbm.2012.01.018}
}

BibTeX:
@article{Rollin2012b,
  author = {Rollin, L. and Boucher, L. and De Blasi, G. and Gehanno, J.-F.},
  title = {Apport d’une consultation pluridisciplinaire spécialisée dans le retour au travail après un cancer},
  journal = {Archives des Maladies Professionnelles et de l'Environnement},
  year = {2012},
  volume = {73},
  number = {3},
  pages = {393--394},
  doi = {10.1016/j.admp.2012.03.174}
}

BibTeX:
@inproceedings{Gehanno2012b,
  author = {Gehanno, J.-F.},
  title = {Information sur les dangers et les risques},
  booktitle = {32eme congres National de Médecine et Santé au Travail},
  address = {Clermont-Ferrand},
  month = {June},
  year = {2012}
}

BibTeX:
@inproceedings{Gehanno2012c,
  author = {Gehanno, J.-F.},
  title = {Grossesse et travail},
  booktitle = {Salon de Gynécologie Obstétrique Pratique},
  address = {Paris},
  month = {March},
  year = {2012}
}

BibTeX:
@inproceedings{Braeckman2012,
  author = {Braeckman, L and Valcke, M and van Dik, F and Gehanno, JF and Pauncu, EA and Popescu, F and Hanna, M and Bulat, P},
  title = {{EMUTOM} : A European Module on Undergraduate Teaching in Occupational Medicine},
  booktitle = {30th International Congress on Occupational Health},
  month = {March},
  publisher = {Icoh},
  year = {2012},
  url = {http://icoh.confex.com/icoh/2012/webprogram/Paper8046.html}
}

BibTeX:
@inproceedings{Darmoni2012,
  author = {Darmoni, SJ and Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Dutoit, D},
  title = {Combining WordNet and Crosslingual multi-terminology health portal to access health information},
  booktitle = {6th International Global Wordnet Conference (GWC2012)},
  address = {Matsue, Japan},
  month = {January},
  year = {2012},
  pages = {94-99},
  url = {http://lang.cs.tut.ac.jp/gwc2012/index.html}
}

Abstract: Background: The Catalogue of French-speaking health resources available
on the Internet (French acronym: CISMeF) is a portal that gathers
French medical Web resources (n 90,000). Doc'UMVF is a semantic search
engine that allows searching in this database but filtering only
medical teaching materials (n=9,697). Currently, Doc'UMVF is based
on multi-terminology indexing, consequently, it works with the French
(n 500,000) and English terms (n 1,000,000) of the 32 terminologies
included in information system (IS). Using terminologies translated
in other language than only French and English would allow cross
lingual indexing and information retrieval of teaching material.
Objective: To make Doc'UMVF working in several languages. Method:
Some terminologies integrated in CISMeF IS have been translated in
numerous languages (e.g. International classification of disease,
tenth revision, is available in 11 languages, Medical Subject Heading
in 16 languages, etc). An enhanced version of the IS was necessary
to manage multiple translations and Doc'UMVF has to be adapted to
this new IS. Results: HeTOP is a portal that allows cross lingual
access to multiple terminologies. A semantic search engine based
on such tool could be useful in at least two use-cases. First, for
resources that exist in numerous languages, like European Medical
Agency (EMA) resources, there is only need for one indexing in one
language to allow their retrieval in many European languages. Second,
this provides a language independent tool: any teacher, whatever
his speaking language was, may index his own teaching material in
his own language and any student, whatever his speaking language
was, may find it. Conclusions: Doc'UMVF will soon work in the new
IS. Nevertheless, its natural language processing tools work only
in French, therefore its use should be reserved to advanced user
(those who know terminologies). There is not too much development
to achieve an operational language independent search engine dedicated
to teaching material.
BibTeX:
@inproceedings{Griffon2012d,
  author = {Griffon, N and Darmoni, SJ},
  title = {A cross lingual semantic search engine dedicated to medical teaching resources},
  booktitle = {MEI - Medical Education Informatics},
  address = {Thessaloniki, Greece},
  month = {April},
  year = {2012},
  url = {http://www.mei2012.org/content/cross-lingual-semantic-search-engine-dedicated-medical-teaching-resources}
}

BibTeX:
@inproceedings{Griffon2012b,
  author = {Griffon, N and Savoye-Collet, C and Massari, P and Daniel, C and Darmoni, SJ},
  title = {An interface terminology for medical imaging ordering purposes},
  booktitle = {AMIA Annual Symposium proceedings},
  address = {Chicago},
  month = {November},
  year = {2012},
  pages = {1237--1243},
  url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540496/}
}

Abstract: The Health Terminology/Ontology Portal (HeTOP) was developed to provide
easy access to health terminologies and ontologie. The repository
is not only dedicated to professionals but is also a valuable teaching
tool. Currently, it provides access to thirty two health terminologies
and ontologies available mainly in French or in English, but also
in German, Italian, Chinese, etc. HeTOP can be used by both humans
and computers via Web services. To integrate new resources into HeTOP,
three steps are necessary: (1) designing a meta-model into which
each terminology (or ontology) can be integrated, (2) developing
a process to include terminologies into HeTOP, (3) building and integrating
existing and new inter &amp; intra-terminology semantic harmonization
into HeTOP. Currently, 600 unique machines use the MeSH version of
HeTOP every day and restricted terminologies/ontologies are used
for teaching purposes in several medical schools in France. The multilingual
version of HeTOP is available (URL: http://hetop.eu/) and provides
free access to ICD10 and FMA in ten languages. Conclusion: HeTOP
is a rich tool, useful for a wide range of applications and users,
especially in education and resource indexing but also in information
retrieval or performing audits in terminology management.
BibTeX:
@inproceedings{Grosjean2012a,
  author = {Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Darmoni, SJ},
  title = {Teaching medicine with a terminology/ontology portal},
  booktitle = {MIE},
  address = {Pisa, Italy},
  month = {August},
  journal = {Stud Health Technol Inform},
  year = {2012},
  volume = {180},
  pages = {949-53},
  doi = {10.3233/978-1-61499-101-4-949}
}

Abstract: Because of the ever-increasing amount of information in patients'
EHRs, healthcare professionals may face difficulties for making diagnoses
and/or therapeutic decisions. Moreover, patients may misunderstand
their health status. These medical practitioners need effective tools
to locate in real time relevant elements within the patients' EHR
and visualize them according to synthetic and intuitive presentation
models. The RAVEL project aims at achieving this goal by performing
a high profile industrial research and development program on the
EHR considering the following areas: (i) semantic indexing, (ii)
information retrieval, and (iii) data visualization. The RAVEL project
is expected to implement a generic, loosely coupled to data sources
prototype so that it can be transposed into different university
hospitals information systems.
BibTeX:
@inproceedings{Thiessard2012,
  author = {Thiessard, F and Mougin, F and Diallo, G and Jouhet, V and Cossin, S and Garcelon, N and Campillo, B and Jouini, W and Grosjean, J and Massari, P and Griffon, N and Dupuch, M and Tayalati, F and Dugas, E and Balvet, A and Grabar, N and Pereira, S and Frandji, B and Darmoni, SJ and Cuggia, M},
  title = {RAVEL: Retrieval And Visualization in ELectronic health records.},
  booktitle = {Quality of Life through Quality of Information - Proceedings of MIE2012},
  journal = {Stud Health Technol Inform},
  year = {2012},
  volume = {180},
  pages = {194--198},
  doi = {10.3233/978-1-61499-101-4-194}
}

BibTeX:
@inproceedings{Bouhaddou2011,
  author = {Bouhaddou, O and Darmoni, SJ and Thonnet, M},
  title = {Expérience avec le réseau national d'échange d'information médicale aux USA.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {287-296},
  url = {http://www.springerlink.com/content/r6318566m2w01705/},
  doi = {10.1007/978-2-8178-0285-5_25}
}

BibTeX:
@inproceedings{Dirieh2011,
  author = {Dirieh Dibad, AD and Soualmia, LF and Merabti, T and Grosjean, J and Sakji, S and Massari, P and Darmoni, SJ},
  title = {Un modèle de données adapté à la recherche d'information dans le dossier patient informatisé : étude, conception et évaluation.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {251-262},
  url = {http://www.springerlink.com/content/rx6402278w6m7863/},
  doi = {10.1007/978-2-8178-0285-5_22}
}

BibTeX:
@inproceedings{Griffon2012c,
  author = {Griffon, N and Massari, P and Joubert, M and Staccini, P and Darmoni, SJ},
  title = {Pertinence médicale des cooccurrences diagnostic-acte dans les résumés standardisés de sortie},
  booktitle = {PCSI (Patient Classification Systems International)},
  address = {Avignon, France},
  month = {October},
  year = {2012}
}

BibTeX:
@inproceedings{Joubert2011a,
  author = {Joubert, M and Vandenbussche, PY and Dahamna, B and Abdoune, H and Merabti, T and Pereira, S and Boyer, C and Staccini, P and Forget, JF and Delahousse, J and Darmoni, SJ and Fieschi, M},
  title = {InterSTIS : interopérabilité sémantique de terminologies de santé francophones.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  year = {2012},
  series = {Informatique et Santé},
  pages = {73-83},
  url = {www.springerlink.com/content/r7h673g11160384g/},
  doi = {10.1007/978-2-8178-0285-5_7}
}

BibTeX:
@inproceedings{Merabti2012b,
  author = {Merabti, T and Soualmia, LF and Grosjean, J and Joubert, M and Darmoni, SJ},
  title = {Méthodes d'alignement de terminologies médicales et leur intégration dans un portail},
  booktitle = {IC'2012 : Atelier IC pour l'intéropérabilité sémantique dans les applications en e-Santé},
  address = {Paris, France},
  year = {2012},
  url = {https://sites.google.com/site/icisante2012/programme}
}

BibTeX:
@inproceedings{Metzger2011,
  author = {Metzger, MH and Gicquel, Q and Kergourlay, I and Cluze, C and Grandbastien, B and Berrouane, Y and Tavolacci, MP and Segond, F and Pereira, S and Darmoni, SJ},
  title = {Codage standardisé de données médicales textuelles à l'aide d'un serveur multi-terminologique de santé : exemple d'application en épidémiologie hospitalière.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  year = {2012},
  series = {Informatique et Santé},
  pages = {109-120},
  doi = {10.1007/978-2-8178-0285-5_10}
}

BibTeX:
@inproceedings{Moalla2011,
  author = {Moalla, Z and Soualmia, LF and Prieur-Gaston, E and Darmoni, SJ},
  title = {Correction orthographique de requêtes : l'apport des distances de Levenshtein et Stoilos.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {3-12},
  url = {http://link.springer.com/chapter/10.1007%2F978-2-8178-0285-5_1},
  doi = {10.1007/978-2-8178-0285-5_1}
}

BibTeX:
@inproceedings{Pereira2011,
  author = {Pereira, S and Letord, C and Darmoni, SJ and Serrot, E},
  title = {Extraction des noms de médicaments dans les comptes rendus hospitaliers.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {145-153},
  doi = {10.1007/978-2-8178-0285-5_13}
}

BibTeX:
@inproceedings{Sakji2011,
  author = {Sakji, S and Elkin, P and Darmoni, SJ},
  title = {Évaluation de l'indexation des comptes rendus médicaux à l'aide d'un outil états-unien adapté pour le français.},
  booktitle = {Systèmes d'information pour l'amélioration de la qualité en santé. Comptes rendus des quatorzièmes Journées francophones d'informatique médicale (JFIM).},
  address = {Tunis},
  month = {Septembre},
  publisher = {Springer},
  year = {2012},
  series = {Informatique et Santé},
  pages = {155-163},
  doi = {10.1007/978-2-8178-0285-5_14}
}

Abstract: The European Health Terminology/ Ontology Portal (EHTOP) is a repository
dedicated to European health professionals and students. Currently,
it provides access to terminologies and ontologies available in French
or in English, but also in German, Italian, Dutch, Spanish, Danish
and other 17 languages. EHTOP can be used by humans and by computers
via Web services. The main objective of EHTOP is to provide an access
to terminologies and ontologies, allowing dynamic browsing and navigation.
Methods: To integrate terminologies and ontologies into EHTOP, three
steps are necessary: (1) designing a meta-model into which each terminology
and ontology can be integrated, (2) developing a process to include
terminologies into EHTOP, (3) building and integrating existing and
new inter & intra-terminology semantic harmonization into EHTOP.
Results: EHTOP is available freely for the ICD-10 and the FMA (URL:
http://www.ehtop.eu/). The access to other terminologies/ontologies
(MeSH, SNOMED CT, WHO-ATC, ...) is restricted and available only
for the scientific community. A total of 32 terminologies are included
into EHTOP, with 980,000 concepts, 2,300,000 synonyms, 222,800 definitions
and 4,000,000 relations. Since January 2010, the bilingual version
of EHTOP is daily used by CISMeF librarians to index health resources
in the CISMeF catalogue in a multi-terminology mode. Currently, 600
unique machines are using this bilingual version, whereas 300 users
are already registered. Conclusion: EHTOP is a rich tool, useful
for a wide range of applications and users for educational purpose,
resources indexing, information retrieval or performing audits in
terminology management.
BibTeX:
@inproceedings{Grosjean2012,
  author = {Grosjean, J and Kerdelhué, G and Merabti, T and Darmoni, SJ},
  title = {The EHTOP: indexing Health resources in a multi-terminology/ontology and cross-lingual world},
  booktitle = {EAHIL 2012},
  year = {2012}
}

BibTeX:
@inproceedings{Coutant2012,
  author = {Coutant, S and Cabot, C and Tair, W and Lefebvre, A and Léonard, M and Prieur-Gaston, E and Campion, D and Lecroq, T and Dauchel, H},
  title = {EVA: Exome Variation Analyzer, A tool for filtering strategies in medical genomics},
  booktitle = {13e édition du colloque JOBIM (Journées Ouvertes en Biologie, Informatique et Mathématiques)},
  year = {2012},
  url = {http://jobim2012.inria.fr/jobim_actes_2012_online.pdf}
}

BibTeX:
@inproceedings{Diallo2012,
  author = {Diallo, G and Grabar, N and Thiessard, F and Garcelon, N and Grosjean, J and Dupuch, M and Pereira, S and Frandji, B and Darmoni, SJ and Cuggia, M},
  title = {Towards complex queries on data from complex patients},
  booktitle = {AMIA},
  address = {Chicago, Illinois},
  month = {November},
  year = {2012}
}

BibTeX:
@inproceedings{Gehanno2012e,
  author = {Gehanno, JF and Bulat, P and Smits, P and Dijk, E and Pauncu, E and Popescu, F and Jarreta, BM and Hanna, M and Chaudry, A and Braeckman, L},
  title = {Undergraduate occupational medicine teaching in european schools of medicine},
  booktitle = {30th International Congress on Occupational Health},
  address = {Cancun, Mexico},
  year = {2012}
}

BibTeX:
@inproceedings{Grosjean2012b,
  author = {Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Soualmia, LF and Darmoni, SJ},
  title = {Multi-terminology cross-lingual model to create the Health Terminology/Ontology Portal},
  booktitle = {AMIA},
  address = {Chicago},
  year = {2012}
}

BibTeX:
@inproceedings{Grosjean2012c,
  author = {Grosjean, J and Soualmia, LF and Merabti, T and Griffon, N and Dahamna, B and Darmoni, SJ},
  title = {Cross-lingual access to biomedical terminologies and ontologies},
  booktitle = {SWAT4LS (Semantic Web Applications and Tools for Life Sciences) Workshop},
  month = {November},
  year = {2012},
  note = {Poster},
  url = {http://ceur-ws.org/Vol-952/paper_17.pdf}
}

BibTeX:
@inproceedings{Merabti2012a,
  author = {Merabti, A and Soualmia, LF and Darmoni, SJ},
  title = {Extracting correspondences between terminologies for an easier access to biomedical information},
  booktitle = {Nettab2012},
  address = {Como, Italy},
  month = {November},
  year = {2012},
  pages = {127-129},
  url = {http://journal.embnet.org/index.php/embnetjournal/article/view/576}
}

BibTeX:
@inproceedings{Smits2012,
  author = {Smits, P and Braeckman, L and Dijk, E and Gehanno, JF and Pauncu, E and Popescu, F and Hanna, M and Bulat, P},
  title = {What every doctor should know about work and health : a needs analysis in six european countries},
  booktitle = {30th International Congress on Occupational Health},
  address = {Cancun, Mexico},
  year = {2012}
}

BibTeX:
@inbook{Duclos2013,
  author = {Duclos, C and Burgun, A and Lamy, JB and Landais, P and Rodrigues, JM and Soualmia, L and Zweigenbaum, P},
  title = {Informatique Médicale, e-Santé - Fondements et applications},
  publisher = {Springer},
  year = {2012},
  url = {http://www.springer.com/public+health/book/978-2-8178-0337-1}
}

BibTeX:
@incollection{Merabti2012,
  author = {Merabti, T and Soualmia, {LF} and Grosjean, J and Joubert, M and Darmoni, {SJ}},
  title = {Aligning Biomedical Terminologies in French: Towards Semantic Interoperability in Medical Applications},
  booktitle = {Medical Informatics},
  month = {March},
  publisher = {{InTech}},
  year = {2012},
  pages = {41--68},
  url = {http://www.intechopen.com/books/indexing/medical-informatics/methods-to-map-biomedical-terminologies-in-french-contribution-to-semantic-interoperability-between-}
}

BibTeX:
@inbook{Soualmia2012a,
  author = {Soualmia, LF and Dahamna, B and Darmoni, SJ},
  title = {eHealth and Remote Monitoring},
  year = {2012},
  pages = {35-62},
  url = {http://www.intechopen.com/books/ehealth-and-remote-monitoring/supporting-e-health-information-seekers-from-simple-strategies-to-knowledge-based-methods},
  doi = {10.5772/50348}
}

BibTeX:
@inbook{Venot2012,
  author = {Venot, A and Charlet, J and Darmoni, SJ and Duclos, C and Dufour, JC and Soualmia, LF},
  title = {Informatique Médicale, e-Santé - Fondements et applications},
  publisher = {Springer},
  year = {2012},
  url = {http://www.springer.com/public+health/book/978-2-8178-0337-1}
}

BibTeX:
@phdthesis{DiriehDibad2012,
  author = {Dirieh Dibad, AD},
  title = {Recherche d'information multi-terminologique - Application au Dossier patient Informatisé},
  school = {University of Rouen, France and University of Djibouti},
  year = {2012},
  url = {http://www.chu-rouen.fr/cismef/wp/wp-content/uploads/2017/01/theseDIRIEHDIBADAumedDiouf_LITISCISMeF_VFF.pdf}
}

2011


Abstract: Outer-membrane-vesicle vaccines for meningococcal B outbreaks are complex and time consuming to develop. We studied the use of already available vaccine to control an outbreak caused by a genetically close strain. From 2006 to 2009, all individuals younger than 20 years living in the region of Normandy, France, in which an outbreak caused by a B:14:P1.7,16 strain occurred, were eligible to receive MenBvac, a Norwegian vaccine designed 20 years earlier against a strain sharing the same serosubtype (B:15:P1.7,16). The immunogenicity (in a randomly selected cohort of 400 children aged 1-5 years), safety, and epidemiological effect of the vaccination were assessed. 26,014 individuals were eligible to receive the vaccine. Shortage of vaccine production prompted start of the campaign in the highest incidence groups (1-5 years). 16,709 (64%) received a complete vaccination schedule of whom 13,589 (81%) received a 2+1 dose schedule (week 0, week 6, and month 8). At 6 weeks after the third dose, of 235 vaccinees for whom samples were available, 206 (88%) had a seroresponse, and 108 (56 %) of 193 had a seroresponse at 15 months. These results were similar to those described for tailor-made vaccines and their homologous strain. Only previously described adverse effects occurred. The incidence of B:14:P1.7,16 cases decreased significantly in the vaccine targeted population after the primary vaccination period (from 31·6 per 100,000 to 5·9 per 100,000; p=0·001). The ready-to-wear approach is reliable if epidemic and vaccine strains are genetically close. Other meningococcal B clonal outbreaks might benefit from this strategy; and previously described outer-membrane-vesicle vaccines can be effective against various strains. French Ministry of Health.
BibTeX:
@article{Caron2011,
  author = {Caron, François and du Châtelet, Isabelle Parent and Leroy, Jean-Philippe and Ruckly, Corinne and Blanchard, Myriam and Bohic, Nicole and Massy, Nathalie and Morer, Isabelle and Floret, Daniel and Delbos, Valérie and Hong, Eva and Révillion, Martin and Berthelot, Gilles and Lemée, Ludovic and Deghmane, Ala-Eddine and Bénichou, Jacques and Lévy-Bruhl, Daniel and Taha, Muhamed-Kheir},
  title = {From tailor-made to ready-to-wear meningococcal B vaccines: longitudinal study of a clonal meningococcal B outbreak.},
  month = {June},
  journal = {The Lancet. Infectious diseases},
  year = {2011},
  volume = {11},
  pages = {455--463},
  doi = {10.1016/S1473-3099(11)70027-5}
}

Abstract: BACKGROUND:General practitioners and medical specialists mainly rely
on one "general medical" journal to keep their medical knowledge
up to date. Nevertheless, it is not known if these journals display
the same overview of the medical knowledge in different specialties.
The aims of this study were to measure the relative weight of the
different specialties in the major journals of general medicine,
to evaluate the trends in these weights over a ten-year period and
to compare the journals.METHODS:The 14,091 articles published in
The Lancet, the NEJM, the JAMA and the BMJ in 1997, 2002 and 2007
were analyzed. The relative weight of the medical specialities was
determined by categorization of all the articles, using a categorization
algorithm which inferred the medical specialties relevant to each
article MEDLINE file from the MeSH terms used by the indexers of
the US National Library of Medicine to describe each article.RESULTS:The
14,091 articles included in our study were indexed by 22,155 major
MeSH terms, which were categorized into 81 different medical specialties.
Cardiology and Neurology were in the first 3 specialties in the 4
journals. Five and 15 specialties were systematically ranked in the
first 10 and first 20 in the four journals respectively. Among the
first 30 specialties, 23 were common to the four journals. For each
speciality, the trends over a 10-year period were different from
one journal to another, with no consistency and no obvious explanatory
factor.CONCLUSIONS:Overall, the representation of many specialties
in the four journals in general and internal medicine included in
this study may differ, probably due to different editorial policies.
Reading only one of these journals may provide a reliable but only
partial overview.
BibTeX:
@article{Gehanno2011,
  author = {Gehanno, JF and Ladner, J and Rollin, L and Dahamna, B and Darmoni, SJ},
  title = {How are the different specialties represented in the major journals in general medicine?},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2011},
  volume = {11},
  number = {1},
  pages = {3},
  doi = {10.1186/1472-6947-11-3}
}

Abstract: BACKGROUND:The identification of patients who pose an epidemic hazard
when they are admitted to a health facility plays a role in preventing
the risk of hospital acquired infection. An automated clinical decision
support system to detect suspected cases, based on the principle
of syndromic surveillance, is being developed at the University of
Lyon's Hopital de la Croix-Rousse. This tool will analyse structured
data and narrative reports from computerized emergency department
(ED) medical records. The first step consists of developing an
application (UrgIndex) which automatically extracts and encodes
information found in narrative reports. The purpose of the present
article is to describe and evaluate this natural language processing
system.METHODS:Narrative reports have to be pre-processed before
utilizing the French-language medical multi-terminology indexer (ECMT)
for standardized encoding. UrgIndex identifies and excludes syntagmas
containing a negation and replaces non-standard terms (abbreviations,
acronyms, spelling errors...). Then, the phrases are sent to the
ECMT through an Internet connection. The indexer's reply, based
on Extensible Markup Language, returns codes and literals corresponding
to the concepts found in phrases. UrgIndex filters codes corresponding
to suspected infections. Recall is defined as the number of relevant
processed medical concepts divided by the number of concepts evaluated
(coded manually by the medical epidemiologist). Precision is defined
as the number of relevant processed concepts divided by the number
of concepts proposed by UrgIndex. Recall and precision were assessed
for respiratory and cutaneous syndromes.RESULTS:Evaluation of 1,674
processed medical concepts contained in 100 ED medical records
(50 for respiratory syndromes and 50 for cutaneous syndromes) showed
an overall recall of 85.8% (95% CI: 84.1-87.3). Recall varied
from 84.5% for respiratory syndromes to 87.0% for cutaneous syndromes.
The most frequent cause of lack of processing was non-recognition
of the term by UrgIndex (9.7. Overall precision was 79.1% (95%
CI: 77.3-80.8). It varied from 81.4% for respiratory syndromes
to 77.0% for cutaneous syndromes.CONCLUSIONS:This study demonstrates
the feasibility of and interest in developing an automated method
for extracting and encoding medical concepts from ED narrative
reports, the first step required for the detection of potentially
infectious patients at epidemic risk.
BibTeX:
@article{gerbier_evaluation_2011,
  author = {Gerbier, Solweig and Yarovaya, Olga and Gicquel, Quentin and Millet, {Anne-Laure} and Smaldore, Veronique and Pagliaroli, Veronique and Darmoni, Stefan and Metzger, {Marie-Helene}},
  title = {Evaluation of natural language processing from emergency department computerized medical records for intra-hospital syndromic surveillance},
  journal = {{BMC} Medical Informatics and Decision Making},
  year = {2011},
  volume = {11},
  number = {1},
  pages = {50},
  url = {http://www.biomedcentral.com/1472-6947/11/50},
  doi = {10.1186/1472-6947-11-50}
}

BibTeX:
@article{Lefebvre2011,
  author = {Lefebvre, F and Merle, V and Savoye, G and Lemée, V and Chapuzet, C and Marini, H and Géhanno, J-F and Chefson-Girault, C and Gueit, I and Freymuth, F and Lerebours, E and Czernichow, P},
  title = {Nosocomial transmission of measles: do we need extra precautions to avoid it?},
  month = {October},
  journal = {The Journal of hospital infection},
  year = {2011},
  volume = {79},
  number = {2},
  pages = {185--187},
  doi = {10.1016/j.jhin.2011.05.025}
}

Abstract: BACKGROUND:The Foundational Model of Anatomy (FMA) is the reference
ontology regarding human anatomy. FMA vocabulary was integrated into
the Health Multi Terminological Portal (HMTP) developed by CISMeF
based on the CISMeF Information System which also includes 26 other
terminologies and controlled vocabularies, mainly in French. However,
FMA is primarily in English. In this context, the translation of
FMA English terms into French could also be useful for searching
and indexing French anatomy resources. Various studies have investigated
automatic methods to assist the translation of medical terminologies
or create multilingual medical vocabularies. The goal of this study
was to facilitate the translation of FMA vocabulary into French.METHODS:We
compare two types of approaches to translate the FMA terms into French.
The rst one is UMLS-based on the conceptual information of the UMLS
metathesaurus. The second method is lexically-based on several Natural
Language Processing (NLP) tools.RESULTS:The UMLS-based approach produced
a translation of 3,661 FMA terms into French whereas the lexical
approach produced a translation of 3,129 FMA terms into French. A
qualitative evaluation was made on 100 FMA terms translated by each
method. For the UMLS-based approach, among the 100 translations,
52% were manually rated as "very good" and only 7% translations as
"bad". For the lexical approach, among the 100 translations, 47%
were rated as "very good" and 20% translations as "bad".CONCLUSIONS:Overall,
a low rate of translations were demonstrated by the two methods.
The two approaches permitted us to semi-automatically translate 3,776
FMA terms from English into French, this was to added to the existing
10,844 French FMA terms in the HMTP (4,436 FMA French terms and 6,408
FMA terms manually translated).
BibTeX:
@article{Merabti2011b,
  author = {Merabti, Tayeb and Soualmia, Lina and Grosjean, Julien and Palombi, Olivier and Muller, Jean-Michel and Darmoni, SJ},
  title = {Translating the Foundational Model of Anatomy into French using knowledge-based and lexical methods},
  journal = {BMC Medical Informatics and Decision Making},
  year = {2011},
  volume = {11},
  number = {1},
  pages = {65},
  url = {http://www.biomedcentral.com/1472-6947/11/65},
  doi = {10.1186/1472-6947-11-65}
}

Abstract: Contexte La prolifération des documents liés à la santé des individus
pose aujourd'hui le problème de leur indexation et de leur recherche
dans de vastes bases de données.Objectif Si l'on veut indexer d'autres
types de documents que des documents pédagogiques ou de la documentation
scientifique, il faut être capable d'indexer des comptes rendus cliniques,
des résultats d'examens, des courriers, etc.Matériel et méthode
Des terminologies à visées différentes sont alors utilisées : la
SNOMED pour le codage d'informations cliniques, la CIM-10 et
la CCAM pour le codage épidémiologique et médico-économique, la
CISP utilisée par les médecins généralistes, etc. Le but d'InterSTIS
était de les unifier et de les rendre interopérables au sein d'un
« serveur terminologique multi-sources ». InterSTIS exploite des
sources de connaissance de UMLS issues de la National Library of
Medicine des États-Unis pour rendre ces terminologies interopérables.Résultat
Un serveur terminologique multi-sources opérationnel apte à délivrer
des services à des utilisateurs et à des applications. InterSTIS
a commencé en janvier 2008 et s'est fini en décembre 2010.
BibTeX:
@article{Joubert2011,
  author = {Joubert, M and le consortium du projet InterSTIS},
  title = {Interopérabilité sémantique de terminologies de santé francophones},
  journal = {{IRBM}},
  year = {2011},
  volume = {32},
  number = {2},
  pages = {80-82},
  url = {http://www.sciencedirect.com/science/article/B94S6-5295K6S-6/2/2a900945a16a740449bd22d6bb379b7a},
  doi = {10.1016/j.irbm.2011.01.030}
}

Abstract: Depuis 2007, 44 chefs de clinique de médecine générale (CCA-MG) ont
été nommés au sein des facultés de médecine françaises. L’étude descriptive
réalisée en 2008 et 2009 par l’association des chefs de clinique
montrait que leur activité était très hétérogène. Malgré la montée
en charge progressive de la filière universitaire (avec en moyenne
15 nouveaux chefs de clinique par an), une insuffisance de visibilité
et de lisibilité sur l’activité des CCA-MG résultait de l’absence
de texte réglementaire encadrant cette activité.
BibTeX:
@article{Schuers2011,
  author = {Schuers, M.},
  title = {Quel modèle pour le clinicat de médecine générale ?},
  journal = {exercer, la revue francophone de médecine générale},
  year = {2011},
  number = {95 suppl 1},
  pages = {38--9}
}

BibTeX:
@inproceedings{Gehanno2011c,
  author = {Gehanno, JF},
  title = {Des indicateurs pour changer les pratiques ou des pratiques pour changer des indicateurs ?},
  booktitle = {31èmes Journées Nationales de santé au travail dans le BTP},
  address = {Versailles, France},
  month = {Mai},
  year = {2011}
}

BibTeX:
@inproceedings{Gehanno2012d,
  author = {Gehanno, JF},
  title = {Accès à la connaissance par l'utilisation des bases de données via Internet},
  booktitle = {26èmes Journées Internationales Méditerranéennes de Médecine du Travail},
  address = {Rennes, France},
  month = {Mai},
  year = {2011}
}

Abstract: Background: the Core Subset of SNOMED CT is part of the UMLS-Core
Project dedicated to study problem list vocabularies. SNOMED CT is
not yet translated into French. Objective: to propose an automated
method to assist the translation of the CORE Subset of SNOMED CT
into French. Material: the 2009 AA versions of the CORE Subset of
SNOMED CT and UMLS; use of four French-language terminologies integrated
into the UMLS Metathesaurus: SNOMED International, ICD10, MedDRA,
and MeSH. Method: an exact mapping completed by a close mapping between
preferred terms of the CORE Subset of SNOMED CT and those of the
four terminologies. Results: 89% of the preferred terms of the CORE
Subset of SNOMED CT are mapped with at least one preferred term in
one of the four terminologies. Discussion: if needed, synonymous
terms could be added by the means of synonyms in the terminologies;
the proposed method is independent from French and could be applied
to other natural languages.
BibTeX:
@inproceedings{Abdoune2011,
  author = {Abdoune, H and Merabti, T and Darmoni SJ and Joubert, M},
  title = {Assisting the translation of the CORE Subset of SNOMED CT into French},
  booktitle = {User Centred Networked Health Care - Proceedings of MIE 2011},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {169},
  pages = {819-823},
  doi = {10.3233/978-1-60750-806-9-819}
}

BibTeX:
@inproceedings{Ammenwerth2011,
  author = {Ammenwerth, E and Hackl, WO and Massari, P and Darmoni, SJ},
  title = {Validation of Completeness, Correctness, Relevance and Understandability of the PSIP CDSS for Medication Safety},
  booktitle = {Patient Safety Informatics - Adverse Drug Events, Human Factors and IT Tools for Patient Medication Safety},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {166},
  pages = {254-259},
  note = {PSIP},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=19731},
  doi = {10.3233/978-1-60750-740-6-254}
}

BibTeX:
@inproceedings{Golbreich2011,
  author = {Golbreich, C and Grosjean, J and Darmoni, SJ},
  title = {The FMA in OWL 2},
  booktitle = {AIME},
  publisher = {Springer-Verlag},
  year = {2011},
  volume = {6747},
  pages = {204-214},
  url = {http://www.springer.com/computer/ai/book/978-3-642-22217-7},
  doi = {10.1007/978-3-642-22218-4_25}
}

Abstract: Background: Following a recent change in the indexing policy for French
quality controlled health gateway CISMeF, multiple terminologies
are now being used for indexing in addition to MeSH®. Objective:
To evaluate precision and recall of super-concepts for information
retrieval in a multi-terminology paradigm compared to MeSH-only.
Methods: We evaluate the relevance of resources retrieved by multi-terminology
super-concepts and MeSH-only super-concepts queries. Results: Recall
was 8-14% higher for multi-terminology super-concepts compared to
MeSH only super-concepts. Precision decreased from 0.66 for MeSH
only super-concepts to 0.61 for multi-terminology super-concepts.
Retrieval performance was found to vary significantly depending on
the super-concepts (p<10-4) and indexing methods (manual vs automatic;
p<0.004). Conclusion: A multi-terminology paradigm contributes to
increase recall but lowers precision. Automated tools for indexing
are not accurate enough to allow a very precise information retrieval.
BibTeX:
@inproceedings{Griffon2011,
  author = {Griffon, N and Soualmia LF and Névéol, A and Massari P and Thirion B and Dahamna, B and Darmoni, SJ},
  title = {Evaluation of Multi-Terminology Super-Concepts for Information Retrieval},
  booktitle = {User Centred Networked Health Care - Proceedings of MIE 2011},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {169},
  pages = {492-496},
  doi = {10.3233/978-1-60750-806-9-492}
}

BibTeX:
@inproceedings{Grosjean2011a,
  author = {Grosjean, J and Merabti, T and Dahamna, B and Kergourlay, I and Thirion B and Soualmia LF and Darmoni, SJ},
  title = {Health Multi-Terminology Portal: a semantics added-value for patient safety},
  booktitle = {Patient Safety Informatics - Adverse Drug Events, Human Factors and IT Tools for Patient Medication Safety},
  year = {2011},
  series = {Studies in Health Technology and Informatics},
  volume = {166},
  pages = {129-138},
  note = {PSIP},
  url = {http://www.booksonline.iospress.nl/Content/View.aspx?piid=19716},
  doi = {10.3233/978-1-60750-740-6-129}
}

BibTeX:
@inproceedings{Grosjean2011b,
  author = {Grosjean, J and Merabti, T and Griffon, N and Dahamna, B and Darmoni SJ},
  title = {Multiterminology cross-lingual model to create the European Health Terminology/Ontology Portal},
  booktitle = {Short papers of the 9th International Conference on Terminology and Artificial Intelligence, TIA},
  address = {Paris},
  month = {November},
  year = {2011},
  pages = {119-122},
  url = {http://tia2011.crim.fr/Proceedings/pdf/TIA20.pdf}
}